Sleep drug sparks hope for tough depression in seniors
NCT ID NCT04680910
First seen Apr 28, 2026 · Last updated May 20, 2026 · Updated 1 time
Summary
This early-phase study tested whether a carefully controlled dose of propofol, a drug used for sedation, could safely improve brain wave patterns linked to deep sleep in 16 older adults with treatment-resistant depression. Participants received two propofol infusions days apart while researchers monitored brain activity and safety. The main goal was to see if the approach was safe and could boost slow brain waves during sleep, which are often reduced in depression.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Washington University School of Medicine/Barnes-Jewish Hospital
St Louis, Missouri, 63110, United States
Conditions
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