Washington University School Of Medicine

This study tests a personalized DNA vaccine designed to target unique markers on a child's tumor. It aims to see if the vaccine is safe and possible to make for children aged 12-25 with brain or spine tumors that have come back or not responded to treatment. The vaccine is custom…

This early-stage trial tests a personalized cancer vaccine for people with bladder or gastroesophageal cancer who have tiny amounts of cancer still detectable after surgery. The vaccine is custom-made from each patient's unique tumor markers and aims to train the immune system to…

This study tests whether the drug selinexor can safely help people with high-risk multiple myeloma stay in remission longer after CAR-T cell therapy. About 20 participants who have already received CAR-T will take selinexor pills as maintenance. The goal is to see if this approac…

This early-phase study tests whether adding the experimental drug zanzalintinib to two immunotherapy drugs (ipilimumab and nivolumab) is safe and can shrink tumors in people with metastatic soft tissue sarcoma. About 18 adults who have already tried 1 to 3 prior treatments will r…

This study compares two treatments for moderate-to-severe obstructive sleep apnea in people who cannot use a CPAP machine. One treatment is a custom mouthpiece that moves the jaw forward, and the other is a surgically implanted device that stimulates a nerve to keep the airway op…

This study looks at two ways to help pregnant people and new mothers with substance use disorder stay in treatment. One way is to screen for social needs like housing or childcare and connect them to community help. The other uses small rewards to encourage healthy behaviors. The…

This study tests whether propranolol, a safe oral drug used for heart conditions, can shrink Kaposi sarcoma tumors in adults. About 25 participants with measurable skin lesions will receive the drug, and researchers will check if at least 45% of patients see their tumors shrink o…

This study tests a combination of two drugs (polatuzumab vedotin and rituximab) as the first treatment for a rare blood cancer called PTLD that can occur after an organ or stem cell transplant. The goal is to see if this combo is safe and works better than the current standard, w…

This early-phase trial tests whether adding the experimental drug emavusertib to standard chemotherapy and immunotherapy can help people with advanced bile duct or gallbladder cancer. About 48 adults who have not had prior treatment for their advanced cancer will receive the comb…

This study compares two different schedules of the chemotherapy drug 5-FU in people with advanced head and neck cancer that has not responded to platinum and immunotherapy. The goal is to see which schedule works better at shrinking tumors and has fewer side effects. About 46 par…

This study tests a bone marrow transplant from a partially matched family donor for children under 21 with severe non-cancer diseases like sickle cell disease, bone marrow failure, or immune disorders. The goal is to see if the transplant can safely replace the diseased bone marr…

This study tests whether adding a behavioral weight loss program to standard hormone therapy helps premenopausal women with obesity and early endometrial cancer or precancer keep their uterus and fertility. About 96 women will receive either hormone therapy plus the weight loss p…

This study tests whether statins, a common cholesterol-lowering drug, can help people with early blood disorders called CCUS and lower-risk MDS. These conditions can progress to more serious blood cancers, and there are no approved treatments to prevent that. The study will measu…

This study looks at whether nerve transfer surgery can improve arm function and quality of life for people with high-level spinal cord injuries (C1-C4). Thirty adults who have stopped recovering naturally will receive standard nerve transfer surgery and be followed for up to 4 ye…

This study tests two programs for people recovering from a stroke who are leaving inpatient rehab to go home. Half of the 520 participants will get a stroke education program, and the other half will get a program that helps modify their home environment. The goal is to see which…

This early-phase study tests an oral drug called PMD-026 in 18 adults with myelofibrosis, a type of blood cancer. Participants must have already tried a JAK inhibitor without success. The main goals are to check safety, find the right dose, and see if the drug can shrink the sple…

This study is for people with HPV-related throat cancer. After surgery, patients receive lower doses of radiation or chemo based on their risk level. The goal is to see if these reduced treatments can still prevent cancer from coming back while causing fewer side effects. About 1…

This study is for people with myelodysplastic syndromes (MDS) who have had a stem cell transplant but still have tiny amounts of cancer cells left (called measurable residual disease). The goal is to see if giving a drug called DEC-C early can lower the chance of the cancer retur…

This study tests whether adding two drugs (defactinib and avutometinib) to targeted radiation can help people with advanced pancreatic cancer live longer without their cancer growing. About 36 adults whose cancer is locally advanced or borderline resectable will receive the combi…

This study tests whether a simple, at-home treatment using a blood pressure cuff can improve heart health in people with spinal cord injury (SCI). The treatment, called remote ischemic conditioning (RIC), involves briefly inflating the cuff to restrict blood flow, then releasing …

This study tests whether personalized stop-smoking plans help cancer patients quit better than standard care. Researchers use each patient's health history, genes, and lab results to recommend the best medication. The goal is to see if more patients take and stick with quitting a…

This study tests whether adding a natural milk component (MFGM) to a standard therapeutic food can improve brain development and reduce death or hospitalization in 1,600 severely malnourished children aged 6–59 months in Sierra Leone. Children receive either the enhanced or stand…

This early-phase study tests whether two drugs, ruxolitinib and abatacept, can prevent graft-versus-host disease (GVHD) and cytokine release syndrome in people receiving a half-matched stem cell transplant for blood cancers. About 41 participants will take the drugs before and af…

This early-stage trial tests a new treatment called WS-CART-CS1 for people with multiple myeloma that has come back or not responded to at least three prior therapies. The treatment uses a patient's own immune cells, modified to target a protein called CS1 found on myeloma cells.…

This study tests a new drug, zanzalintinib, combined with standard chemotherapy (paclitaxel) for people with recurrent high-grade uterine or endometrial cancer. The goal is to find the best dose and see if the combination is safe and shrinks tumors. About 36 adults who have alrea…

This study looks at whether it is possible and acceptable to start hepatitis C treatment during pregnancy in women who have a history of drug use. About 50 pregnant adults will take the medication glecaprevir-pibrentasvir and be followed for one year. Researchers will measure how…

This early-stage trial tests a new drug (CA-4948) combined with standard chemotherapy and immunotherapy for people with untreated stomach or esophageal cancer that cannot be removed by surgery. The study includes two groups: one for HER2-negative cancer and one for HER2-positive …

This study looks at whether a simple blood test can help doctors decide early on if a treatment is working for people with a certain type of advanced breast cancer (HR+ HER2-). About 65 participants will start standard therapy, and those whose blood test shows a poor response wil…

This early-phase trial tests whether combining two drugs, zanzalintinib and eribulin, can help control advanced liposarcoma and leiomyosarcoma better than eribulin alone. About 18 adults whose cancer has worsened after prior treatment will receive the combination. The main goals …

This study tests a new way to choose pre-surgery treatment for postmenopausal women with stage II or III ER-positive, HER2-negative breast cancer. By using biomarkers, doctors aim to improve treatment response and possibly avoid chemotherapy for some patients. The trial enrolls 8…

This study tests whether adding palbociclib to cetuximab helps people with a certain genetic type of head and neck cancer live longer compared to cetuximab alone. The cancer must be HPV-unrelated and have a CDKN2A gene change, and participants must have already tried a PD-1/L1 in…

This study tests a new drug called ONT01 combined with standard chemotherapy (gemcitabine and nab-paclitaxel) for people with metastatic pancreatic cancer that has worsened after initial treatment. The goal is to see if ONT01 can reprogram immune cells in the tumor to make the ch…

This study tests whether a very-low-carbohydrate ketogenic diet can safely improve blood sugar control in adults with type 1 diabetes. Researchers will monitor blood sugar levels, insulin needs, and muscle insulin sensitivity in 58 participants over the study period. The goal is …

This study tests two different daily doses (24 mg vs. 10 mg) of the drug lenvatinib in people with advanced thyroid cancer that no longer responds to radioactive iodine. The goal is to see if the lower dose causes fewer side effects while still controlling the cancer. About 34 ad…

This study compares standard wound care alone to standard care plus a special collagen scaffold called Miro3D. The scaffold acts like a temporary structure to support new tissue growth. Researchers want to see if adding the scaffold helps wounds close faster in 70 adults with acu…

This study tests an experimental drug called CUE-101 in 30 people with a specific type of throat cancer caused by HPV16. The drug is given before standard treatments like surgery or chemoradiation to see if it safely boosts the body's immune response against the cancer. Researche…

This study tests whether adding a new drug called cirtuvivint to standard chemotherapy can help people with small cell lung cancer that has come back after initial treatment. About 42 adults whose cancer has progressed after at least one prior therapy will receive the combination…

This study tests a program to help doctors at community health centers prescribe a recommended asthma treatment called SMART (Single Maintenance and Reliever Therapy). The program includes training, feedback, and educational tools for both doctors and patients. Researchers will t…

This study tests adding an experimental drug called epacadostat to standard chemotherapy and radiation for people with locally advanced rectal cancer. The treatment is given before surgery to remove the tumor. The goal is to find the best dose and see if the combination improves …

This study tests a personalized approach for people with newly diagnosed multiple myeloma after a stem cell transplant. Instead of a one-size-fits-all maintenance plan, doctors use a sensitive blood test (MRD) to decide if and when to give the drug elranatamab. The goal is to kee…

This study tests whether giving smokers a personalized quit plan based on their genes, health history, and biomarkers helps them stop smoking more than standard care. About 850 adult smokers and their doctors will take part. The goal is to see if this approach increases the use o…

This early-phase study tests whether adding the drug azeliragon to standard chemoradiotherapy can help the immune system fight glioblastoma, an aggressive brain cancer. About 12 adults with newly diagnosed tumors will receive either standard treatment or standard treatment plus a…

This study tests a new drug called zunsemetinib combined with the chemotherapy capecitabine in people with a common type of advanced breast cancer (HR+/HER2-) that has spread to the bones. The goal is to see if the combination is safe and can slow down the cancer. About 152 parti…

This study tests whether rivastigmine, a longer-acting drug, can prevent delirium from returning in people poisoned by substances that block muscarinic receptors. After initial control with physostigmine, 42 participants aged 10 and older will receive either rivastigmine or a pla…

This study tests a less intense stem cell transplant for people with non-cancerous blood, immune, or metabolic disorders. The goal is to see if a milder pre-transplant treatment can help donor cells take hold with fewer severe side effects. About 220 participants will be followed…

This study tests a drug called enasidenib in 15 people with clonal cytopenia of undetermined significance (CCUS) who have a mutation in the IDH2 gene. CCUS causes low blood cell counts and can raise the risk of blood cancers. The drug blocks the faulty protein made by the mutated…

This early-phase study tests a new treatment for advanced melanoma that has stopped responding to standard immunotherapy. It combines specially trained natural killer cells (either from the patient or a donor) with two immunotherapy drugs, nivolumab and relatlimab. The goal is to…

This study tests whether tofersen, a drug already approved for a specific type of ALS, can help people with ALS who do not have the SOD1 gene mutation. About 30 adults will receive the drug via spinal injections over 24 weeks. Researchers will measure nerve damage markers and mon…

This study tests a non-invasive device that gently stimulates a nerve in the ear to help patients in the NeuroICU recover from acute brain or spinal cord injuries. Researchers will measure if it reduces complications like infections, shortens hospital stays, and lowers costs. Abo…

This study tests whether taking zanzalintinib after initial chemotherapy can help keep high-grade neuroendocrine tumors from growing or coming back. About 32 adults with this aggressive cancer will receive the drug and be monitored for progression and survival. The goal is to see…

This early-phase trial tests whether adding an experimental MK2 inhibitor (zunsemetinib) to standard chemotherapy (mFOLFIRINOX) can work better for people with metastatic pancreatic cancer that hasn't been treated yet. About 51 adults will join to find the safest dose and watch f…

This study tests a home blood pressure monitoring program for 1,200 pregnant women in Nigeria with hypertensive disorders of pregnancy. The goal is to see if this program helps control blood pressure better than usual care, improving heart health after delivery. Participants will…

This early-stage study tests whether dapagliflozin, a diabetes medicine, is safe for children with brain or solid tumors that have come back or not responded to other treatments. About 20 children will receive the drug alongside standard care. The goal is to see if it can help co…

This study follows 100 breast cancer patients who cannot have surgery for medical or personal reasons. Instead, doctors use a needle to freeze and destroy the tumor. The goal is to see if this freezing treatment is safe and helps control the cancer over time.

This study compares freezing breast tumors (cryoablation) to standard surgery (lumpectomy) in 120 women with low-risk, early-stage breast cancer. The goal is to see if freezing is as safe and effective at controlling the disease, with fewer complications and better quality of lif…

This study tests whether a daily ketone ester drink can reduce liver fat and improve blood sugar control in 40 adolescents and young adults (ages 18–25) with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). Participants are randomly assigned to drink …

This study tests a new way to prepare the body for CAR T-cell therapy (Carvykti) in people with multiple myeloma who also have kidney problems. Standard prep can be hard on the kidneys, so researchers are using low-dose radiation and a chemotherapy drug (cyclophosphamide) instead…

This early-phase study tests whether a diabetes medication called dapagliflozin is safe and tolerable when taken for four weeks before prostate removal surgery in men with localized prostate cancer. The study involves 24 participants with intermediate- to high-risk prostate cance…

This early-phase study tests whether adding a drug called mosunetuzumab after a stem cell transplant is safe and doable for people with aggressive B cell lymphoma that has come back or not responded to prior treatments. Mosunetuzumab is an engineered antibody that helps the body'…

This study tests whether a specific type of stem cell transplant can prevent lymphoma from spreading to the brain in high-risk patients. About 36 people with aggressive B-cell lymphoma who are at high risk for brain relapse will receive a chemotherapy regimen (thiotepa and carmus…

This study tests a community-based exercise program for wheelchair users to improve heart health and fitness. Researchers will measure changes in cardiorespiratory fitness and body composition. The goal is to find effective ways for wheelchair users to get enough physical activit…

This study is testing if giving a higher dose of radiation directly to the prostate (called HDR brachytherapy) can better control early-stage prostate cancer without causing more side effects. About 36 men with low- or favorable intermediate-risk prostate cancer will receive one …

This study tests whether adding choline to a special peanut-based food helps brain development in children with severe malnutrition. About 1,500 children in Malawi, ages 6 months to 5 years, will receive either standard food or food with extra choline. Researchers will measure th…

This study tests whether a custom mouthpiece (mandibular advancement device) can effectively treat severe obstructive sleep apnea in adults who cannot use CPAP and have not benefited from a nerve stimulation implant. Researchers will measure breathing improvements using home slee…

This early-stage trial tests a drug called siltuximab in 30 lung transplant patients who are experiencing antibody-mediated rejection, a serious condition where the immune system attacks the new lung. The goal is to see if adding siltuximab to standard treatment is safe and toler…

This study tests whether adding the immunotherapy drug pembrolizumab to a special type of radiation (hypofractionated radiotherapy) can better prevent mucosal melanoma from returning after surgery. About 19 adults with this rare head and neck cancer will receive the combination t…

This study tests whether giving special immune cells (memory-like NK cells) after a stem cell transplant can help control high-risk acute myeloid leukemia (AML) in children and adults. About 68 participants will receive donor stem cells followed by these NK cells. The goal is to …

This study tests a new way to give radiation for locally advanced cervical cancer. Instead of the usual 5-6 weeks of daily treatments, this approach gives a strong dose of internal radiation (brachytherapy) early, followed by fewer external beam sessions. The goal is to see if th…

This study tests whether a very short course of radiation (5 treatments over 1 week) works as well as the standard shorter course (15-16 treatments over 3 weeks) for people with breast cancer that has spread to lymph nodes. The goal is to see if the ultra-short course causes fewe…

This early-phase study tests a drug called NT-I7 (a long-acting immune booster) given after standard CAR T-cell therapy for people with relapsed or hard-to-treat large B-cell lymphoma. The goal is to see if NT-I7 is safe and can help CAR T-cells grow and last longer in the body, …

This study tests a new way to do stem cell transplants for children with blood cancers like leukemia. It uses a special method to remove certain cells from the donor's stem cells before transplant, aiming to reduce side effects and improve success. About 50 children will take par…

This study tests whether the sleep aid lemborexant can lower levels of amyloid-beta and tau proteins in the blood—proteins linked to Alzheimer's disease. Researchers will enroll 201 healthy adults aged 65 and older. Participants will take either lemborexant or a placebo to see if…

This study tests whether dapagliflozin, a drug used for diabetes, can slow the progression of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 70 adults aged 50 and older with non-foveal geographic atrophy will take the dr…

This study tests a new method called sonobiopsy that uses ultrasound to release DNA from brain tumors into the blood, making it easier to detect without surgery. Researchers will enroll 40 adults with suspected glioblastoma to see if this approach can identify tumor mutations fro…

This study is testing a new endorectal imaging device that combines ultrasound and photoacoustic imaging to better assess rectal cancer after treatment. About 90 adults with rectal cancer who are scheduled for surgery will be scanned with the device. The goal is to see if the dev…

This study tests a special dye (radiotracer) that sticks to inflammatory cells in the lungs. Using PET scans, researchers can see where inflammation is happening in people with fibrotic lung diseases. The goal is to improve how we detect and monitor lung inflammation, not to trea…

This study looks at whether giving women a simple at-home kit to test for HPV (the virus that can cause cervical cancer) makes it easier for those who are overdue for screening to get tested. About 100 women aged 25-65 who haven't had a Pap smear in 3 years will receive a self-co…

This study aims to see if a special PET/MRI scan (18F-DOPA) can accurately find small, treatable spots in the pancreas that cause hyperinsulinism—a condition where the body makes too much insulin, leading to dangerously low blood sugar. About 100 patients who have not improved wi…

This study explores whether mindfulness training can improve brain function and reduce Alzheimer's risk in Latino adults aged 65 and older. Researchers will measure brain activity, attention, and memory using EEG and thinking tests. The goal is to see if a simple, non-drug practi…

This study tests a program that helps people with physical disabilities make their homes safer to prevent falls. Researchers will enroll 80 adults aged 45-64 who have had a disability for at least 5 years and live in St. Louis. Half will get the home hazard removal program right …

This study works with over 1,200 young people (ages 14-24) in Nigeria to see how to keep HIV self-testing and prevention services running long-term. Researchers will compare standard services versus those with extra support to help community groups sustain these programs. The goa…

This study tests whether investigational drugs can prevent or slow the buildup of harmful proteins in the brain that lead to Alzheimer's. It involves 280 adults who carry a gene mutation that almost guarantees they will develop the disease. The goal is to see if early treatment c…

This study tests a music-inspired program called Music4Health to help prevent high blood pressure and stroke in Nigeria. About 1,400 youth (ages 14-24) and their caregivers (ages 40+) will take part. The program uses community-designed music and campaigns to lower blood pressure …

This study tests a drug called remternetug in 280 people who have a genetic mutation that almost always causes Alzheimer's disease. The goal is to see if the drug can prevent or slow down early brain changes before memory problems begin. Participants will receive either the drug …

This study compares two approaches to help adults stop using tobacco and lower their cancer risk. About 5,000 people who smoke will get either extra reminders and support or standard quit advice. The goal is to see which method leads to more people using medication, counseling, o…

This study tests a combination program to help adolescent girls and young women (ages 15-24) at high risk of HIV in Uganda start and stick with PrEP, a daily pill that prevents HIV. The program includes HIV education, support from peers who have used PrEP, and financial help like…

This study tests whether the sleep aid suvorexant can slow the buildup of a protein called amyloid in the brain, which is linked to Alzheimer's disease. About 200 healthy adults aged 65 and older will take either the drug or a placebo for a period of time. Researchers will measur…

This study tests whether adding a decongestant (oxymetazoline) to a steroid nose spray works better than the steroid spray alone for people with chronic nasal blockage that hasn't improved with standard treatment. About 80 adults who have tried steroid sprays without success will…

This study tests whether a numbing injection (nerve block) given before facial fracture surgery can lower the amount of strong painkillers (opioids) needed after the operation. About 70 adults with broken jaw or midface bones will be randomly assigned to receive either the numbin…

This study is testing a mobile app called Wysa for Chronic Pain to see if personalized notifications can help people aged 45 and older who have chronic pain along with depression or anxiety. Participants use the app for several weeks and complete surveys about their mood, pain, p…

This study compares two different skin cuts used during trigger finger surgery to see which one helps people recover better. About 200 adults with trigger finger will be randomly assigned to get either a straight cut along the finger or a cut across the palm crease. Researchers w…

This study tests a special type of proton radiation called GRID to relieve symptoms from large tumors (at least 4.5 cm) that cannot be surgically removed or have spread. The treatment delivers high-dose radiation in a pattern of peaks and valleys, aiming to be effective while red…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms in pregnant women starting treatment for opioid use disorder. About 40 participants will use the patch during the required withdrawal period before switching to standard under-the-tongue buprenorphine. …

This study tests an 8-week group program called PEEPS for women aged 18-48 with endometriosis-related chronic pelvic pain. Participants join weekly sessions with others and get usual care, while a comparison group receives only education. The goal is to see if the group support r…

This study tests whether social media and a smartphone app can help teens and young adults stop vaping. Participants will be recruited through social media, screened by an online chatbot, and given a mobile app with tailored support to quit. The goal is to see if this approach he…

This study tests two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV. Participants must be 25-65, have HIV, chronic pain, and in…

This study tests whether a low or moderate dose of propofol, a sleep-inducing drug, combined with brief behavioral therapy for insomnia, can improve deep sleep and reduce depression in adults aged 60 and older. Seventy participants with depression that hasn't responded to at leas…

This study tests whether exposure to bright blue light can reduce inflammation and organ damage in people hospitalized with serious infections like pneumonia, infected joints, or abdominal infections. About 144 adults will be randomly assigned to receive either blue-enriched ligh…

This study tests whether a specific sequence of position changes can improve outcomes for people experiencing prolonged labor. Researchers will randomly assign 82 participants to either the position-change circuit or standard care. The goal is to see if the circuit shortens the f…

This study tests a smartphone app called Enhearten designed to reduce self-stigma in pregnant and postpartum women with substance use disorder. About 152 participants will use the app, which provides real-time support to help them stick with addiction treatment and improve their …

This pilot study tests whether giving the anti-inflammatory drug Ketorolac before surgery can reduce pain and discomfort from ureteral stents placed after kidney stone treatment. About 36 adults will be randomly assigned to receive the drug or a placebo. The goal is to see if thi…

This study tests whether taking potassium nitrate (a natural salt) can help people with heart failure exercise better and feel stronger. Researchers will give 75 adults either the nitrate or a placebo daily for 6 weeks, measuring muscle power and oxygen use during treadmill tests…

This study tests whether fluvoxamine, a drug typically used for depression, can reduce the risk of delirium (sudden confusion) in older adults after non-cardiac surgery. Researchers will enroll 46 people to see if the approach is feasible and safe. If successful, it could lead to…

This study looks at how spinal cord stimulation combined with training can change the way nerves work in people with spinal cord injuries. Researchers will measure brain-to-muscle signals and reaction times in 120 participants. The goal is to understand how these changes help imp…

This study looks at why some people with Parkinson's disease develop memory and thinking problems (dementia). Researchers will use special brain scans, memory tests, and spinal fluid samples from 320 volunteers to find different types of dementia and identify who is most at risk.…

This study looks at whether using a short-acting paralytic drug (succinylcholine) instead of a longer-acting one (rocuronium) can prevent patients from being awake and aware while paralyzed during emergency breathing support. About 3,090 adults on ventilators in emergency departm…

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk together about stem cell transplant or cellular therapy decisions. About 60 youth and their parents will try the tool and report how easy and helpfu…

This study looks at how blood flow and metabolism affect brain development in children with sickle cell anemia. Researchers will use MRI scans and a special mask to measure brain blood vessel function. They will compare 120 children with sickle cell disease to healthy children to…

This study looks at whether a new whole genome sequencing test called ChromoSeq can be used alongside standard genetic tests for people with myelodysplastic syndrome (MDS). Researchers will compare how well ChromoSeq finds genetic changes compared to current methods. About 60 adu…

This study tests a new 3D imaging device called SkinScan3D to see if it can take better pictures of Kaposi sarcoma lesions than standard 2D photos. The device uses special lenses and AI to measure the height and volume of skin lesions, which may help doctors detect treatment resp…

This study explores how nitrous oxide (laughing gas) changes brain connections related to emotion and depression. About 50 people—half with treatment-resistant depression and half healthy—will inhale the gas or a placebo and get brain scans. The goal is to understand how the drug…

This study looks at whether giving the medicine oxytocin during the pushing stage of labor can shorten delivery time and reduce the need for C-sections or vacuum/forceps. It involves 400 first-time mothers with a single baby at full term. Researchers will compare those who get ox…

This study uses advanced brain scans to investigate a newly discovered brain network, called SCAN, in people with Parkinson's disease. Researchers want to see if this network is disrupted in Parkinson's and how it connects to other brain areas. The goal is to find a specific brai…

This study is testing a web-based tool called CARE that gives cancer patients information about treatment costs, health insurance, and financial resources. About 430 adults with gynecologic, prostate, lung, or colorectal cancer will use the tool to see if it helps them feel more …

This study looks at genetic markers on breast cancer cells before and after chemotherapy. Researchers want to see how these markers change and whether they can help predict if the cancer will come back. The study involves 300 adults with stage II, III, or IV breast cancer who are…

This study tests whether an AI tool can create a personalized list of questions for people with lymphoma or multiple myeloma to use during their doctor appointments. About 40 participants will use the AI-generated list and then report how confident they felt communicating and how…

This study follows 250 girls aged 10-11 to understand how social media use and feelings of rejection affect their mental health during puberty. Researchers will track daily social media experiences and mental health symptoms over time. The goal is to see how these factors influen…

This study looks at whether giving mothers extra oxygen during labor is safe and helpful for babies when fetal heart monitoring shows signs of distress. About 2,100 women in labor will be randomly assigned to receive either oxygen or regular room air. The goal is to see if oxygen…

This study looks at whether proteins in the blood can help predict if someone will develop Alzheimer's disease or memory problems. Researchers will test blood samples from 1,800 older adults and compare them with brain scans and thinking tests. The goal is to develop a simple blo…

This study tests a new tool called Cancer Care Companion that helps parents of children with cancer communicate with doctors and manage care through their electronic health record. About 40 parents will use the tool and give feedback on how easy and helpful it is. The goal is to …

This study aims to find better ways to measure myofascial pain—a common type of muscle pain—using advanced imaging like MRI and electrical sensors. Researchers will study 100 adults with neck or shoulder pain to see if these tools can track pain and predict how well treatments wo…

This study looks at whether watching an animated video before DIEP flap breast reconstruction helps patients understand the procedure better and feel less anxious. About 300 women scheduled for surgery will answer surveys before and after watching the video, and again after their…

This study looks at inflammation in brain tumors using a special PET scan tracer called [C-11]-CS1P1. About 104 adults with brain cancer that hasn't been treated with radiation will get a baseline scan and a follow-up scan within 24 months. The goal is to see how inflammation pat…

This study looks at different types of parathyroid tumors in people with hyperparathyroidism (high calcium levels). Researchers want to understand how common each tumor type is and how they affect surgery outcomes. About 839 adults will take part. The goal is to learn more about …

This study tests an oral drug called DSP-0390 in 20 people with IDH-mutant gliomas who are scheduled for brain tumor removal. Participants take the drug for about two weeks before surgery, and researchers measure how much drug reaches the tumor and blood. The goal is to see if th…

This study looks at whether a blood test that measures TK1 activity can help doctors decide if it's safe to wait longer between routine scans for people with advanced breast cancer. About 55 participants will be followed to see if the test results lead to fewer imaging tests. The…

This study tests whether a wellness program is practical and helpful for Black patients aged 60 and older who are scheduled for surgery and have symptoms of depression or anxiety. Researchers will see how many people join and complete the program. The goal is to learn if this app…

This study builds a worldwide online registry for people with Wolfram syndrome, a rare genetic disorder causing diabetes, vision loss, and hearing problems. Researchers will track how the disease progresses over time and analyze participants' DNA to better understand the conditio…

This study looks at two different training programs for doctors and health workers in community health centers that serve people on Medicaid. The goal is to see which training helps patients lose more weight and get better access to obesity care. About 6,200 patients and their pr…

This study tests a new tool called HPARSS to help doctors identify childhood cancer survivors who are at risk for vision or hearing problems due to their past treatment. The tool links a patient's therapy history to the specific screening tests they need. The goal is to make sure…

This study looks at whether computer-based tests can measure thinking and memory in children with brain tumors who are receiving proton beam radiation. About 80 kids aged 4 to 21 will take brain tests before, during, and after treatment. The goal is to see if these tests are prac…

This study is testing whether a blood test that looks for tiny bits of tumor DNA (ctDNA) can find cancer early after treatment. Researchers will follow about 100 people with different solid tumors, plus healthy volunteers, to see if the test helps predict when cancer comes back. …

This study looks at whether giving children a daily peanut-based drink at school can improve attendance and reduce dropouts. About 6,700 kids aged 5-17 in rural Ghana will take part. One group gets the peanut drink, while the other gets a local rice/millet flour meal. The goal is…

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and thinking tests to see which factors—like insulin resistance or inflammation—are linked to changes in memory, proce…

This study looks at how children with juvenile idiopathic arthritis (JIA) experience pain. Researchers will measure pain responses to heat, cold, and pressure, and collect information through questionnaires and saliva or blood samples. The goal is to better understand what causes…

This study looks at how brain tumors and their treatments affect thinking skills in children aged 4 to 18. Researchers will use brain scans and thinking tests to find early signs of cognitive problems and predict recovery. The goal is to better understand these effects and improv…

This study looks for early signs of Alzheimer's disease in people who carry a genetic mutation that causes it. Researchers will use blood tests, brain scans, and memory tests to find biomarkers that predict when symptoms might start. The goal is to better understand the disease a…

This study is testing a digital tool called PREVENT that helps doctors and patients work together to improve heart health. It is for low-income, rural adults with obesity who are at risk for heart disease. The tool shows patient information and suggests personalized goals for hea…

This study looks at how the FluMist nasal spray flu vaccine and the standard flu shot create immune responses in the nose, blood, and lungs. Researchers will measure antibodies before and 14 days after vaccination in 30 healthy adults aged 18-40. Some participants will also have …

This study looks at whether a campaign originally designed for breast cancer can also encourage women to get screened for lung cancer. About 5,500 women aged 50–80 who get mammograms at Christian Hospital will be invited to learn about lung cancer screening. Researchers will trac…

This study looks at how a newborn's brain is wired and whether daily massage can change brain connections. Researchers will give half of the 80 babies a daily massage and compare their brain scans to those who don't get massages. The goal is to learn more about early brain develo…

This study uses a special PET-MR scan to look at plaque buildup in the carotid arteries of people who have narrowing but no symptoms. The goal is to see if the scan can predict who is at higher risk for a stroke or mini-stroke. About 80 adults with at least 60% blockage will be f…

This study looks at whether a new whole genome sequencing test called ChromoSeq can find more genetic changes in people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) than current standard tests. Researchers will compare ChromoSeq results to conventional meth…

This early-phase study tests a new radioactive tracer called [64Cu]-RYM2 to see if it can safely and accurately detect enzyme activity in abdominal aortic aneurysms (AAA). About 28 healthy volunteers and AAA patients will receive the tracer and undergo PET/CT scans. The goal is t…

This study tests a caregiver-reported questionnaire designed to spot suicidal thoughts and behaviors in children aged 4 to 7. Researchers will ask clinicians and caregivers for feedback to see if the screener works well in a real-world mental health clinic. The goal is to help id…

This study aims to understand how the tumor's surroundings change during chemoradiotherapy for locally advanced cervical and pancreatic cancers. Researchers will collect tissue and blood samples before, during, and after treatment from about 60 participants. The goal is to learn …

This study looks at whether a campaign called Pink & Pearl can encourage more women who are at risk for lung cancer to get screened. Researchers will track how many women complete lung cancer screening after seeing the campaign during their mammogram visit. The goal is to find be…

This study tests a new way to use spinal cord stimulation to help people with spinal cord injury regain movement. Researchers want to see if adjusting the timing and location of stimulation can better target specific muscles. The study involves 48 adults with chronic spinal cord …

This study looks at whether a gentle electrical stimulation of a nerve in the ear can help people who have had a major stroke. Researchers will measure markers of brain injury and inflammation in the blood. 65 adults with a recent stroke will either get standard care or standard …

This study creates a worldwide database for people with malignant peripheral nerve sheath tumors (MPNST), a rare cancer often linked to the genetic condition neurofibromatosis type 1 (NF1). Researchers will collect medical records, tumor samples, and imaging data from over 1,000 …

This study aims to understand how electroconvulsive therapy (ECT) changes sleep patterns and brain communication in people with depression that hasn't improved with other treatments. Researchers will measure brain activity during sleep and wakefulness in 50 adults receiving ECT. …

This study looks at how the immune system reacts to influenza and COVID-19 in people with symptoms. Researchers will compare those who got a flu or COVID vaccine in the past year with those who did not. About 300 participants will provide blood, saliva, and nasal samples over 6 m…

This study tests a computer system that helps doctors decide which surgery patients need blood prepared before their operation. The goal is to make sure blood is ready for those who truly need it, while avoiding unnecessary preparation that wastes blood and money. About 50 patien…

This study looks at why very low-carb (ketogenic) diets can cause high cholesterol in some normal-weight adults. Researchers will enroll 100 healthy, normal-weight adults and identify those whose cholesterol spikes on the diet. They will then measure how the body makes and remove…

This study looks at whether the bacteria in your gut (the microbiome) are linked to the severity and recovery of Complex Regional Pain Syndrome (CRPS), a chronic pain condition. Researchers will compare stool samples from 140 adults with CRPS and their housemates. They also test …

This study looks at 25 people with relapsing-remitting multiple sclerosis to understand why inflammation in the brain doesn't fully go away even after treatment. Researchers will use brain scans and analyze spinal fluid to compare different types of inflammation. The goal is to l…

This study compares a continuous heart monitor patch to standard electrocardiograms (ECGs) in 60 patients taking medications that can cause dangerous heart rhythms. The goal is to see if the patch provides more accurate and timely detection of heart issues. Participants include p…

This study looks at how popular weight-loss drugs (GLP-1 receptor agonists) affect muscle mass and physical function in people with obesity, and whether adding exercise helps. Researchers will follow 40 participants for 2 years, measuring muscle, strength, and metabolism. They al…

This study looks at 86 pregnant people whose water broke early (before 37 weeks). Doctors want to know if using a finger exam (digital) is as safe as using a tool (speculum) to check the cervix. The main goal is to see if the type of exam changes how long the pregnancy lasts befo…

This study tests whether a 16-week text-messaging program can help people with spinal cord injury better manage common health problems like pain, bladder issues, and stress. About 40 adults who have had a spinal cord injury for at least 3 months will receive texts with tips and s…

This study tests a new radioactive tracer called [18F]FZTA to see if it can spot inflammation in the brain using PET scans. Researchers will compare healthy adults and people with Multiple Sclerosis (MS) to see if the tracer lights up areas of inflammation. The goal is to better …

This study looks at how blood flow and oxygen use in the brain change as children grow, and how these changes might affect development. Researchers will use MRI scans and sometimes measure blood flow while participants breathe in extra carbon dioxide. The goal is to better unders…