Washington University School Of Medicine

This study tested whether the drug zonisamide could prevent or reduce hearing damage in police officers after exposure to loud gunfire. Only 3 officers enrolled before the study was stopped early. The goal was to see if the drug could limit permanent hearing loss, but no clear co…

This study tested a method to help people who are dependent on daily nasal decongestant sprays. Participants slowly reduced their decongestant use while adding a steroid spray (triamcinolone) to control symptoms. The goal was to see if they could stop the decongestant completely …

This study aimed to find the highest safe dose of a precise type of proton radiation for people whose rectal cancer returned after previous radiation. It enrolled 15 adults who had already received pelvic radiation. The trial was terminated early, so results are limited.

This study tested whether adding vorolanib to atezolizumab after standard chemotherapy could help people with extensive-stage small cell lung cancer stay cancer-free longer. Only 11 participants were enrolled before the study was stopped early. The goal was to see if the combinat…

This study looked at whether a drug called duvelisib could help keep T-cell lymphoma from returning after a stem cell transplant. The trial was stopped early and included 17 adults with certain types of T-cell lymphoma. The goal was to see if the drug was safe and could improve h…

This study tested a new imaging technique called AWSM-PET/CT, which aims to improve the detection of small cancerous spots that standard PET/CT scans might miss. Eleven adults with known or suspected cancer received both a standard scan and the enhanced AWSM scan. The goal was to…

This study tested whether combining photoacoustic imaging with standard ultrasound can better tell benign from cancerous ovarian growths. Researchers aimed to reduce unnecessary surgeries while catching more cancers early. The study included 185 women scheduled for ovary removal …

This study tested whether giving heart medications (carvedilol and empagliflozin) before or alongside HER2-targeted therapy could prevent heart damage in people with HER2-positive breast cancer. The trial aimed to see if it was possible to enroll enough patients and if the drugs …

This study aimed to see if a nasal spray migraine medicine (ketorolac) combined with oral pills works as well as the standard IV treatment for children with migraines in the emergency room. The trial planned to enroll 41 children but was terminated early. The goal was to reduce p…

This study tested a school-based program designed to help LGBTQ high school students cope with stress, bullying, and mental health challenges like depression, anxiety, and PTSD. About 228 students from 24 high schools took part. The program aimed to reduce minority stress and imp…

This small pilot study tested whether a stronger form of noninvasive brain stimulation, called adaptive tDCS, could help people with depression that hasn't improved with multiple medications. Five adults received up to 20-minute sessions over 4 to 6 weeks. The goal was to see if …

This study looked at whether giving teens a numbing medicine (lidocaine) through an IV during and after spine surgery could lower their need for strong painkillers (opioids) and help them recover faster. The trial planned to include 12- to 18-year-olds having surgery for scoliosi…

This small pilot study looked at whether combining a non-invasive brain stimulation technique (rTMS) with computer-based cognitive training is feasible and tolerable for adults with schizophrenia who have thinking difficulties. Twelve participants were randomly assigned to receiv…

This study aimed to see if offering help with unmet social needs—like food, housing, or transportation—could increase the number of low-income, uninsured, or Medicaid patients who attend their colposcopy appointment after an abnormal cervical cancer screening. The trial planned t…

This study looked at 22 gynecologic cancer survivors to find a better way to measure pelvic floor damage caused by radiation therapy. Researchers compared a simple physical exam with patient questionnaires to see which method catches problems earlier. The goal was to help future …

This study aimed to compare how the immune system responds to two different seasonal flu vaccines, one with an adjuvant (Fluad) and one without (Afluria), in healthy adults aged 18-49 who hadn't had a flu shot in at least three years. Only 2 people enrolled before the study was t…

This study looked at how the brain processes pain signals in people with irritable bowel syndrome (IBS). Researchers used brain scans to see if a medication called desipramine, which affects brain regions involved in emotion and pain, could change these signals. The study was sto…