Washington University School Of Medicine

This study tests whether a single pill containing four standard heart failure medications can help people in Sri Lanka better manage their condition. About 1,656 adults with heart failure and reduced pumping function will either receive the combination pill or usual care. The goa…

This study tests two weight management programs for children and teens who have had leukemia. About 80 kids and their caregivers will join one of two programs: a basic educational program or a more guided family-based approach. The goal is to help survivors avoid unhealthy weight…

This study aims to improve blood pressure control for 10,000 adults across 5 Nigerian states by expanding a proven treatment program. It focuses on helping people manage their hypertension through regular check-ups and support at local health centers. The goal is to keep blood pr…

This study tests whether adding a drug called telaglenastat (which blocks glutaminase) to standard chemoradiation can help people with advanced cervical cancer live longer without the disease getting worse. About 42 adults with stage III–IVA cervical cancer will receive the combi…

This early-phase study tests whether the drug asciminib, approved for leukemia, can reach brain tumors in children and young adults (ages 6-25) with recurrent or progressive brain tumors. Researchers will also see if adding sildenafil helps more drug enter the tumor. The goal is …

This early-phase trial tests a personalized cancer immunotherapy (PCI) designed to train the immune system to attack a patient's unique tumor. It is given alongside standard chemotherapy and immunotherapy for newly diagnosed triple negative breast cancer that has not spread. Some…

This study tests whether adding a drug called NT-I7 (IL-7) after standard CAR-T therapy can help the immune cells stay active longer and control multiple myeloma better. About 52 adults whose myeloma has returned or not responded to treatment will receive either NT-I7 or a placeb…

This study tests two experimental drugs, CTX-009 and CTX-471, in people whose glioblastoma (a type of brain cancer) has come back after standard treatments. The drugs work by cutting off the tumor's blood supply and boosting the immune system to attack the cancer. The goal is to …

This study tests a combination of three drugs (ipilimumab, nivolumab, and nogapendekin alfa inbakicept) as a first treatment for people with stage IV or recurrent non-small cell lung cancer. The goal is to see if this mix can delay cancer growth better than current treatments. Ab…

This study tests giving a short course of radiation along with chemotherapy before surgery for early-stage gastric cancer. The goal is to see if this combination leads to a higher rate of complete tumor disappearance compared to standard treatment. About 20 adults with newly diag…

This study tests a combination of a vaccine (PEP-CMV) and an immunotherapy drug (nivolumab) in children and young adults with certain aggressive brain tumors. The goal is to see if this approach is safe and helps the immune system fight the cancer. About 68 participants will be e…

This study tests a combination of three treatments—ficerafusp alfa, pembrolizumab, and targeted radiation—given before surgery for people with advanced head and neck cancer that is HPV-negative. About 45 participants will receive the drugs and radiation, then undergo standard sur…

This pilot study tests whether a carefully supervised ketogenic diet can help 15 adults with Marfan syndrome who have a chronic aortic dissection. Participants will follow the diet for 12 months while continuing their usual heart medications. The main goal is to see if the diet h…

This early-phase study tests whether adding the experimental drug DSP-0390 to the immunotherapy atezolizumab can safely help keep extensive stage small cell lung cancer under control after initial chemotherapy and immunotherapy. About 20 adults whose cancer did not worsen during …

This study tests a non-invasive device that stimulates a nerve in the ear to see if it can reduce inflammation and help control blood pressure in people with a type B aortic dissection. About 60 adults with this condition will receive the stimulation along with standard ICU care.…

This study looks at whether a special risk score from a mammogram can help women with dense breasts get an MRI when they need it most. About 78 women with dense breasts and normal mammograms will be invited for an MRI based on their risk score. The goal is to catch breast cancers…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help treat depression. About 50 adults with depression will receive psilocybin alongside therapy. Researchers will use MRI brain scans to see how the drug changes brain activity and mood over time.

This study is testing an automated chatbot designed to help adults with eating disorders. The goal is to see if the chatbot can reduce symptoms like concerns about weight and shape. About 800 people in the US who own a smartphone and are not currently in treatment will use the ch…

This study aims to see if a nebulized form of the steroid budesonide, delivered via the NasoNeb device, is safe and effective for treating chronic rhinosinusitis. About 50 adults with the condition will be randomly assigned to receive either the nebulized treatment or a standard …

This study tests a new approach to help people with early Parkinson's disease who have mild memory or thinking problems. Instead of doing brain games, participants will work with a therapist to develop practical strategies for everyday challenges, like remembering appointments or…

This study tests a 3D imaging device (SkinScan3D) to see if it measures Kaposi Sarcoma skin lesions more accurately and consistently than the current manual method using rulers. About 300 adults with confirmed Kaposi Sarcoma and at least 3 skin lesions will participate. The goal …

This study tests whether a single injection of motixafortide can help reveal leftover leukemia cells (measurable residual disease, or MRD) in the blood of people with acute myeloid leukemia (AML) who have finished their first round of chemotherapy. Ten participants will receive t…

This study looks at fat that builds up inside muscles as people age, which may cause inflammation and damage. Researchers will have 16 older adults (ages 65-80) do a 12-week calf exercise program. Before and after, they will measure muscle strength, take CT scans, and collect sma…

This study will check if certain proteins in the blood can show early signs of heart strain in pregnant women with preeclampsia, before symptoms appear. Researchers will also use heart ultrasounds to see how the heart changes during pregnancy. The goal is to find ways to predict …

This study aims to see if a program called ENGAGE-TBI can be successfully delivered to adults who had a traumatic brain injury (TBI) more than 6 months ago. Researchers will enroll 30 people in the St. Louis area who report trouble taking part in social activities. The program fo…

This study looks at whether a new gene test called ChromoSeq® can quickly and accurately classify leukemia in 60 children and young adults (under 30). Participants give blood or bone marrow samples at diagnosis, and researchers compare the test results to standard methods. The go…

This study looks at whether taking a short course of the drug bicalutamide can make PSMA PET/CT scans better at finding small amounts of prostate cancer that standard scans miss. It involves 20 adults with recurrent prostate cancer and very low PSA levels. Participants are random…

This study tests whether a culturally tailored program can help Black women get recommended mammograms. About 176 Black women age 40 and older who are scheduled for a screening mammogram will take part. The goal is to see if the program lowers no-show rates and helps reduce healt…

This study tests a new type of scan (low-count SPECT) to see how the drug Radium-223 spreads in the body of men with advanced prostate cancer that has spread to the bones. About 38 men who are already eligible for Radium-223 will get the scan. The goal is to see if the scan can a…

This study tests a new device called eMotus that tracks a patient's breathing movements during radiation therapy for cancers in the chest or upper abdomen. The goal is to see if this system can accurately guide the radiation beam without needing a backup method. About 20 adults w…

This study looks at whether a special program called HEARTS-D can help health clinics in Nigeria better find and treat diabetes. About 2,800 adults with or at risk for diabetes will take part. The goal is to see if more people get screened and treated for diabetes over time.

This study looks at how doctors and nurses talk to each other in low-resource hospitals that treat children with cancer. The goal is to improve communication so that care is safer and more effective. Researchers will test new strategies and measure changes in teamwork quality ove…

This study looks at how partnerships between universities and local health departments can help put cancer prevention programs into action. About 364 health workers and researchers will answer questions about their collaboration and the programs they offer. The goal is to find be…