Washington University School Of Medicine

This early-phase study tested a personalized DNA vaccine in 9 people with a fast-growing type of brain cancer called glioblastoma. The vaccine was custom-made for each patient based on their tumor's unique genetic mutations. The main goals were to see if the vaccine was safe, pos…

This early-stage trial tests whether a DNA vaccine targeting mammaglobin-A (a protein found on breast cancer cells) is safe and can boost the immune system against cancer. About 27 women with ER+, HER2- breast cancer will receive the vaccine while undergoing standard hormone ther…

This early-phase study tests a new drug called tulmimetostat (DZR123) in 24 adults with advanced mycosis fungoides or Sézary syndrome—rare types of skin lymphoma—who have already tried at least one other treatment. The main goals are to check the drug's safety and find the best d…

This study tests a three-drug combination (cisplatin, nab-paclitaxel, and cetuximab) in 74 people with head and neck cancer that cannot be cured. The goal is to see if this mix works better and causes fewer side effects than the standard treatment. Participants have advanced or r…

This early-phase trial tests a new drug (TTI-101) combined with targeted radiation for people with pancreatic cancer that cannot be removed by surgery right away. The goal is to see if the combination is safe and can help keep the cancer from growing for longer. About 5 participa…

This study tests whether certain drugs can slow memory loss and thinking problems in people who have a genetic mutation that causes Alzheimer's disease. About 490 adults aged 18 to 80 who either know they carry the mutation or are from families with the mutation will receive eith…

This study tested a combination of two drugs—nab-paclitaxel (a chemotherapy) and nivolumab (an immunotherapy)—in 46 people with advanced head and neck cancer that had stopped responding to a prior immunotherapy. The goal was to see if the combo could shrink tumors or slow the dis…

This study tests a treatment plan for people with a rare and aggressive skin cancer called cutaneous angiosarcoma. Participants first receive a chemotherapy drug (paclitaxel) alone, then the same drug combined with radiation therapy, followed by surgery to remove the cancer. The …

This study tests whether a combination of three drugs (elotuzumab, pomalidomide, and dexamethasone) given after a second stem cell transplant can help people with multiple myeloma that has come back. The goal is to keep the cancer under control for as long as possible. The study …

This study tests a new three-drug combination (ADI-PEG 20, gemcitabine, and docetaxel) in people with small cell or non-small cell lung cancer whose disease has worsened after initial treatment. The first part of the study finds the safest dose, and the second part checks how wel…

This early-stage study tests adding an immunotherapy drug (TSR-042) to standard radiation for people with endometrial cancer that cannot be removed by surgery. The goal is to see if the combination is safe and can help the immune system fight the cancer more effectively. About 10…

This study tests a combination of two drugs, mosunetuzumab and polatuzumab vedotin, in people with untreated follicular lymphoma. The drugs work together to help the immune system find and kill cancer cells. The goal is to see how many patients have their tumors completely disapp…

This study tests whether adding a new drug (APL-101) to standard treatment (osimertinib) can better control advanced EGFR-mutated lung cancer. About 27 adults with metastatic non-small cell lung cancer who have been on osimertinib for 8-12 weeks without progression will receive t…

This study tests whether a combination of two drugs, dasatinib and quercetin, can safely slow down accelerated aging in older adults with treatment-resistant depression or schizophrenia. The drugs are known to remove aging cells from the body. The study involves 40 participants a…

This study tests a treatment called extracorporeal photopheresis (ECP) for lung transplant patients who develop bronchiolitis obliterans syndrome (BOS), a condition that causes progressive lung damage. The treatment involves filtering the patient's blood, treating it with light a…

This early-phase study tests a new way to deliver chemotherapy directly into the abdomen for people whose appendix or colon cancer has spread to the lining of the belly. After surgery to remove visible tumors, participants receive a combination of drugs: one given through a port …

This early-phase study tests whether adding the drug duvelisib after CAR T-cell therapy can help the immune cells survive longer and fight non-Hodgkin lymphoma or acute lymphocytic leukemia more effectively. About 42 adults who are eligible for approved CAR T-cell treatments will…

This study tests a mobile app called Suubi-Mhealth for Ugandan teens aged 14-17 who have both HIV and depression. The app uses cognitive-behavioral therapy (CBT) to improve mood and help them stick to their HIV medication. Researchers will track changes in depression scores and m…

This study tests whether adding ramucirumab to the standard immunotherapy pembrolizumab works better than pembrolizumab alone for people with advanced head and neck cancer that has come back or spread. The trial includes 37 adults whose tumors have a specific marker (PD-L1 positi…

This study tests a group prenatal care program called EleVATE GC for African-American women at high risk for postpartum depression. The program aims to reduce depression, preterm birth, and low birthweight by providing support and addressing stress. About 416 pregnant women will …

This study tests whether a special food supplement with extra omega-3s and choline can help undernourished pregnant women carry their babies longer and improve their babies' brain development. It also tests a counseling program to reduce depression during and after pregnancy. Abo…

This early-phase study tests a new drug (ADI-PEG 20) combined with chemotherapy and radiation before surgery for soft tissue sarcoma. The goal is to find the safest dose and see if it helps shrink tumors. Only 6 people are enrolled so far, and the study is actively monitoring for…

This study tests whether helping families with money and parenting skills can improve behavior in children with oppositional defiant disorder or conduct disorder. About 900 children aged 10-14 and their caregivers in Uganda will be split into three groups: one gets financial help…

This study tests whether senolytic drugs—medicines that clear out aging 'zombie' cells—are safe and workable for people with early Alzheimer's or mild memory problems. About 48 adults aged 60 and older with elevated tau protein will receive either the drug or a placebo. The main …

This study tests four different programs to see which combination best helps young people (ages 11-17) with HIV in Uganda keep the virus under control. The programs include financial literacy training, savings accounts, a cartoon-based adherence and stigma reduction guide, and me…

This study tests whether combining the targeted drug cabozantinib with two immunotherapy drugs (nivolumab and ipilimumab) can shrink tumors in people with metastatic soft tissue sarcoma that has not responded to prior treatments. About 105 participants will receive the combinatio…

This early-phase study tests a combination of two drugs (acalabrutinib and durvalumab) for people with primary central nervous system lymphoma, a rare brain cancer. The study includes up to 25 patients whose cancer has returned or who cannot take standard high-dose chemotherapy. …

This study tests a three-drug combination (ixazomib, lenalidomide, and dexamethasone) given after a stem cell transplant to people with multiple myeloma. The goal is to see if this treatment can keep the cancer away longer. After four cycles, participants receive one of two maint…

This study tests a less intense stem cell transplant for children and young adults up to age 28 with various immune system disorders. The goal is to see if a milder pre-transplant treatment can help donor cells take hold with fewer serious side effects. The study tracks engraftme…

This study tests a combination of three drugs (olaparib, pembrolizumab, and carboplatin) as a first treatment for people with head and neck cancer that has come back or spread. The goal is to see if this mix works better than the current standard therapy. About 30 adults with inc…

This early-phase study tests a personalized DNA vaccine made from each patient's unique tumor mutations, given together with an immunotherapy drug (retifanlimab) that helps the immune system attack cancer. The trial enrolls 27 adults with a fast-growing type of glioblastoma that …

This study tests whether combining different drugs can safely and effectively treat onchocerciasis (river blindness) in 300 adults. Participants first receive ivermectin to clear young worms from skin and eyes, then get one of four drug combinations. Researchers will monitor side…

This study tests whether adding a targeted drug (PD 0332991) to standard hormone therapy (anastrozole) can better stop breast cancer cell growth before surgery. It involves 84 women with early-stage ER+ HER2- breast cancer. The goal is to see if the combination leads to more comp…

This study tests whether adding the immunotherapy drug nivolumab to standard chemotherapy before surgery can help the immune system fight triple-negative breast cancer more effectively. About 15 people with early-stage (stage II or III) triple-negative breast cancer will receive …

This study tests a two-step transplant approach for people with high-risk non-Hodgkin's lymphoma. First, patients receive their own stem cells, followed by a donor transplant to boost long-term disease control. The goal is to improve survival and manage the cancer, not to cure it…

This study tests the drug cabozantinib in 35 adults with high-grade neuroendocrine tumors that have worsened after at least one prior treatment. The goal is to see if cabozantinib can shrink tumors or slow disease progression. Participants take the drug orally, and researchers tr…

This study tests a drug called rhIL-7-hyFc in people with high-grade glioma (a type of brain tumor) whose immune cell levels drop after standard radiation and chemotherapy. The goal is to see if the drug can safely increase lymphocyte counts, which help fight infections and may i…

This study tests whether attending prenatal care in a group setting helps women with type 2 or gestational diabetes control their blood sugar and manage weight after giving birth. About 117 pregnant women will be randomly assigned to either group or traditional one-on-one care. R…

This study tests a chemotherapy drug called CPX-351 in 20 adults aged 18-70 with high-risk myelodysplastic syndrome (MDS) who are eligible for a stem cell transplant. The main goal is to see if the drug is safe and tolerable at two different dose levels. Researchers will also tra…

This early-phase study tests whether adding the drug mosunetuzumab to standard chemotherapy is safe and effective for people with aggressive B-cell lymphoma that has returned or not responded to prior treatment. About 24 participants will receive one of two chemotherapy backbones…

This study looks at a different way to use asthma inhalers for people who often forget to take their daily maintenance inhaler. Instead of using a daily inhaler, participants will use a combination inhaler only when they have symptoms. The goal is to see if this approach helps pe…

This study tests whether adding choline (a nutrient found in eggs and meat) to standard food supplements helps children aged 6-59 months with moderate acute malnutrition avoid worsening to severe acute malnutrition. About 1,500 children in Malawi will receive either standard or c…

This study tests whether giving patients with hard-to-treat acute myeloid leukemia (AML) specially trained immune cells (memory-like NK cells) after a half-matched donor stem cell transplant can keep the cancer away longer. About 60 adults whose leukemia did not respond to standa…

This study tests whether nerve transfer surgery can improve hand and arm function in 70 people with complete spinal cord injuries who have no hand function. Participants must be 18-65 years old, within 3 years of injury, and have stable paralysis. The surgery aims to restore move…

This study compares two types of shoulder replacement surgery for people with glenohumeral osteoarthritis: a partial replacement using a special carbon material (hPYC) and a total replacement (aTSA). 74 participants will be randomly assigned to one surgery and followed for 10 yea…

This study tests the drug lecanemab in 40 people who have a gene mutation that causes early-onset Alzheimer's. The goal is to see if removing amyloid plaques from the brain can delay or slow memory loss and other symptoms. Participants previously received another experimental dru…

This study looks at a new way for teens with asthma to use their inhaler only when they have symptoms, instead of every day. Many teens skip their daily maintenance inhalers, which can lead to hospital visits. The goal is to see if this symptom-driven approach improves how often …

This study tests a new way to deliver radiation to the prostate and nearby lymph nodes in men with high-risk or unfavorable intermediate-risk prostate cancer. The approach uses MRI to find the main tumor and gives it an extra dose of radiation. The goal is to see if this method i…

This study tests whether it is safe to reduce or skip radiation on one or both sides of the neck that show no signs of cancer after surgery. The goal is to lessen side effects from radiation without increasing the chance of cancer coming back. About 74 adults with larynx or relat…

This study tests whether helping HIV-positive teenagers in Uganda save money and start small income-generating projects can improve their adherence to HIV medication. 702 adolescents aged 10-16 are participating. The goal is to see if economic stability can be a key ingredient in…

This study tests whether adding a drug called defactinib to targeted radiation therapy can help control advanced pancreatic cancer better than radiation alone. About 42 people with locally advanced pancreatic cancer that cannot be removed by surgery will take part. The main goal …

This early-phase study tests a new type of CAR T-cell therapy made from donor cells (WU-CART-007) for people with CD7-positive blood cancers, including acute myeloid leukemia and T-cell lymphoma that have not responded to standard treatments. The therapy is designed to target and…

This study tests ways to help teens and young adults with HIV stay engaged in their care. Researchers in Kenya will try text message reminders, peer support, and small cash rewards to prevent missed appointments and improve viral suppression. The goal is to find the most effectiv…

This study tests a combination of three drugs (zimberelimab, domvanalimab, and etrumadenant) in 30 adults with advanced non-small cell lung cancer who have already received immunotherapy. The goal is to see if the triple therapy can shrink tumors or stop them from growing. Partic…

This study tests whether an experimental drug (E2814) combined with lecanemab can slow Alzheimer's disease in people who carry a genetic mutation that causes it. About 197 adults aged 18-80 with mild or no symptoms will receive either the drug or a placebo for up to 4 years. Rese…

This study tests a personalized vaccine (made from each patient's unique tumor markers) combined with the immunotherapy drug durvalumab in people with extensive-stage small cell lung cancer. The goal is to see if this combination is safe and can slow cancer growth. Only 6 partici…

This study was designed to see if combining a weight-loss drug (semaglutide) with a hormone-releasing IUD could help premenopausal women with obesity and a precancerous uterine condition keep their uterus and avoid cancer. It planned to enroll women who wanted to preserve their f…

This study compares a single dose of radiation to five doses after breast cancer surgery for people with very early-stage breast cancer. The goal is to see if one dose works just as well at preventing the cancer from coming back, while also reducing side effects and improving qua…

This study looks at whether a catheter-based procedure can help people with long-term leg pain, swelling, or ulcers caused by old blood clots in the deep veins. About 225 adults with disabling symptoms will either get the procedure plus standard care or standard care alone. The g…

This study tests a three-step treatment plan for people with a type of head and neck cancer not linked to HPV. First, patients receive a drug called palbociclib before standard chemoradiation, then they get more palbociclib after treatment. The goal is to see if this approach hel…

This study tests a new community-designed campaign to help prevent HPV, a virus that can cause cancer. About 1,838 mothers and daughters in Nigeria will take part. The campaign encourages girls to get the HPV vaccine and mothers to do a simple self-test for HPV, aiming to make pr…

This study tests whether denosumab, a drug used for bone health, can reduce breast density in premenopausal women with dense breasts. High breast density is a known risk factor for breast cancer. The trial involves 210 women and aims to see if lowering density could open new ways…

This study tests whether giving extra help and resources to families of newborns who are at higher risk can prevent child abuse and neglect. About 150 families are randomly assigned to receive either standard care or an enhanced program that connects them to services like home vi…

This study compares how well children with hearing loss in one ear (asymmetric hearing loss or single-sided deafness) can hear with a cochlear implant versus a hearing aid. About 80 children aged 4 to 14 will be tested before and after getting the implant. The goal is to see if t…

This study tests whether playing a child's favorite music before and after ear tube surgery can reduce confusion and agitation when they wake up. About 160 children aged 3 to 9 will be randomly assigned to hear personalized music or standard care. The goal is to see if music can …

This study tests two types of memory training for people with Parkinson's disease who also have mild memory problems. 120 participants will be randomly assigned to one of two training programs and complete 8 sessions over 8 weeks. The goal is to see if these programs improve thei…

This study tests whether rivastigmine, a drug used for Alzheimer's, can help people with severe confusion and agitation caused by anticholinergic poisoning. About 42 participants aged 10 and older will receive either rivastigmine or a placebo. The goal is to see if rivastigmine s…

This study looks at whether proton beam therapy, a precise form of radiation, causes fewer severe side effects than standard radiation for people with esophageal cancer. About 22 patients with stage II or III esophageal cancer will receive proton therapy, and researchers will tra…

This study tests a 6-8 week therapy program called THRIVE that helps young children (ages 3-7) and their caregivers build emotional skills. School counselors deliver the program via video or in school. The goal is to reduce children's behavioral problems and improve caregivers' w…

This study tests a program to help teens born in the U.S. to refugee parents deal with emotional and behavioral problems like PTSD, depression, and anxiety. About 308 teens and their parents will join weekly group sessions and virtual peer mentoring to learn coping skills. Resear…

This study looks at whether robot-assisted knee replacement surgery leads to better pain relief and recovery than traditional surgery. About 95 adults with knee osteoarthritis will have one type of surgery and track their pain and opioid use for weeks after. The goal is to see wh…

This study tests whether inhaling nitrous oxide (laughing gas) can quickly reduce suicidal thoughts in adults hospitalized for depression. About 50 participants will receive either nitrous oxide or a placebo gas, plus their usual treatment. The goal is to see if this approach is …

This study tests if a single dose of ZYNRELEF applied during shoulder replacement surgery can reduce the need for strong painkillers compared to a nerve block with a catheter. About 86 adults having their first shoulder replacement will be randomly assigned to one of the two pain…

This study compares two standard treatments for stage I non-small cell lung cancer: surgery and stereotactic body radiation therapy (SBRT). About 446 patients are being followed for up to 3 years to see which treatment leads to better disease-free survival and quality of life. Th…

This study looks at whether a lab test can predict how well chemotherapy will work for people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Researchers will take blood samples before treatment and test them in the lab to see if the results match how patien…

This study aims to learn how brain blood flow and metabolism differ between healthy adults and those with brain blood vessel disease. Researchers will use MRI scans and a special mask to control the air participants breathe, measuring how the brain's blood vessels expand and cont…

This study looks at what happens when healthy older adults (65+) are told their personal risk of developing Alzheimer's dementia within five years. Researchers are measuring changes in mood, thinking skills, and distress after participants receive their risk results. The goal is …

This study looks at 112 people with small bowel Crohn's disease who are starting a new biologic therapy. Researchers use MRI scans and blood protein tests to see if early changes can predict who will be in remission without steroids after one year. The goal is to help doctors cho…

This study looks at whether a special recovery plan (called ERAS) helps children and young adults heal faster after bladder reconstruction surgery. The plan includes steps to better manage pain and get patients out of the hospital sooner. Researchers will compare results from 85 …

This study uses a special brain scan called PIB PET to look at different types of dementia in people with Parkinson's disease. The goal is to find out who might develop dementia and what is causing it. Researchers will study 320 participants to better understand the link between …

This study tests whether using a visual consent form with pictures and simple language helps patients better understand research studies. Researchers will compare the standard consent process to a new visual version in studies on cancer and Alzheimer's disease. About 266 patients…

This study looks at how long the JYNNEOS vaccine (used against smallpox and monkeypox) stays effective. Researchers will measure immune responses in the blood, lungs, skin, and bone marrow of 20 healthy adults aged 18-60 who have never had the vaccine or monkeypox before. The goa…

This study tests three new radioactive dyes (tracers) for PET scans to see how well they detect tau protein buildup in the brains of people with Alzheimer's disease compared to healthy older adults. About 38 participants will receive up to three different scans to find which trac…

This study looks at whether checking for leukemia-related gene mutations after initial treatment can help predict which patients will stay cancer-free. About 107 adults aged 18-60 with intermediate-risk acute myeloid leukemia (AML) are being followed. The goal is to see if those …

This study follows nearly 2,000 men with newly diagnosed prostate cancer to see if certain genes make the cancer more likely to spread. Researchers collect blood or tissue samples and track health outcomes over time. The goal is to better understand genetic risk factors, not to t…

This study looks at how a mild electrical stimulation of the ear (called taVNS) affects brain waves in 10 healthy children. The goal is to see if it is safe and tolerable, and whether it changes the EEG. Children will receive one 30-minute session while their heart rate, oxygen l…

This study explores whether a special type of radiation therapy can protect the ovaries of young women (ages 18-50) undergoing pelvic radiation for cancers like uterine, rectal, or cervical cancer. The goal is to see if doctors can consistently see the ovaries on daily scans and …

This study explores how changing sex hormone levels during puberty relate to migraine pain and sensitivity in adolescents aged 11 to 15. Researchers will measure pain responses and hormone levels in both teens with migraines and healthy controls. The goal is to better understand …

This study looks at why some people with obesity develop health problems like diabetes and heart disease while others don't. Researchers will compare three popular weight loss diets—Mediterranean, low-carb, and very-low-fat plant-based—in 180 people with obesity. The goal is to u…

This study looks at whether small amounts of brain inflammation contribute to movement and thinking problems in people with Parkinson disease. Researchers will use a special PET scan with an experimental tracer to measure inflammation in the brain. The study includes 80 volunteer…

This study planned to test whether giving doctors machine-learning risk alerts could reduce serious complications after surgery, like unplanned ICU stays or kidney injury. It was designed for high-risk patients, but the study was withdrawn before any participants were enrolled. N…

This study tests whether giving doctors and patients a personalized risk report (based on clinical or genetic information) increases the number of people who get screened for lung cancer and receive help to quit smoking. About 915 patients and their primary care doctors are takin…

This study follows 71 people with glioma (a type of brain tumor) to see how radiation therapy affects their thinking skills over time. Researchers use special brain scans to map which brain networks are most sensitive to radiation damage. The goal is to learn how to protect these…

This study enrolls 500 adults with REM sleep behavior disorder (RBD) and healthy volunteers to track early signs of brain diseases like Parkinson's and Lewy body dementia. Participants undergo tests of thinking, movement, smell, and vision. The goal is to prepare for future clini…

This study looks at sleep health in 50 pregnant women with low income. Researchers will use a home sleep test and a wrist monitor to measure sleep. They want to see how sleep relates to heart health and social factors. The goal is to create better sleep guidelines and treatments …

This study looks at how vitamin D levels might influence blood pressure in people with type 2 diabetes. Researchers will collect blood samples from 40 participants to see if certain immune cells (monocytes) trigger a hormone that raises blood pressure. The goal is to better under…

This study aims to find out which patient traits, disease features, and surgical factors lead to better results after hip surgery for femoroacetabular impingement (FAI). Researchers are following 747 young adults and military personnel who had hip arthroscopy. They will use surve…

This study aims to find new ways to measure myofascial pain using advanced imaging like MRI. Researchers will compare 52 participants—some with chronic muscle pain and some healthy—to see if imaging can spot differences in tissue stiffness, blood flow, and inflammation. The goal …

This study aims to understand how the immune system remembers vaccines over time. Healthy adults will receive four FDA-approved vaccines at once, and researchers will track their immune responses through blood and bone marrow samples for up to two years. The goal is to learn more…

This study looks at how the body handles carbohydrates and fats after eating, in African American and white adults with obesity. Participants will eat a standard or low-carb meal before and after losing about 16-18% of their weight through a low-calorie diet or gastric bypass sur…

This study aimed to see if a personalized online education program could help patients and caregivers feel more prepared before and after major head and neck surgery. It also hoped to reduce hospital readmissions and unplanned visits. However, the study was withdrawn before any p…

This study compares two methods of rolling out a program called Bridges, which teaches financial skills and provides support to young people ages 11-17 who lost parents to AIDS. About 1,440 students from 48 schools in Uganda will take part. The goal is to see which method works b…

This study looks at how different types of immune cells (dendritic cells) in the skin are involved in graft-versus-host disease (GVHD) after a bone marrow transplant. Researchers will collect skin samples and blood from 22 adults with acute or chronic skin GVHD to analyze cell ty…

This study looks at why storing fat in and around organs like the liver affects some people's health more than others. Researchers will measure insulin sensitivity and inflammation in 144 lean and obese adults. The goal is to better understand these differences to help develop fu…

This study aimed to see if adding simple visual summaries to consent forms helps cancer patients better understand and feel less anxious about joining clinical trials. It was designed for adults with cancer who were already considering a trial. However, the study was withdrawn be…

This study looks at how electroconvulsive therapy (ECT) affects brain wave patterns in 31 adults with treatment-resistant depression. Researchers measure depression symptoms and brain activity during and after ECT sessions to find links. The goal is to better understand why ECT w…

This study was designed to see if combining ketamine injections with talk therapy could help low-income women with depressive symptoms after a C-section. The goal was to check if a larger future study was possible. However, the study was withdrawn before any participants were enr…