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Sleep drug may lift depression in seniors – new trial launches

NCT ID NCT06867549

Recruiting now Symptom relief Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 25 times

Summary

This study tests whether a low or moderate dose of propofol, a sleep-inducing drug, combined with brief behavioral therapy for insomnia, can improve deep sleep and reduce depression in adults aged 60 and older. Seventy participants with depression that hasn't responded to at least one oral antidepressant will receive two propofol infusions and therapy sessions. The goal is to see if boosting slow-wave sleep can ease depressive symptoms and improve thinking.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Washington University School of Medicine/Barnes-Jewish Hospital

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

DEPRESSION