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New drug combo aims to outsmart Treatment-Resistant head and neck cancer

NCT ID NCT04966481

First seen Apr 23, 2026 · Last updated May 25, 2026 · Updated 4 times

Summary

This study tests whether adding palbociclib to cetuximab helps people with a certain genetic type of head and neck cancer live longer compared to cetuximab alone. The cancer must be HPV-unrelated and have a CDKN2A gene change, and participants must have already tried a PD-1/L1 inhibitor. About 81 adults will be randomly assigned to one of the two treatment groups.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Saint Luke's Hospital

    WITHDRAWN

    Kansas City, Missouri, 64111, United States

  • Sanford Medical Center

    RECRUITING

    Sioux Falls, South Dakota, 57104, United States

    Contact Phone: •••-•••-••••

    Contact

  • Sanford Roger Maris Cancer Center

    RECRUITING

    Fargo, North Dakota, 58122, United States

    Contact Phone: •••-•••-••••

    Contact

  • Sanford Worthington Medical Center

    NOT_YET_RECRUITING

    Worthington, Minnesota, 56187, United States

    Contact Phone: •••-•••-••••

    Contact

  • Washington University School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

    Contact

Conditions

Explore the condition pages connected to this study.