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Magic mushroom compound shows promise for Hard-to-Treat depression and suicidal thoughts

NCT ID NCT05220410

Symptom relief Sponsor: Sheppard Pratt Health System Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a single 25mg dose of psilocybin in 20 adults with depression that didn't respond to standard treatments and who also had ongoing suicidal thoughts. The goal was to see if the drug is safe and tolerable in this high-risk group. Participants received the dose in a supportive setting, and researchers measured changes in suicidal thinking and depression severity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

20 people

The number who actually took part.

Started

Mar 2022

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Between 18 and 65 years of age at Screening * Diagnosis of Major Depressive Disorder (MDD) * Significant level of suicidal thoughts with active ideation and without immediate intent * Failure to respond to 2 medications in the current episode Exclusion Criteria: * Current or past history of schizophrenia, psychotic disorder, bipolar disorder, borderline personality disorder, etc. * Current alcohol or substance use disorder

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder Suicidal Ideation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Suicidal ideation Treatment-resistant depression

Contacts and locations

Locations

  • Sheppard Pratt Health System

    Baltimore, Maryland, 21204, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.