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Could a psychedelic and brain zapping beat depression?

NCT ID NCT06132178

First seen Nov 01, 2025 · Last updated Jun 17, 2026 · Updated 35 times

Summary

This study is for adults aged 22-65 with major depression that hasn't improved with other treatments. Researchers want to see if giving psilocybin (the active ingredient in magic mushrooms) followed by a quick, focused brain stimulation technique is safe and can help reduce depression symptoms. The study involves 100 participants and uses brain scans and questionnaires to track changes.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600

    RECRUITING

    Austin, Texas, 78712, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

Depression depressive disorder Depressive Disorder, Treatment-Resistant endogenous depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.