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Magic mushroom microdoses paired with therapy could lift severe depression

NCT ID NCT07183748

Recruiting now Symptom relief Sponsor: Beersheva Mental Health Center Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 21, 2026 · Updated 29 times

Summary

This study tests whether very small, repeated doses of psilocybin (the active ingredient in magic mushrooms) combined with short-term talk therapy can safely reduce depression in people who haven't gotten better with other treatments. Twenty adults aged 18-65 with treatment-resistant depression will stop their usual medications and receive either psilocybin or a placebo for six weeks, then switch. Researchers will track mood, thinking skills, and biological markers like stress hormones.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Mental Health Center Beer Sheva

    RECRUITING

    Beersheba, Israel

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

TREATMENT RESISTANT DEPRESSION