Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could steroids save your joints after a severe infection?

NCT ID NCT07440238

Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a steroid (prednisone) to standard antibiotics can improve joint function in adults with septic arthritis, a serious joint infection. Two hundred participants will receive either prednisone or a placebo for 7 days. The main goal is to see if steroids reduce long-term joint damage and disability at 24 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
prednisone (a corticosteroid)
What this could lead to
If it works, this could mean fewer long-term joint problems after a serious joint infection.
What could go wrong
This is a small, early-phase trial. Corticosteroids may not improve outcomes and could increase infection risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Documented septic arthritis (microorganism identified intra-articularly by culture or PCR, or by turbid synovial fluid with positive Gram stain, or positive blood cultures) * Effective antibiotic therapy initiated within ≤ 3 days * Effective contraception for women of childbearing age during treatment period * Signed informed consent * Affiliation to the French national health insurance system * Ability to read, write, and understand French Exclusion Criteria: * Polyarticular septic arthritis (≥ 2 joints) * Septic arthritis of small joints (e.g., fingers: proximal interphalangeal joint (PIP), distal interphalangeal joints (DIP), MetaCarpoPhalangeal (MCP); toes: MTP) * Systemic sclerosis * Pyomyositis * Diabetic foot infection * Current corticosteroid therapy for another indication * Inability to take oral medication * Contraindication to corticosteroids * Associated endocarditis * Presence of prosthetic joint or osteosynthesis material in the affected joint * Septic shock * Severe soft tissue wound overlying the joint * Aplastic chemotherapy * Neutropenia (defined as neutrophils \< 500/mm³) * Mycobacterial infection * Fungal infection * Sickle cell disease * Current pregnancy * Breastfeeding women * Patients under legal protection (e.g., guardianship) * Participation in another interventional clinical trial * Uncontrolled diabetes * Unstable psychiatric disorders * Adults unable to provide informed consent * Contraindication to corticosteroid therapy

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Septic arthritis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

bacterial arthritis infective arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Septic arthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hopital Robert Ballanger

    Aulnay-sous-Bois, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.