Scientists probe immune System's role in rare brain disorders
NCT ID NCT04925349
First seen Sep 30, 2025 · Last updated Jun 19, 2026 · Updated 35 times
Summary
This study looks at how immune cells called macrophages behave in people with rare brain diseases like adrenoleukodystrophy and metachromatic leukodystrophy. Researchers will collect blood samples from 100 participants to analyze immune cell activity and metabolism. The goal is to understand if these immune responses drive disease progression, which could help develop future treatments.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AP-HP Hôpital Bicêtre
RECRUITINGLe Kremlin-Bicêtre, 94275, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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AP-HP Hôpital La Pitié Salpêtrière
RECRUITINGParis, 75013, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could reveal how the immune system affects these rare brain diseases, pointing toward future treatment targets.
What could go wrong
This is an observational study with no treatment being tested. It is small and early-stage, so findings may not lead directly to therapies.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.