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Brain scans may predict who needs a breathing tube

NCT ID NCT07279831

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the brain and lungs communicate in patients with severe breathing failure who are getting high-flow oxygen. Researchers will use brain wave monitors (EEG), oxygen sensors (NIRS), and muscle activity sensors (EMG) before and after starting oxygen therapy. The goal is to see if these brain signals can help predict which patients will eventually need a breathing tube.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors better understand why some patients with breathing failure need a breathing tube, potentially improving treatment decisions.
What could go wrong
This is a very small, early observational study with only 25 participants. It is not testing a treatment, so it may not lead to any direct changes in patient care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients admitted to critical care for acute renal failure

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \- Age ≥ 18 years * Admitted to the intensive care within the last 48 hours * De novo acute hypoxemic respiratory failure with an indication for high-flow nasal cannula (HFNC), defined by the combination of the following three criteria: * Tachypnea \> 25 breaths/min or labored breathing * PaO2 (partial pressure of oxygen ) /FiO2 ( fraction of inspired oxygen ) ≤ 200 mmHg * Unilateral or bilateral alveolar opacities on chest X-ray * Decision by the attending physician to initiate HFNC treatment * After information, the patient or next of kind did not refuse to participate (according to the French law, written informed consent is waived) Exclusion Criteria: * \- Exacerbation of an underlying chronic respiratory disease * Acute cardiogenic pulmonary edema indicating non-invasive ventilation (NIV) * Hypercapnia \> 45 mmHg indicating NIV * Glasgow Coma Scale \< 13 * Imminent intubation * Underlying central neurological disease likely to alter EEG signals * Pregnancy or breastfeeding * Lack of health insurance coverage * Patient under legal protection

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Conditions

The condition(s) this trial relates to.

acute respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory failure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Médecine Intensive - Réanimation, Hôpital Pitié Salpêtrière

    RECRUITING

    Paris, 75013, France

  • Service de Médecine Intensive et Réanimation, Hôpital Pitié Salpêtrière

    NOT_YET_RECRUITING

    Paris, France

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