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Can a Diaphragm-Sensing ventilator mode reduce breathing asynchrony?

NCT ID NCT01426178

Disease control Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This trial compares two modes of noninvasive ventilation in adults with acute respiratory failure: standard pressure support (PSV) and a newer mode called Neurally Adjusted Ventilatory Assist (NAVA). NAVA uses electrical signals from the diaphragm to trigger breathing support, which may better match the patient's own breathing efforts. The main goal is to see if NAVA reduces the rate of breathing asynchrony—when the ventilator and the patient are out of sync—compared to PSV. Participants are randomly assigned to receive NAVA first or PSV first, and the study also tracks oxygenation and patient comfort.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Neurally Adjusted Ventilatory Assist (NAVA) delivered via a specialized catheter
What this could lead to
If NAVA reduces breathing asynchrony, it could improve comfort and oxygenation for patients needing noninvasive ventilation.
What could go wrong
This is a small early-phase trial, so results may not apply broadly. NAVA requires a specialized catheter, which may not be widely available or comfortable for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

17 people

The number who actually took part.

Start date

Jul 2011

Finished

Jan 2012

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \- Patient older then 18 years * Patient requiring first non invasive ventilation set because of acute respiratory failure Exclusion Criteria: * Patients protected by the law * Pregnant women

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Conditions

The condition(s) this trial relates to.

acute respiratory failure Respiratory Aspiration respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Respiratory insufficiency

Contacts and locations

Locations

  • CHU Clermont-Ferrand

    Clermont-Ferrand, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.