University Hospital, Clermont-ferrand

This study tests a new way to prevent Crohn's disease from returning after bowel surgery. Instead of waiting 6 months for a colonoscopy, doctors will check a stool marker (fecal calprotectin) at 3 months and adjust treatment early if needed. The goal is to reduce the number of pe…

This study tests whether a ketoanalogue supplement, taken alongside a moderately low-protein diet, can prevent muscle loss in people with stage 4 or 5 chronic kidney disease (CKD). About 100 adults will take the supplement or a placebo for several months, and researchers will mea…

This study tests a drug called tislelizumab in people aged 70 and older with advanced esophageal cancer who cannot receive standard chemotherapy. The drug is given by IV and aims to help patients live longer and with better quality of life. Researchers will track how many patient…

This study tests whether raising carbon dioxide levels in the blood during general anesthesia can improve blood flow to the brain before a clot is removed in stroke patients. About 50 adults with a large-vessel blockage stroke will be enrolled. The goal is to see if this simple t…

This study involves 660 brain-injured patients on ventilators to see if a simple clinical score helps doctors decide the best time to remove the breathing tube. The goal is to reduce the need to put the tube back in or prevent death within 5 days. Participants are adults aged 18-…

This study tests two methods to fix heart stents that haven't opened fully. About 80 adults with narrowed stents will get either a special balloon or a shockwave device. The goal is to see which approach opens the stent better, improving blood flow and reducing the need for repea…

This study looks at whether a heart procedure called left atrial occlusion can help people with two conditions: an irregular heartbeat (atrial fibrillation) and bladder damage from past radiation therapy (radiation cystitis). These patients often need blood thinners to prevent st…

This study looks at whether a special diet workshop held 15 days after bariatric surgery can help patients increase their protein intake over the next year. About 88 adults who are scheduled for sleeve gastrectomy or bypass surgery will take part. The goal is to improve protein l…

This study aims to see if an artificial intelligence tool can predict necrotizing enterocolitis (NEC), a severe and often fatal gut infection in premature babies, by analyzing stool samples. Researchers will collect stool from 1,000 premature babies across several hospitals and u…

This study tests whether carvedilol, a drug usually used for heart conditions, can lower high blood pressure in the liver's main vein to prevent dangerous bleeding in people with cirrhosis. About 30 adults with cirrhosis and signs of high liver pressure will take carvedilol for o…

This study tests a less invasive nerve block (sphenopalatine ganglion block) against the standard blood patch for treating headaches caused by spinal fluid leaks after procedures like epidurals. About 80 adults with persistent headaches will be randomly assigned to one of the two…

This study looks at whether hypnosis can help reduce pain and stress when getting stitches in the emergency room. About 180 adults with skin cuts will be randomly assigned to receive either standard care or hypnosis during the procedure. The main goal is to see if hypnosis lowers…

This study tests whether a single dose of misoprostol, a medication often used in gynecology, can reduce blood loss during surgery to remove uterine fibroids (myomectomy). About 80 women having laparoscopic or open surgery will receive either misoprostol or a placebo before their…

This study tests if relaxation methods like sophrology and neurolinguistic programming (NLP) can improve well-being and reduce stress in hospital staff. About 200 workers who feel stressed will learn these techniques and be monitored with questionnaires and wearable devices. The …

This study tests a walking program that uses a short course of anti-inflammatory pain medication to help people with painful hip or knee osteoarthritis walk more. The goal is to see if taking the medication only around planned walks can improve walking ability without causing sid…

This study tests whether using virtual reality (interactive or hypnotic) during needle placement into an implantable port can reduce pain and anxiety in children aged 6 to 16 with acute leukemia. Over 3 months, 120 participants will be randomly assigned to virtual reality or stan…

This study tests if adding active movement to passive hamstring stretches improves flexibility more than passive stretching alone in people with chronic low back pain. About 90 adults aged 18-65 with long-term back pain and tight hamstrings will be randomly assigned to one of two…

This study looks at whether daily adapted physical activity can improve sleep in children aged 5 to 16 who are being treated for blood cancer. About 30 children will take part, and their sleep quality will be tracked by parents and a sleep monitor. The goal is to see if gentle ex…

This study tests a quick-dissolving tablet placed under the tongue (sublingual sufentanil) to relieve moderate to severe pain from a single injury in the emergency room. About 300 adults with arm or leg injuries will receive either the new tablet or standard pain treatment. The g…

This study looks at whether measuring certain proteins (cytokines) in the fluid from surgical drains can identify patients who are safe to start eating just 3-4 days after throat cancer surgery, instead of the usual 7 days. The goal is to reduce hospital stays and improve quality…

This study tests two throat sprays (CDN and CW) for adults with a cough from a viral cold or sore throat. About 58 people will use one of the sprays for 7 days and report side effects and symptom changes. The goal is to see if the sprays are safe and help ease coughing.

This study looks at how sexuality and mental health are related in people aged 60 and older. Researchers will survey 200 volunteers about their sexual satisfaction, anxiety, depression, and quality of life. The goal is to better understand these connections and support healthy ag…

This study uses a powerful 7T MRI scanner to measure brain chemicals in people newly diagnosed with Parkinson's who have not yet started medication. Researchers will compare these measurements to those from healthy volunteers to better understand how the disease affects brain met…

This study looks at whether the size of a screen (like a phone or computer) affects how people rate their stress on a visual scale. Researchers will ask 200 healthy adults to complete stress, anxiety, and sleep quality scales on different devices. The goal is to understand if scr…

This study is testing a new tool called CANoPy that predicts the risk of chronic nerve pain in cancer patients. Researchers will follow 625 adults with breast, gynecological, colorectal, or lung cancer who are about to start treatment. The goal is to give doctors a simple way to …

This study looks at bile acid levels in the blood and tumor tissue of 20 men with testicular germ cell cancer. Researchers want to see if these levels can serve as markers to predict how the disease will progress and how well it will respond to treatment. The goal is to improve m…

This study looks at how osteoporosis might change the way different parts of the brain communicate. Researchers will compare brain scans from 60 postmenopausal women—some with osteoporosis and fractures, some with osteoporosis but no fractures, and some healthy volunteers. Partic…

This study examines whether a mother's physical activity level during pregnancy influences her newborn's heart rate variability, a measure of heart health. Researchers will monitor 100 babies born to mothers in a larger exercise study, tracking heart rhythms and oxygen levels rig…

This study looks at nerve-related issues like numbness, tingling, and pain in people who finished treatment for mouth or throat cancer 1 to 5 years ago. Researchers will examine 120 participants using simple touch tests and pain questionnaires to map these problems. The goal is t…

This study aims to better understand chronic pain by following 5,000 patients through a smartphone app called e-DOL. Participants will regularly report their pain, treatments, and daily experiences. The goal is to learn how pain changes over time and what factors influence it, wi…

This study is for 700 people already living with a chronic disease like arthritis, depression, or heart disease. Researchers will use a small movement sensor worn for 5 days every 4 months to track physical activity and sitting time. The goal is to see if a person's unique activi…

This study looks at how immune cells and inflammation might play a role in migraine. Researchers will compare 396 women with and without migraine, some of whom also have autoimmune diseases like multiple sclerosis or rheumatoid arthritis. The goal is to measure levels of certain …

This study is looking for tiny molecules in the blood, called microRNAs, that might be linked to nerve damage caused by chemotherapy. Researchers will study 90 people with lung or colon cancer who are receiving specific chemo drugs. The goal is to find a way to predict or detect …

This study looks at why some people with migraine don't get relief from triptan medications. Researchers will measure levels of tryptophan, a natural substance that affects pain and inflammation, in 144 adults who either respond well or poorly to triptans. The goal is to understa…

This study looks at whether a set of computer-based attention tests can detect attention problems caused by concussions in young rugby players (ages 11-25). Researchers will compare the test results of 30 players who have had a concussion with those of 60 athletes who have not ha…

This study compares two methods for guiding early treatment of septic shock: the standard approach using lactate levels versus a newer method using the CO2 gap, which measures carbon dioxide in the blood. Researchers want to see if the CO2 gap method can better identify when tiss…

This study looks at how often people with Tourette syndrome have trouble being assertive and managing emotions. About 350 adults with Tourette syndrome will fill out online surveys about their symptoms, quality of life, and mood. The goal is to better understand these challenges,…

This study looks at what motivates or stops people with chronic low back pain from using a health app to stay physically active. Researchers will interview 25 adults to understand their views and needs. The goal is to learn how to design better digital tools that help patients ke…

This study compares a new semi-automatic machine (GAVI®) to the standard manual method for freezing donor eggs. Researchers want to see if the machine can freeze eggs just as well, with the same survival rate after thawing. The study involves 50 egg donors and will also look at f…

This study is looking at whether a molecule in the blood called miR-1 can be used as a marker to track how muscle diseases like Duchenne muscular dystrophy and myotonic dystrophy progress. Researchers will compare miR-1 levels in 104 people, including healthy volunteers and patie…

This study follows 140 working-age stroke survivors in France to understand what factors help or hinder their return to work. Researchers will look at medical details, personal beliefs, and job-related issues. The goal is to create better support plans for people recovering from …

This study looks at children with neuroblastoma or Ewing sarcoma who had ovarian or testicular tissue frozen to preserve their fertility before cancer treatment. The problem is that this tissue might contain hidden cancer cells that could cause the cancer to return if the tissue …