University Hospital, Clermont-ferrand

This study compares four different sequences of biologic drugs (infliximab, filgotinib, ustekinumab, and vedolizumab) in 240 adults with moderate to severe ulcerative colitis. The goal is to see which order of treatments works best to achieve and maintain remission without steroi…

This study tests whether a nurse-led discharge education program helps heart failure patients avoid unplanned hospital readmissions within 30 days. The program includes an educational assessment, a discharge session using the teach-back method, and a follow-up phone call. Researc…

This pilot study tests whether fecal microbiota transplantation (FMT) can improve moderate to severe hidradenitis suppurativa (HS), a painful skin condition. Researchers will give 24 adults a single FMT and track changes in their skin lesions over 12 weeks. The goal is to see if …

This study investigates whether a supervised, adapted physical activity program can improve how the body burns fat during walking in women with overweight or obesity, both with and without polycystic ovary syndrome (PCOS). Researchers will compare changes in fat oxidation and oth…

Many people with diabetes skip regular eye exams, even though early treatment can prevent vision loss. This pilot study tests whether offering retinal photography during routine occupational health visits makes screening easier to access. Workers with diabetes attend one visit wh…

This study explores why some adults struggle to understand speech in noisy environments even when their standard hearing tests are normal. Researchers will use a battery of advanced hearing tests—including extended high-frequency audiometry, inner ear electrical responses, and br…

This study looks at whether a blood test can detect brain bleeding in older adults (75+) who fall repeatedly. Instead of always using a CT scan, which can be hard to get quickly, researchers will measure two proteins in the blood. The goal is to see if this test is accurate enoug…

This trial tests whether applying a 5% lidocaine plaster daily for two months can prevent chronic nerve pain after an osteoporotic vertebral fracture. Participants aged 50 and older with a recent fracture and moderate pain are randomly assigned to receive the plaster plus standar…

This study tests whether a gentle electrical brain stimulation technique called tDCS, given alongside standard rehab, can prevent the development of chronic neuropathic pain after a stroke. Sixty adults who recently had a stroke will receive either real or sham tDCS for 10 sessio…

Researchers are testing a new group-based cognitive rehabilitation program for people with early Parkinson's disease who have mild thinking complaints. The program, called LifeCOG-PD, runs for seven 90-minute sessions at a hospital, with 3 to 4 patients per group. Sessions cover …

This study tests whether using a virtual reality headset (HypnoVR) during interventional radiology procedures can lower patients' anxiety and pain. Seventy adults will be randomly assigned to either use the VR headset or receive standard care. Researchers will measure anxiety wit…

This study looks at whether anti-IL-6 drugs, used for inflammatory conditions like rheumatoid arthritis, can also reduce migraine frequency and intensity. Researchers will compare 320 people taking anti-IL-6 drugs to those on anti-TNF drugs. Participants will report how their mig…

This study looks at two ways to help older adults in the hospital clear mucus from their lungs. One method uses a machine that gently blows air in and then sucks it out to mimic a strong cough. The other is a hands-on technique done by a physical therapist. The goal is to see whi…

This study looks at whether it's practical and safe for ICU patients to have short visits from their own pet dogs. Researchers will test this with 21 adult patients in three ICUs in France. The dog can stay for up to 15 minutes, and staff will check for any problems. The goal is …

This observational study asks whether a parent can accurately gauge the pain their child feels during a dental local anaesthetic. Children aged 6 to 15 and their parents each rate the child's pain on a 0-10 scale after the procedure. The goal is to see if parents can serve as rel…

This study investigates primary parkinsonian pain (PPP), a severe and hard-to-treat pain type in Parkinson's disease. Researchers want to see if PPP is linked to REM sleep behavior disorder (RBD), a condition where people act out their dreams. About 300 people with Parkinson's wi…

This study looks at how a person's migration history and social situation affect how well HIV treatment works. Researchers will compare the health outcomes of 150 migrants living with HIV in France, based on their social and administrative status. The goal is to understand whethe…

This study will measure how well people with gum disease can chew. One hundred adults with periodontitis will chew a special gum for 20 cycles to test their chewing performance. Researchers will also check the severity of their gum disease to see if there is a link. This is an ob…

This study looks at whether treating gum disease (periodontitis) can improve how well people chew and their overall oral quality of life. Researchers will ask 44 adults with gum disease to fill out questionnaires, do a chewing test with colored gum, and provide saliva samples. Th…

This study investigates whether a diet rich in plant-based proteins (70% plant, 30% animal) affects muscle strength, mass, and function in healthy adults aged 65 and older. Over three months, participants follow either a plant-enriched or standard animal-protein diet. Researchers…

This study surveys 1,000 adults with Restless Legs Syndrome (RLS) to find out how often pain is part of their symptoms and how it affects their daily lives. Participants fill out an online questionnaire about their medical history, sleep, pain, and quality of life. The goal is to…

This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the…

This study looks at whether a type of immune cell called regulatory T cells works properly in people with chronic migraine. Researchers will compare blood samples from 24 women with chronic migraine to healthy controls. The goal is to understand if problems with these cells contr…

This study will follow 400 people who had a heart attack and have moderately reduced heart function (ejection fraction 35-50%). Participants will get a small implantable heart monitor to track their heart rhythm for up to 5 years. The goal is to identify markers that could predic…

This study has two parts. First, it will adapt a questionnaire called the Iowa Infant Feeding Attitude Scale for use in France, testing its accuracy with new mothers and co-parents. Second, it will survey pregnant women and their partners to understand their cultural beliefs abou…

This study tests a program called ADD'Pro that combines addiction treatment with personalized job counseling to help people with substance use disorders return to work. About 100 adults will be randomly assigned to either the ADD'Pro program or standard employment services. Resea…

This study looks at how often the airways close in critically ill adults who need a breathing machine (ventilator) in the ICU. About 500 patients across 39 ICUs will have a simple bedside test to check for airway closure. The goal is to learn more about this common but under-reco…

This study looks at whether patients who get a breathing tube in an emergency are more likely to develop pneumonia than those who get one in a planned setting. Researchers will review medical records of 600 adults intubated in 2024. The goal is to understand the risk and improve …

This study looks at why a common gut bacterium, Enterococcus faecalis, sometimes travels to the heart and causes a serious infection called infective endocarditis. Researchers will analyze the gut bacteria of 90 adults with this bloodstream infection to see if an imbalance in the…

This study will look at how a single 30-minute bike ride changes levels of certain liver proteins (FGF21 and follistatin) in 12 people with liver cancer. Researchers want to understand how exercise affects the body in these patients, which could lead to better exercise recommenda…

This study looks at how long-term use of non-nutritive artificial sweeteners (like those in diet drinks) affects brain connectivity. Researchers will use resting-state MRI scans to compare brain activity in 100 healthy young adults who consume either low or high amounts of these …

This study looks at whether older adults (70+) with low muscle mass are more likely to have serious bleeding while taking common blood thinners (apixaban or rivaroxaban). Researchers will compare muscle mass in 110 patients who had a bleeding event with those who did not. The goa…