University Hospital, Clermont-ferrand

This study compares four different biologic treatments (infliximab, filgotinib, vedolizumab, and ustekinumab) as first-line therapies for people with moderate to severe ulcerative colitis. The goal is to see which treatment order works best to keep patients in remission and impro…

This study looks at whether a blood test can detect brain bleeding in older adults (75+) who fall often. Instead of always using a CT scan, which can be hard to get quickly, researchers will measure two blood markers (GFAP and UCH-L1) with a portable device. The goal is to see if…

This study tests whether a gentle brain stimulation technique called tDCS, combined with standard rehabilitation, can prevent the development of chronic pain after a stroke. Researchers will enroll 60 stroke survivors who are at high risk for pain and give half of them real stimu…

This study looks at whether anti-IL-6 medications, already used for inflammatory arthritis, can also reduce migraine attacks. About 320 adults with both a rheumatologic condition and migraines will report if their headaches improve. The goal is to see if targeting inflammation he…

This study will follow 150 adults with colds, sinus infections, or sore throats to see how well four medical devices work and if they are safe. Participants will use the products as needed and report any side effects and symptom changes over two weeks. The goal is to confirm thes…

This study looks at two ways to help older adults in the hospital clear mucus from their lungs. One method uses a machine that gently blows air in and then sucks it out to mimic a strong cough. The other is a hands-on chest therapy done by a physical therapist. The goal is to see…

This study will test four different medical devices (HMG, PHN, PHR, and TUR) in 160 adults with sore throat caused by viral pharyngitis or tonsillitis. The goal is to see how safe and effective they are in real-life conditions. Participants will track their symptoms and any side …

This study will enroll about 958 adults with severe stroke who need a procedure to remove a blood clot from a large brain artery. Researchers want to find out if putting patients fully asleep with general anesthesia or keeping them lightly sedated leads to better recovery and les…

This study tests a new program that combines addiction treatment with personalized job coaching to help people find work. About 100 adults with substance use disorders who are unemployed will be randomly assigned to either the new program or standard employment services. Research…

This study follows 50 adults who have had head and neck cancer and now use a maxillofacial prosthesis (a custom dental or facial device). Researchers will measure how well they chew, speak, and swallow, and how their quality of life changes over time. The goal is to understand th…

This study looks at whether patients who get a breathing tube in an emergency are more likely to develop pneumonia than those who get one in a planned, non-emergency setting. Researchers will review medical records from 600 adults treated in 2024. The goal is to understand how ur…

This study talks to parents of young children with severe tooth decay to understand why changing sugary eating habits is so difficult. The goal is to find better ways to help families prevent cavities from coming back after treatment. About 30 parents will share their experiences…

This study looks at whether it's possible and safe for patients in the intensive care unit (ICU) to have visits from their pet dogs. The researchers will try this with 21 adult patients who own dogs and are expected to stay in the ICU for at least two days. The main goal is to se…

This study looks at why a common gut bacterium, Enterococcus faecalis, sometimes causes serious heart valve infections. Researchers will compare 90 patients with this bloodstream infection to those with other infections, analyzing gut bacteria and bacterial genetics. The goal is …

This study looks at whether certain immune cells (regulatory T cells) work differently in people with chronic migraine compared to healthy individuals. Researchers will measure how well these cells control inflammation, which may help explain why migraines become chronic. The stu…

This study looks at whether an MRI without a bowel-distending drink (like PEG or mannitol) can still accurately measure inflammation in the small bowel of people with Crohn's disease. Many patients find the drink hard to tolerate, causing vomiting or diarrhea. If skipping it work…

This study looks at whether a mother's physical activity during pregnancy changes a substance called calprotectin in her baby's cord blood. Calprotectin levels are linked to infection risk in newborns. Researchers will measure calprotectin in cord blood from 250 babies born to mo…

This study aims to identify markers that can better predict the risk of sudden cardiac death in people who have had a heart attack and have moderately reduced heart function (ejection fraction between 35-50%). Researchers will follow 400 participants for 5 years, collecting data …

This study looks at 130 adults with heart failure who were part of a telemonitoring program but later removed because they no longer met eligibility rules. Researchers will track them for one year to see how many have serious heart events or need urgent care. The goal is to under…

This study aims to find out how often the airways close in critically ill adults who are on breathing machines (ventilators) in intensive care. About 500 patients from 39 ICUs will have a simple, non-invasive measurement to check for airway closure. The goal is to better understa…

This study will use PET-MRI brain scans to compare the reward system in 44 Parkinson's patients, half with and half without a sleep behavior disorder called RBD. The goal is to understand why some patients develop impulse control problems, like gambling or compulsive eating, as a…

This study looks at whether older adults (70+) with low muscle mass have a higher risk of bleeding while taking common blood thinners. Researchers will compare muscle mass, sarcopenia, and nutrition between 110 patients who had a bleeding event and those who did not. The goal is …

This study looks at how long-term use of artificial sweeteners changes brain activity and connections in healthy adults aged 18-30. Researchers will compare brain scans of people who consume a lot of sweeteners with those who consume little or none. They will also ask some low-co…

This study looks at how one session of cycling exercise changes levels of two proteins (FGF21 and follistatin) in the blood of people with liver cancer. Researchers want to understand these changes to help design better exercise programs for patients. The study will involve 12 ad…

This study aims to understand the causes of pain in people with fibrous dysplasia of bone or McCune-Albright syndrome, rare conditions that can cause bone pain, deformities, and fractures. Researchers will compare 20 patients with 20 healthy volunteers using pain tests to see if …