Diet soda alters brain connections, study suggests

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women aged 18 to 30 (and in good health) * Having low or no sweetener consumption (\~8 mg ± 5.05 mg/day) or high consumption (\~80 mg ± 91.72 mg/day) * Having a BMI of 18.5 \< 24.9 * For young women: having effective contraception maintained throughout the study * Able to give informed consent to participate in the research * Affiliation to a Social Security scheme Exclusion Criteria: * Refusing to participate in the research * With impaired understanding, according to the investigator * Volunteer under guardianship/curatorship/deprived of liberty or under legal protection * Incompatibility of healthy volunteers with the medical imaging center's safety criteria for conducting 3 Tesla MRI experiments * Presenting "contraindications" to an MRI examination without injection: presence of metal parts in the body (electronic devices such as a pacemaker, a neurostimulator, cochlear implant, prostheses, intraocular foreign bodies, etc.), claustrophobia, obesity * Refusal to be informed in the event of an incidental discovery of an abnormality on MRI * Volunteer with neurological disease, psychiatric or behavioral disorders\* * Volunteer with addiction\*: * Nicotine: smoker or former smoker of less than 12 months; * Alcoholism - "AUDIT" test: Female score ≥ 6 and male score ≥ 7; * Drugs - "DAST-10": Score ≥ 1; * Gambling - "ICJE": Score ≥ 3 * Video games - Modified DSM IV Video Game Addiction Test: More than 4 positive responses. - Positive urine drug screen * Volunteer with an eating disorder (ED)\*: o Eating disorder - "SCOFF": At least two positive responses. - Volunteers with at least one chronic condition (obesity, diabetes, cardiovascular, renal, or hepatic diseases, etc.)\* * Pregnant or breastfeeding women, or healthy subjects wishing to conceive during the current study year\* * Any illness, health condition, or history deemed incompatible with the trial by the investigator * Volunteers following a specific or highly restrictive diet (vegetarians, vegans, or vegans; multiple dietary exclusions related to religion, food allergies or intolerances; diets related to intensive exercise or weight-loss)\* * Currently excluded from another study * Currently participating in another clinical trial, or in the exclusion period, or having received a total compensation amount exceeding €6,000 in the 12 months preceding the start of the trial, * This study is part of a larger research project, also involving cognitive tasks and the measurement of food preferences. These exclusion criteria were therefore added in order to standardize the profile of the participants.