University Hospital, Clermont-ferrand

This study looked at whether using sevoflurane gas for sedation, instead of the usual propofol, could help people with severe lung injury (ARDS) survive and spend less time on a breathing machine. About 700 adults in the hospital took part. The goal was to see if the gas sedation…

This study tested two ways of using a breathing machine during emergency abdominal surgery. One method used higher pressure to open the lungs, while the other used lower pressure to avoid overstretching. The goal was to see which approach reduced breathing failure and death after…

This study tested two ways of using breathing machines in 420 adults with ARDS, a serious lung condition. One method used lung imaging to tailor settings, while the other followed standard guidelines. The goal was to see if the imaging-based approach could lower the chance of dea…

This study tested a personalized approach to help patients in the intensive care unit (ICU) come off a breathing machine (ventilator). The strategy used daily checks and chose the best method to test breathing based on each patient's risk factors, like obesity or heart disease. T…

This study looked at whether giving a gas called sevoflurane (used for sleep during surgery) for 48 hours can improve oxygen levels and reduce inflammation in people with acute respiratory distress syndrome (ARDS), a severe lung condition. Fifty adults with moderate to severe ARD…

This study looked at whether measuring a protein called S100B in the blood can help doctors decide if a child with a mild head injury needs a CT scan. Over 2,200 children participated, and the goal was to see if using the blood test could safely reduce the number of CT scans, whi…

This study tested a new diagnostic tool called Premaquick, which measures three markers in vaginal fluid, to see if it can better predict whether a woman with threatened preterm labor will deliver within 7 days. The study involved 221 pregnant women between 24 and 34 weeks of pre…

This study tested whether filling dialysis catheters with a 60% ethanol (alcohol) solution could prevent serious infections in critically ill patients with acute kidney failure. Over 1,400 adults in intensive care units took part, receiving either the ethanol lock or a placebo. T…

This study tested whether curcumin (the active ingredient in turmeric) can prevent Crohn's disease from coming back after surgery. Researchers compared curcumin to standard thiopurine drugs in 61 adults who had just had surgery for Crohn's. The goal was to see if curcumin could b…

This study tested whether taking an oral antibiotic the day before colorectal surgery, in addition to standard IV antibiotics, reduces surgical site infections more than IV antibiotics alone. Over 900 adults having elective colorectal surgery participated. The goal was to see if …

This study tested whether a smartphone app (ARTHE-e) helps people with knee osteoarthritis follow their exercise plan better than standard care. About 120 adults aged 40-85 with knee osteoarthritis participated. The app provides guidance and reminders to support exercise adherenc…

This study compared two surgical methods for removing the uterus due to non-cancerous conditions: vNOTES (surgery through the vagina) and standard laparoscopy (surgery through small belly cuts). 145 women were randomly assigned to one method. The main goal was to see if vNOTES ca…

This study tested whether wearing a virtual reality mask during blood tests and skin prick tests can reduce pain and anxiety in allergic children aged 7 to 13. About 300 kids took part across two hospitals. The goal was to see if VR distraction makes these routine procedures less…

This study tested whether ethosuximide, a drug used for seizures, can reduce belly pain in people with irritable bowel syndrome (IBS). 162 adults with IBS took part. The goal was to see if the drug lowers pain and improves quality of life. The study is complete, and results may o…

This study tested a virtual reality program designed to help people quit smoking. The program was based on situations that often trigger a relapse. Researchers measured how many participants quit smoking after 6 weeks and up to one year, and tracked their cravings. The study incl…

This study tested whether using virtual reality during botulinum toxin injections can lower stress and pain in 42 adults with muscle stiffness from conditions like stroke or multiple sclerosis. Participants wore a VR headset during the procedure, and researchers measured heart ra…

This study tested whether a specific type of leg strengthening exercise (eccentric isokinetic) works better than standard exercises for people with knee osteoarthritis. 40 adults aged 40-70 with one-sided knee arthritis participated. The goal was to see if this exercise could imp…

This study tested whether botulinum toxin (Botox) injections can reduce head shaking in people with essential head tremor, a condition that often doesn't respond to standard medications or surgery. About 120 adults with troublesome head tremor received either Botox or a placebo i…

This study tested whether a structured plan for giving diuretics (water pills) to patients hospitalized with worsening chronic heart failure is safer and more effective than usual care. About 299 adults took part. The goal was to see if the protocol could better manage fluid buil…

This study looked at 90 older adults (65+) who needed shoulder replacement after a severe upper arm fracture. Researchers compared two surgical techniques—one through the front and one through the side—to see which leads to better shoulder function and recovery. The goal is to fi…

This small study looked at 7 adults with long-term nerve pain (neuropathic pain) to see if taking memantine or dextromethorphan after a ketamine treatment could help maintain or improve pain relief. Participants had already responded well to ketamine. The study measured pain leve…

This study tested whether ethosuximide, a drug used for epilepsy, can reduce pain in people with nerve damage from injury or surgery. 114 adults with moderate to severe nerve pain took part. The goal was to see if the drug improves pain, sleep, and quality of life compared to a p…

This study looked at 80 adults with a broken upper arm bone who needed surgery with a nail. It compared the usual method of inserting the nail through the rotator cuff to a newer method that goes through a gap in the tendons. The goal was to see if the newer method helps people r…

This study tested whether a single infusion of ketamine combined with magnesium can reduce the number of daily attacks in people with chronic cluster headache that hasn't responded to standard treatments. 93 adults with at least 2 attacks per day received either the ketamine-magn…

This study tested whether a sedative called dexmedetomidine can help calm agitation and shorten delirium in ICU patients who are not on a breathing machine. 168 adults with sudden confusion and agitation took part. The goal was to see if the drug could reduce the time they spent …

This study looked at 140 women who had their tubes tied (tubal ligation) using either standard belly-button laparoscopy or a newer vaginal approach called vNOTES. The goal was to see if the type of surgery affected sexual quality of life 6 months later. Participants filled out a …

This study tested a French version of the Oral Health Impact Profile (OHIP) questionnaire in 200 adults, including people with gum disease and healthy volunteers. The goal was to ensure the questionnaire accurately measures how oral health affects quality of life. Participants si…

This study tested whether augmented reality (AR) can help surgeons during laparoscopic surgery for uterine fibroids or adenomyosis. AR overlays images from prior scans onto the live surgical view. 40 patients took part, and surgeons rated the AR system's ease of use and how well …

This study looked at whether multiple sclerosis (MS) and its treatments affect a woman's egg reserve, measured by a hormone called AMH. Researchers analyzed blood samples from over 800 women with MS or a related condition, aged 18 to 35. The goal was to help doctors decide when t…

This study tested a French version of a questionnaire called DHEQ, which measures how tooth sensitivity (sharp pain from cold or touch) affects quality of life. Researchers enrolled 216 adults across three centers in France, including people with different levels of sensitivity a…

This study looked at 111 couples receiving donated eggs to see if the type of freezing solution used affected pregnancy rates. Researchers compared a solution made just for eggs versus a 'universal' one used for multiple stages. The goal was to see if switching to the universal s…

This study looked at how plant-based protein foods and physical activity change the way older adults digest and use protein. Fifteen inactive older adults took part. Researchers measured protein breakdown and muscle signals before and after a 12-week exercise program. The goal wa…

This study aimed to find out what factors can predict pain after oral surgery, like a tooth extraction. Researchers measured pain levels in 148 adults for five days after surgery and used simple questionnaires and tests done before the procedure. The goal was to create a model th…

This study looked at 467 adults who had childhood leukemia and were treated with a drug called vincristine. The goal was to find out how many still have nerve damage (tingling, numbness, or pain) years later. Researchers used a questionnaire to measure symptoms. The study does no…

This study tested an artificial intelligence tool called EMA to see if it can rank embryos better than traditional methods used in IVF. Researchers looked at data from 333 patients to compare AI scores with manual embryo grading. The goal was to find out if AI can help increase t…

This study looked at over 3,000 adults in operating rooms to see which size of Macintosh blade (a tool used to help place a breathing tube) works best on the first try. The goal was to find the optimal blade size to reduce complications. This was an observational study, meaning n…

This study looked at 332 people having a procedure to remove a blood clot from the brain after a stroke. Researchers wanted to see if using sedation (keeping the patient sleepy but breathing on their own) or general anesthesia (being fully asleep with a breathing tube) led to bet…

This study tested a new approach using a lung ultrasound score to guide treatment decisions after removing a breathing tube in ICU patients who were on a ventilator for more than 48 hours. The goal was to see if this method could reduce the number of patients who develop serious …

This study looked at 60 adults with cirrhosis to see if a simple frailty test (Liver Frailty Index) matches actual leg muscle strength. Researchers measured quadriceps strength and checked for malnutrition and frailty using several tools. The goal is to find better ways to spot p…

This study looked at two different ways of pushing during the final stage of labor: holding your breath while pushing (closed-glottis) versus pushing while breathing out (open-glottis). Researchers wanted to see which method leads to fewer injuries and better outcomes for both mo…