New exercise approach for knee pain shows promise
NCT ID NCT01586130
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether a special type of exercise called isokinetic eccentric strengthening can improve knee function and reduce pain in people with knee osteoarthritis. 40 adults with one-sided knee osteoarthritis participated. The exercises focused on strengthening the quadriceps muscle in a way that mimics walking. The goal was to see if this approach works better than standard concentric exercises.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- isokinetic exercise in eccentric mode
- What this could lead to
- If it works, this could point toward better exercise programs for knee osteoarthritis to improve strength and walking.
- What could go wrong
- This is a small, early-phase study with only 40 participants. The results may not apply to everyone with knee osteoarthritis.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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40 people
The number who actually took part.
- Start date
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Feb 2012
- Finished
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Dec 2018
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient male or female, age ranging from 40 to 70 years old * Patient suffering from one-sided knee O.A. regarding criteria of the American College of Rheumatology (A.C.R.), with radiologic score ranging from 2 to 3 according to the Kellgren \& Lawrence classification. * Patient receiving medical support * Patient that did not receive any infiltration on knee within two months before randomisation. * Patient free from any disease that could be a contraindication to the study treatment * Patient able to understand the protocol and willing to comply with its rules. * Patient willing to give consent. * Patient affiliated to the french social secu Exclusion Criteria: * Patient carrying prosthesis. * Patient suffering from inflammatory arthritis, or flare of arthritis. * Patient suffering from symptomatic patellofemoral osteoarthritis. * Patient suffering from cardio-vascular or pneumologic disease that could a contraindication to the study treatment. * Patient suffering from any pathology that could cause muscular weakness (myopathy, neuropathy, hemiplegia...)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU Clermont-Ferrand
Clermont-Ferrand, 63003, France