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Breathing machine settings may boost chest therapy in ICU

NCT ID NCT06805357

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how different ventilator modes affect lung volume changes during chest physiotherapy in 40 ICU patients on breathing machines. Researchers will compare two common ventilator settings to see which one helps the lungs expand more after chest compressions. The goal is to improve airway clearance and lung function in critically ill patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Chest physiotherapy by rib cage compressions
What this could lead to
If successful, this study could help doctors choose the best ventilator settings during chest physiotherapy to improve lung function in critically ill patients.
What could go wrong
This is a small, early-stage study with only 40 participants, so results may not apply to all ICU patients. It measures short-term lung volume changes, not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2024

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient under assisted ventilation (in V-ACV or PSV) triggering all ventilator cycles * Patient deemed " secretive ": requiring ≥ 2 tracheal aspirations every 3 hours * Patient (or relative) who has given consent to participate in the research * Patient covered by social security Exclusion Criteria: * Age under 18 years * Legal guardian required * Recent cardiac and/or thoracic and/or abdominal surgery (\< 3 months) * Rib fracture(s) * Pneumothorax and/or presence of a chest drain * Recent neurosurgery (\< 3 months) and/or proven or suspected increased intracranial pressure (ICP) * Hemodynamic instability defined as: noradrenaline ≥ 1mg/h, adrenaline ≥ 0.5 mg/h, dobutamine ≥ 5γ/kg/min. * Respiratory instability defined as: PEEP \> 10 cmH2O and/or PaO2/FiO2 \< 150 mm Hg * Pregnancy * Hemoptysis * Sever skin lesions (e.g., burns, Lyell's syndrome) * Patient under foreign health insurance

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Airway clearance Chest physiotherapy Intensive care Invasive mechanical ventilation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Intensive Care Medicine Department Henri Mondor Hospital

    RECRUITING

    Créteil, 94000, France

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