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Could cancer patients with dangerous clots be treated at home?

NCT ID NCT07315347

Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether people with active cancer who have a blood clot in their lungs (pulmonary embolism) can be safely treated at home instead of in the hospital. About 824 participants will be randomly assigned to either go home within 24 hours or stay in the hospital for at least 48 hours. The main goal is to see if home treatment is as good as hospital care at preventing new clots, major bleeding, or death within 14 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
home treatment (early discharge with phone follow-up) vs hospitalisation
What this could lead to
If successful, this could show that many cancer patients with a pulmonary embolism can be safely treated at home instead of in the hospital, improving comfort and reducing healthcare costs.
What could go wrong
This is a non-inferiority trial, so it aims to prove home care is not worse than hospital care, not that it is better. The results may not apply to all cancer patients, and there is a risk of bleeding or recurrent clots that could be harder to manage at home.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 824 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Apr 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Symptomatic or incidental hemodynamically stable PE objectively confirmed ≤ 24h according to the ESC guidelines * Active cancer other than basal-cell or squamous-cell carcinoma of the skin defined at least by one of the followings: * cancer that has been diagnosed within the past 6 months, * cancer for which anti-cancer treatment is being given at the time of enrolment or during 6 months before randomisation, or recurrent locally advanced or metastatic cancer * No HESTIA criteria (i.e. no other medical condition than cancer since cancer is one of the medical condition that can check "yes" to the item). * For woman of childbearing potential: negative beta-HCG before inclusion * Signed informed consent * Affiliated to French " sécurité sociale " * Good understanding of the French language Exclusion Criteria: * Diagnosis of PE established for over 24h before inclusion * Shock or hypotension defined as systolic blood pressure \<90 mmHg or a systolic pressure drop by ≥40 mmHg, for \>15 minutes, if not caused by new-onset arrhythmia, hypovolaemia, or sepsis * Hospitalisation for over 24h * ECOG performans status 3 or 4 * Impossibility for 30-day follow-up, * Estimated life expectancy less than 30 days * Patient in detention by judicial or administrative decision, * Patient placed under a legal protection measure, * Patient unable of giving free and informed consent * Inclusion in another interventional study requiring hospitalisation * Pregnant or breastfeeding women * Patient on AME (state medical aid)

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Conditions

The condition(s) this trial relates to.

cancer pulmonary embolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Active cancer and symptomatic or incidental pulmonary embolism without hestia criteria

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    20 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • C01 - Pneumologie et Soins Intensifs - HEGP

    RECRUITING

    Paris, France, 75015, France

  • C02 - Département interdisciplinaire d'organisation des parcours patients - Institut gustave Roussy

    RECRUITING

    Villejuif, France, 94805, France

  • C03 - Médecine interne et médecine vasculaire - Hospices Civils de Lyon

    RECRUITING

    Pierre-Bénite, France, 69310, France

  • C04 - Oncologie Médicale - Centre Georges-François Leclerc - CLCC

    NOT_YET_RECRUITING

    Dijon, France, 21079, France

  • C05 - Médecine Interne - Hôpital Louis Mourier - APHP

    RECRUITING

    Colombes, France, 92700, France

  • C06 - Pneumologie - Hôpital Cochin - APHP

    NOT_YET_RECRUITING

    Paris, France, 75014, France

  • C07 - Médecine Vasculaire - Hôpital Saint Joseph

    NOT_YET_RECRUITING

    Paris, 75014, France

  • C08 - Département de Médecine interne et pneumologie - CHU la Cavale Blanche

    RECRUITING

    Brest, 29609, France

  • C09 - Médecine vasculaire et thérapeuthique - CHU Saint Etienne

    RECRUITING

    Saint-Priest-en-Jarez, 42270, France

  • C10 - Département médecine urgence - CHU Angers

    RECRUITING

    Angers, 49933, France

  • C11 - Pneumologie - CH René Dubos

    RECRUITING

    Cergy-Pontoise, 95304, France

  • C12 - Médecine Vasculaire - CHU Amiens Picardie

    RECRUITING

    Amiens, 80054, France

  • C13 - Médecine Vasculaire - CHU Dijon

    NOT_YET_RECRUITING

    Dijon, 21000, France

  • C14 - Médecine Vasculaire - CH Toulon

    RECRUITING

    Toulon, 83100, France

  • C15 - Médecine Interne - CHU Rouen

    RECRUITING

    Rouen, 76031, France

  • C16 - Département Urgences - CHU Clermont Ferrand

    RECRUITING

    Clermont-Ferrand, 63000, France

  • C17 - Médecine Interne - CHU Nantes

    RECRUITING

    Nantes, 44000, France

  • C18 - Pneumologie - CH de Versailles Hôpital André Mignot

    RECRUITING

    Le Chesnay, 78157, France

  • C19 - Pneumologie - Hôpital Foch

    RECRUITING

    Suresnes, 92151, France

  • C20 - Médecine Vasculaire - CHU Toulouse

    NOT_YET_RECRUITING

    Toulouse, 31059, France

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