Could a simple block test detect 'Silent' brain fog in liver disease?
NCT ID NCT06619106
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tests a new cognitive test using building blocks to quickly screen for minimal hepatic encephalopathy (MHE), a subtle brain complication in people with liver disease. Researchers will compare the test's accuracy against standard methods in 100 adults with liver fibrosis, cirrhosis, or porto-systemic shunts. If proven reliable, it could offer a faster, simpler way to diagnose MHE.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cognitive test using building blocks
- What this could lead to
- If successful, this could provide a quick, reliable screening tool for minimal hepatic encephalopathy, helping doctors diagnose it earlier and more accurately.
- What could go wrong
- This is a small pilot study (100 participants) testing a new tool against existing tests. It may not prove accurate enough or may not work in broader populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2026
- Expected to finish
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Jan 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with liver cirrhosis or portosystemic shunts with suspicion of minimal hepatic encephalopathy
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age between 18 and 70 years * Hepatic pathology (fibrosis, cirrhosis, porto-systemic shunts) * Evaluation at BLIPS clinic (neuropsychological assessment, MRI, EEG and blood sample with ammonia) Exclusion Criteria: * Opposition to participating in the study * Not being affiliated with French healthcare system
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Hepatic pathology (fibrosis, cirrhosis, porto systemic shunts) are added.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Hepato-gastro-enterology department, Pitié Salpêtrière hospital
RECRUITINGParis, 75013, France