New study tests best way to prevent second stroke in older adults with heart hole

NCT ID NCT05387954

Recruiting now Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Mar 30, 2026 · Last updated Apr 29, 2026 · Updated 6 times

Summary

This study looks at 792 adults aged 60 to 80 who had a stroke linked to a small hole in the heart (PFO). It compares three approaches: closing the hole with a device plus antiplatelet drugs, taking blood thinners alone, or taking antiplatelet drugs alone. The goal is to see which method best prevents another stroke over time.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Contact

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Locations

APHP Hôpital Lariboisière
RECRUITING

Paris, 75010, France

Contact Phone: •••-•••-•••• Email: •••••@•••••
CH Grenoble-Site Nord
RECRUITING

Grenoble, 38043, France

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CH Orsay
RECRUITING

Orsay, 91400, France

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CH Perpignan
RECRUITING

Perpignan, 66000, France

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CH Sud Francilien
RECRUITING

Corbeil-Essonnes, 91100, France

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CH Versailles-Hôpital Mignot
RECRUITING

Le Chesnay, 78150, France

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CH Yves Le Foll
RECRUITING

Saint-Brieuc, 22000, France

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CHRU La Cavale Blanche
RECRUITING

Brest, 29200, France

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CHRU Lille-Hôpital Salengro
RECRUITING

Lille, 59037, France

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CHRU Tours- Hôpital Bretonneau
RECRUITING

Tours, 37000, France

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CHU Amiens
RECRUITING

Amiens, 80054, France

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CHU Bicêtre
RECRUITING

Le Kremlin-Bicêtre, 94370, France

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CHU Bordeaux - GH Pellegrin
RECRUITING

Bordeaux, 33000, France

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CHU Carémeau
RECRUITING

Nîmes, 30900, France

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CHU Clermont Ferrand
RECRUITING

Clermont-Ferrand, 63000, France

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CHU Côte de Nacre
RECRUITING

Caen, 14000, France

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CHU Dijon-Hôpital François Mitterrand
RECRUITING

Dijon, 21079, France

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CHU Jean Minjoz
RECRUITING

Besançon, 25000, France

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CHU La Milétrie
RECRUITING

Poitiers, 86021, France

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CHU Limoges - Site Dupuytren
RECRUITING

Limoges, 87042, France

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CHU Nantes-Hôpital Nord Laennec
RECRUITING

Saint-Herblain, 44093, France

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CHU Rennes-Hôpital Pontchaillou
RECRUITING

Rennes, 35000, France

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CHU Rouen-Hôpital Charles-Nicolle
RECRUITING

Rouen, 76000, France

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CHU Saint-Etienne-Hôpital Nord
RECRUITING

Saint-Priest-en-Jarez, 42270, France

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CHU Toulouse-Hôpital Pierre Paul Riquet
RECRUITING

Toulouse, 31059, France

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CHU de Nice-Hôpital Pasteur
RECRUITING

Nice, 06000, France

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Centre Hospitalier de Valenciennes
RECRUITING

Valenciennes, 59300, France

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Centre Hospitalier de la Côte Basque
RECRUITING

Bayonne, 64100, France

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Fondation Adolphe de Rothschild
RECRUITING

Paris, 75019, France

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GHU Paris Psychiatrie et Neurosciences
RECRUITING

Paris, 75014, France

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GPE Hospitalier La Rochelle-Ré-Aunis
RECRUITING

La Rochelle, 17000, France

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Grand Hôpital de l'Est Francilien
RECRUITING

Meaux, 77140, France

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Groupe Hospitalier Paris Saint-Joseph
RECRUITING

Paris, 75014, France

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HCL-Groupement Hospitalier Lyon Est
RECRUITING

Bron, 69677, France

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Hôpital Foch
RECRUITING

Suresnes, 92150, France

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Hôpital Gui de Chauliac
RECRUITING

Montpellier, 34295, France

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Hôpital Hautepierre
RECRUITING

Strasbourg, 67000, France

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Hôpital Henri Mondor
RECRUITING

Créteil, 94010, France

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Hôpital Novo
RECRUITING

Pontoise, 95300, France

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Hôpital Pitié Salpêtrière
RECRUITING

Paris, 75013, France

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Hôpital Raymond Poincaré
RECRUITING

Garches, 92380, France

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Hôpital de la Timone
RECRUITING

Marseille, 13005, France

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Conditions

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CRYPTOGENIC ISCHEMIC STROKE PATENT FORAMEN OVALE