New hope for older blood cancer patients: study tests better GVHD prevention after transplant

NCT ID NCT06083129

Recruiting now Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Apr 29, 2026 · Last updated Apr 29, 2026

Summary

This study tests which of two drugs (ATG-thymoglobulin or ATLG-grafalon) works better at preventing graft-versus-host disease (GVHD) in adults aged 50-70 with acute myeloid leukemia or myelodysplastic syndrome. Participants receive a stem cell transplant from a matched unrelated donor after a reduced-intensity chemotherapy regimen. The goal is to reduce severe GVHD while controlling the cancer, improving survival and quality of life.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

CHRU Nancy
RECRUITING

Nancy, France

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CHRU Strasbourg
RECRUITING

Strasbourg, France

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CHRU Tours
NOT_YET_RECRUITING

Tours, France

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CHU Amiens
RECRUITING

Amiens, France

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CHU Angers
RECRUITING

Angers, France

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CHU Besançon
RECRUITING

Besançon, France

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CHU Bordeaux
RECRUITING

Bordeaux, France

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CHU Brest
RECRUITING

Brest, France

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CHU Caen
RECRUITING

Caen, France

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CHU Clermont-Ferrand
RECRUITING

Clermont-Ferrand, France

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CHU Grenoble
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Grenoble, France

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CHU Lille
RECRUITING

Lille, France

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CHU Limoges
RECRUITING

Limoges, France

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CHU Lyon Sud
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Lyon, France

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CHU Montpellier
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Montpellier, France

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CHU Nantes
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Nantes, France

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CHU Nice
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Nice, France

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CHU Poitiers
RECRUITING

Poitiers, France

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CHU Rennes
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Rennes, France

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CHU Saint Etienne
RECRUITING

Saint-Etienne, France

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Hôpital Henri Mondor AP-HP
NOT_YET_RECRUITING

Créteil, France

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Hôpital La Pitié Salpêtrière AP-HP
RECRUITING

Paris, France

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Hôpital Necker AP-HP
RECRUITING

Paris, France

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Hôpital Saint Louis AP-HP
RECRUITING

Paris, France

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Hôpital Saint-Antoine AP-HP
RECRUITING

Paris, France

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IPC Marseille
RECRUITING

Marseille, France

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Institut Gustave Roussy
RECRUITING

Villejuif, France

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Oncopole Toulouse
RECRUITING

Toulouse, France

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Conditions

Explore the condition pages connected to this study.

GVHD