New hope for older blood cancer patients: study tests better GVHD prevention after transplant

NCT ID NCT06083129

Recruiting now Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Apr 29, 2026 · Last updated Apr 29, 2026

Summary

This study tests which of two drugs (ATG-thymoglobulin or ATLG-grafalon) works better at preventing graft-versus-host disease (GVHD) in adults aged 50-70 with acute myeloid leukemia or myelodysplastic syndrome. Participants receive a stem cell transplant from a matched unrelated donor after a reduced-intensity chemotherapy regimen. The goal is to reduce severe GVHD while controlling the cancer, improving survival and quality of life.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

CHRU Nancy
RECRUITING

Nancy, France

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CHRU Strasbourg
RECRUITING

Strasbourg, France

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CHRU Tours
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Tours, France

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CHU Amiens
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Amiens, France

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CHU Angers
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Angers, France

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CHU Besançon
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Besançon, France

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CHU Bordeaux
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Bordeaux, France

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CHU Brest
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Brest, France

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CHU Caen
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Caen, France

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CHU Clermont-Ferrand
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Clermont-Ferrand, France

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CHU Grenoble
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Grenoble, France

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CHU Lille
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Lille, France

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CHU Limoges
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Limoges, France

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CHU Lyon Sud
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Lyon, France

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CHU Montpellier
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Montpellier, France

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CHU Nantes
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Nantes, France

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CHU Nice
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Nice, France

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CHU Poitiers
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Poitiers, France

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CHU Rennes
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Rennes, France

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CHU Saint Etienne
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Saint-Etienne, France

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Hôpital Henri Mondor AP-HP
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Créteil, France

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Hôpital La Pitié Salpêtrière AP-HP
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Paris, France

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Hôpital Necker AP-HP
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Paris, France

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Hôpital Saint Louis AP-HP
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Paris, France

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Hôpital Saint-Antoine AP-HP
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Paris, France

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IPC Marseille
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Marseille, France

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Institut Gustave Roussy
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Villejuif, France

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Oncopole Toulouse
RECRUITING

Toulouse, France

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Conditions

Explore the condition pages connected to this study.

GVHD