Heart disorder

This study looks at how well minimally invasive procedures (like balloons and stents) work for people with severe blockages in the leg arteries. It will track 1000 patients to see if these treatments restore blood flow and keep arteries open over time. The goal is to find the bes…

This early-phase study tests a new drug called ERAS-601, alone or with other cancer treatments, in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find safe doses and check for side effects. About 90 participants will take pa…

This trial tests whether adding dapagliflozin—a drug commonly used for diabetes—to standard diuretic treatment helps adults hospitalized with acute heart failure. The goal is to see if it reduces fluid buildup in the lungs (measured by ultrasound), shortens hospital stays, and im…

Researchers are testing whether intensive blood pressure lowering slows heart and valve damage in people with asymptomatic moderate to severe aortic valve stenosis. The trial enrolls 60 adults with high blood pressure and a narrowed aortic valve but no symptoms. Half receive stan…

This study tested whether a half-dose blood thinner (ticagrelor) taken alone after heart stent placement works as well as the standard two-drug therapy in East-Asian patients with chronic coronary syndrome. Sixty participants were randomly assigned to one of three treatment group…

This study tested whether probenecid, a medicine usually used for gout, can improve heart function and exercise ability in veterans with heart failure. About 99 veterans with a specific type of heart failure took probenecid twice daily for 180 days. Researchers measured changes i…

Researchers are testing a stent-like device called the DynamX Drug-Eluting Coronary Bioadaptor System in people with complex coronary artery blockages, including long lesions, chronic total occlusions, and blockages at artery branches. The study enrolls about 55 adults and measur…

This study looks at whether the drug eplontersen can reduce abnormal protein buildup in the heart for people with a condition called ATTR-CM. About 150 participants from a larger trial will get heart scans after 140 weeks of treatment. The goal is to see if the drug helps clear t…

This study is a follow-up to an earlier trial, testing the long-term safety and effects of a drug called AOC 1001 in adults with myotonic dystrophy type 1 (DM1), a genetic muscle disease. 37 participants who completed the first study received multiple doses of AOC 1001 by IV infu…

Researchers are studying whether sacubitril-valsartan, a standard heart failure drug, can lower estimated pulmonary artery systolic pressure in people with reduced ejection fraction heart failure. The trial enrolls adults with an ejection fraction of 40% or less. Participants rec…

Researchers are testing whether adjusting intravenous diuretic doses based on sodium levels in urine helps clear excess fluid more effectively than standard care in people hospitalized with acute heart failure. The trial enrolls adults with fluid overload and compares a strategy …

Researchers at Ege University are testing a mobile phone program called m-BAFY that helps people with atrial fibrillation manage their condition at home. The app lets patients record symptoms and vital signs, sends personalized feedback, and provides guideline-based information o…

This trial tests whether giving higher or lower doses of a water-removing medicine, guided by urine sodium and output, helps adults hospitalized with acute heart failure. Researchers compare two urine-guided strategies with standard care, measuring how much sodium and urine the b…

This trial tests whether people with atrial fibrillation who had a stent placed more than a year ago can safely switch from two blood thinners to just one. Participants receive either a single anticoagulant or the same anticoagulant plus clopidogrel for two years. Researchers tra…

This trial is testing an experimental drug called eplontersen in people with transthyretin-mediated amyloid cardiomyopathy (ATTR CM), a condition where abnormal protein builds up in the heart and leads to heart failure. The study aims to see if the drug, given as a regular inject…

This trial tests whether giving diuretics based on bioimpedance analysis, a body scan that measures fluid levels, can slow heart failure progression in people who have no visible signs of congestion. Participants are adults with heart failure and a reduced ejection fraction, but …

This Phase 3b study is testing whether the drug benralizumab (Fasenra) can allow people with severe eosinophilic asthma to safely reduce their daily maintenance medications. About 504 participants aged 12-75 in China will try to step down from drugs like inhaled steroids or long-…

This trial tests whether placing a piece of the patient's own pericardial fat over a chronic heart scar can improve cardiac function. Participants are people who have had a heart attack and need bypass surgery for other heart areas, but have a scar that cannot be revascularized. …

This Canadian study tests whether remote monitoring of implantable defibrillators can replace regular in-clinic checkups. Over 1,100 participants will either use a home transmission system or receive usual care. The goal is to see if remote monitoring can detect heart issues fast…

This study tests whether collecting and re-infusing unwashed shed blood during off-pump coronary artery bypass surgery can reduce the need for donor blood transfusions and lower complications. Fifty adults undergoing this surgery will have their shed blood returned via a special …

This study looks at two ways to perform coronary artery bypass grafting, a surgery that reroutes blood around blocked heart arteries. One method uses a single chest artery for the graft, while the other uses both chest arteries. Researchers will compare long-term survival, stroke…

This trial tests whether vasopressin or norepinephrine is better at raising blood pressure without straining the lungs' blood vessels in adults having elective cardiac surgery. Participants receive one of the two drugs as a continuous infusion when their blood pressure drops duri…

This phase 3 trial tests an experimental drug called AOC 1001 in 159 adults with myotonic dystrophy type 1, a genetic condition that causes muscle weakness and stiffness. Participants receive either the drug or a placebo by intravenous infusion. The main goal is to see if the dru…

This trial tests whether giving a higher dose of the antibiotic rifampicin (35 mg/kg) can increase drug levels in the fluid around the heart and clear tuberculosis bacteria faster than the standard dose (10 mg/kg). The study enrolls adults with suspected tuberculous pericarditis,…

This Phase 2 trial tested the drug tovinontrine (CRD-750) against a placebo in 557 adults with chronic heart failure and reduced pumping ability. The goal was to see if the drug safely lowers a key heart stress marker called NT-proBNP over 12 weeks. The study is complete, and res…

This Phase 2 study tested the safety and effectiveness of tovinontrine, an experimental drug, compared to a placebo in 303 adults with chronic heart failure with preserved ejection fraction. The main goal was to see if tovinontrine could lower a key biomarker (NT-proBNP) in the b…

This study tests whether the blood thinner edoxaban can prevent strokes in people with atrial fibrillation (an irregular heartbeat) who have already survived a brain bleed. About 948 participants will receive either edoxaban or non-anticoagulant therapy (like aspirin or no blood …

This study looked at data from 500 people in Germany who started taking vericiguat for chronic heart failure with reduced ejection fraction. Researchers wanted to see how well the drug works outside of clinical trials, in routine medical care. They tracked deaths and hospitalizat…

This study looks at whether doing two procedures at once—pulsed field ablation (FARAPULSE) to fix irregular heartbeats and implanting a Watchman device to close off a part of the heart where clots form—is as safe as doing them separately. About 120 people with atrial fibrillation…

This study tests whether using the Impella 5.5 heart pump during and after heart surgery improves outcomes for 100 patients with severely weakened hearts. The pump supports blood flow, aiming to reduce death, stroke, kidney failure, and heart failure after surgery. Participants m…

This trial tests whether a wearable ECG patch called MEMO Patch Plus can detect clinically significant arrhythmias in adults hospitalized with acute heart failure. Participants wear the patch for up to 14 days in the hospital and again for up to 14 days after discharge. The study…

This trial tests whether a cutting balloon, a catheter with tiny blades that score the vessel wall before expanding, can safely widen branch pulmonary arteries that resist standard low-pressure balloon dilation. Researchers will compare the cutting balloon to high-pressure balloo…

This trial tests whether taking vitamin K2 (with vitamin D) every day can slow the progression of calcium buildup in the coronary arteries—a key risk factor for heart attacks. It enrolls 400 men and women with severe coronary calcification, who are randomly assigned to receive th…

This study looks at whether dupilumab, an injectable medication, can improve lung function and reduce symptoms in adults with COPD who have a specific type of inflammation. The researchers are reviewing medical records from patients who received dupilumab as part of routine care,…

This trial compares two guiding catheters—GUIDEX and Launcher—used during a procedure to open narrowed heart arteries (percutaneous coronary intervention, or PCI). About 150 adults with coronary artery disease will be randomly assigned to receive one of the two catheters. The goa…

This trial tests whether using detailed CT images of the heart's arteries to plan invasive procedures can reduce radiation exposure, procedure time, contrast use, and tools needed. Adults with stable angina and significant blockages are randomly assigned to receive either standar…

This study tested a new medicine called CDR132L in 294 people who had a recent heart attack and had weak heart pumping (ejection fraction 45% or less). Participants received one of two doses of CDR132L or a placebo, added to standard care, for 6 months. The goal was to see if the…

This trial tests whether a new physical technique, the reverse vagal maneuver, can restore normal heart rhythm in adults with paroxysmal supraventricular tachycardia (PSVT) more effectively than the standard modified Valsalva maneuver. Participants are randomly assigned to one of…

This trial explores how intensifying neurohormonal blockade—by adding or increasing eplerenone or finerenone—affects sodium excretion in people with chronic heart failure. Researchers will measure urinary sodium before and after diuretic use across three visits to see if treatmen…

This study looks at whether a predefined plan to pause and restart blood thinners (factor Xa inhibitors) around minor procedures—like dental work, cataract surgery, or routine endoscopy—can reduce bleeding in people with atrial fibrillation. It follows 2,500 adults who take rivar…

This study tests whether time-restricted eating—eating only between 11 am and 7 pm—can safely and effectively boost the benefits of standard cardiac rehabilitation for people with coronary artery disease. About 45 participants will be randomly assigned to either standard rehab al…

This trial compares two types of contrast agents used during optical coherence tomography (OCT), a test that takes detailed pictures of the heart's arteries. The study will see if one agent uses less contrast, produces clearer images, and causes fewer heart rhythm changes than th…

This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pill…

This trial compares two types of drug-eluting stents—tiny mesh tubes that prop open arteries—in people with completely blocked coronary arteries. One stent uses a coating that dissolves over time (bioresorbable polymer) to release the drug sirolimus, while the other has a permane…

This trial tests whether using cryoballoon ablation as the first treatment for persistent atrial fibrillation (AF) is more effective and safer than starting with anti-arrhythmic drugs. Adults aged 18-75 with symptomatic persistent AF and a structurally normal heart are eligible. …

This trial tests whether a structured support program can help people with coronary artery disease maintain regular exercise after completing cardiac rehabilitation. Participants receive group counseling calls, personal phone check-ins, and introductions to community exercise pro…

This trial tests whether sacubitril/valsartan, a newer heart failure medication, is safer and more effective for the kidneys than ramipril, an older ACE inhibitor, in people hospitalized with acute decompensated heart failure who also have chronic kidney disease. About 515 partic…

This trial tests whether injecting a local anesthetic into a nerve cluster in the neck—called a stellate ganglion block—can help stop dangerous heart rhythms in people who suffer a cardiac arrest outside a hospital. The study includes adults whose heart stops with a shockable rhy…

This trial tests whether a newer type of heart ablation, called pulsed-field ablation, can effectively isolate the pulmonary veins in people with paroxysmal atrial fibrillation while using very little or no X-ray guidance. The procedure uses the Farapulse system with a special ma…

This early-stage trial is testing a new gene therapy called AB-1002 in people with advanced heart failure (NYHA Class III). The therapy is given as a single infusion directly into the heart's blood vessels, aiming to deliver a gene that may help heart muscle pump more effectively…

This phase 3 trial investigates whether N-acetyl cysteine (NAC), an antioxidant supplement, can improve recovery in people hospitalized with an acute ischemic stroke. Participants receive either NAC or a placebo (saline) shortly after admission, and researchers track their neurol…

This trial tests a new type of pacemaker for people with heart failure who are having coronary bypass surgery. The pacemaker is designed to mimic a natural pattern called respiratory sinus arrhythmia, where the heart rate speeds up when breathing in and slows down when breathing …

This trial tests whether a new device called SynFlow 3.0 can safely support the heart during high-risk angioplasty (a procedure to open blocked coronary arteries) as well as the standard VA-ECMO device. About 222 people with severe coronary artery disease and a weakened heart (ej…

This study tests whether adults with heart failure who have an implanted pulmonary artery pressure sensor can safely adjust their own diuretic (water pill) doses. Participants follow a simple guide to change their medication based on daily pressure readings sent to their phone or…

This study tested a new way to treat paroxysmal atrial fibrillation (a type of irregular heartbeat) using pulsed field energy instead of standard radiofrequency. 292 adults with drug-resistant AF took part. The goal was to see if the new method is faster, safer, and more effectiv…

This trial tests whether doctors using mixed reality goggles (HoloLens 2.0) can perform MitraClip heart valve repair more efficiently and with less stress. Twenty adults with leaky mitral valves will undergo the standard clip procedure, but the surgeon will also wear a headset th…

This phase 2 trial tests whether vericiguat, a drug already used for heart failure, can improve blood vessel function in people with vasospastic angina—a type of chest pain caused by spasms in the heart's small arteries, not by blockages. About 57 adults with frequent angina symp…

This study tests whether giving heart failure patients a one-page checklist of recommended medications helps doctors prescribe them more often. The checklist lists guideline-approved drugs and doses for heart failure with reduced ejection fraction. Researchers will enroll 4000 pa…

This trial tests whether a special compression device called NewMan can reduce bleeding and bruising after a shoulder artery procedure compared to a standard pressure bandage. The study involves 229 adults with blocked leg arteries who need a catheter inserted through the arm. Do…

This trial tests whether a newer cryoballoon device, PolarX, works as well as the standard Arctic Front device for treating paroxysmal atrial fibrillation (a type of irregular heartbeat). About 200 people having their first pulmonary vein isolation procedure will be randomly assi…

This trial tests a new replacement heart valve, the Neovasc Tiara, that is delivered through a small tube (catheter) inserted into the chest. It is designed for people with severe mitral regurgitation—a leaky heart valve—who are too high-risk for traditional open-heart surgery. T…

This trial examines how two standard heart failure medications—bisoprolol (a beta blocker) and SGLT2 inhibitors (dapagliflozin or empagliflozin)—are processed by the body during an acute decompensated heart failure episode. Researchers will measure drug levels and heart function …

This pilot trial tests whether nurse-led motivational interviewing — a counseling style that strengthens a person's own motivation to change — can help adults with heart failure improve self-care behaviors like diet, medication adherence, and symptom monitoring. Participants in O…

This study tests whether adding an Oxiris membrane—a special blood filter that removes toxins and inflammatory molecules—to the ECMO circuit can reduce the harmful inflammation and organ damage that often occurs when blood flow is restored after cardiogenic shock. The trial enrol…

This phase 2 trial tests whether the drug abatacept can safely and effectively treat severe heart inflammation (myocarditis) caused by immune checkpoint inhibitors, a type of cancer immunotherapy. The study enrolls adults with any cancer who develop this rare but often fatal hear…

This trial tests whether a prehabilitation program — including exercise, education, and breathing techniques — helps people recover faster after planned heart surgery. The study enrolls adults scheduled for surgery for coronary artery disease, valve problems, or other heart condi…

This trial studies how long to cool the body after a cardiac arrest to protect the brain. It includes adults who are in a coma after being resuscitated from an out-of-hospital cardiac arrest. Participants are cooled to a target temperature and then rewarmed slowly, with different…

This study investigates whether combining two drugs that block brain-damaging overactivity—ketamine and perampanel—can stop super-refractory status epilepticus in people who remain in a coma after cardiac arrest. Researchers will compare outcomes in 84 patients who received this …

This phase 3 trial investigates whether the drug tolvaptan can safely and effectively correct low sodium levels in patients with hyponatremia, a condition where the body's sodium-water balance is off. The study enrolls adults with mild to moderate hyponatremia who are either euvo…

This trial tests two techniques for treating severely calcified coronary arteries before placing a stent. One uses a super high-pressure balloon to crack the calcium; the other uses intravascular lithotripsy, which sends shockwaves through the artery wall. The study includes 80 a…

This study looks at whether vericiguat, a drug that stimulates a key enzyme, can improve exercise ability and heart pressure during activity in people with chronic heart failure and reduced ejection fraction. Participants take vericiguat alongside their usual heart medications an…

This trial tests a special implantable cardioverter-defibrillator (ICD) that uses a single lead to sense both heart chambers, aiming to detect atrial fibrillation and other arrhythmias early. It includes 56 people who need a single-chamber ICD and are in normal sinus rhythm at th…

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This study compares three common heart medications (nicorandil, diltiazem, and isosorbide mononitrate) to see which best prevents the narrowing or failure of radial artery grafts used in coronary artery bypass surgery. About 150 adults who recently had bypass surgery will take on…

This trial investigates whether a one-year, app-supported home exercise program can improve quality of life and reduce the time spent in atrial fibrillation (AF) compared to usual care. Participants have paroxysmal or persistent AF, are in sinus rhythm at the start, and use a sma…

This study looked at over 17,000 people who had a heart attack to compare two blood thinners: prasugrel and ticagrelor. Hospitals switched from ticagrelor to prasugrel in a stepwise way to see which drug better prevents death, another heart attack, or stroke. The goal is to find …

This study tested whether using a heart MRI to find scar tissue can help decide which people with mild-to-moderate heart failure should get a defibrillator (ICD) to prevent sudden cardiac death. About 449 adults with a weakened heart pump (ejection fraction 36-50%) and scar tissu…

This trial compares two ways to insert a catheter into the heart during a heart attack: through the wrist (conventional) or through the hand (distal). The goal is to see which method is faster and causes fewer complications, such as blocking the wrist artery. About 550 heart atta…

This trial tests whether a newer, simpler 2-lead cardiac resynchronization therapy defibrillator (CRT-DX) works as well as the standard 3-lead system (CRT-D) in people with heart failure. The study includes 640 adults who need a CRT-D and have a normal heart rhythm. The main goal…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study tested whether starting ECMO (a heart-lung bypass machine) right at the location of a cardiac arrest, rather than waiting until the patient reaches the hospital, could improve survival with good brain function. Researchers enrolled 65 adults with refractory cardiac arr…

This trial investigates whether cardiac resynchronization therapy (CRT) — a special type of pacing — can improve how far people can walk in six minutes. It includes adults with congenital heart disease where the right ventricle pumps blood to the body (systemic right ventricle). …

This study tests whether an automated phone system that calls smokers with coronary heart disease after hospital discharge can help them quit. Participants receive calls at several time points over six months, checking on their smoking and offering support. The goal is to see if …

This phase 2 trial investigates whether metformin, a standard diabetes medication, can improve lung blood pressure and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension. Participants take metformin or a placebo for 1…

This trial tests whether a personalized physical activity plan can help children aged 5–18 with congenital heart disease increase their exercise capacity and daily activity levels. The plan is designed with input from parents, teachers, and a pediatric cardiologist to address saf…

This study tested whether a drug-coated balloon can stabilize fatty plaques in heart arteries that are at risk of rupturing and causing a heart attack. Researchers treated 45 patients with a recent heart condition, using a special balloon to deliver medication directly to the pla…

This study tested a bedside device called the Reprieve Decongestion Management System in 100 hospitalized patients with acute decompensated heart failure. The device automatically adjusts the dose of a diuretic (furosemide) and saline based on the patient's real-time urine output…

This completed trial tested whether giving epinephrine and verapamil directly into the heart arteries could help restore blood flow in heart attack patients whose vessels remain blocked despite standard treatment. 104 adults with ST-elevation heart attacks were enrolled. The stud…

This trial tests whether a new 3D-imaging method called vFFR works as well as the standard pressure-wire technique (FFR) to guide treatment for narrowed heart arteries. About 2,200 adults with stable chest pain or a recent non-emergency heart attack will be randomly assigned to o…

This trial tests whether CardiolRx, a pharmaceutical cannabidiol, can improve heart recovery in adults with acute myocarditis (heart muscle inflammation). Participants receive either CardiolRx or a placebo for 12 weeks. The study uses heart MRI scans to measure changes in heart t…

This study tested two different catheters (lattice-tip vs standard irrigated-tip) for a heart procedure called ablation, which treats a fast heartbeat (atrial flutter). 102 adults received the procedure to see which catheter works better and faster with fewer side effects. The go…

This study looked at whether using a blood test (NTproBNP) to guide heart-protecting medications can safely prevent heart damage in people with breast cancer or lymphoma receiving anthracycline chemotherapy. About 108 adults participated, and researchers measured how many joined,…

This study tested a new drug called aficamten against the standard medicine metoprolol in 175 adults with a heart condition that makes the heart muscle thick and blocks blood flow. The goal was to see which drug better improves exercise ability and symptoms like shortness of brea…

This study tested whether blood thinners (DOACs) work better than aspirin to prevent valve damage and serious heart problems after a less invasive aortic valve replacement (TAVI). 360 patients aged 65-80 were randomly assigned to take either a DOAC or aspirin daily. The main goal…

This study tested a surgical technique called femoral tripod eversion for people with blocked leg arteries. 37 patients were followed for two years to check safety and effectiveness. The procedure aims to clear blockages without using synthetic materials. Early results suggest it…

This study followed 500 people who received the Amplatzer PFO Occluder, a device that closes a small hole in the heart called PFO. Researchers tracked serious complications within 30 days and longer-term issues like stroke or blood clots over 3 years. The goal was to confirm the …

This study looked at whether a therapeutic education program, added to standard medical care, helps people who have had a heart attack or stroke better control their risk factors over one year. About 202 adults aged 18-75 took part. The goal was to see if the program improves phy…

This study tested the safety of a drug called maralixibat in 27 infants under 12 months old with Alagille syndrome or progressive familial intrahepatic cholestasis (PFIC), two rare liver diseases that cause bile buildup. The drug is given as an oral solution and aims to reduce bi…

This study tested whether giving a more powerful antiplatelet drug (prasugrel or ticagrelor) for one month after a heart attack, along with a standard blood thinner, could reduce heart attacks, strokes, and deaths in people with atrial fibrillation. The 602 participants were then…

This study looked at whether adding semaglutide (a drug used for diabetes and weight loss) to the standard heart failure medication dapagliflozin helps people with heart failure who have had a surgical heart valve replacement. 160 participants were split into two groups: one got …

This study tested a new device called Firesorb, a temporary scaffold that slowly releases medicine to keep heart arteries open and then dissolves over time. Researchers compared it to a standard permanent stent in 430 people with coronary artery disease. The goal was to see if th…

This study looked at ways to help children aged 5-20 with rheumatic heart disease take their regular antibiotics. Researchers compared having a case manager alone versus a case manager plus a peer support group. The goal was to see if the simpler approach works just as well to ke…

This study tested a program to help veterans with heart disease or rheumatic conditions take their medications as prescribed. Over 5,000 participants received reminders via text or phone calls, with extra support if needed. The goal was to improve medication adherence and reduce …

This study tested whether using a smartphone app and phone calls to monitor patients after a heart failure hospital stay helps doctors safely increase their medications. 66 adults with chronic heart failure and low ejection fraction were split into two groups: one received usual …

This study followed 650 low-risk patients with severe aortic valve narrowing who received a less invasive valve replacement called TAVI. Researchers tracked deaths, strokes, and return hospital visits for heart problems. The goal was to see how well TAVI works in everyday practic…

This study tested whether a drug called dexrazoxane, given through a vein, can reduce permanent heart muscle damage in people having a severe heart attack (STEMI). Fifty adults received either the drug or a placebo during their standard stent procedure. The goal was to see if the…

This study tested whether using a CT scan before heart ablation can make the procedure faster and safer for people with ventricular tachycardia, a fast heart rhythm that can be life-threatening. 119 adults who had a prior heart attack and an implanted defibrillator were randomly …

This study looked at 108 people whose heart stents had narrowed again after being placed. Doctors tested three different devices: two types of drug-coated balloons and one new stent. The goal was to see which one works best to keep the artery open and prevent future heart problem…

This study looked at whether using half the usual dose of heparin during heart surgery (bypass or valve replacement) could reduce bleeding afterward. Heparin is a blood thinner used to prevent clots during surgery, but it can increase bleeding. The study involved 238 adults and c…

This study tested whether giving low doses of two steroids (hydrocortisone and fludrocortisone) helps adults with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. 380 participants received either the steroids or a placebo. The main goal was…

This study tested whether a newer blood thinner, rivaroxaban (Xarelto), is as safe and effective as the older drug warfarin for preventing strokes in people who develop atrial fibrillation after heart surgery. About 100 adults who had open-heart surgery and then experienced a new…

This study tested two different methods of pacing the left side of the heart in people with severe heart failure. The goal was to see if pacing from inside the heart (endocardial) works better than the usual method from outside (epicardial). Only 6 adults took part, and the main …

This study tested a new way to help heart failure patients with weak hearts get the right medications. Over 2,400 people with a heart device took part. A nurse used a simple checklist to guide doctors in prescribing better treatments, aiming to reduce hospital visits and improve …

This study tested whether catheter ablation (a procedure to fix irregular heart rhythm) is better than standard rate-control medication for people with both atrial fibrillation and heart failure. Over 400 participants were randomly assigned to either ablation or medication. The m…

This completed study looked at whether two different blood thinners—dabigatran (Pradaxa) and warfarin (Coumadin)—could help prevent memory loss and dementia in people over 65 with atrial fibrillation (an irregular heartbeat). A total of 101 participants were randomly assigned to …

This study tested whether the diabetes drug ertugliflozin can reduce fluid buildup in the skin and tissues of people with heart failure. 28 adults with reduced heart function took the drug or a placebo for one month each. Researchers measured skin water and sodium content to see …

This study looked at whether short-term diet changes can improve heart health in people who have had a first heart attack. 24 adults were assigned to either a standard heart-healthy diet, a plant-based (vegan) diet, or no special diet for 3 months. Researchers measured weight, bo…

This study looked at whether dapagliflozin, a diabetes medication, can improve how the heart uses sugar and blood flow in people with type 2 diabetes and stable coronary artery disease. 25 adults took either the drug or a placebo for 4 weeks. The goal was to see if the drug helps…

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.

This pilot study tested whether colchicine, an anti-inflammatory drug, can slow the buildup of calcium in the aortic valve. 24 adults with mild-to-moderate aortic stenosis were randomly assigned to take colchicine or a placebo for 6 months. The study measured changes in valve cal…

This study tested a combination of two drugs, rivaroxaban and ticagrelor, in 40 patients with atrial fibrillation who had a stent placed. The goal was to see if this combo causes less bleeding and prevents heart attacks or strokes better than current treatments. Patients took the…

This study tested whether a breathing muscle training device could improve blood flow in the hearts of people with coronary artery disease. Forty participants used the device daily for six weeks. Researchers compared high-intensity versus low-intensity training to see if it incre…

This study tested whether it is safe and feasible to perform two heart procedures—MitraClip to repair a leaky mitral valve and Watchman to close off a part of the heart linked to stroke risk—in one session. The trial enrolled 25 adults with both severe mitral regurgitation and at…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study looked at whether a 12-week course of glecaprevir/pibrentasivir can safely cure hepatitis C in heart transplant patients who got the virus from infected donors. Fifty adults on the transplant waitlist were enrolled, and those who received a hepatitis C-positive heart w…

This study looked at 200 people with both heart failure and permanent atrial fibrillation. Participants received either a standard defibrillator (ICD) or one that also paces both lower heart chambers (CRT/ICD). The goal was to see if the extra pacing reduces heart size and improv…

This study tested whether a small wearable sensor, combined with a smart computer program, could detect early signs of worsening heart failure and alert doctors to adjust treatment before a hospital stay is needed. Researchers enrolled 176 veterans with heart failure and randomly…

This study looked at whether a diabetes drug called empagliflozin, combined with a breathing machine (CPAP), can improve sleep and heart function in 70 adults with both heart failure and obstructive sleep apnea. Participants were randomly assigned to take empagliflozin or not, an…

This study tested whether a drug called Lokelma (SZC) can help people with both chronic kidney disease and heart failure safely reach higher doses of life-saving heart medications (RAAS inhibitors) without dangerous potassium spikes. 112 adults with stable kidney disease and hear…

This study tested whether low doses of digoxin, an old and cheap heart drug, can reduce hospitalizations and death in 982 heart failure patients. Participants received either digoxin or a placebo pill. The goal is to see if keeping digoxin levels low in the blood improves outcome…

This study tested two different drug-coated stents (everolimus-eluting vs. sirolimus-eluting) in 1,466 people with narrowed heart arteries. It also compared taking the blood thinner clopidogrel for 6 months versus 12 months after stenting. The goal was to see which stent and whic…

This study tested whether people with opioid use disorder and severe injection-related infections can be safely treated at home with antibiotics and buprenorphine (a medication for opioid use disorder). 71 participants were enrolled. The goal was to see if this integrated approac…

This study tested whether a drug called mepolizumab, given after a severe COPD flare-up that required hospital care, could prevent future hospital stays or death. It involved 238 adults with eosinophilic COPD (a type with high levels of certain white blood cells). Participants re…

This study looked at whether a high-fat diet changes how children with mitochondrial disease burn energy. 36 children aged 5 to 21 were randomly assigned to eat either a normal or high-fat diet for a month, then switched. Researchers measured their resting energy use and body com…

This study looked at whether Vidaza, a drug used for acute leukemia, could also help treat atrial fibrillation (an irregular heartbeat). The idea was that Vidaza might reverse certain DNA changes that lower the activity of a gene important for heart function. Only one person took…

This completed study tested whether combining valsartan and hydrochlorothiazide works better than valsartan alone for people with hypertensive heart disease. 118 adults aged 18-70 took part over 8 weeks. Researchers measured blood pressure, heart changes on ECG, and symptoms to s…

This study compared two different artificial heart valves (Sapien and Myval) used in a procedure called TAVI to replace a narrowed aortic valve. Over 1,000 patients were randomly assigned to receive one of the two valves. The goal was to see which valve led to fewer major heart p…

This pilot study tested a new, very small lead (under 2 French) designed to improve cardiac resynchronization therapy (CRT) for heart failure. In 20 patients getting a standard CRT device, doctors temporarily placed the new lead to see if it could pace the heart's left ventricle …

This study looked at 222 adults with obstructive hypertrophic cardiomyopathy, a condition where the heart muscle thickens and blocks blood flow. Researchers compared those who took mavacamten (Camzyos) with those on standard therapy, measuring changes in heart function and sympto…

This study followed 152 adults in Greece with severe eosinophilic asthma who were starting benralizumab, a medication that helps control severe asthma. Researchers measured not only standard asthma control but also quality of life, sleep, mood, and physical activity using wearabl…

This Phase 3 trial tested a gene therapy called GS010 in 98 people with Leber hereditary optic neuropathy (LHON), a genetic condition that leads to rapid vision loss. Participants received injections of the therapy or a placebo into both eyes. The study measured changes in vision…

This study tested whether quercetin, a natural compound found in fruits and vegetables, can reduce inflammation and signs of cell aging in 100 people undergoing heart bypass surgery. Participants received quercetin or a placebo before and after surgery. The goal was to see if que…

This trial tested a new ablation catheter (DiamondTemp) against the current standard (Tacticath/Tactiflex) for treating ventricular tachycardia (VT), a life-threatening fast heart rhythm. 61 adults with VT who needed ablation took part. The goal was to see if the new catheter is …

This study looked at the safety and how the body processes two doses of nirsevimab, a medicine to prevent RSV, given 5 to 6 months apart. It included 33 Japanese infants up to 12 months old with heart or lung disease, weak immune systems, Down syndrome, or who were born early. Re…

This study tested two new devices that use energy pulses to treat persistent atrial fibrillation (a type of irregular heartbeat). 89 adults who had not responded to medication received a heart ablation procedure. The goal was to see if the devices are safe and can stop abnormal h…

This study tested two ways of managing breathing during heart bypass surgery to see which better prevents lung complications. Over 1,500 adults having planned heart surgery were randomly assigned to either no breathing support or gentle, low-volume breaths while on the heart-lung…

This study tested a 12-week cardiac rehabilitation program in 65 elderly patients (70+) with heart failure. The program included strength and aerobic exercises twice a week. Researchers measured changes in movement, heart function, and fitness. The goal was to see if exercise can…

This study tested a two-step procedure for people with severely hardened heart arteries. First, doctors used a special device to shave away hard plaque, then inflated a drug-coated balloon to open the artery. The goal was to see if this approach could safely improve blood flow an…

This study looked at 128 heart attack patients who had a procedure to open blocked arteries. Some patients received an extra blood thinner called cangrelor on top of standard ticagrelor. The goal was to see if the combination improved blood flow to the heart and reduced leftover …

This study tested whether a special monitor placed in the breathing tube during heart bypass surgery could help doctors manage fluids and blood flow better. 100 adults having elective coronary bypass surgery were split into two groups: one got standard care, the other used the EC…

This study looked at whether closer collaboration between doctors and pharmacists could reduce hospital readmissions for people with heart failure. About 229 adults hospitalized for heart failure took part. Researchers compared standard care to a more coordinated approach where p…

This study tested a single injection of special stem cells (Rexlemestrocel-L) into the heart for people with chronic heart failure. The goal was to see if it could reduce serious heart events like hospitalizations or death. The trial involved 565 adults and compared the stem cell…

This study looked at whether a high-sensitivity blood test for troponin I can accurately determine the stage of a heart attack. Researchers analyzed data from 312 patients across multiple hospitals. The goal is to provide a faster, simpler way to classify heart attack severity wi…

This study is testing a chest-patch that uses light to measure blood pressure without a traditional arm cuff. Researchers will compare its readings over 24 hours to the standard cuff-based method in 600 adults with or without high blood pressure. The goal is to see if the patch i…

Researchers are testing whether a wearable armband called HeartWatch can record heart rhythm data as well as standard Holter and event monitors. Adults who need extended heart rhythm monitoring wear the armband alongside a standard device for up to three days. The study checks wh…

Researchers are testing whether a new arm-worn heart monitor called the HeartWatch can record heart rhythms as well as the Holter and event recorders used in clinics. Adults who have been recommended for a heart monitor wear the HeartWatch on the upper left arm at the same time a…

Researchers are testing a software update for the Philips HeartStart Intrepid monitor, a device that records 12-lead electrocardiograms (ECGs) to check heart rhythms. The study enrolls people from 29 days to 89 years old who are willing to have ECG tracings taken. The goal is to …

This study tests whether a software program called ElucidVivo can accurately predict blood flow blockages in the heart using images from a standard CT scan. The software analyzes plaque buildup in the coronary arteries to estimate a value called FFRct, which indicates how much a …

This study tests whether a special PET/CT scan can measure changes in amyloid deposits in organs of people with systemic amyloidosis. Participants receive an injection of a radiolabeled peptide that binds to amyloid, then undergo imaging at different times. Researchers compare th…

This trial tests whether an AI software called AI-Gatekeeper can help doctors predict if a patient has significant coronary artery narrowing (at least 50% blockage) using only routine tests like blood work, ECG, chest X-ray, and echocardiogram. About 450 adults with chest pain an…

This study looked at whether using different blood test cutoffs for men and women can better diagnose heart attacks. Current tests use the same cutoff for both sexes, which may miss heart attacks in women and over-diagnose them in men. Researchers tested new sex-specific cutoffs …

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This trial evaluates a new high-sensitivity blood test (Mindray hs-cTnI) for diagnosing heart attacks in people arriving at the emergency room with symptoms like chest pain. Researchers will compare the test's accuracy against an existing approved test, using blood samples taken …

This study explores whether a cardiac MRI can safely and effectively gather the same heart pressure and flow measurements normally obtained through right heart catheterization, a more invasive procedure. Researchers will attempt to perform the catheterization inside the MRI machi…

This study investigates whether an Apple Watch can accurately detect heart rhythm problems (arrhythmias) in children aged 6 to 21 who are already scheduled for standard heart monitoring. Researchers will compare the watch's ECG and heart rate readings to those from conventional c…

This trial evaluates an artificial intelligence algorithm, AutoAS, that analyzes ultrasound images of the heart to detect aortic stenosis — a narrowing of the heart's main valve. Researchers will collect images from adults scheduled for a standard echocardiogram and test how well…

This study aims to improve how doctors diagnose acute heart failure in the emergency department. Currently, diagnosis can be slow and uncertain because symptoms like shortness of breath are vague. Researchers are testing a blood test that measures 21 different proteins to see if …

This study tested whether a special heart scan (SPECT) can predict how well patients with ischemic cardiomyopathy will recover after heart surgery. 120 patients underwent imaging at rest and during stress to measure heart function and blood flow. The goal was to find patterns tha…

This study tested whether a special PET scan using 68Ga-DOTATOC can detect inflammation in the heart muscle of people with myocarditis. 33 adults with suspected acute myocarditis and normal angiograms received the scan. The goal was to see if this method is as good as or better t…

This study tested whether a special heart scan (SPECT) can predict which people with severe chronic heart failure will improve after getting a cardiac resynchronization therapy device. The scan uses a radioactive tracer to measure nerve activity in the heart. Researchers enrolled…

This trial tests whether a magnetic sensor placed on the skin can accurately measure blood pressure in the jugular vein and radial artery, compared to standard invasive methods using catheters. The study involves 10 adults with complex congenital heart disease or chronic right he…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This study tested whether a special PET-CT scan using a radioactive tracer (18F-FDG) can improve diagnosis of infectious endocarditis on natural heart valves. Researchers scanned 31 adults with suspected endocarditis within 5 days of starting care. The goal was to see how well th…

This study looked at 15 patients with a rare heart condition called wild-type transthyretin amyloid cardiomyopathy (ATTRwt) who also had signs of aortic stenosis. Researchers used dobutamine stress echocardiography—a test that uses a drug to make the heart pump harder while imagi…

This study tested whether two wearable devices—the Apple Watch and the Skylab CART-I ring—can accurately detect atrial fibrillation and other irregular heart rhythms compared to the standard 12-lead ECG. Researchers recruited 500 adults from UK cardiology clinics. Each participan…

This study tested a non-invasive mapping system (Cardioinsight®) to help doctors treat heart rhythm disorders. It included 492 patients who needed ablation, pacemaker implantation, or risk assessment for sudden death. The goal was to see if the mapping system improves outcomes co…

This study tested a new blood test called HEARTBiT that uses 9 RNA markers to detect acute rejection in heart transplant patients. Currently, rejection is found through frequent, invasive heart biopsies. The test was developed using samples from 150 patients and will be evaluated…

This study tested whether offering genetic screening to younger heart attack patients (under 60) can uncover hidden cases of Familial Hypercholesterolemia (FH), an inherited condition causing very high cholesterol. Researchers recruited 140 patients admitted with a heart attack a…

This study tested whether a simple bedside heart ultrasound measurement, called the S' wave, can help emergency doctors quickly identify acute coronary syndrome (heart attack or unstable angina) in patients with chest pain. Researchers enrolled 66 adults who came to the ER with c…

This study tested whether a special type of heart MRI, called T1 mapping, can accurately diagnose cardiac amyloidosis—a condition where abnormal proteins build up in the heart muscle. Researchers studied 112 older adults with heart failure and thickened heart walls. They compared…

This study tested whether a special algorithm in a pacemaker can accurately diagnose sleep apnea in people with heart problems. Researchers compared the pacemaker's readings to a standard overnight sleep test in 66 participants. They also looked for a link between sleep apnea sev…

Very premature infants born before 28 weeks often have a blood vessel near the heart, called the patent ductus arteriosus, that stays open when it should close. A large opening can strain the heart and may affect brain development. In this trial, researchers use an early echocard…

This trial tests whether a 12-week program led by a heart health educator can lower cholesterol and improve heart health in spouses, siblings, and children of people hospitalized with coronary heart disease. Participants work with an educator to create a personal plan for smoking…

This study tested whether making a small opening in the lining around the heart (called a left posterior pericardiotomy) can prevent new atrial fibrillation after coronary artery bypass surgery. 270 adults having bypass surgery were randomly assigned to get this extra cut or not.…

This study tested whether colchicine, an anti-inflammatory drug used for gout, can prevent new-onset atrial fibrillation and the need for a permanent pacemaker in people undergoing transcatheter aortic valve replacement (TAVI). About 120 older adults with severe aortic stenosis w…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This study tested whether a low-dose infusion of landiolol, a short-acting beta-blocker, could prevent atrial fibrillation in 400 non-Asian patients after cardiac surgery. Participants received either landiolol or a placebo for up to 48 hours after surgery. The goal was to see if…

Researchers at the University of Minnesota are testing whether exercise reduces the amount of time people spend in atrial fibrillation. The trial enrolls 60 sedentary adults aged 18 to 65 who have symptomatic, non-permanent AF. Participants are assigned to high-intensity interval…

Researchers test whether adjusting cardiac rehabilitation to each person's muscle power profile and heart rate variability helps heart attack survivors recover better. Adults who had acute coronary syndrome in the past six months and received a stent or bypass surgery join the st…

Researchers are testing whether 20 minutes of mindful breathing each day for 8 weeks can reduce symptoms and improve clinical measures in people with heart failure. The trial enrolls 64 adults with NYHA stage II or III heart failure. Half practice mindful breathing with audio gui…

This study tests whether combining progressive muscle relaxation and guided imagery can lower stress, anxiety, and depression in people with stable coronary artery disease. Forty adults will be split into two groups: one gets eight sessions of these mind-body techniques over four…

This study tested whether metformin, a common diabetes drug, along with a text-message activity program, could help people with pulmonary artery hypertension (PAH) walk farther and feel better day-to-day. 73 adults with PAH took part. The goal was to see if these interventions im…

This study tested whether adding leg compression to standard diuretic treatment helps people hospitalized with heart failure and severe fluid buildup. 106 adults received either diuretics alone or diuretics plus leg compression for up to 72 hours. Researchers measured changes in …

Researchers are testing whether a structured Enhanced Recovery After Surgery (ERAS) program improves recovery for people having their first coronary artery bypass graft. The program bundles 31 care steps before, during, and after surgery, including patient education, nutrition su…

Researchers are studying whether the Barostim NEO device, which stimulates a nerve near the carotid artery to lower blood pressure, can help people with heart failure and preserved ejection fraction. The registry follows 11 people who already received the device for resistant hyp…

This study tests whether a nerve block called the serratus posterior superior intercostal plane block can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard…

Researchers are testing whether a pacemaker setting called closed-loop stimulation helps the heart rate rise more naturally during mental and physical stress compared with standard accelerometer-based pacing. The study includes adults with permanent atrial fibrillation, chronotro…

Researchers are testing whether a cardiac rehabilitation education video helps people with cardiovascular implantable electronic devices (CIEDs) such as pacemakers and defibrillators increase their physical activity. The trial enrolls adults aged 20 to 100 who have had a CIED for…

Researchers are testing whether a hybrid cardiac rehabilitation programme can help adults recover after heart surgery. Participants start with two weeks of supervised exercise at the hospital, then continue training at home for six weeks using heart-rate monitors, a cloud care pl…

This early-phase study tests whether anakinra, a drug that blocks inflammation, can make the heart more sensitive to inotropes (medicines that strengthen heart contractions) in people with end-stage heart failure. If successful, patients might need lower, safer doses of inotropes…

This study tests whether allopurinol, a common gout medication, can improve heart function in African American veterans with resistant hypertension. Participants take allopurinol for 8 weeks, and researchers measure changes in heart function, exercise ability, and quality of life…

This study tests whether a single dose of intravenous iron (ferric derisomaltose) can improve exercise capacity in people with heart failure with preserved ejection fraction who also have iron deficiency. About 66 adults will receive either the iron infusion or a placebo, and the…

This phase 2 trial tests whether pitolisant, a wake-promoting drug, can reduce excessive daytime sleepiness in adults aged 18 to 65 with myotonic dystrophy type 1. Participants receive either pitolisant or a placebo for a period, and researchers measure changes in sleepiness, fat…

This study tests whether a ketone drink can improve exercise ability in people with heart failure. Researchers will give 25 participants either the drink or a placebo before exercise tests. The goal is to see if the drink helps them exercise longer and with less shortness of brea…

This study looks at whether people with heart failure can safely receive a special pacemaker (CRT-P) and go home the same day, instead of staying overnight in the hospital. Researchers are tracking serious side effects for six months after the procedure and checking if patients' …

This study looks at whether doing special breathing exercises before heart bypass surgery can help improve oxygen levels afterward. It will include 45 men aged 50 to 60. Some will use an incentive spirometer, some will use an inspiratory muscle trainer, and others will receive st…

This trial compares two standard local anesthetics given during pacemaker or defibrillator surgery: a mixture of lidocaine and bupivacaine versus lidocaine alone. Researchers want to see if the mixture reduces postoperative pain and the need for narcotic painkillers. About 350 pe…

This trial tests whether applying cold packs to the wrist after transradial coronary angiography reduces pain, bruising, and discomfort. About 104 adults who had this heart procedure will be randomly assigned to receive either cold packs or standard care. Researchers will measure…

This study tests whether starting gentle movement earlier than usual can reduce back pain in people who have had a procedure to open blocked heart arteries. After this procedure, patients often lie flat for hours, which can cause back pain. The study will compare early mobilisati…

This trial tests HEARTPrep, a virtual counseling program designed to support mothers who are expecting a baby with congenital heart disease. The program aims to reduce depression, anxiety, and social isolation during pregnancy. Researchers will enroll 30 mothers and their partner…

This study tests two treatments—blood flow restricted resistance exercises and low-level laser therapy—to see if they improve heart function in people with chronic heart failure. Sixty patients aged 40-60 with mild heart failure will be assigned to one of the treatments for 12 we…

This trial tests whether a single educational session about how pain works, given before coronary artery bypass surgery, can lessen chronic pain after the operation. Adults scheduled for elective bypass will either receive this pain neuroscience education plus routine care, or ro…

This trial tests a nurse-assisted eHealth program for patients with heart failure or colorectal cancer. After leaving the hospital, participants use a tablet with the MyDignio app to track vital signs and symptoms, and communicate with a nurse navigator. The goal is to see if thi…

This trial tests whether a structured nurse-led program can improve sleep quality in adults with chronic heart failure. Participants will receive education on healthy sleep habits and cognitive-behavioral techniques, alongside their usual care. The study measures changes in sleep…

This trial compares two simple educational tools—an animated video and a brochure—against routine care to see which best lowers anxiety and fear in children aged 7 to 10 who need an echocardiogram. All participants have a congenital heart condition and are scheduled for a follow-…

This study tests whether a 12-week home-based breathing exercise program (inspiratory muscle training) can improve physical function, fatigue, and quality of life in adults aged 70 and older with advanced heart failure who are receiving palliative care. Participants use a handhel…

This trial investigates whether wearing AI-powered active noise-cancelling headphones during rotational atherectomy — a heart procedure that generates loud drilling noise — can reduce patient anxiety and improve heart rate stability. One hundred adults with severe coronary artery…

This study tests whether virtual reality training can help children aged 6 to 16 with the childhood form of myotonic dystrophy type 1 (DM1) improve their ability to understand others' thoughts and emotions. Participants engage in social scenarios in a virtual environment, guided …

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This study tested whether using a device that electrically stimulates the thigh muscles at home, for 4 weeks after a hospital stay, could help people with heart failure walk farther and feel stronger. Only 8 people took part, so the results are very early. The goal is to find a s…

This phase 2 trial tested a drug called BX1514M in 38 people with hypertrophic cardiomyopathy, a genetic heart condition that can cause shortness of breath, chest pain, and dizziness. The drug aims to improve blood flow by tightening veins, which may reduce blockages in the heart…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether watching a short video before coronary bypass surgery could reduce confusion (delirium) in the ICU and speed up recovery. 220 adults were randomly assigned to either watch the video or receive standard care. The video explained the surgery, ICU environme…

This study tested whether a home-based exercise program is practical for people with chronic heart failure who have just been hospitalized. Thirty patients were taught exercises by a physiotherapist and did them at home for 12 weeks. The goal was to see how many completed the pro…

This study tested whether giving vascular surgery patients access to a website with educational videos could reduce their anxiety before the operation. 250 patients were split into two groups: one got the videos, the other did not. Researchers measured anxiety using a simple 0-to…

This study looked at whether different types of exercise training can help adults with congenital heart disease exercise more easily. 47 participants were split into three groups: interval training, moderate continuous training, or usual care (no training). The main goal was to s…

This study tested whether light exercise or a technique called remote ischaemic preconditioning (rIPC) — using a blood pressure cuff to briefly restrict blood flow to the arm — could protect the heart during dialysis. 33 adults on hemodialysis took part in three sessions: one wit…

This early study tested a new patch-like device that delivers the heart failure drug furosemide under the skin. Twenty hospitalized heart failure patients received a single dose to see if it is safe and works well. The goal is to find a simpler way to give this medication without…

This study tested a new device called VIVHEART EasyCross™ in 20 people undergoing transcatheter aortic valve replacement (TAVR). The device uses a basket-like tip to center itself in the artery, making it easier and quicker to guide a wire through the heart valve. The goal was to…

This completed Phase 2 trial tested whether blood thinners (rivaroxaban) or antiplatelet drugs (aspirin, clopidogrel) work better than standard migraine medication (metoprolol) for people with both migraine and a small heart hole called PFO. 1,000 participants took one of the fou…

This study tested whether heart failure patients can do cardiac rehabilitation at home using a tablet app instead of going to the hospital. Thirty stable patients were split into two groups: one did rehab at home with remote monitoring, the other at the hospital. The goal was to …

This study looked at whether a single intravenous iron dose could improve exercise capacity in people with severe aortic stenosis and iron deficiency who were scheduled for a valve replacement. About 100 participants received either iron or a placebo. The main goal was to see if …

This study looked at whether a short virtual reality mindfulness session could help patients feel less anxious and stressed after heart surgery. 34 adults who had heart bypass or valve repair took part. One group did a 15-minute VR mindfulness exercise, while the other group rece…

This small pilot study tested whether mirabegron, a drug typically used for overactive bladder, can raise blood pressure and reduce fainting in people with POTS who have low blood pressure that standard treatments didn't help. Twenty adults took either 25 mg or 50 mg of the drug …

This study tested whether a parasternal block—an injection of the numbing drug ropivacaine into the chest wall—could reduce the amount of anesthetic needed to keep heart rate and blood pressure stable during coronary artery bypass surgery. Thirty-five patients were randomly assig…

This study tested whether an 8-week telephone stress management program could reduce stress in women who had a heart attack. 153 women with high stress levels were randomly assigned to either the stress management program or enhanced usual care. The program used mindfulness and c…

This phase 2 trial tested whether a new wearable pump that delivers a water pill (furosemide) under the skin could help heart failure patients leave the hospital earlier. 172 adults admitted for heart failure were randomly assigned to either go home with the pump or stay in the h…

This study tested whether adding empagliflozin (a diabetes drug) to standard diuretics helps hospitalized heart failure patients with moderate to advanced kidney disease urinate more fluid. 25 participants were given the combination, and researchers measured urine output. The goa…

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

Some people develop an irregular heartbeat called atrial fibrillation after a stroke or mini-stroke. Researchers want to understand what causes this by comparing nerve function, inflammation, and heart rate patterns in three groups: patients with this post-stroke irregular heartb…

This study looks at a new, less invasive way to monitor blood flow during heart ablation procedures. Doctors will use a special device to track heart function beat-by-beat. The goal is to see if this method helps improve care for 27 adult patients having heart ablation.

Researchers are testing two ways to train VA primary care clinicians to hold goals of care conversations with veterans who have serious illnesses such as cancer, heart failure, or dementia. One approach gives clinicians written materials and online training. The other adds team f…

This study looked for genetic causes of congenital heart disease (heart problems present at birth) in families from Uganda and Nigeria. Over 1,200 people took part, including affected children and their parents. Researchers used advanced DNA testing to find gene changes linked to…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This study looked at whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery helps preserve diaphragm movement and reduce lung problems after surgery. Sixty adults having elective coronary artery bypass surgery were randomly assigned to receive either…

This study uses MRI scans to measure amyloid protein buildup in the hearts of up to 150 people with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). Participants are already enrolled in a larger treatment trial. The goal is to see how amyloid levels change over time, not …

This study looked at whether new computer methods can create higher-resolution images from a standard CT scan. Researchers compared the quality of regular CT images with enhanced versions from the same scan. 148 adults scheduled for a CT scan participated. The goal was to see if …

Animal-derived heart valves replace damaged human valves, but many fail within about a decade. Researchers suspect the recipient's immune response may speed up that breakdown. This international study follows people who receive pig, cow, or horse tissue valves, using echocardiogr…

Researchers want to know whether the number of other health conditions a person has affects their quality of life after transcatheter aortic valve implantation. The study follows 150 patients aged 75 and older who receive a new aortic valve through a catheter. Before the procedur…

This study looked at 120 adults having open heart surgery to see if an AI program could correctly judge whether a pain-relieving nerve block was placed properly. Researchers compared the AI's assessment to that of a human expert and checked if better block placement led to less p…

This study analyzed health records from over 400,000 adults who had heart surgery to see if the sedative dexmedetomidine helped prevent problems like confusion, kidney injury, or death within 30 days. Researchers compared patients who received the drug around surgery time to thos…

Researchers at St. Olavs Hospital are studying how energy moves from the left ventricle to the arteries in people with acute left-sided heart failure caused by a heart attack, cardiomyopathy, or myocarditis. The pilot study enrolls 30 adults with a normal heart rhythm. Participan…

This study followed over 1,000 people who had a heart attack and were given a quick-acting intravenous blood thinner called cangrelor during a procedure to open blocked arteries. Researchers wanted to see how often bleeding occurred when patients then switched to a different oral…

This study looked at how HeartInsight, a monitoring tool inside heart devices, alerts doctors when heart failure gets worse. About 100 patients with special pacemakers took part. The goal was to see how doctors use these alerts in everyday care to prevent hospital visits.

This study compares three ways of delivering genetic counseling to adults with inherited heart conditions. Some participants get counseling before testing, others get it after, with or without a required phone call. The goal is to see which approach is most efficient and empoweri…

This study enrolls 500 people who take a CPR and AED training course based on European standards. Researchers measure how the course changes participants' practical skills, confidence, and attitudes toward helping someone in sudden cardiac arrest. The goal is to understand how we…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study looks at whether a newer, gentler heart procedure called pulse-field ablation (PFA) can reverse harmful changes in the heart's upper chambers caused by atrial fibrillation. Researchers will compare CT scans taken before and 3 months after the procedure in 200 adults. T…

This study tests whether a software tool called Synapse Medicine can help hospital pharmacists who work with medical teams make better and faster medication recommendations. The tool analyzes each patient's health information to flag potential drug-related risks, such as harmful …

This study is testing an implantable heart monitor (LUX-Dx ICM) in 525 people with heart failure. The goal is to collect sensor data to better understand when heart failure events happen. Participants have moderate heart failure (NYHA class II or III) and certain heart structure …

This study checked how well 109 heart attack survivors in Nepal took their prescribed medicines and what made it hard for them. Researchers used a simple questionnaire to find out. The goal is to help doctors and patients improve medicine-taking habits and prevent future heart pr…

This study examines whether the duration a patient spends on cardiopulmonary bypass (heart-lung machine) and with the aorta clamped during coronary artery bypass surgery is linked to how long they stay in the intensive care unit afterward. Researchers will review medical records …

This study tests a hospital-wide treatment guide for people with heart failure and a leaky mitral valve (secondary mitral regurgitation). The goal is to see if the guide helps doctors identify which patients will benefit most from a minimally invasive valve repair procedure calle…

This study looks at children and adolescents aged 6 to 16 with inherited arrhythmias, such as long QT syndrome, to see if a controlled exercise test on a treadmill reflects their actual heart rate and activity levels during daily life. Participants will complete a routine exercis…

Researchers are using wearable sensors and smartphone check-ins to track fatigue as it happens in people with myeloma, long COVID, heart failure, and healthy controls. Participants wear an ECG patch and a wrist sensor that measure heart rate, activity, and posture, and they rate …

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This study investigates whether different types of sleep apnea—a condition where breathing repeatedly stops during sleep—are linked to future heart problems or death in people who have recently had a heart attack. Researchers will use a home sleep test called polygraphy to measur…

This study is investigating how often dangerous heart rhythm problems occur in people receiving hemodialysis for end-stage kidney disease. Researchers will implant a small device under the skin to continuously monitor heart rhythm for 18 months in 70 patients, half of whom have d…

This study aims to establish national reference levels for radiation exposure during X-ray guided procedures to correct heart rhythm disorders, such as pacemaker insertions and ablations. Researchers will collect radiation dose data from over 4,000 adult patients undergoing these…

This study looks at how weight loss surgery (gastric sleeve) affects exercise ability in people with or at risk for heart failure with preserved ejection fraction (HFpEF). Researchers will measure oxygen use during exercise before and 12 months after surgery. The goal is to under…

This study follows 500 heart bypass patients for 10 years to see if taking two blood thinners (ticagrelor plus aspirin) for one year after surgery reduces the risk of heart attacks, strokes, or death compared to taking just one. Participants will be contacted by phone to report t…

This study reviews records from 240 people who experienced cardiac arrest outside a hospital and were treated by an emergency medical service in Switzerland. The goal is to identify which factors, such as initial heart rhythm, response time, and whether CPR was started by a bysta…

This study looks at how the Impella CP, a small mechanical heart pump, changes blood flow and heart function in people with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. Researchers will measure pressures inside the heart and use ultrasou…

This study investigates whether fibromuscular dysplasia (FMD), a condition that causes abnormal growth in artery walls, is more common in people who have had a spontaneous coronary artery dissection (SCAD) — a tear in a heart artery that can cause a heart attack, often in young w…

This study investigates whether people with acute decompensated heart failure are taking their prescribed medications as directed. Researchers will test urine samples from 100 patients at the emergency department to directly measure drug levels, and use questionnaires to explore …

This study looks at how mental stress affects the heart in men and women who have had a heart attack within the past 8 months. Participants undergo a stress challenge and are followed for up to 3 years to see if stress-induced changes in the heart are linked to future heart probl…

This trial investigates whether a short stay at high altitude (up to 3,545 meters) is safe for people with asymptomatic moderate or severe aortic stenosis. Participants will undergo heart tests—including ECG, echocardiography, and exercise stress tests—both at low altitude and af…

This study looks at whether a score based on heart-support medications (the vasoactive-inotropic score, or VIS) can help doctors decide the best time to start ECMO in patients who develop severe heart failure after cardiac surgery. Researchers will review medical records from nea…

This study examines whether closing the left atrial appendage with a device called AMULET changes how well the heart relaxes. It includes 100 adults with atrial fibrillation who are at high risk for stroke but cannot take blood thinners. Researchers measure heart function using u…

This study tested whether a special MRI scan of the wrist can detect amyloid deposits in people with systemic amyloidosis, a condition where abnormal proteins build up in organs. Researchers enrolled 128 adults, including patients with cardiac amyloidosis and healthy volunteers. …

This study tests a two-year educational program for medical and physician assistant students in rural areas. The curriculum includes classroom sessions, simulations, and community rotations to improve teamwork skills. Researchers measure changes in knowledge, attitudes, and team …

This study compares two ways to access blocked leg arteries during a procedure to restore blood flow: through the arm (brachial artery) or the groin (femoral artery). The goal is to see which approach leads to fewer complications, such as bleeding or artery damage. Participants a…

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study investigates whether a blood test measuring how platelets clump under high shear forces can distinguish a first acute coronary syndrome from a recurrent one. Researchers will enroll 97 adults with unstable angina or early heart attack. The goal is to see if this test o…

This study tests whether a single training session can improve police officers' ability to recognize agonal breathing — an abnormal gasping pattern that can be mistaken for normal breathing during cardiac arrest. Over 3,400 officers in New Taipei City will take a 20-minute CPR re…

This pilot study looks at how common iron deficiency is in people who have recently had a heart attack. Researchers will test iron levels in up to 70 patients and review their medical records. The goal is to gather early data to plan a larger study on whether treating low iron co…

This study looks at whether cardiac autonomic neuropathy (nerve damage that affects heart rate control) changes the heart's electrical recovery time (QT interval) in people having coronary artery bypass surgery. Researchers will test nerve function before surgery and measure hear…

This observational study looks at how anthracycline chemotherapy affects inflammation, oxidative stress, and heart function in adult women who had breast cancer. Researchers measure blood markers and use echocardiograms to assess heart changes about 10 years after treatment. The …

This study followed 601 adults who survived a cardiac arrest outside the hospital. Researchers wanted to learn how many survive long-term and how their quality of life and daily functioning are affected. The goal is to better understand what helps people recover and live well aft…

This study examined bleeding inside the heart muscle (intramyocardial hemorrhage) in 60 patients who had a severe type of heart attack called STEMI. Researchers compared two treatment strategies: giving clot-busting drugs followed by a procedure to open the artery, versus going s…

This study tested a decision algorithm to help doctors diagnose the cause of eosinophilia (high levels of a type of white blood cell). The algorithm guides which tests to do and in what order. Researchers enrolled 53 patients and measured how many followed the algorithm correctly…

This study follows 340 people with atrial fibrillation who are having their first ablation procedure. Researchers will track heart rhythm using remote monitoring, along with imaging and blood tests, to find which factors—like patient health, heart structure, or electrical signals…

This study tests a guidance algorithm that tracks the position of an ultrasound probe in real time to help non-specialists capture standard heart images. Researchers will compare the probe positions suggested by the algorithm with those chosen by experts. The goal is to make echo…

This study looked at 179 heart failure patients who used remote monitoring after a hospital stay. Researchers tracked how long patients kept using the system and interviewed some who stopped to understand why. The goal is to learn what helps or hinders sticking with remote monito…

This study looked at how two types of drug-coated heart stents (Orsiro and Resolute Integrity) heal inside the arteries of 50 people with stable heart disease. Researchers used a special camera to check the healing 4 months after the stents were placed. The goal was to see if one…

This completed study looked at blood samples from 47 patients in France (part of a larger European study) to find biological markers linked to diastolic heart failure in people with metabolic syndrome. The goal was to confirm earlier findings about these markers. Participants had…

This study looked at 100 people with coronary artery disease who had a heart procedure through the wrist. Half got a short sheath and half got a long sheath. The goal was to see which one leads to fewer blockages in the radial artery. Researchers used ultrasound to check for bloc…

This study looked at 70 people aged 75 and older with atrial fibrillation who were taking a Xaban blood thinner (dabigatran, rivaroxaban, or apixaban) during an unplanned hospital stay. Researchers wanted to see if certain clinical or lab factors were linked to higher drug levels…

This study looked at over 2,100 patients aged 80 and older with atrial fibrillation who were taking the blood thinner warfarin. Researchers wanted to see if having multiple other health conditions (comorbidities) made it harder to keep their blood thinning levels stable. The goal…

This completed study looked at 172 patients who received either a new-generation biological aortic valve or a traditional one during heart surgery. Researchers tracked survival and valve function over five years to see how the newer valves compare. The goal is to provide real-wor…

This study looked at two ways to improve CPR during cardiac arrest: changing how often rescuers switch (every 2 vs. 4 minutes) and using a device called CPRmeter that gives real-time feedback on chest compressions. Researchers measured the quality of compressions in 51 patients. …

This study tested whether a newer type of MRI called 4D flow can more accurately measure leakage in the pulmonary valve and heart chamber size in people born with tetralogy of Fallot who had corrective surgery. Researchers compared 4D flow MRI with standard 2D MRI in 21 patients …

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This study tested whether simpler ultrasound measurements can accurately predict left ventricular function in patients with septic shock. Researchers enrolled 80 patients and compared standard heart function tests (LVEF and GLS) with easier-to-collect parameters like mitral annul…

This study tested whether giving personalized nutrition training to mothers of children with congenital heart disease helps their kids grow better after heart surgery. The training covered feeding from birth to age 3, including breastfeeding and starting solid foods. Researchers …

This completed study looked at 44 patients who had lung cancer surgery to understand how the arteries in the lungs can vary from person to person. Using CT scans and 3D models, researchers mapped these variations to help surgeons avoid complications during lobectomy. The goal was…

This small, completed study tested whether special pacing signals from a pacemaker could help control blood pressure in people with slow heartbeats. Five adults who needed a pacemaker or similar device took part. Researchers measured blood pressure and heart function during brief…

This study looks at how inherited heart rhythm problems (like Long QT Syndrome) and heart muscle diseases (like Hypertrophic Cardiomyopathy) affect the quality of life and physical activity of children aged 6 to 18. Researchers will compare 107 children with these conditions to 1…

This study follows 150 people with bicuspid aortic stenosis—a narrowed heart valve present from birth—who receive a transcatheter aortic valve replacement (TAVI) using the Evolut Pro or Evolut R XL device. Researchers will measure how well the valve works over time, including blo…

This study reviewed records of 630 adults who survived a cardiac arrest and were treated in an ICU in Italy over 14 years. Researchers compared outcomes across three time periods when different official treatment guidelines were in use. The goal was to see if newer guidelines led…

This study looked at whether ECMO, a machine that does the work of the heart and lungs, helps people with severe COVID-19 who have lung failure or heart failure. Researchers tracked 761 patients across France to see how many survived and how quickly they recovered. The goal was t…

This study tested a skin sensor that measures carbon dioxide (CO2) levels continuously during exercise, comparing it to standard blood tests. Researchers included 140 healthy volunteers and people with lung or heart conditions. The goal was to see if the sensor could accurately t…

This study tested a simple flowchart to help doctors monitor and manage heart conduction problems after transcatheter aortic valve replacement (TAVR). The goal was to see if this approach could safely reduce the need for intensive care and permanent pacemakers. Researchers follow…

This study tracked 883 adults with atrial fibrillation to see how consistently they took their direct oral anticoagulants (blood thinners). Researchers used pharmacy refill records and a simple questionnaire to measure adherence. The goal was to find patterns that could help iden…

This completed study observed 528 adults who had heart surgery and were admitted to the intensive care unit (ICU). Researchers tracked deaths, serious complications like stroke or infection, and patient details to identify risk factors. The goal is to use this information to impr…

This study looked at whether it's safe to skip the defibrillation test when implanting a subcutaneous implantable cardioverter-defibrillator (S-ICD). The test involves purposely triggering a dangerous heart rhythm to make sure the device can stop it. About 965 people took part. T…

This study tested if using the lower leg to push on the chest during CPR works as well as the standard hand method. About 99 paramedic and nursing students performed two minutes of chest compressions on a manikin, either with their hands or their dominant foot. The goal was to se…

This study looked at 49 adults aged 30-65 who had a first heart attack about 4 months earlier. Researchers used brain scans to see if changes in the brain's blood vessels or structure are linked to memory or thinking problems. The goal is to better understand these issues and hel…

This study looks at people with end-stage heart failure who have a mechanical heart pump (LVAD). It checks whether the pump's flow rate, adjusted for body size, is linked to liver and kidney function and the chance of being readmitted to the hospital. The goal is to see if this m…

This study tested whether individually adjusting the timing (atrioventricular delay) of a pacemaker improves heart function in 39 adults with conduction system pacing. Researchers used echocardiography to optimize settings and measured changes in heart strain, pumping ability, an…

This study tested whether long-term digital education, like online lessons or app-based guidance, helps people who had a heart attack lower their LDL (bad) cholesterol more than standard care. Researchers followed 121 patients in the Czech Republic for 12 months. The goal was to …

This study looked at how common cardiac cachexia (unintentional weight loss) is in people with advanced heart failure and how it affects their outcomes. Researchers followed about 200 patients for one year to compare survival and hospitalizations between those with and without th…

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This study tested whether using a pulse oximeter (a small sensor on the foot or hand) to measure oxygen levels in all seemingly healthy newborns can help find hidden, life-threatening heart defects early. Over 44,000 babies took part. The goal was to see if this screening reduces…

This study measured how two common blood thinners (rivaroxaban and apixaban) behave in 193 adults with active cancer who also had blood clots or atrial fibrillation. Researchers aimed to understand factors like age, weight, and kidney function that affect drug levels. The goal wa…

This study looked at how blood vessel function relates to heart blockage in people with a genetic heart condition called hypertrophic cardiomyopathy. Researchers measured blood flow and vessel flexibility in 40 adults. The goal was to understand the connection, not to test a trea…

This study looked at 150 patients who had a heart attack 12 to 36 hours earlier. Researchers wanted to see if opening the blocked artery right away was better than waiting a few days. They used MRI scans to measure heart muscle damage and function.

This study checked how often nerve damage (neuropathy) occurs in people with a rare heart condition called wild-type TTR cardiac amyloidosis. Researchers examined 65 patients using interviews, physical exams, and nerve tests (electromyograms). The goal was to find out if nerve pr…

This study looked at whether electrically stimulating scarred heart muscle after a heart attack could improve how well the heart contracts. Ten patients undergoing a standard procedure for abnormal heart rhythms had their heart function measured before and after stimulation of th…

This study tested whether a CT scan before a heart procedure could help doctors better target the source of a dangerous heart rhythm called ventricular tachycardia. 23 people who had a prior heart attack and needed catheter ablation took part. The approach aimed to see if using C…

This study tested a new catheter designed to measure the heart's electrical signals in people with irregular heartbeats (atrial fibrillation, ventricular fibrillation, or junctional tachycardia). Researchers enrolled 42 adults to see if the device could better identify abnormal e…

This study looks at whether bacteria living on heart valves can be detected in the blood. Researchers collected blood, valve tissue, and other samples from 100 patients having aortic valve replacement. The goal is to see if a simple blood test could guide treatment and predict co…

This study looked at two different heart stents (tiny mesh tubes used to open blocked arteries) to see which one works better in routine hospital care. Over 1,000 patients who needed a stent took part. The goal was to compare costs, procedure time, and how many extra devices were…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This study collected medical and social information from 111 patients having their first ablation for atrial fibrillation, a common heart rhythm problem. Researchers wanted to understand how factors like income, education, location, and ethnicity might affect who receives this tr…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study looked at 200 adults having a cardiac arrest outside the hospital to see how long it takes paramedics to get a working IV or IO line. The goal was to find out what causes delays or failures when trying to start an IV first and then switching to an IO if needed. The res…

This study examines how often patients and their relatives develop post-traumatic stress disorder (PTSD) after a sudden cardiac arrest. Researchers interviewed 45 people (20 survivors and 20 relatives) within a week of the event and again at 3 months using standard questionnaires…

This study looked at how certain heart devices change a blood-clotting protein called von Willebrand factor. Researchers studied 500 adults with heart failure or aortic stenosis who received a mechanical heart pump or a valve replacement. The goal was to understand when these pro…

This study looked at 70 people who had a tissue heart valve replacement. It compared two common blood-thinning treatments (high-dose aspirin alone vs warfarin plus low-dose aspirin) to see which one better prevented tiny blood clots from traveling to the brain. Researchers used u…

This study looked at how often cardiac amyloidosis occurs in older Tunisian patients with a type of heart failure called HFpEF. Researchers used heart scans and imaging to find cases and identify early warning signs. The goal is to make diagnosis easier and faster for this seriou…

This study tracked 555 adults hospitalized with acute coronary syndrome (a serious heart condition) to see how quickly they called for help and what factors influenced their recovery. Researchers focused on delays in calling an ambulance and how those delays affected short- and l…

This study looked at how well a new heart monitor (Assert-IQ) detects atrial fibrillation (an irregular heartbeat) in people who have had a heart ablation procedure. 151 participants wore the monitor as part of their normal care. Researchers compared the monitor's readings to a s…

This study tracked 300 patients with severe aortic stenosis who had a minimally invasive heart valve replacement (TAVI) to see how long they stayed in the hospital and why some stayed longer than 3 days. The goal was to find out what factors, like needing a blood transfusion or a…

This study looked at whether CT scans can help doctors choose the right size for the Perceval sutureless heart valve. The valve is used to replace a leaky aortic valve. Researchers studied 50 patients to see if CT-based sizing leads to good early results after surgery, like prope…

This study used computer simulations to compare three types of radiation (photons, protons, and carbon ions) for treating a dangerous heart rhythm called ventricular tachycardia. Researchers created treatment plans for 23 patients who were already scheduled for standard catheter …

This study looked at different types of immune cells (eosinophils) in the blood of people with asthma, chronic sinusitis with nasal polyps, or both, compared to healthy volunteers. The goal was to find patterns that could help doctors choose the best targeted therapy for each pat…

This study looked at over 3,300 people having a heart procedure through the wrist artery. Doctors tested different types of introducers (the tube used to access the artery) to see if a smaller size or a special coating could lower the risk of problems like artery blockage or spas…

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to understand normal stiffness values and how they change with disease or treatment. This is an observa…

This study looked at 502 people with heart failure who were getting an implantable defibrillator (ICD) to prevent sudden cardiac arrest. Researchers used a special MRI to see if heart scarring patterns could predict who would later need a shock from the device. The goal was to le…

This study screened 233 children aged 6 to 66 months with congenital heart disease for neurodevelopmental disorders like delays in communication, movement, and problem-solving. Researchers used a parent questionnaire to identify children at risk. The goal is to better understand …

This study gathered information from routine medical care for 198 adults with atrial fibrillation who had a prior procedure to close a small heart pouch (left atrial appendage occlusion) and later needed a heart ablation. Researchers looked at patient details, procedure steps, bl…

This study looked at how high-intensity interval training (HIIT) changes heart cells in people with heart failure. Forty stable patients were split into two groups: one did 36 sessions of HIIT plus standard medication, the other took medication only. Researchers measured fitness,…

This completed study followed over 7,200 heart patients in Tunisia to see how well they stick to their heart medications after a heart attack or procedure. Researchers simply observed and recorded data without giving any new treatment. The goal is to understand real-world medicat…

This study tested whether a special MRI scan (31P-MRS) can detect early signs of damage to heart and muscle cells caused by chemotherapy drugs like doxorubicin. Twelve cancer patients scheduled for chemo underwent three scans over time. The goal was to see if the scan could measu…

This study observed 49 adults hospitalized with acute heart failure to learn how fluid congestion behaves during treatment. Researchers tracked clinical signs, lab tests, and ultrasound measures, then followed patients for a year to see who was readmitted or died. The goal is to …

This study aimed to create a new questionnaire that measures how atrial fibrillation (AF) affects a person's quality of life. Researchers worked with 206 adults who have AF to develop and test this tool. The goal was to better understand the real-world impact of AF beyond just me…

This study looked at 468 Italian adults who take blood thinners (anticoagulants) to understand their health knowledge, quality of life, and confidence in managing their condition. Researchers used questionnaires to measure these factors and see how they relate to age, education, …

This study looked at 300 women undergoing frozen embryo transfer as part of IVF treatment. Researchers measured progesterone levels in the blood to understand how the body processes the hormone. The goal was to find out if low progesterone on transfer day leads to higher failure …

This study looked back at the medical records of 168 adults who survived a cardiac arrest and were treated in the intensive care unit. Researchers wanted to find early signs that could predict which patients were more likely to die within 30 days or six months. By analyzing lab r…

This study examined how the Impella heart pump changes platelet function in 30 patients with cardiogenic shock or cardiac arrest. Researchers measured markers of platelet activation and aggregation before and during pump support. The goal was to understand why some patients devel…

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study looked at 140 adults having mitral valve surgery to see if a special heart ultrasound measure (called global longitudinal strain) could predict a serious complication called low cardiac output syndrome. Researchers checked ultrasound images taken during surgery and tra…

This study looked at 321 people with pacemakers or heart monitors who had short, symptomless episodes of atrial fibrillation (silent AF). Researchers measured certain proteins in the blood to see if they could predict who might later have a stroke or other heart problems. The goa…

This study tested how well an Apple Watch measures heart and fitness data compared to standard medical equipment. About 50 adults with heart conditions or athletes wore the watch during exercise. The goal was to see if smartwatches can reliably help monitor heart disease.

This study looked at whether a special MRI scan (4D Flow) can accurately measure blood flow to the lungs in people with both congenital heart disease and pulmonary hypertension. The standard test for this is a heart catheterization, which is invasive and uncomfortable. The study …

This study looked at whether adding a brain MRI and a check by a nerve specialist could help doctors make better treatment decisions for people with a serious heart infection called infectious endocarditis. The infection can cause silent strokes, and the goal was to see if findin…

This study analyzed data from over 16,500 adults with chronic heart failure who were part of a remote monitoring program in France. Researchers looked at how having diabetes, other health conditions, and short-term weight changes were linked to survival. The goal was to better un…

This study tested whether simple nudges—like an alert in a doctor's daily task list or an email comparing their prescribing habits to peers—could increase the use of two types of heart failure medications (SGLT2 inhibitors and MRAs) that are proven to save lives but are often und…

This study looked at 200 people with atrial fibrillation to see if treatments like catheter ablation or exercise training change levels of a brain chemical called BDNF. Researchers also checked if these changes relate to mood and quality of life. The goal was to gather knowledge,…

This study looked at data from 100 patients who had heart artery imaging and pressure measurements. Researchers developed a new computer algorithm to analyze ultrasound images of the arteries and estimate how much they block blood flow. The goal was to see if the algorithm could …

This completed registry followed over 17,000 Korean patients with coronary artery disease who received drug-eluting stents. Researchers compared several types of stents to see which ones work best and are safest over the long term in everyday medical practice. The goal is to prov…

This study followed 520 French adults with central or mixed sleep apnea to see how a treatment called adaptive servo-ventilation (ASV) improved their sleep quality. Participants used a breathing device that adjusts pressure in real time. The goal was to measure changes in sleep q…

This completed study looked at 530 heart attack survivors from 25 Spanish hospitals to see if women and men differ in how well they follow prevention advice, like taking medications, eating healthy, exercising, and joining rehab programs. Researchers matched women and men by age …

This study looked at whether ultrasound measurements of the vena cava and femoral artery can predict which sepsis patients with low blood pressure will benefit from extra fluids. 90 spontaneously breathing adults in intensive care were studied. The goal is to avoid giving too muc…

This study tested whether using a video call (telemedicine) to guide bystanders in CPR is better than standard phone-only instructions. Researchers studied 108 adults with suspected cardiac arrest in Bangkok, Thailand. The goal was to see if video help leads to more people receiv…

This study looked at 54 people with severe mitral regurgitation who received the MitraClip device. Researchers used heart MRI and ultrasound before, right after, and 6 months after the procedure to see how the heart's shape and function changed. The goal was to understand the hea…

This study looked at 346 adults who had a cardiac arrest outside the hospital. Doctors used an ultrasound within the first 12 minutes of CPR to see if a still heart (no movement) meant the heart would not restart. The goal was to help decide on next steps like ECMO or organ donat…

This study looked back at the medical records of 140 adults who had surgery for a serious heart infection called infective endocarditis. The goal was to see how many patients survived 30 days after surgery and what factors might lead to complications. Researchers also checked if …

This study examined 297 adults who had a cardiac arrest outside the hospital and were treated by emergency services. Researchers wanted to see if placing a breathing tube before arriving at the hospital helped more people survive for 28 days and have better brain function. They a…

This study looked at 541 premature babies with a heart condition called patent ductus arteriosus (PDA). Half received ibuprofen to close the vessel, while the other half got only supportive care like fluids or diuretics. Researchers compared closure rates and complications to see…

This completed study with over 1,000 participants looked at whether patient surveys and interviews can help doctors spot changes in heart failure. Researchers also collected blood samples to explore links between biology and quality of life. The goal was to see if these tools are…

This study tested a device that automatically measures foot volume to help monitor fluid levels in heart failure patients. Researchers wanted to see if it could help doctors adjust diuretic treatment at home and detect early signs of fluid overload before a hospital stay. The stu…

This study looked at 100 people who had a heart attack to see if certain inflammation markers in the blood could predict who might die or develop heart failure within 6 months. Researchers measured these markers at several time points after the attack. The goal was to better unde…

This study looks at how a cardiac arrest affects brain function, including memory, thinking, and emotions. Researchers will follow 48 survivors for one year, using cognitive tests and brain scans (fMRI) to track changes. Their results will be compared to a healthy control group t…

This completed study looked at 334 adults with heart failure and reduced pumping ability. Researchers used ultrasound to measure left atrial strain before and after starting sacubitril/valsartan, a drug known to improve survival. The goal was to see if these measurements could pr…

This study looked at 66 people with Takotsubo syndrome, also known as broken heart syndrome, to understand how their bodies react to emotional stress. Participants recalled a stressful event while researchers measured stress hormones and heart rate. The goal was to learn more abo…

This study tested whether a simple electronic wristband could help doctors understand how patients recover after heart surgery. 137 adults wore the wristband for two months after leaving the hospital, and it counted their daily steps. The goal was to measure when patients returne…

This study looked at 70 adults having open heart surgery (aortic valve or bypass). It compared a newer, smaller heart-lung machine to the standard one. The goal was to see which method better protects the body's tissues and the brain during surgery. Results will help doctors choo…

This study tested whether routinely asking heart failure patients a 12-question survey about their symptoms and quality of life during clinic visits leads to better care. Over 1,200 participants were randomly assigned to start the survey right away or after a one-year delay. Rese…

This study looks at how the drug Sacubitril-Valsartan changes heart function in people with heart failure and reduced pumping ability. Researchers used a non-invasive method to measure heart pressure and volume in 117 participants. The goal is to uncover the mechanisms behind the…

This study looked at 1,003 people who had a cardiac arrest outside the hospital and were revived. It compared getting a coronary angiogram (an X-ray of the heart's arteries) within 2 hours versus waiting 3 days. The goal was to see if early imaging improves survival at 30 days. P…

This completed study looked at 309 adults with heart failure to see if increased pressure in the brain is linked to atrial fibrillation (an irregular heartbeat). Researchers measured eye nerve sheath diameter as a sign of brain pressure and used echocardiography to check heart fu…

This study looked at 623 adults with heart failure or high blood pressure in the lungs to see how well different tests measure pressure inside the heart. Doctors used both non-invasive ultrasound (echocardiogram) and invasive catheter measurements to check for elevated filling pr…

This completed study tested whether giving families of children with long-term illnesses (like cancer, heart disease, or premature birth) a tablet computer with a special app helps them manage care at home. Researchers measured satisfaction, cost-effectiveness, and how well famil…

This study observed how emergency medical teams give breaths to adults suffering cardiac arrest outside the hospital. Using a portable device, researchers measured the volume, frequency, and pressure of ventilations during CPR. The goal was to describe current practices, not to t…

This study tested two types of cameras—a newer CZT camera and a standard Anger camera—to see how well they measure heart nerve function in people with heart failure. Forty-five patients received a special tracer injection (I-123-MIBG) and were scanned with both cameras. The goal …

This pilot study looked at whether giving extra oxygen during heart surgery (when a heart-lung machine is used) affects kidney function afterward. 104 adults having elective heart surgery were randomly assigned to receive either high or normal oxygen levels. The main goal was to …

This study tested an AI system that reads medical records of 308 heart disease patients and pulls out key information like test results and diagnosis types. The AI's accuracy was compared to that of seven doctors. The goal was to see if AI can help make clinical data collection f…

This study compared two heart-mapping systems, RHYTHMIA and CARTO, in 49 adults undergoing a repeat procedure for atrial fibrillation (AF). The goal was to see which system better finds gaps from previous ablations. The study did not test a new treatment but aimed to improve unde…