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Pacemaker tweak may boost heart performance in small study

NCT ID NCT07624552

Knowledge-focused Sponsor: Bursa Yuksek Ihtisas Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether individually adjusting the timing (atrioventricular delay) of a pacemaker improves heart function in 39 adults with conduction system pacing. Researchers used echocardiography to optimize settings and measured changes in heart strain, pumping ability, and blood flow. The goal was to see if this extra step provides benefits beyond standard pacing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Echocardiography-guided atrioventricular delay optimization (a pacemaker programming adjustment)
What this could lead to
If successful, this could show that fine-tuning pacemaker settings improves heart function beyond standard pacing alone.
What could go wrong
This is a small, completed study with only 39 participants. Results may not apply to all patients, and the benefits may be modest or not clinically significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

39 people

The number who actually took part.

Started

Oct 2025

Finished

Feb 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 80 years * Permanent conduction system pacing implantation for atrioventricular block * At least 1 month elapsed since device implantation * Sinus rhythm at the time of enrollment * Left ventricular ejection fraction \>40% * Adequate echocardiographic image quality for comprehensive assessment * Ability and willingness to provide informed consent Exclusion Criteria: * Permanent or persistent atrial fibrillation * Significant valvular heart disease * Active malignancy * Severe systemic illness with limited life expectancy * Sinus node dysfunction requiring alternative pacing strategies * Inadequate echocardiographic image quality * Inability to comply with study procedures * Refusal to participate in the study

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Conditions

The condition(s) this trial relates to.

atrioventricular block

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrioventricular block Conduction system pacing

Contacts and locations

Locations

  • University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital

    Bursa, Yıldırım, Turkey (Türkiye)

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