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Heart valve drug aims to stop stroke and kidney failure in one shot

NCT ID NCT05145283

First seen Apr 24, 2026 · Last updated Apr 30, 2026 · Updated 2 times

Summary

This study tested a drug called conestat alfa to see if it could prevent strokes and kidney injuries in people undergoing a minimally invasive heart valve replacement (TAVI). 141 patients with severe aortic stenosis received either the drug or a placebo before their procedure. The goal was to see if the drug reduced brain lesions and kidney damage seen on MRI scans.

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Contacts and locations

Locations

  • Stadtspital Triemli Zürich, Division of Cardiology

    Zurich, 8063, Switzerland

  • University Hospital Basel, Division of Internal Medicine

    Basel, 4031, Switzerland

Conditions

Explore the condition pages connected to this study.