Heart valve disorder

This early study tests a robotic catheter system to replace the tricuspid valve in 10 patients with severe leakage (regurgitation) who are too high-risk for open surgery. The robot aims to improve precision and safety while reducing radiation exposure for doctors. The main goal i…

This study tests a new, less invasive way to replace a leaky aortic heart valve (aortic regurgitation) using a device called the JenaValve Trilogy, compared to standard open-heart surgery. About 1,000 people with moderate to severe aortic regurgitation will be randomly assigned t…

This study tests a new device to replace the mitral valve in people with severe mitral regurgitation (a leaky heart valve) who cannot have standard surgery or a less invasive repair. About 1,056 participants will receive the device and be followed for safety and quality of life. …

This study tests a device called the Edwards PASCAL System, which is threaded through a blood vessel to repair a leaky tricuspid valve in the heart. It is for people with severe symptoms who are not good candidates for open-heart surgery. About 1,270 participants will be randomly…

This study tests whether special force feedback instruments, used with the da Vinci surgical robot, can safely and effectively repair leaky mitral valves. The trial includes 30 adults with moderate-to-severe mitral regurgitation. Researchers will check for major complications and…

This study tests a new device called the Cephea Mitral Valve System for people with a leaky or narrowed mitral heart valve. The goal is to see if it is safe and works well for patients who are not good candidates for open-heart surgery. About 50 people will get the device and be …

This trial tests a procedure called TEER, which uses a clip to repair a leaky heart valve (mitral regurgitation) caused by an irregular heartbeat (atrial fibrillation). The study will include 400 people with moderate-to-severe or severe leakage who still have symptoms despite tak…

This study tests a home-based cardiac rehabilitation program delivered through a custom app for people who have had a heart valve procedure. Participants who choose not to attend center-based rehab are randomly assigned to usual care, the app with self-guided content, or the app …

This study tests whether the Edwards EVOQUE system, a valve replacement delivered through a catheter, can safely and effectively treat tricuspid regurgitation, a condition where the tricuspid valve fails to close properly. Researchers will enroll 500 adults in Europe who are deem…

This trial tests whether traditional open-heart surgery to replace a narrowed aortic valve works as well as a less invasive catheter-based approach in patients with severe aortic stenosis who are otherwise at low surgical risk. Researchers will compare rates of death, stroke, and…

This trial is testing a new heart valve called SAPIEN X4/X4S in over 1,200 people with severe aortic stenosis, a condition where the heart's aortic valve narrows. The valve is inserted through a catheter, avoiding open-heart surgery. Researchers are measuring how many patients di…

This study is checking how safe and well a device called TriClip works for people with a leaky heart valve (tricuspid regurgitation). The device is already approved for use, and this study will watch 1000 adults who get it to see how they do. The goal is to make sure the device w…

This pilot study tests whether heart failure patients whose heart function has returned to normal can safely stop taking two medications (sacubitril/valsartan and dapagliflozin or empagliflozin). Eighty adults whose heart failure was caused by a treatable condition like a heart v…

This study looks at whether people with heart failure caused by a treatable problem, like a blocked artery or a faulty heart valve, can safely wait to start certain heart failure medications after the problem is fixed. About 80 adults whose heart function improved after surgery o…

This trial tests a new device called the MRace implant, designed to reduce severe mitral regurgitation—a condition where the heart's mitral valve leaks blood backward. The implant is placed via a catheter through a vein in the leg, avoiding open-heart surgery. The study will enro…

This early study tests a device called the MRace implant to treat moderate-to-severe mitral regurgitation, a condition where the heart valve leaks. About 15 people will get the implant and be followed for up to 5 years to see if it safely reduces the leak and improves symptoms. T…

This trial tests a new device called the MRace implant, which is placed in the mitral valve through a catheter inserted via a vein in the leg. The goal is to reduce severe mitral regurgitation, a condition where the valve leaks blood backward, to a milder level. The study enrolls…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study tests a new device called LuX-Valve Plus for people with a severely leaky heart valve (tricuspid regurgitation). About 680 adults will get either the new device or a standard one to see which is safer and works better. Participants will have one procedure and be follow…

This early study tests a new device called the Capstan System, which replaces the mitral valve without open-heart surgery. It is for people with severe mitral regurgitation (a leaky heart valve) who are too sick for traditional surgery. The trial will check if the device can be s…

This study tests a new device called EmStop that captures debris during a heart valve replacement procedure (TAVR) for aortic stenosis. About 663 people will be randomly assigned to receive either the EmStop device or a standard device. The goal is to see if EmStop reduces the ri…

This study follows 550 patients whose first TAVI heart valve has failed. Researchers will compare a second TAVI procedure (redo TAVI) with open-heart surgery or medication alone. The goal is to see which approach works best and why, helping doctors make better decisions for futur…

This early study tests a new device called GEMINUS, which replaces a narrowed heart valve without open-heart surgery. It involves 30 people with severe aortic stenosis. The goal is to see if the procedure is safe and feasible, with follow-up for up to 5 years.

This study is testing whether a common heart valve procedure called TAVI can be performed safely in hospitals that do not have on-site cardiac surgery backup. About 1,600 patients with severe aortic stenosis will be randomly assigned to get TAVI either at a center with or without…

This study tests whether valsartan, a common blood pressure drug, can slow the worsening of atrial functional mitral regurgitation (a leaky heart valve) in 50 adults with normal heart pumping function. Participants take either valsartan or a placebo twice daily for 12 months, wit…

This early study tests a new device that fixes a leaky mitral valve without open-heart surgery. It is for people with severe symptoms who are too high-risk for traditional surgery. Only 5 participants will be enrolled to check if the device is safe and works as intended.

This study is testing a new heart valve called Hydra for people with severe aortic stenosis, a condition where the heart's main valve becomes narrow. About 250 participants will get the valve through a tube in an artery, and researchers will check how safe and effective it is for…

This study tests a new device called the VDyne System, which is placed inside the heart through a tube in a blood vessel to replace a leaky tricuspid valve. The trial will include 730 people with severe symptoms who have not improved with medication. Researchers will compare the …

This trial tests whether a new transcatheter heart valve (Myval) works as safely and effectively as two existing valves (Sapien and Evolut) in people with severe aortic stenosis, a condition where the heart's main valve narrows. About 768 patients who are eligible for valve repla…

This study compares two standard procedures—minimally invasive TAVR and open-heart surgery (SAVR)—for replacing a diseased aortic valve in people with a bicuspid aortic valve. About 1,200 participants aged 50 and older with severe aortic stenosis will be randomly assigned to one …

This study tests the drug acalabrutinib in people with chronic lymphocytic leukemia (CLL) who also have moderate to severe heart failure. Researchers want to see if acalabrutinib causes fewer heart-related side effects compared to other standard treatments. About 60 adults will t…

This study tests a new device called the VDyne System, which is placed through a tube in a blood vessel to replace the tricuspid valve in the heart. It is for people with severe tricuspid regurgitation, a condition where the valve does not close properly, causing blood to leak ba…

This study tests whether a newer, less invasive procedure called transcatheter aortic valve replacement (TAVR) using the J-VALVE device is as safe and effective as traditional open-heart surgery for people with severe aortic regurgitation (a leaky heart valve). About 1,250 adults…

This study tests two blood-thinning strategies in people with severe aortic regurgitation who have had a new heart valve placed without open surgery. Participants receive either daily aspirin for a year or warfarin for six months followed by aspirin. The goal is to see which appr…

This study tests a special heart valve that can be adjusted to fit children as they grow. It involves 36 kids aged 1.5 to 16 years with congenital heart disease who need a new pulmonary valve. The valve is placed during surgery and can later be expanded without another operation.

This early study tests a new device called the SATURN TS TMVR System, which is implanted through a catheter to replace the mitral valve in people with severe mitral regurgitation. Up to 15 patients who are too high-risk for open-heart surgery will be enrolled. The goal is to see …

This trial tests whether using a supraglottic airway (a mask-like device) instead of a breathing tube during heart surgery can reduce lung complications and speed recovery. Adults having elective heart valve surgery or bypass will be randomly assigned to either the nonintubated a…

This study will track 100 people with severe aortic stenosis who receive the Hydra THV heart valve through a less invasive procedure (TAVR). The goal is to see how well the valve works and how safe it is in everyday practice. Participants will be followed for short- and mid-term …

This trial tests whether an eight-week digital cardiac rehabilitation program using the Peloton app can improve physical activity and recovery in people who have had a transcatheter aortic valve replacement (TAVR). Participants are randomly assigned to either the digital rehab pr…

This trial tests whether combining a minimally invasive heart valve repair (TEER) with an electrical shock to restore normal heart rhythm (cardioversion) can improve outcomes for people with severe mitral regurgitation and atrial fibrillation. Participants who have already had a …

This trial is testing a new device called the AltaValve System, which is placed inside the heart to replace a leaky mitral valve. The study includes adults with moderate-to-severe mitral regurgitation who are not suitable for surgery or a less invasive repair procedure. The goal …

This registry will follow 500 adults with severe aortic stenosis who receive a SAPIEN 3 Ultra Resilia heart valve through a minimally invasive procedure. Researchers will track how well the valve works and how safe it is over 10 years. The goal is to see if this newer valve desig…

This large trial tests two types of intravenous fluids given during heart surgery: hydroxyethyl starch (HES) and balanced crystalloids. The goal is to see which fluid leads to fewer serious kidney problems, such as kidney failure or death. About 1,292 adults having heart surgery …

This early study is testing a new device called the ReValve System to replace the mitral valve in people with severe mitral regurgitation (a leaky heart valve). The trial will enroll 20 people who are eligible for mitral valve surgery. The main goal is to see if the device can be…

This trial compares two single antiplatelet therapies—ticagrelor versus aspirin—in people who have just undergone transcatheter aortic valve implantation (TAVI) for severe aortic stenosis. The goal is to see which drug better prevents serious complications like stroke, heart atta…

This early study tests a new device called CARLEN for people with a leaky heart valve (functional mitral regurgitation). The goal is to see if the device is safe and works well. About 30 adults with moderate-to-severe symptoms will be enrolled, and the main focus is on any seriou…

This study tests a new device, the Medtronic Intrepid™ TTVR System, to replace a leaky tricuspid heart valve without open-heart surgery. It is for people with severe symptoms despite medication. About 1,186 participants will be followed to see if the device reduces complications …

This study is testing a new heart valve called the SAPIEN X4 in 200 people whose existing artificial aortic valve is failing. The valve is placed using a thin tube through an artery, avoiding open-heart surgery. The goal is to see if it is safe and effective at improving survival…

This study is testing the Navitor heart valve in 1000 people with severe aortic stenosis, a condition where the heart's main valve narrows. Participants receive the valve through a catheter, and researchers track survival and complications for one year. The goal is to see how wel…

This study tests a drug called inclisiran in children aged 2 to 12 who have a rare genetic condition that causes extremely high cholesterol. The goal is to see if the drug safely lowers their bad cholesterol compared to a placebo. Participants will receive either inclisiran or pl…

This trial tests a new minimally invasive procedure called TRANSOM for people with a leaky mitral valve, a condition where the valve doesn't close properly. Instead of opening the chest, surgeons make a small incision between the ribs and insert a tube directly into the beating h…

This early study is testing a new device called the TRiCares Topaz, which is threaded through a vein to replace the tricuspid valve in the heart. It is for adults with severe tricuspid valve leakage who are not good candidates for open-heart surgery. The study will check if the d…

This trial tests a new device, the Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System, designed to replace the tricuspid valve in people with severe, symptomatic tricuspid regurgitation. The procedure is done through a catheter, avoiding open-heart surgery. The study…

This study is testing a new heart valve (SAPIEN 3) in 108 people who have a dysfunctional right ventricle outflow tract (RVOT) due to a congenital heart defect or a previous valve replacement. The goal is to see if the valve is safe and effective at improving blood flow and reduc…

This early study tests a new device called the Laplace TTVR System, which is designed to replace the tricuspid valve without open-heart surgery. It involves 15 people aged 60-90 with severe tricuspid regurgitation that continues despite medication. The main goal is to see if the …

This study compares two approaches for people with severe aortic stenosis who have no symptoms: early valve replacement (surgery or TAVI) versus watchful waiting. About 2,844 participants will be followed for at least 3 years to see which strategy reduces heart-related death and …

This study is testing a new CT-based sizing algorithm (the ABC Bicuspid Sizing Algorithm) to help doctors choose the right valve size and procedure for people with bicuspid aortic stenosis who need a transcatheter aortic valve replacement (TAVR). About 290 participants will have …

This study will follow up to 250 adults who receive the KONECT RESILIA device, which replaces both the aortic valve and the ascending aorta in one surgery. The goal is to see how safe and effective the device is in real-world use. Participants must have a diseased aortic valve an…

This study compares a new heart valve, the DurAVR®, to standard TAVR valves in up to 1650 people with severe aortic stenosis. The valve is designed to mimic natural blood flow. Participants are randomly assigned to get the new valve or a standard one and are followed for up to 10…

This study is tracking 80 people with severe pulmonary valve regurgitation (a leaky heart valve) who receive the Harmony Transcatheter Pulmonary Valve. The valve is placed through a catheter, avoiding open-heart surgery. Researchers will check if the valve works well and stays in…

This study is testing the safety and performance of the Navitor TAVI system, a device used to replace a narrowed heart valve (aortic stenosis) without open-heart surgery. About 1,000 participants who are eligible for the procedure will receive the Navitor valve and be followed fo…

This study tests whether a special method to expand a new heart valve during TAVI can reduce harmful thickening of the valve leaflets. About 620 people with severe aortic stenosis who do not have atrial fibrillation will be randomly assigned to either the optimized expansion meth…

This trial tests a new device called the TruGamma system, which replaces the tricuspid valve without open surgery. It is for people aged 65 and older with severe tricuspid regurgitation who are not candidates for surgery. The study compares the device plus standard medication to …

This study tests a new device (Intrepid TMVR) to replace the mitral valve in people with severe mitral regurgitation (leaky heart valve) who are not candidates for standard surgery or repair. About 400 participants will receive the device and be followed for safety and effectiven…

This study tests whether a newer blood thinner (rivaroxaban) works as well as the standard drug (warfarin) for preventing clots and bleeding in people who have a mechanical aortic valve. About 1,300 adults who had valve surgery at least 3 months ago will take one of the two pills…

This early study will test a new polymer artificial heart valve in 10 people aged 60 or older with severe mitral valve disease. The goal is to see if the valve is safe and can be implanted successfully. Researchers will track deaths, reoperations, and how well patients can walk a…

This study compares aspirin to the blood thinner warfarin in 1058 people who just had a bioprosthetic heart valve replacement. For 6 months after surgery, participants take either daily aspirin or warfarin. The goal is to see if aspirin is just as safe and effective at preventing…

This study tests whether a daily medication called ataciguat can slow the progression of moderate aortic valve stenosis, a condition where the heart's aortic valve becomes narrowed. About 1,276 adults aged 50 and older will receive either ataciguat or a placebo for up to 3 years.…

This registry is following 500 adults in Portugal who have severe aortic stenosis and are getting a new type of heart valve replacement called the Medtronic Evolut FX+ TAVI system. The goal is to see if using a standardized procedure makes the treatment safer and more effective. …

This study compares aspirin and clopidogrel to prevent leaflet thrombosis (blood clots on the valve) in 254 people who had a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. After 4 weeks of both drugs, participants take either aspirin or clopidogrel alon…

This study tests whether a small wireless sensor placed in the pulmonary artery can help doctors better manage medications for people with heart failure and a leaky mitral valve. The sensor constantly measures pressure inside the heart, giving doctors real-time data to adjust tre…

This study tests whether a drug called enavogliflozin can prevent major heart problems or worsening heart failure in people who have had a heart valve replacement (TAVR) and still have heart failure. About 1,040 participants will receive either the drug or a placebo, in addition …

This study is testing a new type of biological heart valve that features an 'easy change' system, designed to make future replacements simpler. Researchers will implant these valves in 500 people with aortic valve disease and track complications like blood clots, infections, and …

This study tests whether using just one Perclose device to close the artery after TAVR is as safe and effective as the usual two devices. Researchers will measure bleeding time and complications in 300 adults undergoing TAVR. The goal is to see if a simpler approach can reduce pr…

This study tests a monthly injection called pelacarsen to see if it can slow the worsening of calcific aortic valve stenosis, a condition where the heart valve becomes stiff and narrow. About 502 adults aged 50-79 with high levels of lipoprotein(a) and mild-to-moderate valve dise…

This trial compares two blood products—prothrombin complex concentrate (PCC) and fresh frozen plasma (FFP)—for controlling bleeding in people undergoing heart valve surgery. Doctors use a special test to guide which product to give and measure how quickly bleeding stops. The goal…

This study tests a new device called CHORDS that catches loose debris during a heart valve replacement procedure (TAVR). The debris can travel to the brain and cause a stroke. The trial will compare CHORDS to an existing device in 240 people with severe aortic stenosis. Participa…

This study compares two different devices (Allegra and Sapien) used to replace a failing surgically implanted aortic heart valve without open-heart surgery. About 104 adults with a deteriorated biological aortic valve will be randomly assigned to get one of the two devices. The m…

This study tests a new device called DragonFly-T that clips a leaky tricuspid heart valve closed, avoiding open-heart surgery. About 236 people with severe symptoms who are too high-risk for surgery will be randomly assigned to get the clip or continue medical therapy. The goal i…

This study tests a pre-set treatment plan for managing heart rhythm issues that can occur after transcatheter aortic valve replacement (TAVR). The goal is to reduce the number of patients who receive a permanent pacemaker while ensuring no one is put at risk of sudden cardiac dea…

This study tests whether giving two steroids (hydrocortisone and fludrocortisone) to high-risk patients before heart surgery can lower the chance of serious complications like kidney injury and lung problems. The trial will include 196 adults with a EuroSCORE II above 4% who are …

This early study is testing a new device called the DUO System, which is placed through a catheter to reduce leakage in the tricuspid valve. The study will include 15 people with severe tricuspid regurgitation who still have symptoms despite medical therapy. The main goal is to s…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study looks at whether starting rhythm control early—using drugs or procedures like ablation—can improve outcomes for people with both atrial fibrillation and tricuspid regurgitation (a leaky heart valve). About 5,800 participants will be randomly assigned to early rhythm co…

This early study tests a new device called the INNOVALVE system for people with a leaky mitral valve who are too high-risk for open-heart surgery. The device is delivered through a catheter to repair the valve. Researchers will check if it is safe and works well in 65 participant…

This study is for people whose first TAVR heart valve is failing. Doctors will place a new TAVR valve inside the old one. The goal is to see if this 'redo' procedure is safe and works well. About 225 people will take part, and researchers will check how the valve performs at 30 d…

This study is testing the Navitor heart valve, a device used to replace a narrowed aortic valve without open-heart surgery. It will include 100 people in Japan with severe aortic stenosis. Researchers will check how many patients die within 30 days and whether the valve leaks aft…

This study looks at how safe and effective a less invasive heart valve replacement (called Sapien 3 TAVR) is for younger patients (ages 50-70) in China with severe aortic stenosis. Researchers will track 450 participants for up to 5 years to see survival rates and complications. …

This early-stage study tests a new device called the ReValve system to replace the mitral valve in people with severe valve leakage. About 25 adults with symptoms like shortness of breath will get the device to see if it can be delivered safely and works as intended. The goal is …

This study tests whether a CT scan 3 months after TAVI (aortic valve replacement) can help doctors decide who needs blood thinners and who can stop them. Currently, patients take aspirin for life, which can cause bleeding. The trial will enroll 2,500 people and compare this perso…

This study tests a new device called the SATURN system, which is implanted through a tube in a blood vessel to replace a leaky mitral heart valve. It is for people aged 65 and older with severe symptoms who are not good candidates for open-heart surgery. The goal is to see if the…

This study follows 550 people who receive Abbott annuloplasty rings or bands during surgery to fix leaky mitral or tricuspid heart valves. Researchers will track survival, need for repeat surgery, and symptom improvement for five years. The goal is to confirm the devices work wel…

This study is testing a new device called the inQB8 MonarQ system, which replaces the tricuspid valve using a thin tube (catheter) instead of open-heart surgery. It includes 50 people with severe tricuspid regurgitation, a condition where the valve leaks. The goal is to see if th…

This study compares two approaches for people with a severe leaky heart valve (mitral regurgitation) who have no symptoms yet. Half will get early valve repair surgery, while the other half will be monitored closely every 6 months. The goal is to see which strategy leads to fewer…

This study tests a drug called inclisiran in children aged 6 to 12 who have a genetic condition that causes very high cholesterol. The drug is given as a shot under the skin and aims to lower 'bad' LDL cholesterol. The trial compares inclisiran to a placebo for one year, then eve…

This study follows 100 adults with severe tricuspid regurgitation who receive the TricValve implant. Researchers will track survival, heart failure hospitalizations, kidney function, and quality of life for up to one year. The goal is to understand how well the device works and i…

This study tests whether a newer, less-invasive valve replacement (Myval THV) works as well as traditional open-heart surgery in people aged 65 to 75 with severe aortic stenosis. About 1,180 participants will be randomly assigned to one of the two procedures. The goal is to see i…

This study tests a new device called the Cardiovalve system to treat severe tricuspid regurgitation, a condition where a heart valve leaks. About 150 people aged 18-84 who are too high-risk for open-heart surgery will receive the valve. The goal is to see if the valve safely redu…

This study tests a small implantable sensor that monitors pressure in the lung artery for patients with severe tricuspid regurgitation and heart failure. The sensor is placed before a minimally invasive valve repair, and pressure readings are tracked for a year. The goal is to se…

This study tests a minimally invasive procedure to repair a leaky heart valve in people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. About 144 adults in intensive care will be randomly assigned to either standard medical therapy or…

This study is testing a new device called the J-Valve, which is a replacement heart valve delivered through a tube in the leg, to treat severe aortic regurgitation (a leaky heart valve). The trial will include 194 people with severe symptoms who are at high risk for open-heart su…

This study is testing a new heart valve called Hydra in 50 people with severe aortic stenosis, a condition where the heart's main valve narrows. The goal is to see if the valve is safe and works well for up to one year after a minimally invasive replacement procedure. Researchers…

This study tests a new device (TS-RF system) that uses radiofrequency energy to help doctors safely reach the left side of the heart during procedures for abnormal heart rhythms or mitral stenosis. About 70 adults will be randomly assigned to receive either the new device or a st…

This study tests a new device called GeminiOne that repairs a leaky heart valve (mitral regurgitation) without open-heart surgery. It involves 15 adults with severe symptoms who are not good candidates for surgery. The goal is to see if the device is safe and effectively reduces …

This study tests whether replacing a narrowed heart valve right away (within 12 hours) helps people with severe aortic stenosis who are in cardiogenic shock, compared to the usual approach of stabilizing them in the ICU first. Thirty participants will be randomly assigned to one …

This study follows 225 adults who have the Ross procedure, a surgery that replaces a diseased aortic valve with the patient's own pulmonary valve. Researchers will track survival, hospital readmissions, and need for repeat surgeries over 1, 5, and 10 years. The goal is to confirm…

This study is testing a new device called the TRiCares Topaz system to replace a leaky heart valve (tricuspid valve) without open-heart surgery. It will enroll 80 adults with severe leakage who are at high risk for traditional surgery. The goal is to see if the device is safe and…

This study tests whether a special heart scan called CT-FFR can help doctors make better decisions about treating blocked arteries before valve replacement surgery. 300 patients with severe aortic stenosis will be randomly assigned to have their treatment guided by either standar…

This study tests a new balloon device used during a minimally invasive heart valve replacement procedure (TAVI) for people with severe aortic stenosis. The main goal is to see if the balloon causes fewer heart rhythm problems, like blockages that might need a pacemaker. About 93 …

This study tests a device called the Carillon Mitral Contour System in 300 people with heart failure and a leaky mitral valve. The device is placed in a vein to help the valve close better, reducing blood backflow. The goal is to see if it improves symptoms, walking ability, and …

This study is testing a device called a valved graft, which replaces both the aortic valve and the ascending aorta in one surgery. It includes 260 people with aortic valve disease, an enlarged aorta, or aortic dissection. The goal is to see how safe and effective the device is by…

This study compares a new, less invasive heart valve implant (TAVR) with standard medication for people who have severe aortic regurgitation, a condition where the heart's aortic valve doesn't close properly. The trial will enroll 210 participants across multiple centers. The goa…

This study tests a new device called the Siegel TAVR System to replace a narrowed heart valve in people with severe aortic stenosis. About 1,025 participants with symptoms will receive the device. Researchers will track deaths, strokes, and heart-related hospitalizations for one …

This study is checking how well the TriClip device works and how safe it is for people in Japan with a leaky tricuspid valve. The device is already approved for use, and this study will follow 250 patients to confirm its benefits in everyday medical practice. The main goal is to …

This early study is testing a new device called MitraFix® for people with a severe leaky heart valve (mitral regurgitation) who are too high-risk for open-heart surgery. The device is implanted through a small tube in a leg vein. The main goals are to see if the procedure is safe…

This study tests a new device called the VDyne System to replace the tricuspid valve in people with severe tricuspid regurgitation (a leaky heart valve). The goal is to see if the device is safe and can improve symptoms, exercise ability, and quality of life. About 30 adults with…

This study compares two types of pacemaker settings in people who need a pacemaker after a TAVI procedure (a minimally invasive heart valve replacement). The two methods are 'physiological pacing' (which tries to mimic natural heart activation) and standard 'right ventricular pac…

This study compares a newer, minimally invasive heart-lung machine (MiECC) to the standard machine used during heart surgery. Researchers want to see if the newer machine reduces serious problems like heart attack, stroke, or kidney injury. About 1,300 adults having elective hear…

This study is tracking 150 people who receive a new type of heart valve (SAPIEN 3 Ultra RESILIA) to see how well it works over time. The valve has special features to prevent calcium buildup and improve durability. Researchers will use echocardiograms to measure valve function an…

This study tests whether a catheter ablation procedure can reduce severe mitral valve leakage in people with persistent atrial fibrillation (a type of irregular heartbeat). About 146 adults aged 18-80 with both conditions will either get the ablation plus standard care or just st…

This study looks at whether a procedure to repair a leaky tricuspid heart valve can improve kidney function, reduce swelling, and boost physical activity in older adults. Researchers will follow 100 participants for changes in kidney health, walking ability, and daily function. T…

This study compares two procedures for people whose surgically implanted heart valve has worn out: repeat open-heart surgery (rAVR) or a less invasive catheter-based approach (valve-in-valve TAVR). About 890 patients aged 18–75 at low-to-intermediate surgical risk will be randoml…

This study looks at the best blood-thinning medicine after a minimally invasive heart valve repair for mitral regurgitation, a common heart condition. About 1,032 participants will be randomly assigned to take either aspirin alone or aspirin plus clopidogrel. The goal is to see w…

This study looks at 880 people who had a minimally invasive heart valve repair and also need long-term blood thinners. It compares taking just one blood thinner (rivaroxaban) versus taking two (rivaroxaban plus clopidogrel) to see which causes fewer bleeding problems over one yea…

This study tests whether using remote monitoring devices after a heart valve procedure (TAVI) allows patients to safely go home the same day instead of staying in the hospital. 216 adults who are eligible for same-day discharge will be randomly assigned to either standard care or…

This study tests a less invasive method to replace a narrowed heart valve in 20 people with severe aortic stenosis. Instead of using X-rays, doctors will guide the procedure using only ultrasound, which may reduce radiation exposure. The goal is to see if this approach is safe an…

This trial tests a new device that clips together the leaflets of a leaky tricuspid valve, aiming to fix it without open-heart surgery. It will enroll 132 people with severe tricuspid regurgitation who are already on standard medications. The study compares the clip plus medicati…

This study tests a new device called SAPIEN M3 that can replace a leaky mitral heart valve using a thin tube inserted through a vein in the leg. It is for people with severe symptoms who cannot have standard surgery or other less invasive treatments. The goal is to see if the dev…

This study looks at whether a special type of pacemaker, called cardiac resynchronization therapy (CRT), can help people with heart failure who develop a heart block after having their aortic valve replaced. The trial will include 360 adults who have a new, persistent heart block…

This study looks at whether early surgery to repair or replace the aortic valve is better than waiting until symptoms appear in people with severe aortic regurgitation (a leaky heart valve). About 217 adults with no symptoms but severe valve leakage will be randomly assigned to e…

This study is testing the RENATUS transcatheter aortic valve in 800 people with severe aortic stenosis, a condition where the heart's aortic valve narrows and makes it hard to pump blood. The valve is implanted through a catheter, avoiding open-heart surgery. Researchers are trac…

This early study tests a new device called the CardioMech Mitral Valve Repair System in 25 people with moderate to severe mitral regurgitation (a leaky heart valve) who are at intermediate or high risk for surgery. The device is delivered through a catheter to repair the valve wi…

This trial tests a device called 'Pivot Bridge' for people with a severe leaky heart valve (tricuspid regurgitation). The device is inserted through a leg vein and sits in the valve to help it close better. It is only used for about a week. The study involves 20 adults who have a…

This study tests a new way to replace the aortic valve in people with severe aortic regurgitation (a leaky heart valve). About 180 patients will get either the new VitaFlow valve or another device through a tube in the leg. The goal is to see if the new valve is safe and effectiv…

This study tests a new surgical technique called the 'Y incision' for people with a small aortic annulus (the ring where the heart valve sits) who need aortic valve replacement. The standard methods often limit how large a replacement valve can be placed, which can lead to poor b…

This study tests new plastic tubes (cannulas) used to connect patients to a heart-lung machine during heart surgery. The trial has two parts: first, a small safety check, then a larger comparison with existing tubes. About 80 adults having planned heart surgery will take part to …

This registry will follow 150 people in Portugal who receive the Myval heart valve through a minimally invasive procedure called TAVI. The goal is to see how safe and effective the valve is for treating severe aortic stenosis. Researchers will track complications like death, stro…

This study is testing a new way to replace a damaged heart valve (the mitral valve) without open-heart surgery. It uses a special valve delivered through a thin tube (catheter) for people with severe symptoms who are not healthy enough for standard surgery. The study will enroll …

This early study tests a new device called the AMEND Trans-Septal System, which is designed to repair a leaky mitral valve without open-heart surgery. The device is implanted through a catheter, making it a safer option for older or sicker patients. Up to 15 people with severe, s…

This study is testing a new artificial heart valve (MITRIS RESILIA) in 250 Chinese patients who need their mitral valve replaced. The goal is to see how safe and well the valve works over time by measuring blood flow and leaks. Participants must be 18 or older and willing to foll…

This study tests whether using a heart-lung machine (ECMO) before a high-risk aortic valve replacement can prevent death, cardiac arrest, or emergency surgery. It includes 30 adults with severe aortic stenosis who are unstable or have complex anatomy. Participants receive ECMO su…

This study tests if adding the drug landiolol to the fluid that protects the heart during mitral valve surgery can reduce a serious complication called low cardiac output syndrome, where the heart struggles to pump enough blood after surgery. About 1500 adults having elective mit…

This study is testing a new heart valve replacement system (VitaFlow Liberty) in 122 people with severe aortic stenosis who are too high-risk for open-heart surgery. The goal is to see how safe and effective the valve is over 12 months, focusing on preventing death and disabling …

This study is testing a device called JenaValve Trilogy to replace the aortic valve without open-heart surgery in 75 people with severe aortic regurgitation (a leaky heart valve). Participants are at high risk for surgery. The main goal is to see if the device works safely and st…

This study compares two approaches for people aged 65+ with moderate aortic stenosis (a narrowed heart valve): either getting a new valve placed through a thin tube (TAVR) or just having regular check-ups. The goal is to see if early treatment prevents death or heart failure bett…

This early study tests a new device called the Pivot Extend in 10 adults with severe tricuspid regurgitation (a leaky heart valve) who are too high-risk for surgery. The device is threaded through a vein in the leg to the heart, where it helps the valve flaps close tightly. The g…

This large trial tests whether the sedative dexmedetomidine can prevent long-term memory and thinking problems that often follow heart surgery. Researchers will give the drug to 2,400 adults aged 60 and older during and after their operation, then track their cognitive function f…

This study tests the DragonFly device, a clip that repairs leaky mitral valves without open-heart surgery. It enrolls 168 people with moderate-to-severe mitral regurgitation who are too high-risk for surgery. The goal is to see if the device safely controls the leak and reduces h…

This early study tests a new device called the Trisol System, which replaces the tricuspid valve using a tube inserted through blood vessels, avoiding open-heart surgery. It includes 30 adults with moderate or severe tricuspid regurgitation who have symptoms like shortness of bre…

This study tests a new device called the Encompass F2, which is designed to catch debris that might travel to the brain during a common heart valve replacement procedure (TAVR). The goal is to see if it reduces the risk of stroke and brain damage compared to standard care. About …

This study tests a new device called the Tioga TMVR System to treat a leaky heart valve (mitral regurgitation) without open-heart surgery. It will include 30 people with moderate to severe symptoms who are not good candidates for surgery. The main goals are to see if the device i…

This study is for babies, infants, and small children who have narrowed arteries in or near the heart. Doctors will use a special tiny stent to open the blockage and improve blood flow. The goal is to see how well the stent works and to track any side effects in everyday medical …

This study tests a program called Transition to Cardiac Rehabilitation (T2CR) for Veterans with heart disease who also have other health problems or frailty. The program starts in the hospital and continues at home, helping patients build skills and motivation to do cardiac rehab…

This study tests whether repairing a leaky mitral valve soon after a heart attack can lower the chances of death or repeat hospital stays for heart failure. About 250 adults with moderate-to-severe valve leakage will either get the MitraClip procedure within 60 days or standard m…

This study tests whether a cardiometabolic clinic can help obese adults with heart disease lose weight and improve health. Sixty participants will receive care from the clinic and be followed for 12 months. Researchers will measure weight loss, body mass index, and fat distributi…

This study tests whether using one stitch device (Perclose) is as safe and effective as using two to close the leg artery after a minimally invasive heart valve replacement (TAVR) in people with severe aortic stenosis. About 876 participants will be randomly assigned to one of th…

This clinical trial is testing two different surgical methods to repair a bicuspid aortic valve, a common heart defect where the valve has two flaps instead of three. The study will enroll 100 people with this condition who also have a leaky valve (aortic regurgitation). Half wil…

This study tests whether using a slightly smaller artificial heart valve (downsizing) works better than the standard method for people with a bicuspid aortic valve—a heart valve with only two flaps instead of three. About 206 adults with severe narrowing of this valve will be ran…

This study tests a new type of heart valve made from a patient's own tissue to treat a leaky pulmonary valve. Seven adults will receive the valve to see if it is safe and works well in the short term. The valve is designed to grow with the patient, potentially reducing the need f…

This study tests a device called CoolCryo that freezes small areas of heart tissue to stop atrial fibrillation (an irregular heartbeat). It is being used in 20 people who are already having mitral valve surgery. The goal is to see if the freezing treatment can keep the heart in n…

This early study is testing a new device called CathHELIX that aims to repair a leaky mitral valve using a thin tube (catheter) instead of open-heart surgery. The trial will enroll just 5 people with moderate to severe mitral regurgitation who have symptoms like shortness of brea…

This study is testing a new device called the HighLife 28mm mitral valve, which is placed through a tube in a vein to replace a leaky heart valve without open-heart surgery. It is for 120 people with moderate-severe or severe mitral regurgitation who are at high risk for surgery.…

This study compares two surgical timings for babies born with Tetralogy of Fallot, a serious heart defect. One group gets corrective surgery within 28 days of birth, the other at the usual 3-6 months. Researchers will track deaths, reoperations, and recovery to see if earlier sur…

This study tests a new device called the CorMatrix Cor TRICUSPID ECM Valve to replace a diseased tricuspid valve in the heart. The trial involves 78 people who need valve surgery, including those with congenital heart disease. The goal is to see if the device is safe and works we…

This study is testing a new replacement valve for the tricuspid valve, which controls blood flow in the heart. The valve is made from natural materials and is designed to treat tricuspid valve disease in both adults and children. Researchers want to see if the valve can be safely…

This study looks at whether a special 3D ultrasound technique called TrueVue can better find and measure calcium buildup on the mitral valve, a common heart problem. Researchers will compare the ultrasound images to CT scans in 100 adults who already need these tests. If successf…

This study tests whether a newer type of CT scan, called photon-counting CT, can accurately measure blood flow to the heart muscle and detect scarring or fibrosis. Researchers will compare the CT results with cardiac MRI and invasive coronary angiography in 100 patients with aort…

This study tests an artificial intelligence (AI) model that can screen for heart valve disease using standard chest CT scans that people already get for other reasons. The goal is to see how well the AI catches moderate-to-severe cases without needing extra tests or contrast dye.…

This trial tests whether an artificial intelligence tool can help doctors detect undiagnosed atrial fibrillation and structural heart disease from routine electrocardiograms (ECGs). About 1,000 healthcare providers are randomly assigned to either receive AI-generated risk alerts …

This trial is testing a digital stethoscope that uses artificial intelligence to detect clinically significant heart murmurs in emergency department patients. Researchers will enroll 300 adults with symptoms like chest pain or shortness of breath. The device records heart sounds …

This study is testing whether an artificial intelligence (AI) program can detect aortic stenosis—a narrowing of the heart's main valve—from a standard electrocardiogram (ECG). Researchers will compare the AI's results with traditional diagnosis in 5,000 adults. If successful, thi…

This study investigates whether a blood test measuring clotting and clot-busting markers can predict complications in patients undergoing aortic valve replacement. Researchers will follow 750 adults with aortic stenosis who receive either surgical or catheter-based valve replacem…

This study investigates whether using a lower dose of iodine contrast dye in CT scans can still produce high-quality images needed to plan a heart valve replacement procedure (TAVR). Normally, 100 ml of contrast is used, but reducing the dose may help avoid kidney injury and save…

This study tests whether artificial intelligence can analyze standard ultrasound images of the heart to measure calcium buildup on the aortic valve. If accurate, this could help doctors diagnose severe aortic stenosis without the extra cost and radiation of a CT scan. The study w…

This study tests an artificial intelligence program that analyzes heart rhythm data from a small, wearable patch to estimate how well the heart pumps blood. Researchers will compare the AI's results to standard ultrasound in 2,000 adults. If accurate, this could offer a simpler, …

This study explores whether a smartphone can detect aortic valve stenosis, a serious heart condition, by recording heart sounds and chest vibrations. Researchers will compare smartphone data with standard echocardiograms in 500 patients. If accurate, this could lead to a simple, …

This study tests whether a quick blood test (CT-ADP) can help doctors detect and fix leaks around a new heart valve during a minimally invasive TAVI procedure. Currently, doctors often use general anesthesia and an ultrasound probe in the throat to check for leaks, but this study…

This study tests whether a portable electronic stethoscope, combined with machine learning, can accurately detect valvular heart disease. About 125 people with and without the condition will use the device and also receive standard heart tests. Researchers will compare the device…

This study explores whether kinocardiography (KCG), a portable device that measures chest vibrations from heartbeats, can diagnose aortic valve disease and thoracic aortic aneurysm. Researchers will compare KCG readings with standard imaging in 180 adults, including those with an…

This study tests a new artificial intelligence software that uses 3D echocardiography to measure mitral regurgitation (a leaky heart valve) more accurately than the standard 2D method. Researchers will compare the 3D tool against cardiac MRI, the current gold standard, in 200 adu…

This study tests whether wearing a portable ECG monitor for 30 days after a heart valve replacement (TAVI) can detect dangerous heart rhythm problems better than the usual 1-2 days of hospital monitoring. 250 patients will be randomly assigned to either the extended monitoring gr…

This study is testing whether a small implantable heart monitor (Reveal LINQ) can detect serious heart block in people who develop a new electrical problem (left bundle branch block) after having their aortic valve replaced (TAVI). About 80 participants will get the monitor and b…

This study tests whether an artificial intelligence (AI) tool can diagnose aortic regurgitation—a leaky heart valve—more accurately than standard manual methods. About 540 adults with confirmed aortic regurgitation will be randomly assigned to either AI-assisted or traditional di…

This study is testing a special vest called HALD that records heart and lung sounds. Researchers want to see if the recordings are as accurate as what a doctor hears with a stethoscope. About 200 adults with or without heart or lung conditions will wear the vest during a clinic v…

This study tests whether artificial intelligence (AI) can analyze routine heart tests (ECGs) to find hidden heart problems like weak heart muscle, valve issues, or high lung pressure. About 590 adults without a prior heart disease diagnosis will have ECGs taken with standard mach…

This study at Mayo Clinic is testing whether artificial intelligence can help standard electrocardiograms (ECGs) detect two common heart valve problems: aortic stenosis and diastolic dysfunction. Researchers will enroll 2000 adults aged 60 and older who are already scheduled for …

This study is testing whether a simple, non-invasive sensor called photoplethysmography (PPG) — already found in many smartwatches — can accurately predict how well the heart pumps blood (ejection fraction) and other heart health measures. Researchers will have 500 adults wear a …

This study trains non-expert staff in GP practices to perform quick heart ultrasounds on people 65 and older. The goal is to find hidden heart valve disease or heart failure early, especially in diverse communities. Researchers hope this approach can reduce emergency hospital vis…

This study compares two heart imaging methods—echocardiography (ultrasound) and cardiac MRI—to see which measures heart valve disease more accurately. Researchers will enroll 200 adults with suspected moderate or severe valve problems. The goal is to improve how doctors assess va…

This study will give heart ultrasounds to 1050 nursing home residents to see if catching heart problems early reduces flare-ups and unplanned hospital stays. Researchers will also check if the scans are practical and affordable for nursing homes. The goal is to improve heart care…

This study tests an artificial intelligence (AI) tool to help doctors accurately diagnose severe low-gradient aortic stenosis, a heart valve condition that can be hard to identify. About 300 adults with suspected disease will have their standard echocardiograms analyzed by the AI…

This study tests whether artificial intelligence can help guide heart ultrasounds in rural and remote Australia, where access to expert imaging is limited. Over 600 adults with heart risk factors or symptoms will receive either AI-guided or standard echocardiography. The goal is …

This study tests whether giving fish oil through a vein during heart surgery can prevent a common complication called atrial fibrillation (irregular heartbeat) and help patients recover faster. About 550 high-risk adults having elective heart surgery will receive either fish oil …

This study is testing whether having a dental checkup before heart valve surgery can prevent serious complications like infection of the heart lining, repeat surgery, or death. About 1,300 adults scheduled for valve surgery will be randomly assigned to either get a dental screeni…

This early-phase study tests whether placing amiodarone directly into the sac around the heart during open-chest surgery can prevent a common and serious irregular heartbeat called atrial fibrillation. About 63 adults aged 20-85 having bypass or valve surgery will receive this tr…

This trial tests whether placing trained nurses in schools can prevent rheumatic heart disease in children aged 5 to 16 in Nepal and Zambia. The nurses will teach about the disease, check for strep throat, and help kids get antibiotics. The study will measure if this approach low…

Tricuspid regurgitation happens when the heart's tricuspid valve leaks, letting blood flow backward. Open heart surgery to fix it carries high risks, and some people are not eligible for other catheter-based repairs. This study tests the Lux-Valve Plus, a replacement valve delive…

Researchers are testing a new balloon device called SmartWave that uses shock waves to break up calcium in severely narrowed mitral valves. The study enrolls 10 adults with symptomatic mitral stenosis caused by mitral annular calcification or severely calcified rheumatic heart di…

This study tests a special shockwave balloon (intravascular lithotripsy) to safely widen heavily calcified arteries in the pelvis, allowing a less invasive heart valve replacement (TAVR) in patients who otherwise would need a more risky approach. About 50 adults with severe aorti…

This study tests whether using shockwave therapy on the leg artery before a TAVR heart valve procedure can reduce bleeding and other complications. It involves 100 adults with severe aortic stenosis and heavily calcified arteries. The goal is to make the procedure safer by prepar…

This study looks at two different nerve-block techniques to manage pain during a minimally invasive heart valve replacement called TAVI. About 60 adults having TAVI will receive either a pericapsular nerve group block, a fascia iliaca block, or local anesthesia. The goal is to se…

This study tests whether myofascial release, a gentle hands-on therapy, can help people recover after heart surgery that splits the breastbone. Fifty adults with heart disease will receive either standard physical therapy or standard therapy plus seven daily sessions of myofascia…

This study tests whether a specific nerve block, called the serratus posterior superior intercostal plane block, can reduce pain and the need for opioid painkillers after minimally invasive heart valve surgery. 90 adults will be randomly assigned to receive either the nerve block…

This study compares two sedation approaches during a minimally invasive heart valve replacement (TAVI) in 80 elderly patients. One group receives dexmedetomidine, a sedative that may cause less breathing depression, while the other gets standard propofol-remifentanil. Researchers…

This study tests whether the type of sedation given during a minimally invasive heart valve replacement (TAVR) affects how well patients recover the next day. 126 adults will be randomly assigned to receive propofol, dexmedetomidine, or midazolam with fentanyl during their proced…

This study tests whether keeping a special chest tube in place for up to 3 days after heart surgery can lower the chance of developing a fast, irregular heartbeat called atrial fibrillation. About 624 adults having routine heart surgery will be randomly assigned to get the tube p…

This study tests whether applying mild electrical stimulation to specific acupoints before anesthesia can help maintain stable blood pressure during TAVR heart valve surgery. Researchers will compare two different stimulation frequencies in 150 adults aged 60 and older. The goal …

This study tests whether giving a numbing medicine (ropivacaine) through chest tubes after heart surgery helps patients recover better than a placebo. About 116 adults having planned heart surgery will take part. The goal is to see if this approach reduces pain and improves overa…

This study tests whether watching an AI-made video before and after mitral valve repair surgery can reduce unplanned calls, emails, or visits to the doctor. About 100 adults scheduled for this heart surgery will be randomly assigned to receive the video or standard instructions. …

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

This study tests whether giving iron infusions after a minimally invasive heart valve replacement (TAVI) helps patients with aortic stenosis and iron deficiency feel better and walk farther. About 402 older adults will be randomly assigned to receive iron or standard care. Resear…

This study will collect information from 15 patients in Asia-Pacific who have had or will have a less invasive procedure to fix a failed mitral or tricuspid heart valve. The goal is to learn how well these procedures work in this population, since most existing data comes from We…

Researchers are studying how non-invasive tools can characterize tricuspid regurgitation, a heart valve condition linked to heart failure and liver problems. The trial enrolls 450 adults with moderate or worse tricuspid regurgitation and uses a lung fluid sensor and a liver stiff…

Researchers are tracking outcomes for 30 people with severe pure aortic regurgitation who receive a transcatheter aortic valve implantation using the JenaValve or J-Valve system. All participants are considered high-risk for open heart surgery. The study uses CT scans at 6 months…

This study tests whether a structured shared decision-making process helps patients with severe aortic stenosis choose between two valve replacement options: TAVR (less invasive) and SAVR (surgery). 140 patients aged 70+ will be randomly assigned to either the structured approach…

This study aims to develop and test new MRI methods for imaging the heart and blood vessels to improve diagnosis and management of heart disease. It will enroll up to 3,400 adults, including both patients with heart conditions and healthy volunteers. Participants will undergo MRI…

This global registry will follow 800 patients receiving a new, less-invasive tricuspid valve replacement (TTVR) for leaky heart valves. Researchers aim to track complications like pacemaker needs and how well the valve works over time. The study does not test a new drug but gathe…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study is a registry that collects information from 1,000 people with symptomatic mitral valve disease, including mitral regurgitation and stenosis. The goal is to better understand how correcting these heart valve problems with a less invasive procedure called transcatheter …

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study tests a new paired-ring sizing tool used during mitral valve repair surgery. The tool measures the length of leaflet coaptation, which is how well the valve leaflets seal. Researchers want to see if this method gives accurate measurements compared to standard echocardi…

This study looks at whether advanced imaging can detect a hidden heart condition called cardiac amyloidosis in people with severe aortic valve stenosis. The condition can complicate treatment and recovery. Researchers will use echocardiography, CT, and SPECT/CT scans to check for…

This study is looking at whether a simple exercise test and other health factors can predict how well people recover after a procedure called TAVI, which replaces a narrowed heart valve. Researchers will follow 161 patients with severe aortic stenosis to see which factors before …

This registry will follow 2,500 people who receive Abbott heart devices, such as implants for holes in the heart or replacement heart valves. The goal is to check how safe and effective these devices are when used in everyday hospital practice. Data will be collected from standar…

This observational study follows 1000 adults with cardiac implantable electronic devices, such as pacemakers and defibrillators, to see how these devices affect tricuspid regurgitation, a condition where the heart's tricuspid valve leaks. Researchers will use 3D echocardiography …

This study looks at people with severe aortic stenosis, a narrowing of the heart's main valve, who are scheduled for a procedure called TAVI to replace that valve. Researchers want to see if improving blood flow through the valve also reduces fluid buildup in the lungs, a sign of…

This observational study tests a new spectroscopic device designed to measure oxygen levels in the heart muscle during open-heart surgery. The goal is to see if the device can safely record this data and how it relates to surgical events and patient parameters. Participants are a…

This study will compare two newer pacemaker technologies—left bundle branch area pacing and leadless pacing—to see how they affect heart function and the tricuspid valve. Twenty adults with certain heart block conditions will receive both types temporarily during their routine pa…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study compares people who have had a mitral valve procedure for mitral stenosis with healthy volunteers. Researchers will measure exercise capacity, muscle oxygen levels, and artery stiffness to understand long-term effects. The goal is to gather knowledge that may improve f…

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study looks at whether people with heart rhythm problems after a TAVI procedure can safely leave the hospital early if they wear a non-invasive heart monitor at home. About 100 adults who had a successful TAVI for severe aortic stenosis and have certain conduction disorders …

This study is a large registry that collects data from thousands of patients across Asia who have undergone transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. Researchers will analyze medical records to see how well the valves perform over time and what fac…

This study follows 141 adults with atrial fibrillation and moderate-to-severe functional mitral or tricuspid valve regurgitation (leaky valves). Researchers will use echocardiograms, exercise tests, and blood work to identify patterns and predict how the disease progresses over o…

This study compares different types of heart valve prostheses used to treat severe aortic stenosis in people with a small aortic annulus. Researchers will test the valves in the lab and then in patients using echocardiograms and a special MRI scan that measures blood flow. The go…

This study investigates why some people with moderate aortic valve stenosis get worse while others remain stable. Researchers will analyze immune system markers and detailed heart images from about 938 participants to find patterns that predict disease progression. The goal is to…

This study is creating a large database of information from 10,000 adults undergoing heart surgery. Researchers will collect detailed data before, during, and after surgery to identify factors that affect recovery and complications. The goal is to improve risk prediction, persona…

This study follows 3,450 patients with aortic valve narrowing (aortic stenosis) to better understand their long-term outlook. Researchers will look at ultrasound measurements and other factors to find what predicts how the disease progresses. The goal is to improve how doctors as…

This study is tracking 500 people who receive the INSPIRIS RESILIA aortic valve during surgery. Researchers will measure how well the valve works by checking blood flow and leakage over time. The goal is to see how the valve performs in everyday medical practice.

This study at Mayo Clinic looks at how changes in the blood vessels of the lungs affect people with heart valve disease. Researchers will use echocardiograms during routine heart catheterization to measure these changes in 600 adults scheduled for valve procedures. The goal is to…

This study is observing 400 adults with moderate or severe tricuspid regurgitation, a condition where a heart valve does not close properly. Researchers will track participants over time to learn how the disease progresses and what factors affect survival. No new treatments are b…

This study follows 232 people with a bicuspid aortic valve (a heart valve with two flaps instead of three) over 10 years. Researchers want to learn how the condition naturally progresses and what factors lead to serious problems like valve disease or bulging of the aorta. Partici…

This registry tracks the safety and real-world outcomes of a minimally invasive procedure to repair a leaky mitral valve (mitral regurgitation) using a device called a leaflet clip. It will enroll up to 4,000 patients across many hospitals. The goal is to monitor adverse events a…

This study is observing 1,000 adults with multiple or mixed heart valve disease to learn more about how the condition progresses and how it is best managed. Researchers will use heart imaging and blood tests to find markers that predict outcomes. The goal is to create better guid…

This registry will collect health information from 8,000 patients with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will track what treatments patients receive and how they fare, including survival rates in the hosp…

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study follows 500 adults with severe mitral valve disease who are not candidates for surgery. Researchers will track deaths and heart-related hospitalizations over two years to understand how these patients fare. The goal is to gather real-world data to help doctors make bet…

This study is for people getting a minimally invasive procedure to fix leaky heart valves. Researchers will use MRI scans to see how the heart changes shape and works better after the procedure. The goal is to learn which patients benefit most and why, helping doctors improve fut…

This study looks at whether inflammation after a minimally invasive heart valve replacement (TAVI) can cause dangerous heart rhythm problems. Researchers will use a special PET scan to measure inflammation in the heart's electrical pathways. The goal is to better predict which pa…

This study observes 1000 people with severe aortic stenosis and kidney disease who are getting a TAVI procedure. Researchers want to see how removing the blocked valve affects the kidneys' response to contrast dye used during the procedure. The goal is to understand if TAVI lower…

This study looks at 600 people getting a new heart valve through a tube in the leg (TAVI). Doctors want to know if using a second tube in the arm (radial artery) instead of the groin (femoral artery) causes fewer bleeding or blood vessel problems. The goal is to find the safest w…

This study uses 3D echocardiography to track changes in the tricuspid valve of 66 people with atrial fibrillation (AF) who do not yet have significant valve leakage. Researchers want to see if the valve's shape changes as AF becomes more persistent. The goal is to better understa…

This study is examining heart valve tissue from 100 people undergoing surgery for aortic stenosis to see how often ATTR amyloid deposits are present. Researchers will use mass spectrometry to identify the type of amyloid. The goal is to better understand the link between amyloido…

This study examines bacteria living on heart valves in 200 patients having aortic valve surgery. Researchers want to see if these bacteria are linked to serious complications after surgery, like stroke or infection. The goal is to better understand how oral health and heart disea…

This study will follow 300 people with aortic stenosis who are scheduled for a TAVI procedure to replace their heart valve. Researchers will use heart scans, blood tests, and checkups to measure how the heart's condition changes over time. The goal is to better understand short- …

This study compares two treatments for a common heart valve problem in people over 60: a less invasive catheter-based repair versus open-heart surgery. Researchers will track which approach leads to better long-term outcomes, including survival, heart function, and quality of lif…

This study is collecting blood samples and quality-of-life questionnaires from 125 people with aortic stenosis, a heart valve condition. Researchers want to find biological markers (biomarkers) that could signal inflammation or scarring in the heart before symptoms appear. The go…

This study is looking at whether a blood test measuring DNA methylation can predict the risk of silent brain injury in elderly patients undergoing TAVR, a minimally invasive heart valve replacement. About 542 people over age 70 with severe aortic stenosis will have their DNA test…

This study looks at why some replacement heart valves (TAVI) may wear out faster than others. Researchers will use special PET-CT scans to detect early signs of valve damage in 180 people who had TAVI about five years ago. They want to see if small blood clots on the valve or the…

This study is a registry that collects information from routine care to see how well minimally invasive heart valve procedures work over 5 years. It includes adults over 18 who have had a transcatheter aortic valve replacement or similar treatment. No new treatments are given; th…

This study follows 1,500 people who are scheduled for heart surgery or a less invasive valve procedure. Researchers want to learn what factors predict major heart problems later, like heart failure or stroke. No new treatment is being tested—the goal is to gather information to i…

This study looks at 82 people with severe aortic stenosis who need open-heart surgery to replace their aortic valve. Before surgery, each person gets a CT scan to measure the valve. During surgery, doctors also measure the valve with special tools. The goal is to see which method…

This registry is following 1,000 patients with a leaky mitral valve (mitral regurgitation) who undergo a minimally invasive procedure called transcatheter mitral valve replacement (TMVR). The goal is to see how well the procedure works in everyday medical practice, including how …

This study looks at two ways to check for blocked heart arteries in people with severe aortic stenosis who are getting a new heart valve (TAVI). One method is the usual invasive X-ray test; the other uses non-invasive risk management. The goal is to see which approach leads to be…

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This early study looks at whether a non-invasive test called impedance cardiography (the HYPERGRAPH test) can detect early signs of heart failure in people with aortic stenosis, a condition where the heart's main valve narrows. Researchers will compare the test results with heart…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study looks at whether filtering out blue light at night in hospital rooms can reduce inflammation, protect thinking skills, and improve mood and sleep in 80 adults having elective heart surgery. Participants will be randomly assigned to wear blue-blocking glasses or regular…

This study looks at people getting a new heart valve (TAVR) for a narrowed aortic valve. It compares two ways of placing the valve: one carefully aligned and one random. The goal is to see if the random method still allows doctors to easily reach the heart arteries later if neede…

This study follows 2500 people who had a TAVR procedure to replace a narrowed heart valve. Researchers will track bleeding and clotting events over time to see how different blood-thinner medicines affect risk. The goal is to find the best treatment plan for each patient based on…

This study tests whether artificial intelligence (AI) can help cardiologists read echocardiograms (heart ultrasounds) more quickly and consistently. Researchers will give AI analysis to doctors in real time as they review heart images from 50 participants with valve disease. The …

This pilot study is testing a new device called HemoCept that measures blood volume and heart efficiency during trans-aortic valve replacement (TAVR) surgery for aortic stenosis. The study will enroll 20 adults aged 18-80 who need TAVR. Researchers want to see if the device's rea…

This study is testing a new device called HemoCept during a standard heart procedure called right heart catheterization. The goal is to see if the device can accurately measure pressure in the heart's blood vessels. About 50 adults with conditions like pulmonary hypertension or h…

This study is a registry that will follow up to 2,700 people who have received or will receive a Medtronic heart valve product during surgery. The goal is to monitor the long-term safety and performance of these devices by identifying any unexpected problems or trends. Participan…

This study watches 150 adults with heart valve problems who are getting a procedure (TAVI or M-TEER) to see if it helps their sleep-disordered breathing. Participants take a sleep test before the procedure and again 6 months later. The goal is to learn how fixing heart valves mig…

This registry is tracking 1,350 people with severe low flow, low gradient aortic stenosis who are getting a TAVR procedure. Researchers are collecting data on risks, complications, and survival for up to 5 years. The goal is to better understand who does well with this treatment …

This study compares two self-expanding heart valves used in a procedure called TAVR, which replaces a narrowed aortic valve without open-heart surgery. Researchers will look at how well each valve works one month and six months after the procedure in about 419 patients. The goal …

This study compares two methods—ultrasound (echocardiography) versus direct pressure measurements (catheterization)—to guide additional balloon inflation after valve-in-valve TAVR. About 310 people with failing surgical aortic valves will be randomly assigned to one method. The g…

This study is re-examining 1,400 adults in Stockholm to find early signs and risk factors for heart, lung, and liver diseases. Participants will get advanced scans, blood tests, and questionnaires. The goal is to better understand how these diseases develop and how to predict the…

This study follows 200 adults who have had or will have a procedure to fix a leaky or narrowed valve in the right side of the heart. Researchers track survival, unplanned hospital stays, and heart function using blood tests and ultrasound. The goal is to learn which treatments wo…

This study watches which guidewires doctors use during a minimally invasive heart valve replacement (TAVI) and checks if a newer wire, the Savvywire, works better. About 300 people aged 50 or older getting TAVI through the groin will take part. Researchers will collect data from …

This study is testing a new way to use MRI scans to measure how well the heart's main pumping chamber works in people with severe aortic stenosis who are scheduled for valve replacement. Researchers will develop computer models to automatically analyze heart images and compare th…

This study will implant a small heart monitor (loop recorder) in 20 young adults aged 18-60 who have a heart condition called mitral annular disjunction and mild or no symptoms. The goal is to detect hidden dangerous heart rhythms that could lead to sudden cardiac death. Particip…

This study aims to find the genetic causes of bicuspid aortic valve (BAV), a common heart defect where the valve has two flaps instead of three. Researchers will collect blood samples from 700 people with BAV and their family members to compare DNA. The goal is to identify gene c…

This pilot study at Mayo Clinic will use cardiac MRI scans to examine how the heart's main pumping chamber changes in people with severe mitral regurgitation before and after valve repair surgery. The goal is to see if this approach can help identify patients at risk of developin…

This study is looking at how well the Mosaic mitral heart valve works over time in people under 65. Researchers will review medical records of 300 patients who had this valve placed at ProMedica Toledo Hospital. The goal is to understand survival rates, valve stability, and the n…

This study will follow 60 adults with a bicuspid aortic valve (a heart valve with two flaps instead of three) for five years. Each year, participants will get a special 4D CT scan to take detailed measurements of the valve's shape and movement. The goal is to learn more about how…

This study looks at whether a special heart ultrasound measurement, called global longitudinal strain (GLS), can predict if a person will have trouble coming off the heart-lung machine during heart surgery. About 213 adults having planned heart surgery will have their hearts meas…

This study aims to understand why people with tetralogy of Fallot and other congenital heart diseases experience shortness of breath, palpitations, and changes in heart structure. Researchers will use remote heart rhythm monitors and imaging to track 300 participants over two yea…

This study looks at 300 people with mitral valve prolapse, a common heart valve condition, to find ways to predict if they have scarring in the heart muscle. Researchers will use heart scans, EKGs, and other tests to build a scoring system. The goal is to better identify who is a…

This study is developing an artificial intelligence (AI) system to automatically analyze 3D ultrasound images of the heart in people with mitral valve prolapse, a condition where a heart valve doesn't close properly. The AI will measure the valve's shape and movement, and create …

This study looks at whether measuring a substance called presepsin in the blood during and after aorta surgery can help doctors decide when to use antibiotics. About 50 adults having surgery for a thoracic aortic aneurysm or dissection will take part. The goal is to see if presep…

This observational study is testing whether a noninvasive finger imaging device can detect and evaluate two types of heart valve disease: aortic regurgitation and aortic stenosis. Researchers will record arterial waveforms from participants' fingers and see if the patterns can di…

This study aims to measure how often a heart valve leak (tricuspid regurgitation) develops or worsens after getting a pacemaker or defibrillator with a lead that crosses the valve. About 200 adults who need their first device will have heart ultrasounds before and after the proce…

This study looks at whether replacing a narrowed heart valve (TAVI) can reverse damage to the heart muscle in people with severe aortic stenosis. Researchers will use special PET scans to measure scarring and remodeling in the heart before and 6 months after the procedure. The go…

This study aims to find biological differences between men and women with heart valve disease using advanced MRI techniques. Researchers will enroll 200 adults with moderate to severe aortic or mitral valve problems. The goal is to better predict how the heart recovers after valv…

This study is a large registry that will follow 10,000 people who have had a procedure called TAVR to replace a faulty heart valve. The goal is to see how patients do over the long term in everyday medical practice. No new treatment is being tested; instead, researchers are colle…

This study tests a new imaging tracer called 11C-Martinostat that lights up a specific enzyme (histone deacetylase) in the heart during a PET-MRI scan. Researchers will compare enzyme activity in people with aortic stenosis or diabetes to healthy volunteers. The goal is to see if…

This study will use cardiac MRI scans to measure heart muscle scarring in 125 people with heart failure and a leaky mitral valve who are scheduled for a MitraClip procedure. Researchers want to see if the amount of scarring predicts how well the heart recovers six months later. P…

This study compares two types of replacement heart valves for people with aortic stenosis (a narrowed heart valve). Researchers will use exercise MRI scans to see which valve type works better during physical activity. About 90 adults who are already scheduled for valve replaceme…

This study looks at how different fluids used to fill the heart-lung machine before heart surgery affect the body's balance. 80 adults having bypass or valve surgery will be split into four groups, each receiving a different priming solution. Researchers will track changes in aci…

This study is following 10,000 adults with heart valve disease to see how their condition changes over time. Researchers will use scans, blood tests, and health records to track progression and the effects of treatments like surgery or medication. The goal is to better predict ou…

This study looks at whether it is safe to temporarily stop taking beta-blockers before a procedure called transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. About 498 adults who are scheduled for TAVR and have been on beta-blockers for at least a month will…

This study looks at whether a new 3D ultrasound method can measure heart muscle stiffness in people with a leaky mitral valve (mitral regurgitation). The goal is to see if these measurements match findings from MRI scans that show scarring in the heart. About 40 adults with diffe…

This study looks at whether replacing a narrowed heart valve (TAVI) changes the types of bacteria living in the gut. Researchers will collect stool and blood samples from 40 patients before and after the procedure. The goal is to see if improved blood flow from the new valve help…

This study is for adults with a weak heart muscle and a leaky mitral valve (functional mitral regurgitation). Researchers will use advanced MRI scans to better predict which treatments—medication or a minimally invasive valve repair—will work best for each person. The goal is to …

This study uses artificial intelligence to analyze data from 21,000 patients who had heart valve procedures. The goal is to make AI tools that can predict surgery outcomes, like which device to use and risks of complications, with over 90% accuracy. This is a non-interventional s…

This study is looking at whether certain substances in the blood, related to inflammation and scarring, can predict if a person will develop heart rhythm problems after a procedure called TAVI (transcatheter aortic valve implantation). TAVI is a less invasive way to replace a nar…

This registry will track 800 adults with valvular heart disease to see if women and men receive different diagnosis, treatment, and follow-up care. Researchers will compare how quickly each group gets guideline-recommended therapies and whether gender, age, or ethnicity affect ou…

This study looks at whether common blood tests for heart damage (troponin and CK-MB) match what an MRI shows after heart valve surgery. Researchers will enroll 100 adults having aortic or mitral valve surgery. The goal is to improve how heart attacks are diagnosed after surgery, …

This observational study will follow 400 patients with mitral stenosis who undergo a procedure called percutaneous mitral balloon commissurotomy (PMBC), where a balloon is used to open a narrowed heart valve. Researchers want to see how patients fare afterward and find the best w…

This study involves 70 adults with severe heart valve disease who are already scheduled for a routine heart catheterization. Researchers will use special catheters to measure how well the right side of the heart works with the lungs. The goal is to see if simpler, non-invasive te…

This observational study in Scotland aims to understand what causes aortic stenosis to worsen and how the heart responds after valve replacement. About 300 participants with mild to severe aortic stenosis or a replacement valve will undergo regular heart scans and imaging over se…

This study will follow 10,000 people who come to a clinic in Davos, Switzerland for cardiac rehabilitation after a heart attack, surgery, or other heart problem. Researchers will collect health data, blood samples, and genetic information to understand what helps people recover b…

This observational study will follow 1900 people with moderate mixed aortic valve disease (a combination of aortic stenosis and regurgitation) to see how symptoms and heart function relate to survival and the need for valve replacement. Researchers hope to identify which patients…

This study will follow 90 people with mitral valve prolapse who are already scheduled for mitral valve surgery. Researchers will use heart scans and 7-day rhythm monitors before and 6 months after surgery to see if the procedure reduces dangerous heart rhythms and scarring. The g…

The MIRACLE study is following 2000 adults diagnosed with moderate or severe mitral regurgitation, a common heart valve problem. Researchers will use detailed heart ultrasound exams and track patients over time to identify factors that raise the risk of death or heart failure hos…

This study is following 4,000 people with heart valve disease to look for new substances in the body (called metabolites) that might be linked to the disease. Researchers hope to find better ways to predict who will get worse and understand why. No new treatments are being tested…

This study aims to see if CT and echo scans taken before and after a TAVI procedure can help predict how the new heart valve will perform. Researchers will collect scan data from 40 adults with severe aortic stenosis and use it to train a computer algorithm. The goal is to improv…