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Massive 20-Year heart study aims to unlock secrets of cardiovascular disease

NCT ID NCT04388943

Knowledge-focused Sponsor: University Hospitals, Leicester Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future. Researchers will analyze proteins, chemicals, and genes to understand disease mechanisms and improve treatment decisions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 9,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2010

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants recruited from secondary care, inpatient and outpatient departments.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All outpatients and inpatients with cardiovascular disease, of either gender * Aged 18-90 years old * Examples of conditions include: coronary artery disease, heart failure, heart attacks (myocardial infarction), valve disease, cardiac surgery, dysrhythmias (including atrial fibrillation), aneurysms, embolism, strokes, peripheral vascular disease, hypertension (and its complications, such as left ventricular hypertrophy) or those presenting with chest pain * Healthy volunteers * Aged 18-90 years old * From the community without cardiovascular or other diseases Exclusion Criteria: * Any patient who is unable to give consent * Any patient with non-cardiovascular comorbidity likely to cause death within 6 months * Patients know to be infected with HIV, Hepatitis B or any other agent posing an infection risk from unfixed material

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Conditions

The condition(s) this trial relates to.

cardiac rhythm disease cardiovascular disorder coronary artery disorder heart failure heart valve disorder hypertensive disorder myocardial infarction peripheral vascular disease stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular diseases Cardiovascular risk factor

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Hospitals Leicester

    RECRUITING

    Leicester, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.