CARDIOVASCULAR DISEASES

This study is testing if implanting a mechanical heart pump (called HeartMate 3) helps people with advanced heart failure live longer and have fewer hospital visits compared to staying on their current best medications. Researchers will use a special sensor to monitor lung pressu…

This study is testing a medical device designed to physically remove dangerous blood clots from the lungs of patients with a sudden pulmonary embolism. Doctors will use a special suction system during a procedure to see if it safely reduces the clot burden and improves heart func…

This study is testing a new heart pump device called the BrioVAD System for people with severe, treatment-resistant heart failure. It will compare the new pump's safety and effectiveness to an existing, widely used pump called the HeartMate 3. The goal is to see if the new device…

This study is testing a new digital app called VIRTUES, designed to help people manage various heart conditions from home. It will enroll 2000 participants across Canada to try seven core modules that give personalized advice on things like blood pressure, cholesterol, and heart …

This study is testing a new type of clinic designed to help obese adults who also have heart disease. The goal is to see if the clinic helps participants lose weight, improve their diet and fitness, and better manage their heart condition over one year. Researchers will track wei…

This study is testing whether a smartwatch-like device, combined with artificial intelligence, can help people with chronic heart failure stay healthier and avoid hospital trips. About 205 adults with stable heart failure will either use the device for six months or receive their…

This study is testing if a new, leadless pacemaker works as well as a standard pacemaker for improving patients' ability to exercise. The new device is much smaller and has no wires, which could mean fewer complications. About 100 patients with a slow heart rate will be randomly …

This study is creating a national Danish registry to track the long-term results of a procedure called renal angioplasty. The procedure widens narrowed arteries to the kidneys in patients with hard-to-control high blood pressure. It will follow 160 patients for up to 5 years to s…

This study is testing whether a simple, non-invasive treatment can help patients recover better after emergency surgery for a ruptured brain aneurysm. The treatment involves repeatedly inflating and deflating a blood pressure cuff on the arm, which may trigger the body's natural …

This study is testing a new medical device called the Supernova stent retriever. Doctors use it during a procedure to physically grab and remove the blood clot causing a stroke, aiming to quickly restore blood flow to the brain. The goal is to see if this device is safe and effec…

This study is testing whether hands-on cooking classes that teach the Mediterranean diet can improve heart health and mental well-being in racially and ethnically diverse seniors aged 55 and older. Researchers will compare 48 participants who take 3 months of cooking classes with…

This study is monitoring how well a specific heart stent performs when patients take blood thinners for only 3 months after their artery-opening procedure, instead of longer periods. Researchers will track 2,000 real-world patients with heart artery disease for one year to check …

This study is testing a new community health worker program to help people in Philadelphia better manage their risk for heart disease. The program combines group education sessions with one-on-one support to address both health behaviors and social needs like housing and food sec…

This study is investigating whether restricting daily eating to specific time windows can help people with type 2 diabetes, high blood pressure, and obesity better manage their health. Participants will be assigned to either a daytime eating schedule or a nighttime eating schedul…

This study is testing whether receiving home-delivered healthy groceries, chosen with a dietitian's help, can lower blood pressure in adults with high blood pressure. Researchers will compare this approach to giving people a grocery stipend and diet information to shop on their o…

This study is testing the safety of a new inhaled drug, mosliciguat, when added to an existing inhaled medication (treprostinil) for people with pulmonary hypertension caused by scarred lungs (interstitial lung disease). The goal is to see if the two-drug combination is safe and …

This study is testing a 24-week community program designed to improve heart health and reduce stress in Black men who have risk factors like high blood pressure or prediabetes. Participants are randomly assigned to either start the program right away or join a waitlist, and they …

This study is testing whether a standard two-drug inhaler for COPD can improve not just breathing, but also heart function and overall quality of life. It will involve 80 adults newly diagnosed with moderate-to-severe COPD. Researchers will measure changes in exercise capacity, h…

This large study is testing whether adding a new oral drug called vicadrostat to an existing diabetes medicine (empagliflozin) provides better protection against heart and kidney problems in adults who have type 2 diabetes, high blood pressure, and existing heart disease. About 1…

This European study is testing a new catheter-based heart valve replacement system for people with severe tricuspid valve leakage who are at high risk for traditional surgery. The procedure involves inserting a new valve through a catheter without open-heart surgery. Researchers …

This study is testing a small implant called the Carillon device for people with heart failure and a leaky mitral valve. The device is placed in a vein near the heart to help the valve close better. Researchers will compare 300 people who get the implant to those who have a simil…

This study aims to see if a healthy diet containing cottonseed oil improves cholesterol and other markers of heart and metabolic health more than diets with other common plant oils. Researchers will provide all meals to 52 adults with moderately high cholesterol for three separat…

This study is testing a new digital tool called PREVENT, designed to help doctors in rural clinics provide better diet and exercise counseling to patients with obesity. The tool displays patient health information to guide conversations and set personalized goals. Researchers wil…

This study tests whether providing monthly cash assistance, weekly grocery incentives, and phone-based heart health education can reduce the risk of heart disease in African American adults who struggle to afford enough food. Researchers will follow 200 participants for one year …

This study is testing whether an online portal can help connect patients with support services. It's for people who speak English, Chinese, or Spanish and have been diagnosed with breast cancer or cardiovascular disease. The goal is to see if virtual patient navigation is a usefu…

This international study is testing whether using just one blood-thinning medication is as safe and effective as using two after a specific type of heart artery procedure. It focuses on patients aged 75 and older or those at high risk for bleeding. The goal is to find the best ba…

This study is testing if simple, at-home strategies can reduce the health risks linked to too much evening screen time. Researchers are recruiting 30 adults at risk for heart disease and diabetes to try strategies like avoiding food after 8 PM, blocking blue light, and breaking u…

This study is collecting real-world information on how well a special balloon works for treating blocked heart arteries. The balloon is coated with a drug (sirolimus) meant to keep arteries open after treatment. Researchers will follow 960 patients for one year to see if the trea…

This study aims to find the best way to help heart patients maintain healthy behaviors after they finish cardiac rehabilitation. Researchers will test whether simple text message reminders or a more detailed online program works better initially, and then test different levels of…

This study is testing whether adding a digital heart health program—including an app and online coaching sessions—to a person's usual medical care is better at controlling cholesterol and preventing heart attacks and strokes than usual care alone. It will involve about 1,100 adul…

This study is testing if getting a flu shot right after a heart attack can help reduce harmful inflammation in the heart's arteries. Researchers will compare a real flu vaccine to a placebo (saltwater shot) in 90 recent heart attack patients. They will use special heart scans and…

This study is testing the safety and early effectiveness of a new medical procedure that targets nerves in both the kidney and liver to help lower blood pressure. It is for adults with uncontrolled high blood pressure, including those with other heart or kidney risks. The goal is…

This study is collecting real-world information about an FDA-approved device that treats high blood pressure in people who can't control it with lifestyle changes and medications. The device uses a catheter to deliver ultrasound energy to calm overactive nerves around the kidneys…

This early study is testing a new device called the Topaz system, which aims to replace a leaky tricuspid heart valve without major open-heart surgery. It will enroll about 15 adult patients with severe valve leakage who are at high risk for traditional surgery. Doctors will asse…

This study aims to see how well two newer heart stents (Synergy XD and Synergy Megatron) work and how safe they are compared to other drug-coated stents already in use. It will follow 2,000 adults with clogged heart arteries in their normal medical care. The main goal is to track…

This study is testing a smartphone app called HeartSteps to see if it helps people with heart disease stay physically active after finishing a cardiac rehab program. For 3 months, 60 participants will use the app, which sends encouraging messages and helps with activity planning,…

This study is testing a new, non-surgical treatment for high blood pressure. It uses focused ultrasound waves to target and modify a specific type of fat around the kidneys, which researchers believe plays a role in raising blood pressure. The trial will first find the best treat…

This study aims to see if a medical procedure called renal denervation, when added to standard blood pressure medications, provides better long-term blood pressure control for Medicare patients. Researchers will compare health records from about 1,000 patients who received the pr…

This study is observing whether an ultrasound treatment called the Recor Paradise System helps control high blood pressure long-term in older adults whose blood pressure remains high despite medication. Researchers will follow 1,000 Medicare-eligible patients to see how well the …

This study is testing a new cardiac rehabilitation program designed specifically for women. Researchers want to see if women who join this women-only program attend more sessions and see better improvements in their heart health and mood compared to women in the usual mixed-gende…

This study is testing if adding a specially trained 'heart health doula' to standard care helps new mothers recover from pregnancy-related high blood pressure. Researchers will compare two groups: one gets standard home blood pressure monitoring, and the other gets that plus week…

This study is testing a new 'Transition to Cardiac Rehabilitation' (T2CR) program designed to help Veterans with heart disease and other chronic health problems start home-based recovery. The program provides in-person coaching and planning before patients begin standard home-bas…

This study is testing whether drinking traditional kefir daily for 12 weeks can help control blood sugar, improve cholesterol, and reduce inflammation in adults who have or are at high risk for Type 2 Diabetes. Participants will be randomly assigned to drink either kefir or a mil…

This study is testing whether drinking whole milk or nonfat milk for one year affects children's weight, body fat, and risk factors for heart disease and diabetes. Researchers will enroll 200 children aged 9-12 who are above average weight and randomly assign them to drink three …

This study is testing whether different remote exercise programs—using a fitness app, live video sessions, or in-person training—can help people at risk for heart disease become more active. Researchers want to see which approach people find easiest to stick with and if it improv…

This study is testing a special balloon coated with a drug called sirolimus to see if it's safe and effective for treating narrowed small arteries in the heart. About 1,605 adults with coronary artery disease will be randomly assigned to receive either this new balloon treatment …

This study is testing whether a home-based cardiac rehabilitation program delivered through a custom mobile app can help people with heart failure. The program aims to improve physical activity, quality of life, and reduce hospital visits by guiding exercise and healthy behaviors…

This study is testing a new device called SoniCracker IVL that uses sound waves to break up hardened calcium deposits in heart arteries. The goal is to see if this device can safely help doctors place stents more effectively in patients with these challenging blockages. Researche…

This study looks at whether free exercise classes in community parks help older adults improve their health. Researchers will analyze data from 1,000 Miami-Dade County residents aged 50+ who participate in regular park-based fitness sessions. The program includes aerobic exercise…

This study is testing whether empagliflozin, a medication originally for diabetes, can improve heart function in older adults at risk for heart failure. Researchers will give 80 participants either the medication or a placebo pill daily for 9 months to see if it strengthens the h…

This study is testing whether a medication called bempedoic acid can help reduce heart disease risk in people living with HIV. Researchers want to see if the drug lowers cholesterol, reduces artery inflammation, and improves heart health markers. The trial involves 121 HIV-positi…

This study tests two different church-based programs to help reduce heart disease risk in Black adults in New Orleans. It will compare a program led by trained community health workers, which includes coaching and support, to a simpler group education program. The goal is to find…

This study is testing if adding a heart specialist to the hospital care team for people admitted with a COPD flare-up helps find and treat hidden heart problems. Patients are randomly assigned to see either just their lung doctor or both their lung doctor and a heart doctor durin…

This study is testing a 24-week lifestyle program called Inspire HER, designed specifically for Black women at risk for heart disease. The program provides health education, physical activity guidance, and social support resources. Researchers will compare the program's effective…

This study aims to find the best virtual exercise program for women with coronary heart disease. Researchers will compare two types of workouts—high-intensity interval training (HIIT) and moderate continuous training (MICT)—to see which better improves fitness, mental health, and…

This study aims to see if adding short daily stair climbing to regular brisk walking lowers high blood pressure more effectively than walking alone in inactive adults who are overweight and have hypertension. It will involve 450 participants split into three groups: one combining…

This study is testing if adding a special program to manage sleep and stress helps people recover better from heart problems. It will involve 200 adults already enrolled in standard cardiac rehabilitation who report issues with sleep or stress. Half will get the standard rehab, a…

This study is testing if a faster version of a kidney nerve-calming procedure works as well as the older, longer method to lower high blood pressure. It will involve about 130 adults whose blood pressure remains high despite treatment. Researchers aim to see if simplifying where …

This study is developing and testing a new program called 'One Mind One Heart' that combines mindfulness training with behavior change support delivered through text messages. It aims to help older adults with HIV (age 50+) who are experiencing psychological distress reduce their…

This study aims to see if a person's voice can reveal signs of pulmonary hypertension, a serious condition of high blood pressure in the lungs. Researchers will analyze voice recordings from 7,000 patients who are already scheduled for a standard heart ultrasound at Mayo Clinic. …

This study aims to see if a faster CT scan can work as well as a standard MRI for detecting heart muscle damage and predicting future heart problems. Researchers will enroll 2,200 adults who need a heart scan for various reasons, like chest pain or heart failure. The goal is to d…

This study is testing a new, non-invasive device called the Cardiac Performance System (CPS) to see if it can accurately measure heart function. It will compare the CPS readings to the standard, invasive right heart catheterization procedure in 1,000 adult patients who are alread…

This study is testing whether a new artificial intelligence (AI) tool can help doctors more completely diagnose the many complications that can occur with rheumatoid arthritis (RA), such as lung, heart, or thyroid problems. Researchers will give doctors AI-generated predictions a…

This study aims to see if using a special heart CT scan to plan a procedure is as good as or better than the current standard method, which uses an ultrasound probe inside the artery. Researchers will compare the two approaches in 700 patients with hardened, clogged heart arterie…

This study is testing a new type of PET/CT scan to see if it can better detect and measure areas of scarring (fibrosis) and tumors in the body. It will involve 30 participants, including patients with various diseases and healthy volunteers. The goal is to see if this imaging met…

This study is testing new computer software designed to analyze heart stress tests more accurately. The goal is to better identify which patients with chest pain are truly at risk of a heart attack, potentially reducing the need for more invasive follow-up tests. The software use…

This study is testing if a special heart scan can better identify which patients waiting for a kidney transplant are at the highest risk of a heart attack or stroke. It will involve 332 patients on the transplant waiting list. The goal is to see if this scan can improve the curre…

This study is testing a portable, headset-like device that measures brain waves (EEG) to help ambulance crews quickly identify if a patient is having a severe type of stroke. The goal is to get these patients directly to the right specialized hospital for urgent treatment, avoidi…

This large study aims to see if taking a daily cholesterol-lowering drug (atorvastatin) can help prevent dementia, disability, and death in healthy adults aged 75 and older. It will enroll 20,000 participants who do not have heart disease or dementia. Half will take the drug, and…

This study tests different ways churches can help Latina women become more physically active to prevent heart disease. Researchers will work with 28 churches to train leaders and community health workers, then compare which approaches work best. They'll measure whether 560 partic…

This study is testing whether taking low-dose aspirin for six months after giving birth can help women recover from preeclampsia, a serious pregnancy complication. Researchers want to see if aspirin improves blood vessel function and lowers blood pressure in 60 new mothers. The m…

This study is testing a school-based program called 'Healthy School Recognized Campus' that aims to prevent future heart disease by improving kids' physical activity and nutrition. Researchers are working with 20 schools in Texas to see if the program helps students maintain a he…

This large study aims to find out if taking daily aspirin and/or a high-dose statin medication can prevent heart attacks, strokes, and other serious heart problems in people who have a high amount of calcium buildup in their heart arteries but no current symptoms. It will enroll …

This study is testing whether a free phone app called PulsePoint can help save more lives from sudden cardiac arrest. When someone calls 911 for a suspected cardiac arrest in a public place, the app can alert CPR-trained citizens within a short distance so they can start help bef…

This study tests a school program that teaches middle school students how to advocate for healthier food options and more opportunities for physical activity in their own schools. The goal is to see if empowering students to make these changes can improve their health and reduce …

This study is testing a new program that starts heart disease prevention for patients visiting the emergency room for chest pain. The program checks cholesterol, calculates heart risk, and prescribes medication right away, with the goal of preventing future heart attacks and stro…

This large study is testing whether two existing, low-cost medications—colchicine (an anti-inflammatory) and aspirin (a blood thinner)—can prevent serious heart problems in people with type 2 diabetes who are at high risk. It will enroll 10,000 adults aged 55-80 who have diabetes…

This study aims to find affordable ways to stop prediabetes from progressing to full diabetes and reduce heart disease risk in Hispanic adults. Researchers will test four different 6-month drug combinations, including some common diabetes medications, alongside nutritional counse…

This study is testing whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis reduce their risk of heart disease. The coordinator will work with 520 patients aged 40-75 to better manage cholesterol, blood pressure, weight, and other heart health…

This study is testing a new program called Mom♥Health that aims to help mothers of young children reduce their risk of heart disease. Researchers are working with 40 mothers at two childcare centers to see if offering support and connections to health services at these locations …

This study is testing whether telling people their genetic risk for heart disease, combined with personalized coaching, helps them make healthier lifestyle changes. It involves 650 hospital staff members aged 40+ who are at low-to-high risk for heart problems. Participants get a …

This study is testing a web-based app called IAMABLE, designed to help people with chronic conditions like arthritis, heart disease, or neurological issues better manage their daily lives. Fifty adults aged 45-75 will use the app for four months to see if it improves their physic…

This study is testing if specially designed video games that require physical movement (exergames) can help inactive people with heart failure become less sedentary and more active. About 750 participants will be randomly assigned to either receive general activity advice or use …

This study is testing whether a prescription smartwatch app called NightWare can improve sleep and heart health in Veterans with PTSD. The app detects when a nightmare is happening using heart rate and movement, and gently interrupts it. Researchers will enroll 125 Veterans to se…

This study is testing a non-invasive method to help people with chronic spinal cord injury who experience dangerous drops in blood pressure when they sit up, a condition causing dizziness and fatigue. Researchers will use gentle electrical stimulation on the skin over the spine w…

This study is testing if an 8-week couples program can improve relationship quality, mental health, and overall well-being for heart patients and their partners. About 600 couples will be randomly assigned to either join the program or continue with their usual care. Researchers …

This study is testing a new type of stroke rehabilitation therapy. It combines an enhanced version of mirror therapy, which uses visual feedback, to help people recover movement in their arm and hand after a stroke. The goal is to see if this personalized approach works better th…

This study tests whether a specific talk therapy for depression, delivered via video calls to veterans at home, can help them get back to their normal activities and improve their mood after being hospitalized for a heart condition. It will compare 12 sessions of this home-based …

This study is testing if a personalized exercise program, guided by a FitBit and digital health tools, can help people with a common heart rhythm problem called atrial fibrillation (AFib) feel better. Researchers will enroll 120 adults with symptomatic AFib to see if this tech-su…

This study is testing if a gentle, non-invasive electrical stimulation on the spine can safely raise and stabilize low blood pressure in people who have had a recent spinal cord injury. It aims to help these individuals avoid dizziness and nausea when sitting up, which currently …

This study is testing whether giving iron infusions to older patients with iron deficiency after a minimally invasive heart valve replacement (TAVI) helps them feel better and walk farther. Researchers will compare patients who receive iron infusions to those who receive standard…

This study aims to build a large database of health information and DNA samples from 1000 people with panvascular disease. Researchers will analyze this data to learn more about what causes these diseases and how to better predict and treat them. The goal is to improve future dia…

This study aims to understand how lifestyle habits like physical activity, diet, and stress levels relate to heart health markers. Researchers will collect questionnaire data and health measurements from 100 adults and young people. The goal is to build a database to better under…

This study is creating a collection of health information and DNA samples from 500 adults to help future researchers understand heart disease, high blood pressure, diabetes, and obesity. Participants provide their health history and a blood sample, which will be stored in a bioba…

This study is building a large database of detailed medical scans and health information from 50,000 people. The goal is to help researchers discover hidden patterns in the images that could predict a person's risk of developing serious diseases like cancer or heart problems in t…

This study is testing if a short, structured conversation helps emergency room patients understand their personal risk of future heart disease. Researchers will talk with patients who had chest pain but no heart attack, sharing their blood test results and discussing healthy chan…

This study aims to understand how the body's heart and blood vessels react to short-term mental stress and how those reactions might be linked to the health of the brain's blood vessels. Researchers will measure heart activity during a challenging task and use brain scans to look…

This study aims to gather detailed health information from 600 active-duty U.S. Army soldiers. Researchers will measure diet, fitness, body composition, blood markers, and mental health to understand how these factors relate to conditions like high blood pressure and diabetes. Th…

This study aims to understand how obesity relates to heart disease risk in Black men and women, as past research shows risk factors may work differently in this population compared to others. Researchers will recruit 2000 healthy, non-diabetic Black adults to measure body fat, bl…

This study aims to find out if simple nutrition tests before heart surgery can help predict how well patients recover. Researchers will check the nutrition status of 250 patients using questionnaires, blood tests, and strength measurements. They will then see if these results are…

This study is testing a new computer tool called B-COMPASS, which aims to predict which patients might struggle to follow their treatment plans. It will involve 3,100 patients across Europe with conditions like heart disease, cancer, and rare diseases. The goal is to see if the t…

This study aims to understand why people with hemophilia (a bleeding disorder) are 40% less likely to die from heart disease than the general population. Researchers will use a new, highly detailed type of heart scan to compare plaque buildup in the arteries of 80 men with hemoph…

This study aims to collect blood samples from 1,500 patients to discover new biological markers that can better predict who will have future heart attacks or strokes. Participants will have regular check-ups over several years while researchers analyze their samples to identify w…

This study aims to understand how adding trees and green spaces to neighborhoods affects the health of people who live there. Researchers will measure heart health, stress, fitness, and other factors in about 835 Louisville residents over two years. The goal is to see if making n…

This study aims to improve genetic counseling for people from all backgrounds. Researchers are testing different counseling approaches to see what creates the best patient experience. The study partners with Somali, Latino/Hispanic, Black/African American, and Hmong communities t…

This study aims to understand if omega-3 fatty acid supplements improve heart health differently for people based on their genetic background and ancestry. Researchers will give 200 healthy adults either omega-3 pills or a placebo for 12-week periods and measure changes in blood …

This study aims to understand why people who survive serious pneumonia, including from COVID-19, have a higher long-term risk of heart disease and poor fitness. Researchers will follow 650 survivors and healthy volunteers for three years, collecting blood and health data to find …

This study aims to better understand why people with immune system disorders (like rheumatoid arthritis) have a higher risk of heart disease. Researchers will collect health data and blood samples from 600 UK patients over time to see if certain blood tests can predict future hea…

This study aims to create a long-term collection of biological samples to help researchers better understand heart and blood vessel diseases. It will collect blood, urine, and stool samples from 500 adults who have or are at risk for these conditions. The goal is to build a share…

This study aims to understand how weight loss surgery changes the bacteria in your gut and how those changes might improve heart health and diabetes. Researchers will follow 300 patients for up to 10 years after their surgery, collecting blood and stool samples to look for patter…

This study aims to understand how aging changes the way our bodies respond to exercise, especially for older adults with prediabetes or related heart and metabolic risks. It will enroll 26 people who previously completed an exercise study to participate in a new 6-month aerobic e…

This study aims to understand how tiny particles released by fat cells might influence the development of heart disease, diabetes, and other metabolic conditions. Researchers will collect fat and blood samples from 100 adults undergoing weight-loss surgery to analyze these partic…

This study aims to understand how being born prematurely affects kidney development and long-term health. Researchers will follow 300 preterm babies for up to 10 years, using blood tests, urine tests, and ultrasounds to track kidney growth and function. The goal is to identify ea…

This study aims to understand how sleep and the body's natural daily rhythms affect blood pressure in people with high blood pressure. Researchers will observe 32 adults with hypertension in both home and controlled lab settings, measuring sleep patterns, heart activity, and stre…

This study aims to understand if the severe symptom flare-up after exertion, common in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), is specific to that condition. Researchers will compare 80 people with ME/CFS to people with heart disease, both groups undergoing a…

This study aims to understand how the bacteria in our gut (the microbiome) and our diet are linked to major diseases like cancer and heart disease. It will enroll 16,000 adults over 40 to collect health information and samples over time. The goal is to build a research resource t…

This study aims to understand the long-term health of people who have survived a rare and life-threatening blood clotting disorder called immune thrombotic thrombocytopenic purpura (iTTP). Researchers will look back at the medical records of over 1,200 patients in France to learn…

This study aims to understand how often people with psoriasis have hidden heart problems and what puts them at risk. Researchers will follow 1,000 adults with psoriasis, checking their blood for specific markers and performing detailed heart scans. The goal is to find early signs…

This study aims to understand how a person's genes affect their body's natural ability to stop inflammation. Researchers will analyze blood samples and health records from 200 volunteers of South Asian descent who are already part of a larger genetics program. The goal is to see …

This study is creating a large collection of blood, urine, stool, and tissue samples from people with and without heart or metabolic diseases. The goal is to build a library for future researchers to use, helping them understand the causes and effects of these common conditions f…

This study aims to understand why some people with fatty liver disease develop serious liver or heart complications while others do not. Researchers will follow 2,500 middle-aged blood donors who are overweight or have related health issues. They will use genetic tests, blood mar…

This Mayo Clinic study aims to find out if a simple voice recording from your smartphone can help monitor your heart health. Researchers will collect voice samples and health data from up to one million adult participants using a special app. The goal is to see if artificial inte…

This study aims to find out how many people with heart disease also have a lung condition called COPD. It will follow 3000 adults with heart conditions to see if a coordinated approach to managing both heart and lung health can reduce hospital visits and improve quality of life. …

This early study from UC Davis is testing whether products made from Chardonnay grape skins can improve blood vessel function and metabolic health. Five participants will try different products in a single-day test, with measurements taken over 6 hours to see how their bodies res…

This study is collecting information on how well and how safely Medtronic heart surgery devices work in real-world hospital settings. It will follow 5,000 patients who have already received these devices as part of their standard care. The goal is to confirm the devices are safe …

This study is collecting small samples of heart tissue from patients undergoing heart procedures to build a research database. The goal is to better understand how different heart diseases work at a molecular level and to search for new markers that could help with diagnosis. Res…

This study aims to learn more about how a specific inherited heart condition (PKP2-ACM) progresses over time in people receiving standard care. Researchers will observe 36 patients who have this genetic variant and an implanted heart device, collecting data on their heart health,…

This study aims to discover the genetic causes of bicuspid aortic valve (BAV), a common heart defect where the aortic valve has two leaflets instead of three. Researchers will recruit 700 participants, including people with BAV and their family members, to compare their DNA and i…

This study is collecting blood and tissue samples from 500 patients undergoing heart surgery to create a research biobank. The goal is to help scientists better understand how heart diseases develop and progress. This knowledge could lead to improved treatments in the future, but…

This study aims to see if new, non-invasive skin measurements can detect early signs of heart disease. Researchers will test about 900 Swedish adults aged 60-75 using special scanning devices on the skin and compare the results to detailed heart scans. The goal is to find a simpl…

This study aims to understand if a short, 3-month course of high-dose cholesterol medication (statin) can change the fatty buildup (plaque) in heart arteries, as seen on special heart scans. Researchers will follow 140 patients with chest pain but no prior statin use for 24 month…

This early study aims to understand how stimulating nerves near the kidneys affects the body before and after a blood pressure treatment called renal denervation. It will enroll 19 adults with high blood pressure who are already on 1-3 medications. The main goal is to gather safe…

This study aims to understand how daily experiences like stress and discrimination, along with neighborhood factors, affect heart health behaviors and blood vessel function in Black women. Researchers will monitor 80 participants' daily activities, moods, and environments while m…

This study aims to better understand how diseases involving blood clots, inflammation, and blood vessels start and progress over many years. Researchers will observe 1,000 participants, including people with these conditions, their healthy relatives, and unrelated healthy volunte…