New shortcut for blood pressure treatment?
NCT ID NCT07115953
First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times
Summary
This study tests a faster version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. About 130 adults with uncontrolled high blood pressure will receive the quicker procedure. The goal is to see if it works as well as the standard method while taking less time.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 130 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Dec 2029
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Individual is diagnosed with hypertension and has a baseline office systolic blood pressure ≥140 mmHg 2. Individual has a baseline office diastolic blood pressure ≥ 90 mmHg 3. Individual has an average systolic baseline home blood pressure ≥135 mmHg (with ≥7 days of valid pre-procedure measurements) 4. Individual has a valid 24-hour Ambulatory Blood Pressure Measurement at baseline Exclusion Criteria: 1. Individual lacks appropriate renal artery anatomy 2. Individual has undergone prior renal denervation 3. Individual has a documented condition that would prohibit or interfere with ability to obtain an accurate blood pressure measurement 4. Individual requires chronic oxygen support or mechanical ventilation other than nocturnal respiratory support for sleep apnea 5. Individual has an estimated glomerular filtration rate (eGFR) of \<45 mL/min/1.73m2 6. Individual has one or more episode(s) of orthostatic hypotension 7. Individual is pregnant, nursing or planning to become pregnant 8. Individual has documented primary pulmonary hypertension 9. Individual has documented type 1 diabetes mellitus or poorly-controlled type 2 diabetes mellitus with glycosylated hemoglobin greater than 8.0%
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
20 sites in 8 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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AZ Sint Jan Brugge-Oostende av
RECRUITINGBruges, 8000, Belgium
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Algemeen Stedelijk Ziekenhuis - Campus Aalst
RECRUITINGAalst, Belgium
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CHC MontLégia
RECRUITINGLiège, Liège, 4000, Belgium
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Erasmus University Medical Center
RECRUITINGRotterdam, Netherlands
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Hippokration General Hospital of Athens
RECRUITINGAthens, 11527, Greece
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Institut Jantung Negara - National Heart Institute
RECRUITINGKuala Lumpur, 50400, Malaysia
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Leipzig Heart Institute
RECRUITINGLeipzig, Germany
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MacKay Memorial Hospital, Tamsui Branch
RECRUITINGTaipei, Taiwan
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Mater Misericordiae University Hospital
TERMINATEDDublin, Dublin, D07 R2WY, Ireland
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National Taiwan University Hospital
RECRUITINGTaipei, Taiwan
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Oxford University Hospitals NHS Trust - John Radcliffe Hospital
RECRUITINGOxford, United Kingdom
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Royal Perth Hospital
RECRUITINGPerth, Australia
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Sana Kliniken Lübeck GmbH
RECRUITINGLübeck, Schleswig-Holstein, 23560, Germany
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Sarawak Heart Center
RECRUITINGKota, Malaysia
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Schwarzwald-Baar Klinikum Villingen-Schwenningen
RECRUITINGVillingen-Schwenningen, Germany
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The Alfred Hospital
RECRUITINGMelbourne, Australia
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Universitair Ziekenhuis Gent
RECRUITINGGhent, 9000, Belgium
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Universitat des Saarlandes
RECRUITINGHomburg, Saarland, 66123, Germany
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Universitätsklinikum Erlangen
RECRUITINGErlangen, Germany
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Ziekenhuis Oost Limburg
RECRUITINGGenk, Limburg, 3600, Belgium
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Zuyderland Medisch Centrum Heerlen
RECRUITINGHeerlen, 6419 PC, Netherlands
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