VASCULAR DISEASES

This study tests whether sildenafil (a drug often used for erectile dysfunction) can reduce blood vessel damage in people with a left ventricular assist device (LVAD), a mechanical heart pump for advanced heart failure. About 50 adults with an LVAD will receive either sildenafil …

This study looks at how well a procedure called ultrasound renal denervation works over time to lower blood pressure in people 65 and older whose blood pressure is not well controlled with medication. Researchers will review medical records from 1,000 Medicare patients to see if …

This study looks at whether a procedure called renal denervation (RDN) helps lower blood pressure over two years in Medicare patients with uncontrolled hypertension. Researchers will compare patients who received RDN plus standard care to those who received standard care alone, u…

This study tests a non-invasive treatment called remote ischemic conditioning (RIC) for people recovering from a serious brain bleed (aneurysmal subarachnoid hemorrhage) after surgery. RIC uses a blood pressure cuff on the arm to create brief, harmless blood flow interruptions, w…

This study is for adults with high blood pressure that stays high even with lifestyle changes and medication. It tests a device called the Paradise System, which uses ultrasound to calm overactive kidney nerves. Researchers will check if the treatment safely lowers blood pressure…

This study tests whether taking low-dose aspirin for six months after childbirth can help women who had preeclampsia recover their blood vessel health and lower their blood pressure. About 60 new mothers will be randomly assigned to receive aspirin or a placebo. The goal is to se…

This study tests if a device called the Gemini System can safely lower blood pressure by disrupting certain nerves in the kidney and liver. It includes 175 adults with uncontrolled high blood pressure, with or without other health risks like heart or kidney disease. The main goal…

This study tests whether injecting a clot-dissolving drug directly into the blocked brain artery can improve recovery for people with a medium vessel stroke. About 282 adults whose stroke is caused by a blockage in a medium-sized brain artery will receive either the drug injectio…

This study tests whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as two blood thinners (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 p…

This study looks at whether a spinal cord stimulator can reduce pain and improve blood vessel health in people with type 2 diabetes who have nerve pain in their legs. About 25 adults with diabetes for over a year and poor circulation will get the device. Researchers will check pa…

This study tests a new inhaled drug, mosliciguat, added to an existing treatment (treprostinil) for people with high blood pressure in the lungs caused by scarring lung disease. About 20 adults will take part to see if the combination is safe and tolerable. The goal is to manage …

This study compares two imaging methods for guiding treatment of hardened coronary arteries. About 700 adults with heart disease will either receive CT-guided or standard ultrasound-guided care during stent placement. The goal is to see if the CT approach improves stent expansion…

This study tests whether adding a specially trained doula to standard care helps new mothers with pregnancy-related high blood pressure improve their blood pressure one year after giving birth. About 454 women who had preeclampsia or similar conditions will be randomly assigned t…

This study tests a new device called the efemoral vascular scaffold system (EVSS) in 100 people with blocked leg arteries (peripheral artery disease). The scaffold is placed inside the artery to hold it open and improve blood flow. The goal is to see if it is safe and works well …

This study tests a streamlined version of a procedure called renal denervation, which uses energy to calm overactive nerves in the kidneys to lower blood pressure. The goal is to see if a faster approach works just as well as the standard method. About 130 adults with uncontrolle…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to see if it can accurately identify patients with a large vessel occlusion stroke, who need to go directly to a hospital that offers a specialize…

This study is testing whether a new smartphone-based 12-lead ECG device can accurately diagnose heart attacks (STEMI and NSTEMI) compared to standard hospital ECG machines. About 1,000 adults with chest pain will be enrolled in emergency departments. The goal is to see if the por…

This early study tests a new device called the A-FLUX Reducer for people with chest pain caused by small heart vessel disease (microvascular dysfunction). The device is placed in a vein near the heart to improve blood flow and reduce symptoms. About 30 adults with persistent ches…

This study aims to learn more about stroke and TIA by observing up to 4,000 adults who have had or are at risk for these conditions. Researchers will collect data from standard medical tests and some extra research procedures, such as blood draws and brain scans, to track changes…

This study reviews medical records of 5,000 adults who had heart surgery at UC Davis Medical Center. Researchers want to find out which factors influence recovery and survival after surgery. The goal is to use this information to improve care and outcomes for future heart surgery…

This study looks at how things like education, race, and income might affect a person's memory and thinking after a stroke. Researchers will talk with 450 adults who had a stroke and review their brain scans. The goal is to understand why some people recover better than others.

This study tests whether a live video call between a neurologist and ambulance paramedics can improve the detection of strokes before reaching the hospital. About 512 adults with suspected stroke will take part. The goal is to see if video assistance helps paramedics use stroke s…

This study looks at how a protein called AT2R affects blood vessels in women with preeclampsia, a serious pregnancy condition. Researchers will collect tissue from 166 women during C-sections to compare those with and without preeclampsia. The goal is to learn more about the dise…

This study compares two methods—road mapping and ultrasound—for guiding a needle into a leg artery during a procedure to open blocked vessels. It includes 32 adults with severe leg artery disease who need this approach. The goal is to see which method is safer and more successful…

This study is for people aged 5 and older who have a disease related to blood clots, the immune system, or blood vessels, as well as their healthy relatives and unrelated healthy volunteers. The goal is to understand how these conditions start and change over time by collecting m…

This study looks at 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). The goal is to understand why some people still have strokes even when taking blood thinners. Researchers will collect blood samples and heart ultrasound images to fin…

This study looks at whether eating beef every day as part of a heart-healthy diet helps older adults (ages 55-70) absorb zinc better and improve blood vessel function. Researchers will measure zinc inside cells and how well blood vessels work. The goal is to understand how beef's…

This study looks at why women who had high blood pressure during pregnancy are more likely to develop heart and blood vessel problems later in life. Researchers will use MRI scans to measure heart structure in 200 women who gave birth 10 to 25 years ago. The goal is to better und…

This study looks at how a short course of high-dose statins affects fatty buildup (plaque) in the heart arteries of 140 people with mild blockages. Participants get either statins or a placebo for 3 months, and advanced CT scans track plaque changes. The goal is to understand who…

This study aims to learn how the body responds to kidney nerve stimulation in people with high blood pressure. Researchers will measure these responses before and after a procedure that quiets certain kidney nerves. About 19 adults with hypertension will take part. The goal is to…