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Could a blood pressure cuff boost brain recovery after aneurysm surgery?

NCT ID NCT06819657

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after surgery for a ruptured brain aneurysm. RIC involves using a blood pressure cuff on the leg to create brief, harmless blood flow interruptions, which may trigger protective effects in the brain. The trial will enroll 40 adults who had aneurysm clipping surgery, giving them RIC twice daily for a week alongside standard care, to see if it reduces complications and improves neurological function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Remote ischemic conditioning (using a blood pressure cuff on the leg to create brief, harmless blood flow interruptions)
What this could lead to
If it works, this could offer a simple, non-drug way to reduce complications and improve recovery after brain aneurysm surgery.
What could go wrong
This is a very early, small trial with only 40 people, so results may not apply widely. The treatment may cause limb pain or skin damage, and it is unclear if it will actually improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Imaging examination confirmed aneurysmal subarachnoid hemorrhage. 2. Responsible aneurysms received craniotomy clipping within 24 hours. 3. 18≤ age ≤80 years old. 4. Informed consent of the participant or legally authorized representative Exclusion Criteria: 1. Patients with other types of cerebral hemorrhage. 2. Prior neurological impairment (mRS Score \>1) or mental illness may confuse neurological or functional assessment. 3. Severe comorbidities with a life expectancy of less than 90 days. 4. Refractory hypertension (systolic blood pressure 180\>mmHg or diastolic blood pressure 110\>mmHg). 5. RIC contraindications: severe soft tissue injury of lower limbs. 6. Simultaneously participate in another research program to study a different experimental therapy. 7. Any condition that the investigator believes may increase the patient's risk.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beijing Tiantan Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100000, China

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