NERVOUS SYSTEM DISEASES

This study tests a non-invasive treatment called remote ischemic conditioning (RIC) for people recovering from a serious brain bleed (aneurysmal subarachnoid hemorrhage) after surgery. RIC uses a blood pressure cuff on the arm to create brief, harmless blood flow interruptions, w…

This study tests whether injecting a clot-dissolving drug directly into the blocked brain artery can improve recovery for people with a medium vessel stroke. About 282 adults whose stroke is caused by a blockage in a medium-sized brain artery will receive either the drug injectio…

This program provides access to an investigational drug, AOC 1044, for people with Duchenne muscular dystrophy (DMD) whose genetic mutation can be treated by skipping exon 44. It is for eligible patients aged 6 and older living in the US. The goal is to offer treatment while gath…

This early-stage trial tests a specially engineered virus, G207, in children and young adults (ages 3 to 21) whose cerebellar brain tumors have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a single low dose of radiation is …

This study tests a single dose of a gene therapy called NTLA-2001 in 60 people with a rare inherited nerve disease (ATTRv-PN). The goal is to see if it can safely reduce harmful protein buildup and slow nerve damage compared to a placebo. Participants must have a confirmed diagno…

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems that often occur after heart surgery. Researchers will enroll 2,400 adults aged 60 and older who are having bypass or valve surgery. Participants will receive either dexm…

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to see if it can accurately identify patients with a large vessel occlusion stroke, who need to go directly to a hospital that offers a specialize…

This study looks at whether increasing physical activity using a motivational smartphone app can slow down cognitive decline in people with isolated REM sleep behavior disorder (iRBD), an early sign of Parkinson's disease. Researchers will enroll 80 people with iRBD and 50 health…

This study tests a special home therapy program for people aged 75+ with dementia who were recently hospitalized for a fall. The program involves an occupational therapist who makes the home safer and trains a family caregiver to provide support. The goal is to see if this approa…

This study tests whether combining virtual reality (VR) exercises with a gentle brain stimulation technique (tDCS) can improve arm and hand movement in people who had a stroke at least three months ago. About 100 adults will be assigned to different therapy groups to see which ap…

This study tests a non-invasive spinal stimulation technique to help control blood pressure in people who had a spinal cord injury within the past month. Many of these individuals experience dangerous drops in blood pressure when sitting up, causing dizziness and nausea that can …

This study is testing whether a smartphone app can help doctors better understand and treat depression by tracking symptoms every day. About 200 adults with depression will use the app or receive standard care. The goal is to see if the app leads to greater improvement in mood an…

This study tests a device called ATNC MDD-V1 that combines magnetic brain stimulation with cognitive training to help people with mild Alzheimer's disease. Researchers want to see if it improves thinking and memory over 24 weeks. The study involves 180 adults aged 60-85 who are a…

This study tests whether gentle electrical stimulation on the back can help people with chronic spinal cord injury maintain healthy blood pressure when they sit up. Participants will lie on a tilt table while their blood pressure is measured with and without stimulation. The goal…

This study collects blood samples and health data from 1,000 people with rare neurological diseases that may be caused by the immune system attacking the body. The goal is to build a large, organized collection of samples that researchers can use to discover new biomarkers and de…

This study tests whether a live video call between a neurologist and ambulance paramedics can improve the detection of strokes before reaching the hospital. About 512 adults with suspected stroke will take part. The goal is to see if video assistance helps paramedics use stroke s…

This study tests whether temporarily stimulating a specific part of the brain can improve hand, arm, and speech abilities in people who had a stroke at least 6 months ago. Ten participants will have a thin wire placed in the brain for less than 30 days to deliver mild electrical …

This study looks at a blood marker called BD-tau, which may show how much brain injury happens after a stroke. Researchers will take blood samples every hour for 48 hours from 100 adults who had a stroke. The goal is to learn when the marker rises and how long it stays high, whic…

This study tests a new, non-invasive brain scan called fNIRS to see if it can predict recovery in unconscious ICU patients with severe stroke or brain injury. Researchers will compare fNIRS results with standard tests like evoked potentials and EEG. The goal is to find a simpler …