CEREBROVASCULAR DISORDERS

This study tests a non-invasive treatment called remote ischemic conditioning (RIC) for people recovering from a serious brain bleed (aneurysmal subarachnoid hemorrhage) after surgery. RIC uses a blood pressure cuff on the arm to create brief, harmless blood flow interruptions, w…

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after mechanical clot removal helps people recover better from a severe stroke. About 462 adults with a large vessel occlusion stroke will be randomly assigned to receive either…

This study tests whether injecting a clot-dissolving drug directly into the blocked brain artery can improve recovery for people with a medium vessel stroke. About 282 adults whose stroke is caused by a blockage in a medium-sized brain artery will receive either the drug injectio…

This study tests whether an investigational drug called Dimephosphon can improve recovery in people who have had an acute ischemic stroke (a stroke caused by a blood clot). The trial involves 184 adults aged 35-80 who receive either Dimephosphon or a placebo within 24-72 hours of…

This study tests whether lowering blood pressure can slow the growth of white matter lesions (small brain changes linked to thinking problems) in older adults. About 820 people aged 60-88 with high blood pressure and mild cognitive concerns will take part. Researchers will compar…

This early-phase study tests whether inhaled nitric oxide is safe for people having a stroke caused by a blood clot. About 36 adults will receive the gas during a procedure to remove the clot. The main goal is to find the highest safe dose without causing bleeding in the brain.

This study tests a new type of stroke rehabilitation that combines mirror therapy with other techniques to help people who had a stroke at least 3 months ago. The goal is to improve arm movement, strength, and daily life skills. About 81 adults aged 20-80 will participate, and th…

This study is testing whether virtual reality (VR) and mixed reality (MR) games can help stroke survivors improve arm and hand function. About 45 adults who had a stroke will try these high-tech mirror therapy systems or standard therapy. The goal is to see if the VR/MR approache…

This small pilot study tests whether a home-based cognitive strategy program (PRPP-I) can help adults with chronic stroke become more independent in daily activities like dressing, cooking, and bathing. Researchers will enroll 18 participants to see if the program is feasible and…

This study collects blood, clots, and tissue from 1000 people having stroke-related procedures. Researchers will analyze these samples to find biological markers and understand how stroke affects the body. The goal is to improve future treatments by learning directly from human s…

This study aims to understand how different types of brain damage (from stroke, tumors, or diseases) cause specific problems with thinking, memory, and other mental skills. Researchers will use advanced brain scans and cognitive tests in 400 adults (both with and without brain in…

This study tests whether a live video call between a neurologist and ambulance paramedics can improve the detection of strokes before reaching the hospital. About 512 adults with suspected stroke will take part. The goal is to see if video assistance helps paramedics use stroke s…

This study looks at a blood marker called BD-tau, which may show how much brain injury happens after a stroke. Researchers will take blood samples every hour for 48 hours from 100 adults who had a stroke. The goal is to learn when the marker rises and how long it stays high, whic…

This study looks at 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). The goal is to understand why some people still have strokes even when taking blood thinners. Researchers will collect blood samples and heart ultrasound images to fin…

This study explores how brief psychological stress affects heart and brain health in 450 midlife adults. Participants complete questionnaires, physical tests, and a stressful task while heart activity is measured. They also undergo brain scans and memory tests. The goal is to und…

This study looks at why women who had high blood pressure during pregnancy are more likely to develop heart and blood vessel problems later in life. Researchers will use MRI scans to measure heart structure in 200 women who gave birth 10 to 25 years ago. The goal is to better und…