Could dimephosphon help stroke patients recover faster?
NCT ID NCT07167550
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This Phase 3 trial tests whether the drug Dimephosphon can improve recovery in people who have had an acute ischemic stroke. About 184 adults aged 35-80 will receive either Dimephosphon or a placebo within 24-72 hours of their stroke. The main goal is to see if more patients achieve functional independence (scored 0-2 on the Modified Rankin Scale) by day 15.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Dimephosphon
- What this could lead to
- If successful, Dimephosphon could become a new treatment option to improve recovery after an acute ischemic stroke.
- What could go wrong
- This is an early Phase 3 trial with only 184 participants. The drug may not prove more effective than placebo, and side effects are still being evaluated.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 184 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2025
An estimate. Start dates often move.
- Expected to finish
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Apr 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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35 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Written informed consent was obtained from the patient or their legally authorized representative prior to study participation. 2. Age 35-80. 3. Patients must exhibit neurological manifestations consistent with acute ischemic stroke, with a documented onset-to-intervention interval ranging from 24 to 72 hours at the time of scheduled initial administration of the investigational drug. 4. Verified by CT/MRI current hemispheric ischemic stroke. 5. NIHSS score ≥5 and ≤15 at screening. 6. Ability to comply with all protocol-specified procedures, prohibitions, and restrictions. 7. Willingness and ability to adhere to highly effective contraceptive methods as outlined in the study protocol. Exclusion Criteria: 1. Hemorrhagic stroke or hemorrhagic transformation of ischemic focus, traumatic brain injuries 2. Vertebrobasilar stroke and/or development of acute insufficiency syndromes in the arteries of the vertebrobasilar system 3. A patient with ischemic stroke who is a candidate for reperfusion therapy or who has undergone reperfusion therapy before participation in this study. 4. The presence of anatomical abnormalities of the cerebral vessels (arteriovenous malformations, cavernous malformations, aneurysms, atresia of at least one of the extracranial arteries) according to the anamnesis or CT/MRI data. 5. Progression of neurological symptoms of stroke, defined as an increase in the NIHSS score by 4 points at the second assessment (immediately before randomization) from the value obtained at the first assessment (immediately after signing the informed consent form). 6. Surgery on the carotid arteries less than 1 year before screening. 7. History of stroke less than 1 year before screening. 8. Myocardial infarction less than 6 months before screening. 9. Chronic renal failure stage 2-3 (creatinine clearance less than 40 ml/min). 10. Pregnancy or lactation. 11. Participation in another trial within 28 days prior to enrollment. 12. Use of prohibited medications.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
6 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Federal State Autonomous Educational Institution of Higher Education "Peoples' Friendship University of Russia named after Patrice Lumumba"
RECRUITINGMoscow, 117198, Russia
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Saint Petersburg State Budgetary Healthcare Institution "City Hospital No. 40 of the Kurortny District"
RECRUITINGSaint Petersburg, 197706, Russia
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State Budgetary Healthcare Institution "City Hospital No. 4 of Sochi" of the Ministry of Healthcare of the Krasnodar Region
RECRUITINGSochi, 354057, Russia
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State Budgetary Healthcare Institution "Research Institute - Regional Clinical Hospital No. 1 named after Professor S.V. Ochapovsky" of the Ministry of Health of the Krasnodar region
NOT_YET_RECRUITINGKrasnodar, 350086, Russia
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State Budgetary Healthcare Institution of the Leningrad Region "Vsevolozhsk Interdistrict Clinical Hospital
RECRUITINGVsevolozhsk, Leningradskaya Oblast', 188643, Russia
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The FSBI "Federal Center of Brain Research and Neurotechnologies" of the Federal Medical and Biological Agency
RECRUITINGMoscow, 117513, Russia
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