PHYSIOLOGICAL EFFECTS OF DRUGS

This study tests whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as two blood thinners (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 p…

This study tests whether an investigational drug called Dimephosphon can improve recovery in people who have had an acute ischemic stroke (a stroke caused by a blood clot). The trial involves 184 adults aged 35-80 who receive either Dimephosphon or a placebo within 24-72 hours of…

This study tests whether a sedative called dexmedetomidine can prevent long-term memory and thinking problems that often occur after heart surgery. Researchers will enroll 2,400 adults aged 60 and older who are having bypass or valve surgery. Participants will receive either dexm…

This study tests whether a new drug called (2R,6R)-HNK can quickly improve symptoms in adults with major depression that hasn't responded to other treatments. About 50 participants will receive four infusions of the drug and four of a placebo over several weeks, with their mood a…

This study tests an injection called NT 201 (a type of botulinum toxin) against a placebo to see if it safely reduces the appearance of moderate to severe neck bands (platysma prominence) in adults. About 300 participants in Europe will receive either the treatment or a placebo, …

This study follows 500 adults with depression, bipolar disorder, or suicide risk who are already receiving care. Researchers will use interviews, questionnaires, and optional tests like blood draws and brain scans to track how symptoms change over time. The goal is to find better…