ISCHEMIC STROKE

This study tests an experimental drug called DM199 in people who have had a moderate stroke and cannot receive standard clot-removal treatments. The goal is to see if DM199 helps improve recovery and reduce disability. About 728 participants will receive either the drug or a plac…

This study compares two drug combinations—aspirin plus ticagrelor versus aspirin plus clopidogrel—in people who recently had a minor stroke or transient ischemic attack (TIA) caused by a large blood vessel blockage. The goal is to see which combo better prevents new strokes and h…

This study tests different methods of removing blood clots from the brain in people having a stroke. It aims to find the best approach to reduce long-term disability and improve recovery. About 1,600 adults with a stroke caused by a blocked large or medium artery will take part.

This study looks at how well and how safely the Tigertriever device works to remove blood clots from large brain blood vessels in people having an ischemic stroke. About 150 adults will be treated within 8 hours of their first symptoms. The goal is to restore blood flow and impro…

This study tests a tool called Savvy to help stroke survivors take their medication regularly. The tool includes short phone exercises, a weekly pill organizer, and text reminders. Researchers will compare medication adherence and blood pressure control between those using Savvy …

This study looks at whether young people (60 or younger) who had a stroke and then a procedure to close a hole in their heart (called PFO closure) can safely stop taking blood thinners one year later. The goal is to see if stopping these medications increases the risk of another …

This study tests whether giving extra oxygen (normobaric hyperoxia) to acute ischemic stroke patients before they undergo a clot-removal procedure (thrombectomy) can improve their recovery three months later. About 1500 adults with a new stroke and a blocked large artery in the b…

This study looks at whether giving a second dose of a clot-busting drug called tenecteplase can help people having a stroke caused by a medium or large blocked artery. About 198 adults who do not improve one hour after the first dose will be randomly assigned to get either a seco…

This study tests whether taking atorvastatin (a cholesterol-lowering drug) before a brain stent procedure can prevent strokes and keep the stent open. About 354 people with brain aneurysms will receive either atorvastatin or a placebo before their stent surgery and be followed fo…

This study tests whether injecting a clot-dissolving drug directly into the blocked brain artery can improve recovery for people with a medium vessel stroke. About 282 adults whose stroke is caused by a blockage in a medium-sized brain artery will receive either the drug injectio…

This study tests whether giving a second dose of the clot-busting drug tenecteplase can help stroke patients who don't improve within an hour after the first dose. About 120 adults who had a stroke within the last 3 hours will be enrolled. The goal is to see if this rescue approa…

This study tests a device called OsciPulse to see if it reduces blood clot risk better than standard leg compression in people hospitalized after a stroke. About 40 adults with leg weakness will use either the OsciPulse or standard care for up to 7 days. Researchers will measure …

This study compares a procedure to remove blood clots from smaller brain arteries (endovascular thrombectomy) with standard medical care for people who have had a stroke. About 584 participants will be randomly assigned to one of the two treatments. The goal is to see if the proc…

This study tests whether doing two heart procedures at once—fixing faulty electrical signals and closing a small heart pouch—can prevent future strokes better than standard treatments in people who recently had a stroke due to atrial fibrillation. About 240 participants will be r…

This study tests whether giving the clot-busting drug tenecteplase directly into the brain's arteries can improve recovery for people with a medium vessel occlusion stroke. About 488 adults who have had a stroke within the last 24 hours will be randomly assigned to receive either…

This study looks at the best way to prevent another stroke in older adults who have a small hole in the heart (PFO) and had a stroke from an unknown cause. It compares two treatments: closing the hole with a device or taking blood thinners. The study will follow 400 people aged 6…

This study tests a non-drug treatment called remote ischemic preconditioning (RIC) in 910 people who recently had a mild stroke caused by a blocked small artery. RIC involves briefly inflating a blood pressure cuff on the arm to trigger the body's natural protection against brain…

This study tests whether giving a low dose of albumin (a natural protein) during emergency stroke treatment can protect brain tissue and improve recovery. About 100 adults with a certain type of stroke will receive either albumin or a placebo (salt water) alongside standard proce…

This study compares two anti-clotting drug combinations—aspirin plus ticagrelor versus aspirin plus cilostazol—to see which better prevents another stroke in people who recently had a minor stroke or transient ischemic attack (TIA). About 900 adults aged 18-75 with large-artery b…

This study tests whether adding a drug called urinary kallidinogenase (HUK) to standard stroke treatment (tenecteplase) helps people recover better after a stroke. About 200 adults who have had a moderate-to-severe stroke within the last 4.5 hours will receive either the combo or…

This study tests whether stroke patients who take FXa inhibitor blood thinners can safely receive a standard clot-busting drug (IVT) without raising their risk of brain bleeding. Current guidelines deny IVT to these patients due to bleeding concerns, but new evidence suggests it …

This early-stage trial tests a new treatment called NouvSoma001 for people who have had an ischemic stroke within the past week. The treatment uses tiny particles from stem cells to possibly help the brain heal. The main goal is to check if it is safe, and researchers will also l…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and bleeding in the brain after emergency treatment. About 240 adults will be randomly assigned to start blood thinners early or later. The goal is to find the safest tim…

This study tests a simple, non-invasive treatment called remote ischemic conditioning (RIC) for people who have had a moderate stroke in the back part of the brain. RIC involves briefly inflating a blood pressure cuff on the arm to trigger the body's natural protective responses.…

This study tests whether a computer-based decision-support system helps doctors and patients manage cholesterol-lowering medication (evolocumab) more effectively. About 4000 people who recently had a stroke or mini-stroke will take part. The goal is to see if the system helps mor…

This study tests a new device called the Adaptive Tip Catheter for removing blood clots in people having a stroke. About 74 adults who have had a stroke within the last 24 hours will be enrolled. The goal is to see if the catheter can safely restore blood flow to the brain in up …

This study tests a new drug called TS23 in people having an ischemic stroke. The drug is an antibody that may help break up blood clots more effectively. About 300 adults with moderate to severe stroke will receive either TS23 or a placebo, and researchers will monitor safety and…

This study tests whether wearing a custom-made external skull prosthetic can prevent Sunken Flap Syndrome—a condition where the brain sinks after a large piece of skull is removed to relieve pressure. About 72 adults who had this surgery will be offered the prosthetic. Researcher…

This study is testing a drug called Mexidol, given as an injection or a pill, in people who have just had an ischemic stroke (a stroke caused by a blood clot). The goal is to see if Mexidol can reduce the size of the brain injury and improve recovery. The study will involve 120 a…

This study tests whether adding an anti-inflammatory drug (tocilizumab) to standard emergency stroke treatment helps people recover better after a severe stroke in the back part of the brain. About 348 adults with a blocked artery will receive either the drug or a placebo alongsi…

This study tests whether an investigational drug called Dimephosphon can improve recovery in people who have had an acute ischemic stroke (a stroke caused by a blood clot). The trial involves 184 adults aged 35-80 who receive either Dimephosphon or a placebo within 24-72 hours of…

This study looks at the best time to start blood thinners after a stroke caused by a clot in the brain, in people who also have an irregular heartbeat (atrial fibrillation). All participants will have had emergency surgery to remove the clot. The goal is to see if starting blood …

This study tests whether a smartphone-based management system can help people who have had a stroke or mini-stroke avoid future strokes and death. About 4,490 participants will either receive usual care or use a WeChat-based system to track risk factors like blood pressure and bl…

This study tests whether lying with the head down before a procedure to remove a blood clot in the brain can improve recovery for people having a severe stroke. About 210 adults with a large blocked artery will be randomly assigned to either a head-down or flat position before tr…

This study looks at 600 adults who had their first small vessel stroke. They all get clopidogrel and aspirin, and half also get either atorvastatin or rosuvastatin within 24 hours. The goal is to see if adding a statin lowers the chance of having another stroke within three month…

This study tests whether combining a statin with ezetimibe works better than a statin alone to lower LDL (bad) cholesterol below 70 mg/dL in people who recently had a stroke. About 300 adults with atherosclerosis and high LDL will be randomly assigned to one of the two treatments…

This study tests whether giving a clot-busting drug directly into the brain artery after mechanical clot removal helps people recover better from a severe stroke. About 132 adults aged 18-85 with large-vessel strokes will be enrolled. The goal is to see if the drug improves disab…

This study tests whether closing a small heart pouch (left atrial appendage) with a device, along with taking blood thinners, can better prevent another stroke in people with atrial fibrillation who already had a stroke despite being on blood thinners. About 482 participants will…

This study tests whether a telerehabilitation coaching program (TeleSCoP) helps people who had an ischemic stroke feel more confident managing their health, lower their blood pressure and cholesterol, and avoid going back to the hospital. Sixty participants will receive either st…

This study tests a new way to treat ischemic stroke using a special suction device called the Zoom System. The goal is to quickly restore blood flow to the brain by removing the clot. About 750 adults who have had a stroke will be enrolled to see if this technique is safe and eff…

This study tests a treatment called hemoadsorption, which filters harmful substances from the blood, for people with severe ischemic stroke. Researchers want to see if it can reduce disability and improve outcomes. The trial will include 116 adults who have had a major stroke wit…

This study looks at whether adding a statin (atorvastatin or rosuvastatin) to the standard blood thinner clopidogrel within the first 24 hours after a large-vessel stroke can lower the chance of having another stroke within 90 days. About 600 adults aged 18-75 who have had their …

This study tracks 800 adults who recently had a stroke or have narrowed neck or brain arteries. They receive high-dose statins for at least one week to see how much their cholesterol drops. The goal is to understand why some people respond better than others and to guide more per…

This study tests whether briefly stopping and restarting blood flow in the neck right after a stroke procedure can help the brain recover better. About 120 adults who had a major stroke and received emergency treatment to reopen a blocked artery will be included. The goal is to s…

This study tests whether a medication (edaravone dexborneol) taken as a tablet under the tongue can help people recover from a stroke caused by small vessel disease. About 600 adults aged 30–80 who had a recent small stroke will receive either the drug or a placebo for 24 weeks, …

This study tests a new drug called TBO-309 in people having a severe stroke caused by a blockage in two neck arteries (tandem occlusion). The drug is given through a vein during standard clot-removal procedures to help keep the treated artery open and reduce the risk of bleeding …

This study tests whether a balloon procedure (angioplasty) can prevent early worsening in people who have had a minor stroke due to narrowed arteries in the brain. About 100 adults whose symptoms are not controlled by medication will be enrolled. The goal is to see if opening the…

This study compares two treatments for people having a small type of stroke called a lacunar stroke. One group gets a standard clot-busting medicine through an IV, while the other takes a combination of antiplatelet pills (similar to aspirin). The goal is to see if the pills work…

This study is testing whether a special PET/MR scan can better identify risky plaque buildup in the carotid arteries (the main arteries in the neck) that could lead to a stroke. About 100 adults with known carotid plaque will get two types of PET tracers along with an MRI to meas…

This study aims to develop a machine learning system that can detect delayed cerebral ischemia early in patients with subarachnoid hemorrhage. Researchers will analyze heart rate, brain waves, and blood markers from 1,500 participants. The goal is to create an early warning tool …

This study tests a portable EEG device called StrokePointer that ambulance crews can use on people with suspected stroke. The goal is to see if it can accurately identify patients with a large vessel occlusion stroke, who need to go directly to a hospital that offers a specialize…

This study compares a new wireless heart sensor patch to standard hospital monitoring for detecting atrial fibrillation (AF) in people who recently had a stroke or mini-stroke. About 450 adults will be randomly assigned to wear the patch for up to 14 days or receive usual care wi…

This study tests whether a dissolvable oral film with a tiny dose of capsaicin (the hot part of chili peppers) is safe for adults who had a stroke within the last 24 hours. The film aims to stimulate nerves that may improve blood flow to the brain. 46 participants will receive ei…

This study tests whether pairing vagus nerve stimulation (a mild electrical pulse to a nerve in the neck) with mobility training can help people who had a stroke at least 6 months ago walk better. About 20 adults with slow walking speed will receive the therapy in clinic. Researc…

This study tests whether a daily dose of acetyl-leucine (4 grams for 3 months) can improve balance and reduce unsteadiness in people who had a stroke affecting the back part of the brain. The trial includes 200 adults aged 18-80 who recently had their first stroke of this type an…

This study tests whether a gentle electrical brain stimulation, combined with physical therapy and exercises that pair walking with thinking tasks, can improve movement, thinking, and brain activity in people who have had a stroke. Researchers will enroll 60 adults who had a stro…

This study tests whether a tongue endurance exercise program can improve swallowing in adults who have trouble swallowing after a stroke. About 70 people will be randomly assigned to do either the tongue exercises or a sham therapy at home for 8 weeks. Researchers will measure ch…

This study tests whether using a PAP machine (a device that helps keep airways open during sleep) can improve recovery in people who have had a stroke and also have moderate to severe sleep apnea. About 360 participants will be randomly assigned to receive PAP therapy or usual ca…

This study compares a same-day outpatient stroke unit to standard hospital care for people aged 60 and older who have had a mild stroke or mini-stroke. The goal is to see if the outpatient approach is just as good at helping patients recover without needing to stay in the hospita…

This study tests a special vest that keeps body temperature normal for 72 hours after an ischemic stroke. Researchers want to see if this helps the brain recover better and reduces disability. The trial will include 22 adults who had a stroke within the last 48 hours.

This early-stage study at Johns Hopkins University is testing whether psilocybin, a psychedelic compound, is safe for people who had a stroke at least one year ago. The study will enroll 20 adults and closely monitor their blood pressure and any psychiatric changes. The goal is t…

This study tests whether a safe, non-invasive brain stimulation technique called tDCS, combined with standard cognitive therapy, can improve memory and thinking in people who recently had a stroke. Researchers will enroll 70 adults aged 18-90 who had a stroke within the past mont…

This study compares robot-assisted training to standard physical therapy for people who had a stroke 6-24 months ago and still have moderate to severe movement problems. The goal is to see if robot training improves leg function, daily activities, fatigue, and quality of life. Fo…

This study is a large registry that will collect information from 1,000 people treated for brain aneurysms or stroke using MicroVention devices. The goal is to see how well these treatments work in real-life settings, such as how completely aneurysms are closed or how well blood …

This study tests whether personalized transcranial direct current stimulation (tDCS) can help people with chronic stroke regain arm function. Researchers will use brain scans to see if the stimulation improves connections in the brain. The study involves 80 adults who had a strok…

This study examines blood samples from 500 people who recently had a stroke and healthy volunteers to find RNA patterns that could help diagnose strokes and predict recovery. Researchers will use advanced genetic sequencing to identify potential biomarkers. The goal is to improve…

This study tests a new way to measure blood flow in the tiny blood vessels of the brain right after a stroke is treated. Even when doctors successfully remove a clot, many patients still have disabilities—possibly because the smallest vessels aren't getting enough blood. Research…

This study uses advanced 3D X-ray imaging to track how fatty plaques in brain arteries change shape and size over one year in people who have had a stroke. Researchers want to understand plaque evolution under strict control of risk factors like blood pressure and cholesterol. Pa…

This study will follow 15,000 people who have had an ischemic stroke (a type of stroke caused by a blocked blood vessel in the brain) in Shanghai, China. Researchers aim to learn more about what causes strokes in younger adults, how risk factors like high blood pressure, diabetes…

This study looks at using a rapid genetic test in the hospital to help doctors pick the most effective blood thinner for stroke patients. Some people have a gene variation that makes a common drug, clopidogrel, less effective. The test checks for these variations so doctors can p…

This study reviews medical records from 100 adults who had a stroke and were treated at hospitals in Villavicencio, Colombia. Researchers want to see how quickly and effectively stroke care is given, and whether it follows best-practice guidelines. The goal is to find ways to imp…

This study is tracking 5,000 adults hospitalized for an ischemic stroke to see how different treatment strategies affect their recovery. Researchers will collect medical records and brain scans to build models that predict outcomes. The goal is to learn which treatments work best…

This study follows 1,300 people who had a stroke or mini-stroke and completed a 1-year exercise program. Researchers want to see if regular physical activity helps prevent new strokes over the next 3 years. Participants will be observed for stroke, heart attack, and disability ou…

This study looks at brain plaques that can break loose and cause strokes. Researchers will compare plaques in people who have had a stroke with those who have not, using special scans. The goal is to find early warning signs of dangerous plaques. About 140 adults aged 30 to 85 wi…

This study is building a large registry of people who have had a stroke and still have symptoms. The goal is to connect them with researchers working on new ways to improve recovery. No treatment is given; participation simply involves joining the registry.

This study looks at how the immune system and blood clotting change in the first 24-36 hours after a stroke treated with a clot removal procedure (thrombectomy). Researchers will collect blood samples from 1,200 participants to find patterns that might predict how well people rec…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and remove medications too quickly. It focuses on adults in the intensive care unit with life-threatening brain problems like stroke, severe injury, or infection. Researchers w…

This study is for adults who have had a stroke (blood clot or bleeding in the brain). Researchers want to learn why some people develop memory and thinking problems after a stroke, while others do not. They will use brain scans, blood tests, and memory tests to find clues. The go…

This early-stage study tests a new drug called LWP779 in 76 healthy adults to see if it is safe and how the body processes it. Participants receive either the drug or a placebo, and researchers monitor for side effects. The goal is to gather safety information before testing the …

This study looks at 150 people who had a stroke to see if damage to the blood-brain barrier (the brain's protective shield) can predict who will have memory or thinking problems in the next 3 years. Participants will have their brain scanned and then take short phone tests every …

This study follows 1875 people who had an ischemic stroke (a clot-caused stroke) and are taking blood thinners to prevent another one. Researchers use MRI scans to see if these drugs cause tiny brain bleeds or larger ones. The goal is to find out who is at higher risk, so doctors…

This study aims to find new biomarkers in blood, urine, and other samples that could help predict who is at risk for ischemic stroke and how the disease will progress. Researchers will compare 7,000 participants—including stroke patients and healthy volunteers—over four years usi…

This study enrolls 500 adults who had an ischemic stroke and are eligible for clot-busting treatment or clot removal. Researchers will collect medical images, blood samples, and health data to discover new biological and imaging markers that can predict recovery and heart complic…

This study is tracking 350 stroke patients in the Asia-Pacific region to see how well a procedure called endovascular thrombectomy (clot removal) works outside of clinical trials. Researchers want to understand what helps or hinders recovery in everyday hospital settings. The goa…

This study looks at 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). The goal is to understand why some people still have strokes even when taking blood thinners. Researchers will collect blood samples and heart ultrasound images to fin…

This study looks at whether an imbalance in gut bacteria is linked to stroke risk and recovery in young adults (ages 18-45). Researchers will analyze stool and blood samples from 60 stroke patients to find patterns that could help predict strokes earlier. The goal is to better un…

This early study tests a technique that uses mild electrical stimulation to help stroke patients improve arm movement. The idea is to fix mismatched signals between vision and body awareness that can make rehabilitation harder. Only 3 people will take part, and the goal is to see…

This study looks at how the bacteria in your gut might help the brain heal after a stroke. Researchers will compare 100 stroke patients with 100 healthy volunteers to see differences in gut microbes, immune signals, and inflammation. The goal is to find new ways to improve recove…

This study follows 50 people who have had a stroke and at least one risk factor like high blood pressure or diabetes. Researchers use repeated MRI scans over 15 months to watch how small blood vessel damage in the brain gets worse. The goal is to learn more about how this damage …

This study looks at specific blood markers related to inflammation and clotting in people who have lost oxygen to the brain due to stroke or bleeding. Researchers will compare these markers between affected patients and those without brain oxygen loss. The goal is to better under…