Ischemic stroke

Researchers are testing whether an educational and implementation tool helps hospitals follow best-practice guidelines for preventing second strokes caused by heart conditions. The trial enrolls about 2,400 patients who have had an ischemic stroke or a transient ischemic attack. …

This pilot study tests whether giving semaglutide (Ozempic) to 100 stroke patients who had a clot-removal procedure can improve recovery. Patients are randomly assigned to receive weekly injections for 12 weeks or no drug. The main goal is to see if a larger, definitive trial is …

This study tests whether a non-invasive brain stimulation technique called cTBS, guided by each patient's brain scan, can improve arm and leg movement after a stroke. About 584 adults who had a stroke within the past two weeks will receive either real or sham stimulation alongsid…

This study tests a personalized brain stimulation technique called cTBS to help people recover movement after a stroke. Researchers use each patient's brain scan to target the stimulation precisely. Sixty participants will receive either real or sham stimulation alongside standar…

This trial tests whether a non-invasive brain stimulation technique, called transcranial temporal interference stimulation, can improve swallowing in adults who have difficulty swallowing after an ischemic stroke. Participants will receive either active or sham stimulation combin…

This study tests a new, drug-free treatment for people having an ischemic stroke (a clot blocking blood flow to the brain). The treatment uses blood pressure cuffs on the arms and inflatable leg sleeves to temporarily reduce blood flow in the limbs, which may trigger the body to …

This study tracks the safety and effectiveness of J&J MedTech devices used to remove blood clots in people with acute ischemic stroke. It will follow about 5,000 adults who receive these devices as part of their routine care, measuring how well blood flow is restored and how pati…

This trial tests whether a TeleStroke network can help peripheral hospitals in Oman safely give clot-busting drugs (alteplase or tenecteplase) to people having an acute ischemic stroke. A remote neurologist will assess patients via video, review scans, and guide the local medical…

This phase 2 trial tests whether taking a probiotic supplement (OMNi-BiOTiC® SR-9) twice daily for 90 days can improve gut health and recovery in people aged 60 and older who have had an acute ischemic stroke. The study will compare the probiotic to a placebo in 220 participants,…

This study tests whether people who have had a minor stroke or a high-risk mini-stroke can safely stop one of their two blood thinners earlier than usual. About 3,800 participants will have their blood tested to see how they respond to the drug clopidogrel. Those who are sensitiv…

This Phase 3 trial tests a new injectable drug, ongericimab, in about 4,800 people who recently had a stroke due to narrowed arteries. The goal is to see if lowering LDL cholesterol more than current standard care can prevent future strokes, heart attacks, or death from heart dis…

This study compares two approaches for people who have had a stroke or mini-stroke due to a blocked brain artery that hasn't opened on its own. One group gets a procedure to reopen the artery plus medication, while the other gets medication alone. The goal is to see which approac…

This study tests whether sending people with suspected severe stroke directly to the angiography suite (instead of first getting a CT or MRI) can speed up treatment and improve recovery. About 568 adults with stroke symptoms within 6 hours will be randomly assigned to the direct …

This study tests whether adding two common medicines—colchicine (an anti-inflammatory) and low-dose rivaroxaban (a blood thinner)—to standard care can prevent future heart attacks, strokes, or death in people who recently had a stroke. About 4,500 adults who had a stroke within t…

This trial tests a new device called Supernova that removes blood clots from large brain arteries in people having a stroke. The goal is to restore blood flow within 24 hours of symptoms starting. The study will include 3,000 participants and measure how well the device works and…

This study tests whether a diabetes drug called sentagliptin (a DPP4 inhibitor) can improve thinking and memory in people who have had a mild stroke and also have type 2 diabetes. About 312 participants will receive either the drug or a placebo daily for 180 days. Researchers wil…

This early study tests whether nasal drops containing tiny particles from umbilical cord stem cells are safe for people who had an ischemic stroke. Nine patients will receive the drops four times over two weeks, alongside standard care. The main goal is to check for serious side …

This Phase 3 trial tests whether butylphthalide, a compound from celery seed, can improve long-term recovery in people who have had a minor ischemic stroke. 1,200 participants aged 40–80 will take either the drug or a placebo for 12 months. Researchers will measure survival, stro…

This study tests whether adding WhatsApp-based education and counseling to standard care helps stroke patients with type 2 diabetes improve their lifestyle, blood sugar control, and disease knowledge. 84 participants will be split into two groups: one gets routine education, the …

This study tests whether stem cells from umbilical cords can help people recover movement after a stroke. About 86 adults who had a stroke 2 weeks to 3 months ago will receive either the stem cells or a placebo. The main goal is to see if the treatment improves motor function and…

This study will test a new radioactive tracer called FBFP in 30 stroke patients and 20 healthy volunteers. The tracer is used with a PET/MR scanner to take detailed pictures of the brain. The goal is to see if FBFP can help doctors diagnose and understand stroke better. Participa…

This study tests whether using artificial intelligence (AI) along with a smartwatch and a heart monitor patch can find a hidden heart rhythm problem called atrial fibrillation (AF) in people who have had a stroke. AF can cause strokes, but it often comes and goes without symptoms…

This study will check if an artificial intelligence (AI) system can accurately score stroke severity as well as a trained doctor. About 297 adults with a recent stroke will have their speech and facial movements recorded. The AI will analyze these recordings to produce a G-FAST s…

This study looks at whether a detailed MRI of the blood vessel wall can help doctors tell the difference between two common causes of stroke: hardening of the arteries (plaque buildup) and inflammation of the vessel wall (vasculitis). About 46 people who recently had a stroke wil…

Researchers are testing whether a digital program that combines a smart bracelet and a mobile app can help people who have had an ischemic stroke avoid another one. The study enrolls adults who recently had a stroke and also have high blood pressure and diabetes. Half receive usu…

This trial tests whether an AI-driven health management program can reduce the chance of a first ischemic stroke in adults at high risk. Participants in Beijing communities will be randomly assigned to either AI-supported care or usual community health services. The AI program us…

This phase 3 trial will test whether a low dose of the blood thinner rivaroxaban plus aspirin can prevent recurrent strokes better than the standard clopidogrel plus aspirin in people with narrowed brain arteries. About 1,172 participants who recently had a stroke or high-risk TI…

This trial tests whether combining electroacupuncture with a sedative drug called dexmedetomidine can prevent depression in people who recently had an ischemic stroke. Participants at high risk for post-stroke depression will receive either the combined treatment, a sham version,…

This phase 3 trial tests whether zastaprazan, a stomach-acid-blocking drug, can prevent upper gastrointestinal bleeding in adults who have recently had a transient ischemic attack (TIA) or ischemic stroke and are taking antiplatelet or anticoagulant medications. Participants take…

This study tests whether the drug cilostazol can prevent recurrent strokes and heart problems in 1100 recent stroke survivors in Ghana. Participants take either cilostazol or a placebo twice daily for 24 months. The goal is to see if this affordable drug, already used in Asia, ca…

This study tests whether adding cilostazol, a drug that improves blood flow, to standard aspirin or clopidogrel therapy can prevent another stroke or heart attack in people who have recently had a stroke or mini-stroke. About 2,000 participants will take either cilostazol or a pl…

This study tests a new way to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) with virtual reality therapy to stimulate the brain's vision areas. The study will enroll 28 adults who had a stroke 6 to 24 months ago and now have partial …

This study tests whether a non-invasive technique called transcranial focused ultrasound can help stroke survivors recover movement and thinking skills. Researchers will use brain scans and EEG to guide stimulation to specific areas. 60 adults who had a first stroke within the la…

This study tests whether combining neuromuscular electrical stimulation with upper limb nerve exercises can improve hand grip strength and range of motion in people who have had a stroke. The trial will include 44 adults who had an ischemic stroke at least 3 months ago and have s…

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This study will test a new type of rehabilitation robot that uses brain signals and mirror therapy to help stroke patients with arm weakness. The robot is non-invasive and designed to encourage the brain to re-learn movement. Researchers will enroll 40 adults aged 30 to 80 who ha…

This study tests a personalized brain stimulation technique called IAF-rTMS to help people recover movement after a stroke. Thirty-four adults who had a first ischemic stroke will receive either real or sham stimulation for two weeks each, in a crossover design. Researchers will …

This study tests whether a feeding tube placed in the upper esophagus (oro-esophageal) helps stroke patients with swallowing difficulties recover faster than the standard nasogastric tube (through the nose). The trial will include 422 adults who recently had a first ischemic stro…

This study tests a safe, non-invasive therapy that uses gentle pressure on the arms to improve sleep and mood in people who have had a stroke and suffer from insomnia. The treatment, called remote ischemic adaptation, aims to help the brain recover by briefly restricting and rest…

This study compares early task-oriented rehabilitation (practicing daily-life activities) to traditional physiotherapy in 158 adults who had a stroke within the past 48 hours. The goal is to see which approach leads to better motor function and quality of life after 3 months. Par…

This study looks at two ways to feed stroke patients who have trouble swallowing: a standard nasogastric tube (through the nose) and an oro-esophageal tube (through the mouth). The goal is to see which method better protects the airway and improves swallowing function. About 156 …

This study tests whether taking probiotics can improve quality of life, daily activities, and anxiety in people who have had a moderate stroke. Researchers will enroll 110 adults aged 18 to 80 who had a stroke within the past 3 months. Participants will take probiotics and be mon…

This study tests whether adding occupation-based bilateral arm training (OBBT) to standard therapy helps stroke survivors improve arm movement and daily activities. 150 participants in inpatient rehab will either get OBBT plus standard care or standard care alone for 6 weeks. The…

This study will test whether using smart technologies like brain-computer interfaces and robotic hand therapy can improve recovery in people who recently had a stroke. 200 participants will be split into four groups: three using different high-tech devices and one receiving stand…

This study investigates whether tiny particles called extracellular vesicles, released by brain cells into the blood, can serve as reliable markers of nerve damage in people with multiple sclerosis or stroke. Researchers will measure these particles in blood samples from 60 parti…

This study explores whether the type of symptoms a person has at the start of a stroke influences how quickly they get to the hospital and how well they recover. Researchers will follow 120 adults with a first-ever ischemic stroke, comparing those with classic, high-urgency sympt…

This study looks at whether patients recovering from a first acute stroke do better in a specialized stroke unit than in a conventional neurology ward. Researchers will follow 140 adults admitted within 48 hours of symptom onset, comparing outcomes like daily independence, disabi…

This study will follow up to 12,750 stroke patients in Germany to learn how care is given from the moment symptoms start through hospital treatment, rehab, and long-term recovery. It includes both adults and children with ischemic stroke or brain bleeding. The goal is to collect …

This study tests if a non-invasive device called Electrical Impedance Tomography (EIT) can safely monitor brain blood flow in 100 ICU patients with conditions like stroke or brain bleeding. Currently, doctors must insert a probe into the skull to check this, which can cause infec…

This pilot study will use advanced MRI scans to create detailed maps of brain connections in 10 people who have had a stroke in the middle cerebral artery. The goal is to understand how stroke disrupts the brain's network and whether these maps can help predict recovery and guide…

This study will observe 300 adults in the intensive care unit with serious brain conditions like bleeding, stroke, or injury. Researchers will use noninvasive monitors to track brain activity and blood flow, linking this data to patients' recovery. The goal is to better understan…

This study tests a new way to recruit women into stroke research using easy-to-understand materials like brochures and videos. Researchers will compare this approach to usual recruitment methods with 1,600 participants. The goal is to make stroke studies more inclusive so treatme…

This study aims to find brain activity markers that can predict how well people recover after an ischemic stroke. Researchers will first study healthy volunteers to establish normal brain patterns, then test 120 stroke patients. Patients will receive either real or sham brain sti…

This study tests whether a program called PEER-HOMEcare is practical and helpful for people recovering from stroke at home. The program involves therapists and family members working together to adapt the home environment and use wearable sensors to track movement. Researchers wi…

This study will follow 30 adults who have had a stroke and have arm weakness. Researchers will use functional MRI scans at several time points over six months to see how the brain reorganizes itself. The goal is to link different patterns of brain activity to different levels of …

This study tests a 5-week support program for stroke survivors after they leave the hospital. The goal is to see if the program helps them feel more confident and independent in managing their daily health. Researchers will compare participants who get the program plus usual care…

This study will test whether mild electrical brain stimulation, combined with physical therapy, changes brain activity in people who had a stroke. Sixty participants will receive either direct or alternating current stimulation during rehab sessions. Researchers will measure bloo…

This study will collect detailed information from 200 adults with severe brain injuries treated at Örebro University Hospital. Researchers will track their recovery, including brain function and healthcare needs, for up to a year. No new treatments are being tested—the goal is to…

This study looks at blood clots removed from 500 stroke patients to understand their composition and how they relate to blood markers, treatment success, and patient recovery. The goal is to learn more about stroke causes and find new ways to dissolve clots. Participants are adul…

This study looks at how the body's immune and inflammatory systems change in people having a stroke who receive clot-busting drugs or mechanical clot removal. Researchers will take blood samples at several time points over a year to measure inflammation markers. The goal is to se…

This study will look at 300 adults with acute ischemic stroke to find out how many have a large vessel occlusion (a big clot in a major brain artery). Researchers at Assiut University Hospitals will use CT or MRI scans to identify these patients and describe their characteristics…

This study will check how common thinking and memory problems are in people who have had their first stroke. Researchers will evaluate 400 adults aged 18 to 60 within three months of their stroke. The goal is to better understand the impact of stroke on the brain, not to test a n…

This study looks at whether giving different amounts of protein early on can help people with serious brain injuries or strokes recover better in the ICU. 216 adults will be split into three groups, each receiving a different protein dose through a feeding tube. The main goal is …

This study will test a new robotic and virtual reality system called NeglectARm 3D in 15 people who have spatial neglect after a stroke. The system uses a robot arm and VR headset to measure how well patients notice objects in 3D space. Researchers want to see if the device is ea…

This study will follow 500 people who recently had a stroke or mini-stroke to see how well they stick with cholesterol-lowering treatments like statins and diet changes. Researchers want to learn how many patients reach their LDL cholesterol goals and whether better control reduc…

This study will compare how quickly stroke-related brain damage worsens in 135 Afro-Caribbean patients in Guadeloupe versus patients from mainland France. Researchers will use brain scans to track blood flow and collateral circulation. The goal is to learn if stroke progression d…

This study looks at whether waiting until day 3 after a stroke to start physical therapy is better for patients with a persistent blocked artery. Researchers will test if this delayed approach is feasible and if it helps prevent further brain damage. The study involves 50 adults …

This study will look at the genes of 1,000 people in Brazil—half who had a stroke and half who did not—to find genetic differences that may increase stroke risk. Researchers will use whole genome sequencing to analyze DNA and compare it with international data. The goal is to bet…

This study looks at how tightness in the ankle muscles (spasticity) after a stroke affects a person's balance, risk of falling, and ability to move around. Researchers will study 68 people who had a stroke at least six months ago, comparing those with mild versus moderate-to-seve…

This study tests a new way to use magnetic stimulation (TMS) to help stroke survivors recover thinking and memory. Instead of a one-size-fits-all approach, researchers will use brain scans to find the exact spot to stimulate for each person. The study will include 10 healthy peop…