ISCHEMIC STROKE

This study tests whether semaglutide, a drug used for diabetes and obesity, can improve recovery in people who have had a severe stroke. About 100 patients in Canada will receive weekly injections for 12 weeks after a clot-removal procedure. The goal is to see if the drug limits …

This early study tests the safety of a nasal spray made from tiny particles (extracellular vesicles) derived from umbilical cord stem cells in 9 people who had an ischemic stroke. The goal is to see if it is safe and if it might help the brain heal. Participants must be between 1…

This study tests whether a single dose of stem cells from donated umbilical cords can help people recover motor function after an ischemic stroke. About 86 adults who had a stroke 2 weeks to 3 months ago will receive either the stem cells or a placebo. The main goal is to see if …

This study compares two approaches for people with a blocked brain artery who have already had a mini-stroke or stroke despite medication. One group gets a procedure to reopen the artery plus aggressive medication; the other gets medication alone. The goal is to see which approac…

This study tests two devices, Supernova and Neutron, that doctors use to remove blood clots from large brain arteries in people having a stroke. The goal is to restore blood flow within 24 hours of symptoms starting. About 3,000 participants will be followed for 90 days to see if…

This study tests whether a drug called butylphthalide can improve recovery and prevent further strokes in people who have had a minor stroke. About 1,200 adults aged 40-80 will take the drug or a placebo daily for 12 months. Researchers will measure survival, stroke recurrence, d…

This study compares two ways to treat people having a severe stroke caused by a blocked large artery. One group goes straight to a special X-ray room (angiography suite) for treatment, while the other group gets standard CT or MRI scans first. The goal is to see if the direct rou…

This study tests whether a common diabetes medication (a DPP4 inhibitor) can improve thinking and memory after a mild stroke in people with type 2 diabetes. About 312 adults aged 40-75 will take either the drug or a placebo for 180 days. The goal is to see if the drug reduces the…

This study tests whether lying flat (0 degrees) or with the head elevated (30 degrees or more) after a stroke clot removal procedure helps patients recover better. About 2,240 adults who had a stroke from a large blood vessel blockage will be randomly assigned to one of the two h…

This study tests whether two drugs—colchicine (anti-inflammatory) and low-dose rivaroxaban (blood thinner)—can reduce the risk of another stroke, heart attack, or death in people who recently had a stroke. About 4,500 adults who had a stroke in the last 14 days and do not need st…

This study looks at two treatments for a severe type of stroke where a large clot blocks the main artery at the back of the brain. About 518 adults will be grouped based on whether they received a procedure to remove the clot or standard medication. The goal is to see which appro…

This study tests whether adding cilostazol to aspirin or clopidogrel can prevent another stroke or heart attack in people who have already had a stroke or mini-stroke. About 2,000 adults who had a stroke within the last 6 months and are already on one blood thinner will take eith…

This study tests whether a combination of two blood thinners (rivaroxaban and aspirin) works better than the standard combination (clopidogrel and aspirin) at preventing another stroke in people who have had a stroke due to narrowed arteries inside the brain. About 1,172 adults o…

This study compares early task-oriented rehabilitation (practicing real-life activities like walking or dressing) with traditional physical therapy for people who recently had a stroke. About 158 adults with ischemic or hemorrhagic stroke will start therapy within 48 hours and be…

This study tests whether a personalized brain stimulation technique, called IAF-based rTMS, can help people recover movement after a first ischemic stroke. Thirty-four adults will receive either active or sham (fake) stimulation over four weeks. The goal is to see if the tailored…

This study tests a new therapy that uses a brain-computer interface (a device that reads brain signals) combined with mirror therapy (watching a video of your good arm moving) to help stroke survivors regain arm movement. The robot helps move the affected arm based on brain signa…

This study tests whether adding a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to standard physical therapy can improve arm and hand function in people who have had a first ischemic stroke. Researchers will compare real rTMS …

This study will test if a gentler form of exercise, using a blood pressure cuff to limit blood flow, can improve leg strength and balance as well as traditional resistance training in people who have had a stroke. Eighty adults aged 30-40 who had a stroke 3-12 months ago will par…

This study looks at how the immune system and inflammation change in people having a stroke who receive clot-busting drugs or mechanical clot removal. Researchers will take blood samples at several time points over a year to measure inflammatory markers. The goal is to see if the…

This study will collect detailed information from 200 adults with severe traumatic brain injury or other severe brain injuries treated at Örebro University Hospital. Researchers will track their health, brain scans, and recovery for up to a year to better understand how these inj…

This study watches brain activity and blood flow in 300 adults admitted to the intensive care unit with serious brain conditions like bleeding, stroke, or injury. Researchers use noninvasive monitors already in use to collect data during standard care. The goal is to better under…

This study looks at how the brain changes and reorganizes after a stroke that causes arm weakness. Researchers will use MRI scans to track brain activity and connections in 30 adults over six months. The goal is to learn why some people recover better than others, which may help …

This study will enroll about 958 adults with severe stroke who need a procedure to remove a blood clot from a large brain artery. Researchers want to find out if putting patients fully asleep with general anesthesia or keeping them lightly sedated leads to better recovery and les…

This study will follow about 12,750 adults and children who have had a stroke (either from a clot or bleeding in the brain). Researchers will collect information from before hospital arrival through recovery and long-term follow-up to understand what treatments work best and how …

This study looks at when to start physical therapy after a stroke caused by a blocked artery. The goal is to see if waiting until day 3 is safer and helps recovery better than starting earlier. About 50 adults with persistent artery blockages will take part. The findings may guid…

This study looks at how a gentle electrical current applied to the scalp (called transcranial electrical stimulation) changes blood flow in the brains of people who have had a stroke. Researchers will combine this stimulation with physical therapy and walking exercises in 60 adul…

This study looks at whether giving different amounts of protein early on can help people with serious brain injuries or strokes recover better. About 216 adults in the ICU will be split into three groups, each receiving a different protein dose. Researchers will check their consc…

This study will compare how quickly stroke-related brain damage progresses in Afro-Caribbean patients in Guadeloupe versus patients in mainland France. Researchers will look at brain scans and blood flow to understand differences. The goal is to learn more about stroke patterns i…

This study will look at 200 people who had a stroke and received clot-busting medication. Researchers want to see if a measurement called net water uptake on a CT scan can predict how well someone recovers. The goal is to better understand why some people improve and others do no…

This study will look at 300 adults who had a stroke caused by a blood clot and arrived at Assiut University Hospitals within 24 hours. Researchers want to find out how many of these strokes are due to a blockage in a large brain artery. They will also describe the patients' featu…

This study aims to find brain activity patterns that predict how well people recover after an ischemic stroke. Researchers will use EEG and brain stimulation to measure these signals in 120 participants, including healthy volunteers and stroke patients. The goal is to build a mod…

This study uses advanced MRI scans and computer tools to create a detailed map of brain connections in people who have had a stroke in the middle cerebral artery. Researchers will track how the stroke disrupts these connections and see if the changes can help predict recovery ove…

This study tests whether a community education campaign can help people having a stroke get to the hospital within the critical 4.5-hour window. Over 1.6 million people in 16 communities across China will take part. The goal is to reduce delays, increase life-saving treatments, a…

This study watches how the brain heals in the first week after a stroke clot is removed. It involves 180 adults who had a stroke and successful treatment. Researchers use brain scans and electrical readings to track recovery and predict long-term outcomes, which could lead to bet…

This study looks at blood clots removed from stroke patients during a procedure called mechanical thrombectomy. Researchers want to see if the clot's makeup is linked to how well treatment works, what caused the stroke, and how patients recover. 500 adults with ischemic stroke or…