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Could a celery seed extract help prevent another stroke?

NCT ID NCT07230587

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether butylphthalide, a compound from celery seed, can improve long-term recovery in people who have had a minor ischemic stroke. 1,200 participants aged 40–80 will take either the drug or a placebo for 12 months. Researchers will measure survival, stroke recurrence, disability, new brain damage, and cognitive changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
butylphthalide (NBP), a compound from celery seed
What this could lead to
If it works, this could provide a new long-term treatment to reduce disability, prevent recurrent strokes, and protect cognitive function after a minor stroke.
What could go wrong
This is a large Phase 3 trial, but butylphthalide is not yet proven for long-term use in minor stroke. The benefits may be modest, and side effects are possible. Results may not apply to all stroke types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 1,200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

1.Inclusion Criteria: 1. Age between 40 and 80 years old. 2. NIHSS score 0-5 at the time of stroke diagnosis, with MRI-confirmed acute ischemic infarct. 3. Time from stroke onset to enrollment ≤ 2 weeks. 4. Pre-stroke mRS score ≤ 1. 5. No prior diagnosis of cognitive impairment or dementia. 6. Informed consent must be voluntarily signed by the patient or their legal representative. Exclusion Criteria: 1. Based on the TOAST classification, consider cardioembolic stroke, stroke of other determined etiology, or stroke of undetermined etiology. 2. Intracranial hemorrhagic diseases on imaging: hemorrhagic stroke, epidural hematoma, subarachnoid hemorrhage, etc. (If hemorrhagic transformation is present, eligibility is at investigator's discretion.) 3. Carotid artery stenosis \> 50% requiring surgical intervention. 4. Systemic diseases causing cognitive impairment (e.g., endocrine diseases, vitamin deficiency, systemic autoimmune diseases). 5. Neurological disorders causing cognitive impairment, such as CNS infections, Creutzfeldt-Jakob disease, primary Parkinson's disease, traumatic brain injury, epilepsy, brain tumors. 6. Pre-stroke diagnosis of severe psychiatric disorders, including but not limited to depression, non-vascular cognitive impairment, or dementia (e.g., Alzheimer's disease, Parkinson's disease dementia, Lewy body dementia, frontotemporal dementia, drug or alcohol-induced cognitive impairment). 7. Severe hemiplegia and aphasia that significantly affect cognitive assessment. 8. Use of cognitive-enhancing drugs within 4 weeks before screening, including cholinesterase inhibitors (donepezil, rivastigmine, galantamine), NMDA receptor antagonists (memantine), sodium oligomannate (GV-971), or monoclonal antibodies (lecanemab, donanemab, aducanumab). 9. Severe liver disease (e.g., acute hepatitis, active chronic hepatitis, cirrhosis) or ALT/AST \> 2× ULN. 10. Severe kidney disease or renal impairment (serum creatinine \> 1.5× ULN). 11. Coagulation disorders or thrombocytopenia (platelet count \< 100 × 10⁹/L). 12. Severe systemic diseases with an expected survival \< 1 year. 13. Contraindications for MRI or inability to complete MRI scan. 14. Allergy to butylphthalide. 15. Pregnancy, lactation, or planned pregnancy. 16. Participation in another clinical trial within 30 days before randomization. 17. Deemed unsuitable for the study by the investigator.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The official record

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    Open the record ↗

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