Could a celery seed extract help prevent another stroke?
NCT ID NCT07230587
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tests whether butylphthalide, a compound from celery seed, can improve long-term recovery in people who have had a minor ischemic stroke. 1,200 participants aged 40–80 will take either the drug or a placebo for 12 months. Researchers will measure survival, stroke recurrence, disability, new brain damage, and cognitive changes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- butylphthalide (NBP), a compound from celery seed
- What this could lead to
- If it works, this could provide a new long-term treatment to reduce disability, prevent recurrent strokes, and protect cognitive function after a minor stroke.
- What could go wrong
- This is a large Phase 3 trial, but butylphthalide is not yet proven for long-term use in minor stroke. The benefits may be modest, and side effects are possible. Results may not apply to all stroke types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 1,200 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2025
An estimate. Start dates often move.
- Expected to finish
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Oct 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
1.Inclusion Criteria: 1. Age between 40 and 80 years old. 2. NIHSS score 0-5 at the time of stroke diagnosis, with MRI-confirmed acute ischemic infarct. 3. Time from stroke onset to enrollment ≤ 2 weeks. 4. Pre-stroke mRS score ≤ 1. 5. No prior diagnosis of cognitive impairment or dementia. 6. Informed consent must be voluntarily signed by the patient or their legal representative. Exclusion Criteria: 1. Based on the TOAST classification, consider cardioembolic stroke, stroke of other determined etiology, or stroke of undetermined etiology. 2. Intracranial hemorrhagic diseases on imaging: hemorrhagic stroke, epidural hematoma, subarachnoid hemorrhage, etc. (If hemorrhagic transformation is present, eligibility is at investigator's discretion.) 3. Carotid artery stenosis \> 50% requiring surgical intervention. 4. Systemic diseases causing cognitive impairment (e.g., endocrine diseases, vitamin deficiency, systemic autoimmune diseases). 5. Neurological disorders causing cognitive impairment, such as CNS infections, Creutzfeldt-Jakob disease, primary Parkinson's disease, traumatic brain injury, epilepsy, brain tumors. 6. Pre-stroke diagnosis of severe psychiatric disorders, including but not limited to depression, non-vascular cognitive impairment, or dementia (e.g., Alzheimer's disease, Parkinson's disease dementia, Lewy body dementia, frontotemporal dementia, drug or alcohol-induced cognitive impairment). 7. Severe hemiplegia and aphasia that significantly affect cognitive assessment. 8. Use of cognitive-enhancing drugs within 4 weeks before screening, including cholinesterase inhibitors (donepezil, rivastigmine, galantamine), NMDA receptor antagonists (memantine), sodium oligomannate (GV-971), or monoclonal antibodies (lecanemab, donanemab, aducanumab). 9. Severe liver disease (e.g., acute hepatitis, active chronic hepatitis, cirrhosis) or ALT/AST \> 2× ULN. 10. Severe kidney disease or renal impairment (serum creatinine \> 1.5× ULN). 11. Coagulation disorders or thrombocytopenia (platelet count \< 100 × 10⁹/L). 12. Severe systemic diseases with an expected survival \< 1 year. 13. Contraindications for MRI or inability to complete MRI scan. 14. Allergy to butylphthalide. 15. Pregnancy, lactation, or planned pregnancy. 16. Participation in another clinical trial within 30 days before randomization. 17. Deemed unsuitable for the study by the investigator.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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