Could a common circulation drug stop strokes before they strike again?
NCT ID NCT07174414
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether adding cilostazol, a drug that improves blood flow, to standard aspirin or clopidogrel therapy can prevent another stroke or heart attack in people who have recently had a stroke or mini-stroke. About 2,000 participants will take either cilostazol or a placebo twice daily for several years. The goal is to see if the combination reduces major cardiovascular events like stroke, heart attack, or vascular death.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Cilostazol
- What this could lead to
- If it works, this could provide a new, affordable way to reduce the risk of another stroke or heart attack in people who have already had one.
- What could go wrong
- This is a large phase 3 trial, but cilostazol may not reduce events more than placebo, and it carries risks like bleeding or heart-related side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 2,000 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Jul 2031
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosis of stroke or mini-stroke (also called TIA) within the last 180 days * Currently taking aspirin or clopidogrel (not both) to prevent another stroke Exclusion Criteria: * Had a spontaneous brain bleed within the last 2 years. * Moderate to severe heart failure. * Life expectancy is less than 6 months.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Stanford University
Stanford, California, 94305, United States
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