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Tailored brain zaps could boost stroke recovery

NCT ID NCT07498777

Symptom relief Sponsor: National Taiwan University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a personalized brain stimulation technique called IAF-rTMS to help people recover movement after a stroke. Thirty-four adults who had a first ischemic stroke will receive either real or sham stimulation for two weeks each, in a crossover design. Researchers will measure motor function and brain activity to see if the tailored approach works better than placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Individual Alpha Frequency-based repetitive Transcranial Magnetic Stimulation (IAF-rTMS)
What this could lead to
If it works, this could offer a new, personalized way to improve arm and leg movement after a stroke, without drugs or surgery.
What could go wrong
This is a small, early-stage trial with only 34 people. The effect may be small or not last long, and results may not apply to all stroke patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \>18 * First ischemic stroke patient, confirmed by brain MRI * Has not received repetitive transcranial magnetic stimulation (rTMS) treatment after this stroke episode * Cortical, subcortical infarction with motor impairment * Baseline ADL intact (Full score of pre-stroke Barthel Index) * Clear consciousness and with the ability to understand and cooperate with the study * NIHSS 5-20, or FMA-UE 20-50, or FMA-LE 15-25 * Within 2 to 12 weeks after stroke onset * Participants had received stable treatment prior to the trial or were evaluated by a physician as having an inadequate response to conventional rehabilitation therapy Exclusion Criteria: * Hemorrhagic transformation in the brain * Unstable condition * Stroke primarily caused by cancer-related hypercoagulability or autoimmune diseases (e.g., systemic lupus erythematosus, antiphospholipid syndrome) * Known previous peripheral nerve injury or peripheral neuropathy on the affected side that impairs mobility * Individual history of epilepsy * Presence of cardiac pacemakers, cochlear implants, drug delivery pumps, implantable cardioverter-defibrillators, implanted neurostimulators, or other metal objects in the body. This also includes patients who have undergone cranioplasty or have other implanted devices incompatible with rTMS * Pregnancy * Multiple sclerosis patient * Use of tricyclic antidepressants or other medications that may lower the seizure threshold * Severe alcoholism * Hamilton Depression Rating Scale suicide item score ≥ 2 * Patients with skin lesions or damage at the intended site of stimulation. * Family history of epilepsy * Patients with brain injuries that may affect the seizure threshold * Patients who develop sleep disorders during the course of rTMS treatment * Patients currently using anti-epileptic drugs * Patients with severe heart disease or patients with uncontrolled migraines caused by increased intracranial pressure

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Conditions

The condition(s) this trial relates to.

ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ischemic stroke

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of neurology, National Taiwan Univeristy Hospital Yunlin branch

    Douliu, Yunlin County, 640, Taiwan

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