Vascular disorder

When babies lack oxygen around birth, they can suffer lasting brain damage. No treatment currently repairs that injury. Researchers are testing whether oral sildenafil, a drug already used safely in babies for lung blood pressure, can help. In this Phase 2 trial, 60 newborns with…

Researchers are testing XC001, an experimental gene therapy, in people with refractory angina, a type of chest pain caused by blocked heart arteries that persists despite medication and is not suitable for surgery or stenting. The trial delivers XC001 directly into the heart musc…

Researchers are testing a gene therapy called NXL-001 in people who have lasting movement problems from an ischemic stroke. The study enrolls 9 adults, 2 to 12 months after their stroke, who have moderate to severe arm or leg weakness despite rehabilitation. Each participant rece…

This study tests alpelisib, a drug that targets a specific gene mutation (PIK3CA), in people with lymphatic malformations—abnormal growths of lymph vessels. The trial includes children and adults and compares alpelisib to a placebo to see if it can shrink the growths and ease sym…

This study tracks 152 adults with cirrhosis who receive a special stent to treat complications like fluid buildup in the belly or bleeding from enlarged veins. The stent creates a new blood-flow path in the liver. Researchers will monitor how well it works and its safety over 2 y…

This phase 3 trial tests whether an experimental drug called MK-8748 can treat diabetic macular edema (DME), a condition where fluid builds up in the retina and blurs vision. About 960 adults with DME will receive either MK-8748 or the standard treatment aflibercept via eye injec…

This study tests whether using a tiny ultrasound camera inside the leg arteries during a procedure to open blockages can prevent major problems like amputation or the artery narrowing again. About 772 adults with severe peripheral artery disease (chronic limb-threatening ischemia…

This study tests whether baricitinib, a drug already approved for arthritis, can help people with Kohlmeier-Degos (KD) disease that affects the brain and spine. KD causes inflammation and blood clots that damage small blood vessels, and there is currently no treatment. The trial …

This study tests if a catheter-based device that closes a small pouch in the heart (left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are already taking blood thinners. About 4000 participants at high risk of stroke will be enrolled.…

Researchers at the University of South Carolina are testing a program that pairs nurses with community health workers to coach adults who have chronic conditions like diabetes, high blood pressure, heart disease, kidney disease, or a prior stroke. Each patient joins with a carepa…

This early study tests a robotic catheter system to replace the tricuspid valve in 10 patients with severe leakage (regurgitation) who are too high-risk for open surgery. The robot aims to improve precision and safety while reducing radiation exposure for doctors. The main goal i…

This study is testing whether placing stroke patients in a head-down position (Trendelenburg) before a clot-removal procedure can improve their recovery. Researchers will enroll 210 adults with a severe stroke caused by a large blocked artery. The goal is to see if this simple po…

This Phase 3 trial tests the drug benralizumab (Fasenra) in children aged 6 to 17 with two rare eosinophilic diseases: EGPA and HES. The study aims to see if the drug is safe, how it works in the body, and whether it can help control the disease. Fourteen children will receive in…

This study tests whether anifrolumab, a drug that blocks certain immune signals, can improve blood vessel function and reduce inflammation in people with lupus. About 45 adults with lupus will receive either the drug or a placebo over 8 months. Researchers will measure changes in…

This phase II trial tests whether adding the immunotherapy cemiplimab to the targeted drug cabozantinib works better than cabozantinib alone for advanced adrenocortical cancer. About 48 adolescents and adults whose cancer has spread or cannot be removed will take part. The study …

This early-phase trial tests giving radiation therapy before surgery to people whose adrenal cancer has come back. The goal is to find a safe radiation dose and see if it helps shrink tumors before removal. About 32 adults with resectable recurrent ACC will receive daily radiatio…

This study tests a new device (Sphere-9 catheter and Affera system) to treat ventricular tachycardia, a fast, dangerous heart rhythm, in 260 adults who have had a heart attack. Participants must have had repeated episodes despite medication or a defibrillator. The goal is to see …

This study tests two ways to treat proliferative diabetic retinopathy, a serious eye problem caused by diabetes. One group gets eye injections of faricimab plus laser treatment; the other gets vitrectomy surgery with laser. Researchers will track vision and how many extra treatme…

This phase 3 study is testing an injectable drug called zilebesiran in about 11,000 adults whose high blood pressure is not well controlled despite taking at least two standard medications. Participants also have heart disease or are at high risk for it. The goal is to see if add…

This study tests a drug called sovateltide in 160 people who have had an ischemic stroke (a stroke caused by a blood clot). The goal is to see if the drug helps patients recover better and is safe. Participants receive either the drug or a placebo within 24 hours of their stroke,…

Researchers are testing whether a home-use pulsed electromagnetic therapy device can slow cognitive decline in people with mild to moderate Alzheimer's disease, Lewy body dementia, or vascular dementia. About 48 participants will use the device three times a day for 15 minutes ov…

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This phase 3 trial tests whether an experimental oral drug called engasertib can reduce the number of nosebleeds in adults with moderate to severe hereditary hemorrhagic telangiectasia (HHT), a genetic condition that causes abnormal blood vessels and frequent bleeding. About 240 …

This study tests whether coaching and support from community health workers, delivered by phone or video, can help people with dangerously high blood pressure avoid serious heart problems. Over 3,600 adults who came to the emergency room with very high blood pressure will be rand…

Researchers compare two ways of using a leg vein as a second bypass graft during coronary artery bypass grafting. In one method, the vein connects as a Y-shaped branch off the left internal thoracic artery. In the other, the vein connects directly from the aorta. The trial enroll…

This phase 1 study tests a combination of two drugs, pomalidomide (a pill) and nivolumab (an infusion), in adults with cancers caused by viruses like Epstein-Barr, HPV, or hepatitis. The goal is to find a safe dose and see if the drugs can shrink tumors. Up to 58 people with Kapo…

Researchers are testing whether adding bempedoic acid to high-intensity statin and ezetimibe therapy within 72 hours after a heart procedure helps adults with acute coronary syndrome reach very low LDL cholesterol. Participants receive either the three-drug combination or the sta…

This study tests a one-time gene therapy called surabgene lomparvovec (Sura-vec) for diabetic retinopathy, a common eye problem from diabetes that can lead to blindness. About 576 adults with moderate-to-severe non-proliferative diabetic retinopathy will receive either the gene t…

This study is testing whether a device that uses mild electrical pulses to stimulate arm muscles and the tongue can help stroke survivors regain arm movement. Researchers will enroll 288 participants, including stroke patients with arm weakness and healthy controls. The main goal…

This study tests whether a personalized blood-thinner plan can reduce bleeding in people with coronary artery disease who have received a heart stent. About 3,944 participants will either get the usual dual antiplatelet therapy (two blood thinners) or a shorter course followed by…

This study tests whether combining a gentle brain stimulation technique (tDCS) with exercises that challenge both thinking and walking can improve how stroke survivors handle doing two things at once. Seventy-two participants who had a stroke at least six months ago will receive …

This study tests a new, less invasive way to replace a leaky aortic heart valve (aortic regurgitation) using a device called the JenaValve Trilogy, compared to standard open-heart surgery. About 1,000 people with moderate to severe aortic regurgitation will be randomly assigned t…

This study tests a new device called the Zenith Fenestrated+ Endovascular Graft, used with special stents, to repair aortic aneurysms that involve arteries to the kidneys and other organs. About 105 people with large or fast-growing aneurysms will be enrolled. The goal is to see …

This trial tests whether the drug sebetralstat can prevent swelling attacks in people with hereditary angioedema (HAE) when taken before a medical procedure. Participants aged 12 and older with HAE type I or II will take sebetralstat just before their scheduled procedure. The mai…

This study tests whether a simple, non-invasive treatment called remote ischemic conditioning (RIC) can help people recover better after a moderate stroke in the back part of the brain. RIC involves briefly inflating a blood pressure cuff on the arm to restrict blood flow, then r…

This study tests a second-generation travoprost implant placed inside the eye to lower pressure in people with open-angle glaucoma or ocular hypertension. About 610 participants will receive either the implant, timolol eye drops, a sham procedure, or placebo drops. The main goal …

Researchers test a device that uses a laser to create holes in stent grafts during minimally invasive repair of aortic aneurysms. The holes allow blood to keep flowing to the kidneys and intestines when the aneurysm is close to those arteries. About 15 people who are not good can…

This study compares two different doses of the blood thinner bemiparin to see which works better at preventing dangerous blood clots in people with severe obesity after surgery. About 2,400 participants will be enrolled. The goal is to find the safest and most effective dose for …

This study tests whether a 6-week self-management program, done with a caregiver's help, can improve diabetes control and thinking skills in adults aged 55+ who have both diabetes and mild cognitive impairment. About 309 participants will attend weekly group sessions and provide …

This study tests a new device called the RevCore Thrombectomy Catheter to treat blocked stents in the leg veins. About 100 adults with stents that have been in place for at least 6 weeks will be enrolled. The device is inserted into the vein to remove the blockage and restore blo…

This study compares three oral medications used to prevent migraines: atogepant (a newer drug), topiramate, and propranolol (both older). About 1,335 adults with migraine will be randomly assigned to one of the three drugs for 12 weeks. Researchers will track headache frequency a…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This large phase 3 trial tests an experimental drug, REGN7508, against the standard blood thinner apixaban for preventing strokes in people with atrial fibrillation (an irregular heartbeat). The study will enroll over 15,000 participants to compare how well each drug prevents str…

This trial tests whether a single daily pill that combines treatments for high blood pressure, high cholesterol, and type 2 diabetes can lower the risk of heart disease and dementia. The study involves over 8,000 adults aged 50 to 75 in China who have all three conditions. Partic…

This phase 3 trial is testing atogepant, a daily pill already approved for adults, to prevent episodic migraines in children aged 6 to 17. About 450 participants will receive either a low or high dose of the drug or a placebo for 12 weeks. The goal is to see if it safely reduces …

This study tests whether starting inclisiran early during a hospital stay for a heart attack can lower bad cholesterol more than a placebo, when both are added to standard care. About 300 adults hospitalized for a heart attack will receive either inclisiran or a placebo shot at t…

Researchers in China are studying whether newer flow diverter stents can safely and effectively treat wide-neck brain aneurysms. About 280 patients will receive one of these stents, which is threaded through blood vessels to the brain and left in place to redirect blood flow away…

This study tests a new device called the Elevate™ heart pump in 290 people who need high-risk angioplasty (a procedure to open blocked heart arteries). The pump helps keep blood flowing during the procedure. The goal is to see if it is safer and works better than current methods.…

This phase 3 trial is testing whether a once-daily inhaled medication called treprostinil palmitil can help adults with pulmonary arterial hypertension (PAH) walk farther. About 344 participants will receive either the drug or a placebo for 24 weeks. The main goal is to see if th…

This trial tests whether adding endovascular treatment, a procedure to remove blood clots, to standard medical care improves recovery in people with a mild stroke caused by a blockage in the basilar artery. Participants receive either standard care alone or standard care plus the…

This study compares a new balloon coated with everolimus to standard paclitaxel-coated balloons for opening blocked leg arteries in people with peripheral artery disease. About 410 participants will be randomly assigned to one of the two balloons. The goal is to see if the new ba…

Researchers are testing whether regularly checking a marker called Gd-IgA1 can help doctors adjust treatment for IgA nephropathy, a kidney disease. Adults with biopsy-confirmed IgA nephropathy or IgA vasculitis-associated nephritis receive Nefecon or telitacicept. Half have Gd-Ig…

This early study tests a new device called the GORE Multibranch Arch Endoprosthesis for people with aortic arch conditions like aneurysms or dissections. The device is placed inside the blood vessel to repair the damaged area. The study will enroll 20 participants and follow them…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and then emergency treatment to remove a clot. Some patients develop bleeding in the brain after the procedure, and doctors want to know if starting blood thinners early …

This study compares the safety of the drug flecainide against standard treatments (sotalol or amiodarone) in about 988 adults with atrial fibrillation and stable coronary artery disease. Participants will be randomly assigned to one treatment and followed for at least a year to t…

This study tests whether inclisiran, a twice-yearly injection that lowers cholesterol, can prevent major heart and limb events in 6,000 people who recently had artery-opening procedures. Participants receive either inclisiran or a placebo shot at the start, at 90 days, and every …

This study tests an experimental drug called REGN13335 in 99 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes the heart work harder. Participants will receive either the drug or a placebo, on top of their usual PAH medica…

This study is collecting information from 5,000 people with peripheral vascular disease who are being treated with Boston Scientific drug-eluting devices in everyday medical practice. The goal is to see how well these devices work and how safe they are in a wide range of patients…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study tests an experimental drug called REGN7508 (cenvacibart) to prevent venous thromboembolism (blood clots) in adults after elective total knee replacement. About 2,000 participants will receive either REGN7508, apixaban, or enoxaparin to compare effectiveness and safety.…

This early-stage trial tests a personalized cell therapy called lifileucel for people with advanced uveal melanoma (a rare eye cancer) or certain sarcomas (connective tissue cancers). The treatment involves removing immune cells from the patient's tumor, growing them in a lab, an…

This early-phase trial tests a nasal spray called NEO100 (a purified natural compound) in 12 children with certain aggressive brain tumors. The goal is to see if it's safe, find the best dose, and check if the drug reaches the tumor. Participants will receive increasing doses, an…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can lower brain pressure in people with idiopathic intracranial hypertension (IIH). IIH causes high pressure inside the skull, leading to headaches, ringing in the ears, and vision problems. The trial…

This phase 2 trial is testing whether a new drug called obinutuzumab beta, combined with a short course of steroids, can help people with newly diagnosed ANCA-associated glomerulonephritis—a rare autoimmune disease that causes kidney inflammation and damage. The study will enroll…

This study tests whether giving two medicines (acetaminophen and ibuprofen) together works better than ibuprofen alone to close a common heart blood vessel in extremely premature infants (born before 27 weeks). About 310 babies will take part. The goal is to see if the combo redu…

This study tests whether the clot-busting drug tenecteplase can help people who have a stroke more than 4.5 hours ago, including those who wake up with stroke symptoms. About 1,325 adults with brain imaging showing salvageable tissue will be randomly assigned to receive tenectepl…

This Phase 3 trial tests whether sovateltide, a drug that stimulates ETB receptors, can improve recovery after an acute ischemic stroke. About 514 adults aged 18-80 will receive either sovateltide or a placebo alongside standard care. The main goal is to see if more patients achi…

This trial tests whether removing a brain bleed with a minimally invasive scope within hours of symptoms improves recovery. 300 adults with a specific type of brain bleed will be randomly assigned to either get the surgery plus standard care, or standard care alone. The study wil…

This study tests a drug called DM199 in about 728 people who have had a moderate stroke and cannot get clot-removing treatments. The drug is given through a vein and then as shots under the skin for three weeks. Researchers want to see if it helps patients recover better than a p…

Researchers are observing whether a tiny implant that releases travoprost can be safely placed inside the eye during an office visit. The implant is designed to lower eye pressure in people with open angle glaucoma or ocular hypertension. The study follows 30 participants to see …

This study tests an experimental drug called REGN7508 (cenvacibart) against aspirin to prevent blood clots in 2000 adults having knee replacement surgery. The drug targets a clotting factor to reduce clot risk. Researchers will compare how many people develop clots or die from cl…

This study tests whether a dietary supplement made from omega-3 fatty acids (called SPM) can reduce blood vessel damage caused by inflammation in people with obesity and high blood pressure. Researchers will give 60 participants either the supplement or a placebo for 12 weeks and…

This study tests a single dose of an experimental drug called ALN-AGT01 in adults with mild to moderate high blood pressure who have already been treated with another drug, zilebesiran. The goal is to see if it safely helps control blood pressure by measuring changes in blood pre…

This study follows 125 people who received a special stent graft (GORE TAG TBE) to treat a tear or bulge in the main artery near the heart (aortic arch). The goal is to see how well the device works and how safe it is over 5 to 10 years. Participants are treated as part of their …

This study tests a device called the Edwards PASCAL System, which is threaded through a blood vessel to repair a leaky tricuspid valve in the heart. It is for people with severe symptoms who are not good candidates for open-heart surgery. About 1,270 participants will be randomly…

This early-stage trial tests an experimental drug called RO7663498, given as an injection into the eye, for people with diabetic retinopathy. The main goal is to check safety and how the drug moves through the body. About 30 participants will receive multiple doses to see if it i…

Researchers are testing whether a balloon catheter coated with the drug sirolimus can safely open narrowed coronary arteries in adults with heart disease. The balloon inflates to press the drug into the artery wall, aiming to keep the vessel open without leaving a permanent stent…

This trial is testing a device called the Heli-FX EndoAnchor system, which is used during minimally invasive repair of abdominal aortic aneurysms (a bulging, weakened area in the main artery). The device helps secure the stent graft in place, potentially preventing leaks or movem…

Researchers are testing an inhaled drug called mosliciguat in people who have pulmonary hypertension caused by interstitial lung disease, a condition where lung scarring leads to high blood pressure in the lungs. The phase 3 trial enrolls about 376 participants who receive either…

This trial tests whether adding robotic rehabilitation devices to standard physiotherapy can improve arm and leg function in adults with movement problems from stroke, spinal cord injury, traumatic brain injury, or orthopedic surgery. Participants will receive robotic-assisted se…

This trial tests whether losartan, a common blood pressure medication, can reduce scarring in the heart's main pumping chamber and improve exercise capacity in adults who had surgery to repair coarctation of the aorta. Participants will take losartan, amlodipine, or a placebo dai…

This early-stage trial tests an experimental drug called RO7823653, given as an eye injection alone or with an approved drug (faricimab), for people with diabetic macular edema—a condition where diabetes causes fluid buildup and vision loss in the center of the eye. The study wil…

This trial tests whether a powered leg exoskeleton called ZEPU AI9 can safely and effectively help people with walking difficulties caused by stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will be randomly assigned to receive either exoskeleton-assiste…

This study tests whether a personalized blood-thinning plan, guided by a blood test, can prevent dangerous blood clots better than the standard one-size-fits-all approach in people with peripheral artery disease who have had leg surgery. About 484 adults will be randomly assigned…

This study is testing a long version of the Ultimaster Nagomi stent in people with long blockages in their heart arteries. About 1,039 participants will receive the stent and be followed for one year to see if it works well and stays safe. The goal is to see if one long stent can…

Researchers are following 500 people with resistant hypertension who have received the Barostim Neo device, an implant that stimulates blood pressure sensors in the neck. The registry tracks blood pressure readings, changes in blood pressure medications, and health care visits ov…

This trial is testing an experimental drug called HS235, given as a shot under the skin, in adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes it hard to breathe and can strain the heart. The study aims to see if adding HS2…

This trial tests whether adding a robotic leg-training device (ZEPU-AI5) to standard rehab can safely improve walking, strength, and balance in adults aged 18–60 with lower-limb problems from stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will receive …

Researchers are studying how well benralizumab works in adults with eosinophilic granulomatosis with polyangiitis (EGPA), a rare disease that inflames blood vessels and can affect the lungs, nerves, and sinuses. The study follows about 100 patients at European referral centers wh…

This study is testing whether it is safe and effective to perform two heart procedures at the same time in people with atrial fibrillation (AF). The first procedure uses pulsed field ablation to correct the heart's rhythm, and the second closes off a small pouch in the heart to r…

This study tests whether doing wall squat exercises for 14 minutes, three times a week, can lower blood pressure and slow the buildup of plaque in arteries. Researchers will compare 100 people doing the squats with 100 people doing gentle stretching, all with high blood pressure.…

This study tests whether a robotic device called ZEPU-AI3 can safely help people with lower limb weakness from stroke, spinal cord injury, or orthopedic surgery improve their walking. Participants receive either standard rehabilitation alone or standard rehab plus robot-assisted …

Researchers are testing whether an intravenous dose of the enzyme dornase alfa can reduce the body's inflammatory response after an acute ischemic stroke. The trial enrolls 36 adults who arrive at the hospital within 12 hours of symptom onset and have moderate to severe stroke sy…

This study will test a special balloon coated with the drug paclitaxel to treat long blockages in the leg arteries. About 300 people with severe leg pain or wounds will receive the balloon treatment during a standard angioplasty procedure. Researchers will track how well the arte…

This study follows 1,200 people who received special fabric tubes (grafts) to repair or replace damaged arteries in the neck, belly, or legs. Researchers want to see how well the grafts work over time and how often problems like blockages or infections happen. It is an observatio…

This trial tests whether robotic devices that guide arm and leg movements can safely improve strength, coordination, and daily function in adults with movement problems from stroke, spinal cord injury, brain injury, or orthopedic conditions. Participants will use the devices thre…

This registry follows 1000 people who received Advanta VXT or Flixene grafts to repair peripheral arteries. Researchers will check how well the grafts stay open and how often serious problems like amputation or repeat surgery occur. The goal is to confirm these devices are safe a…

This study tests a robotic device called ZEPU-AI1 that helps people with leg weakness practice standing and walking. The trial includes adults aged 19 to 60 who have walking problems from stroke, spinal cord injury, or orthopedic surgery. Half of the participants will use the rob…

This study is checking how well a new drug-coated stent (Coroflex ISAR NEO) works in people with coronary artery disease. Researchers will follow 3,000 patients who get the stent during a routine procedure to see if it keeps arteries open safely. The goal is to confirm the stent …

This pilot study tests whether giving tenecteplase directly into brain arteries after thrombectomy can restore blood flow in acute ischemic stroke patients whose vessels remain partly blocked. Thirty adults with a large vessel blockage in the front of the brain receive the drug t…

Researchers compare two imaging strategies for planning left atrial appendage closure in adults with nonvalvular atrial fibrillation. Participants are randomly assigned to have their heart anatomy assessed either by transesophageal echocardiography or by cardiac CT angiography be…

This study is testing a device called FlowTriever that removes blood clots from the lungs in people with a severe, high-risk pulmonary embolism. About 200 participants will be randomly assigned to get either the device or standard care. The goal is to see if the device reduces de…

This pilot trial asks whether adding a robotic hand-training device to standard rehabilitation is safe, practical, and helpful for people with arm and hand motor problems caused by stroke, incomplete spinal cord injury, traumatic brain injury, or orthopedic conditions. Participan…

This study tests a special balloon coated with medicine to open narrowed arteries in the brain and prevent strokes. About 264 people with severe artery narrowing will be treated and followed for 12 months. The goal is to see if the balloon is safe and keeps arteries open better t…

Researchers are testing whether intravenous tenecteplase, a clot-dissolving drug, can improve recovery for people with acute ischemic stroke when given 4.5 to 6 hours after symptoms begin. The trial enrolls adults with confirmed stroke and moderate to severe symptoms. Participant…

Researchers at one hospital are observing 400 people with arteriosclerosis obliterans, a condition where plaque blocks arteries in the legs. The study compares four common procedures: bypass surgery, bare metal stents, plain balloon angioplasty, and drug-coated balloons. Over thr…

This study looks at whether people who take GLP-1 receptor agonists (like Ozempic or Wegovy) should continue them after having bariatric surgery. Researchers will compare weight loss, blood sugar control, gut health, and hunger in 150 adults who either keep taking the drug or sto…

This phase 2 study tests whether spironolactone, a drug already used for fluid retention, can improve exercise capacity and blood vessel function in people with pulmonary arterial hypertension (PAH). About 70 adults with PAH will receive either spironolactone or a placebo for 24 …

This trial tests a special balloon coated with a drug (paclitaxel) to treat blockages in the leg arteries caused by cholesterol buildup. The balloon is inflated to open the artery and release the drug to help keep it open. The study will include 200 people and check if the balloo…

This phase 3 trial is testing an experimental drug called ADX-324 in 90 adults with hereditary angioedema (HAE) types 1 or 2. HAE causes sudden, painful swelling in the body. ADX-324 uses a technology called siRNA to lower levels of a protein involved in triggering these attacks.…

This study compares a new temporary heart pump called the Supira System to the existing Impella pump in 358 patients undergoing high-risk coronary stenting. The goal is to see if Supira is as safe and effective at supporting the heart during the procedure. Participants are random…

This study tests a new drug called RTN-001 in adults whose high blood pressure is not controlled by at least two other medications. About 280 participants will take either RTN-001 or a placebo daily for 12 weeks. The main goal is to see if RTN-001 lowers blood pressure more than …

This study compares standard medical care to a new, less invasive surgery for people with a severe bleeding stroke. The surgery uses a small tube to drain the blood clot and delivers clot-busting medicine directly into the brain. Researchers want to see if this approach helps pat…

This pilot study tests whether a virtual-reality system controlled by muscle activity can help improve arm and hand movement in people recovering from stroke or spinal cord injury. Participants use a wearable device that detects muscle signals through sensors on the skin and prov…

This study tests a drug called YN001 in 456 adults with coronary atherosclerosis (plaque buildup in heart arteries). Participants receive weekly injections of YN001 or a placebo for 13 weeks. The main goal is to see if YN001 reduces plaque volume in the arteries, as measured by a…

This long-term study follows people with pulmonary arterial hypertension (PAH) who previously took part in sotatercept trials. Sotatercept is a targeted therapy that aims to stop PAH from getting worse. Researchers will monitor safety, side effects, and how well patients tolerate…

This study compares a device that physically removes blood clots from leg veins (ClotTriever) to standard blood-thinning medication alone for people with deep vein thrombosis (DVT). About 300 participants with recent, severe DVT in one leg will be randomly assigned to either trea…

This study tests whether a drug called Brezavvy (an SGLT2 inhibitor) can improve blood flow in the tiny vessels of the heart and reduce chest pain in women who have angina but no blocked major arteries. 150 women will take either the drug or a placebo for 12 weeks and undergo hea…

This study tests whether closing a small pouch in the heart (left atrial appendage) with a device, along with blood thinners, can prevent another stroke better than blood thinners alone. It includes 482 adults with atrial fibrillation who had a recent stroke despite taking antico…

This trial tests whether adding tocilizumab, an anti-inflammatory drug, to standard blood thinners improves recovery in people with acute cerebral venous thrombosis, a type of stroke caused by a blood clot in the brain's veins. Researchers will give 80 adults either a single infu…

This study tests a new eye injection called KIO-104 for people with macular edema, a condition where fluid builds up in the eye and blurs vision. About 28 adults will receive multiple doses to see if the drug is safe and helps reduce swelling. The goal is to find a steroid-free o…

This phase 3 trial tests whether adding tocilizumab, an anti-inflammatory drug, to standard emergency stroke treatment improves outcomes for people with a severe stroke in the back of the brain. About 348 adults will receive either tocilizumab or a placebo by IV right before a pr…

This early-stage trial tests AGX101, a drug that delivers chemotherapy directly to cancer cells by targeting a protein called TM4SF1. About 80 adults with advanced solid tumors (like breast, prostate, or pancreatic cancer) who have run out of standard options will receive the dru…

This study tests the safety and tolerability of sotatercept in Japanese children aged 1 to 18 with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs narrow, making the heart work harder. Participants receive sotatercept injections every three wee…

This study involves 8,100 adults who had a heart attack and received a stent. It compares different approved blood-thinning strategies to see which one best prevents another heart attack, stroke, or death while also reducing serious bleeding. Participants will either receive a sh…

This study tests whether shining a specific red laser light on the wrist (over the radial artery) can improve blood pressure and blood vessel function in people with hypertension who are already taking the medication losartan. Eighty adults will be randomly assigned to receive ei…

This study tests whether shining a special low-level laser on chronic leg ulcers can help them heal faster. 96 adults with venous leg ulcers will receive either real laser treatment plus standard compression, or a sham laser plus compression, twice a week for 16 weeks. The goal i…

This study looks at whether a cardiac rehabilitation program can improve recovery for people who have had a stroke. Researchers will enroll 150 stroke survivors and add cardiac rehab to their usual care. They will measure walking ability, daily function, and whether the program r…

Researchers are testing a smartphone app designed to support patients after a pulmonary thromboembolism, a blood clot in the lungs. The app sends education and alerts tailored to each patient's clot and bleeding risk, and lets thrombosis doctors reach out during follow-up. The tr…

Researchers in Belo Horizonte, Brazil, are testing iVIDAVC, a behavior-change program adapted from an Irish model, to help stroke survivors adopt healthier habits. The program combines an educational session, one-on-one coaching, and weekly group meetings led by a physiotherapist…

This study is testing a device called a flow modulator to treat wide-necked brain aneurysms. The device is placed inside the artery to redirect blood flow away from the aneurysm, helping it close off. Researchers will check if the device is safe and effective in 214 adults over 1…

The JAGUAR trial compares two approaches to endovascular aneurysm repair (EVAR) in adults with abdominal aortic aneurysms. Participants are randomly assigned to receive either the Alto Abdominal Stent Graft System or another FDA-approved stent graft. Researchers track complicatio…

This study tests whether a proactive, pharmacist-led telephone program can help people who have had a heart attack reach safer cholesterol levels. Participants receive pharmacist calls, repeat blood tests, and medication adjustments based on national guidelines. The goal is to se…

This trial tests whether anisodine hydrobromide can reduce brain damage in people who have had a severe ischemic stroke and are undergoing a procedure to remove the blood clot. The study includes about 200 adults aged 18 to 80 with a blockage in a major artery in the front of the…

This study tests whether giving the protein albumin (given as an IV drip for four days) along with standard clot-removal treatment helps people recover better after a severe stroke caused by a large blockage. About 1,200 adults aged 18-80 with anterior circulation strokes will be…

This study tests whether eptinezumab, given through a vein, can safely reduce the number of migraine days in children and teens aged 6 to 17 with episodic migraine. Participants receive either the drug or a placebo, and researchers track monthly migraine days over 12 weeks. The g…

This phase 3 trial tests whether giving a clot-busting drug called rhPro-UK before a mechanical clot removal procedure improves recovery for people with severe stroke. About 820 participants who had a stroke 4.5 to 24 hours earlier will receive either the drug or a placebo, follo…

This study tests whether a device called Bioboosti, which delivers pulsed electromagnetic fields, can improve blood flow to the heart in people with coronary artery disease. Researchers will measure blood flow during stress and track symptoms like chest pain and exercise capacity…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 600 minority patients with coronary artery disease. The goal is to see which approach leads to better survival and quality of life. Participants will be followed over time to track outcome…

This early-phase trial tests an experimental antibody called DIAG723 in 93 adults with hereditary hemorrhagic telangiectasia (HHT), a condition that causes abnormal blood vessels and frequent nosebleeds. The study will check if the drug is safe and how the body processes it, with…

This phase 2 trial tests an injected drug called TX000045 in 25 people who have high blood pressure in the lungs due to scarring lung disease. The main goal is to see if the drug lowers lung blood pressure and is safe over 16 weeks. Researchers will also check for side effects an…

This study looks at a newly recognized disease called KSHV Inflammatory Cytokine Syndrome (KICS), caused by a virus that can also lead to certain cancers. Researchers aim to learn more about the disease and test experimental treatments, including antiviral and chemotherapy drugs,…

This study tests different lengths of body cooling in children who remain unconscious after a cardiac arrest outside the hospital. The goal is to see if longer cooling helps protect the brain and improve recovery. The trial will enroll 900 children and follow them for one year.

This study tests whether a laptop-based memory training program can help people who had a stroke more than a year ago improve their ability to learn and remember new information. Participants will complete memory exercises twice a week for five weeks. Researchers will measure cha…

After hip or knee replacement, all patients currently get the same dose of blood thinners to prevent clots, but some still get clots while others bleed. This trial will test whether giving a shorter course to low-risk patients and a stronger, longer course to high-risk patients c…

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks or strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years.…

This study tests whether using a CT scan to guide heart stent placement is better than the current standard (IVUS ultrasound) for people with hardened, calcified coronary arteries. About 700 adults with evidence of reduced blood flow to the heart will be randomly assigned to one …

This study tests a drug called lepodisiran in 252 adults with high levels of Lp(a), a protein linked to heart disease. Participants must have heart disease or be at risk for a first heart event. The drug is given as an injection and compared to a placebo to see if it reduces plaq…

This pilot study will test whether training hair stylists to check blood pressure, combined with home monitoring, health coaching, and pharmacist support, can help Black and Hispanic women lower their blood pressure. About 144 women who visit participating salons will be randomly…

This pilot study tests whether midodrine, a drug that raises blood pressure, can help heart failure patients with low blood pressure tolerate standard heart medications. About 56 hospitalized adults with weak heart pumps and low blood pressure will receive midodrine or usual care…

This study looks back at medical records of heart attack patients with a large clot in a coronary artery. It compares two ways to reopen the blocked artery during emergency angioplasty: a drug-coated balloon that delivers medication and is then removed, versus a drug-eluting sten…

This trial tests whether injecting nicorandil directly into the coronary artery before balloon angioplasty and stenting can prevent a drop in blood flow, a complication called no-reflow. The study enrolls adults with coronary artery disease who have a high lipid core burden index…

Researchers are testing a single injection of MWX401 in healthy volunteers and people with mild high blood pressure. The trial aims to see if the drug is safe and how the body processes it. Participants receive one dose or a placebo, and doctors monitor blood pressure and side ef…

This Phase 3 trial is testing an injectable drug called HRS9531 in about 9,200 people with atherosclerotic cardiovascular disease (hardened arteries). The goal is to see if it can lower the chance of major heart problems like heart attack, stroke, or death. Participants receive e…

This study looks at whether SGLT2 inhibitors, a class of diabetes and kidney drugs, can improve blood flow through the heart's small arteries in women with HIV who also have diabetes or chronic kidney disease. Eighty women aged 45-75 will be randomly assigned to health education …

This study enrolls 600 women with blocked heart arteries to compare two common procedures: bypass surgery (CABG) and stenting (PCI). The goal is to see which one leads to better survival and quality of life. Participants will be followed over time to measure outcomes.

This study tests a home-based cardiac rehabilitation program delivered through a custom app for people who have had a heart valve procedure. Participants who choose not to attend center-based rehab are randomly assigned to usual care, the app with self-guided content, or the app …

This study looks at whether starting insulin to lower high blood sugar on day 4 after a severe stroke is better than starting on day 1. About 200 adults with severe stroke and high blood sugar will be randomly assigned to early or delayed treatment. The goal is to see if delaying…

This Phase 2 trial tests an experimental drug called EYE103 (Restoret) in 160 people with wet age-related macular degeneration or macular edema from a branch retinal vein occlusion. Participants receive three eye injections of either a low or high dose of EYE103, spaced four week…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This study tests a new treatment plan for people with advanced liver cancer that has spread to blood vessels or a few other spots. The plan combines chemotherapy directly into the liver, two immunotherapy drugs, a targeted therapy, and precise radiation. The goal is to see if thi…

This study tests a 3-month home program for people aged 50+ who recently had a stroke and are returning home. The program combines guided stepping training with tips to reduce long periods of sitting. Researchers measure changes in daily steps, mobility, and disability over 12 mo…

This study tests whether giving patients electrical muscle stimulation and high-protein shakes soon after a type of stroke (aneurysmal subarachnoid hemorrhage) can prevent muscle loss and improve recovery. Thirty adults will receive the combo therapy or standard care. The main go…

This trial is investigating whether adding a clot-removal procedure, called endovascular treatment, to standard medical care can improve outcomes for people who have had a severe stroke caused by a blockage in the basilar artery, a major vessel at the back of the brain. The study…

This study tests whether the Edwards EVOQUE system, a valve replacement delivered through a catheter, can safely and effectively treat tricuspid regurgitation, a condition where the tricuspid valve fails to close properly. Researchers will enroll 500 adults in Europe who are deem…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This Phase 3 trial tests an oral drug called muvalaplin in over 10,000 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease and stroke. Participants either have had a prior cardiovascular event or are at high risk for a first one. The study measures …

This study tests whether taking stroke patients directly to a special imaging and treatment room (angio suite) speeds up care compared to the usual approach of getting a CT or MRI first. About 594 adults with severe stroke symptoms will be randomly assigned to one of the two path…

This trial tests whether traditional open-heart surgery to replace a narrowed aortic valve works as well as a less invasive catheter-based approach in patients with severe aortic stenosis who are otherwise at low surgical risk. Researchers will compare rates of death, stroke, and…

This study is for people with hereditary angioedema (HAE) who have already completed a previous trial of the drug ADX-324. ADX-324 is an RNA-based medicine designed to lower a protein involved in swelling attacks. The goal is to see if long-term use is safe and can reduce the num…

This study tests whether a procedure called hemoadsorption, which filters the blood, can help people with severe ischemic stroke. Researchers will compare standard care plus hemoadsorption to standard care alone in 116 adults. The goal is to see if the procedure reduces the chanc…

This trial tests whether task-specific drawing exercises can improve hand dexterity and motor function in people recovering from a stroke, compared with standard fine motor training. Adults aged 40 to 70 with subacute stroke will be randomly assigned to one of two four-week progr…

This study tests whether extra support from a navigator can help pregnant people with high blood pressure use a home monitoring program (Connected MOM) and follow up after giving birth. The trial includes about 2,000 participants who have a smartphone and speak English or Spanish…

This trial is testing a new heart valve called SAPIEN X4/X4S in over 1,200 people with severe aortic stenosis, a condition where the heart's aortic valve narrows. The valve is inserted through a catheter, avoiding open-heart surgery. Researchers are measuring how many patients di…

This phase 3 study is testing whether a new drug called maridebart cafraglutide (MariTide) can reduce the risk of heart attacks, strokes, and death in people with heart disease who are overweight or obese. About 12,800 participants will receive either the drug or a placebo, added…

This study tests whether raising carbon dioxide levels slightly during general anesthesia can improve blood flow to the brain before clot removal in stroke patients. Fifty adults with large-vessel stroke will be randomly assigned to either normal or moderately high carbon dioxide…

This study tests an oral medication called BI 1815368 in 300 adults with center-involved diabetic macular edema, a common cause of vision loss in diabetes. Participants take tablets twice daily for about 11 months, and doctors compare vision changes between those on the drug and …

This trial tests whether the amount of therapist supervision during home-based telerehabilitation changes arm recovery in stroke survivors. Researchers will enroll 30 adults aged 40 to 70 with mild to moderate arm impairment and randomly assign them to either three videoconferenc…

This trial tests whether tailoring breathing support to each patient protects the lungs better than a standard fixed setting during heart bypass surgery. Researchers will compare two methods of setting positive end-expiratory pressure, or PEEP, in 86 adults having on-pump coronar…

This study tests whether the drug atogepant (Qulipta) can safely prevent chronic migraines in teenagers aged 12 to 17. About 420 teens with chronic migraine will take either atogepant or a placebo pill daily for 12 weeks. Researchers will track side effects and changes in monthly…

This study tests a drug called selnoflast in 162 people with atherosclerosis (hardened arteries) who are at high risk for heart attacks or strokes. The goal is to see if selnoflast can reduce inflammation inside the arteries, measured by a special PET scan, compared to a placebo.…

This pilot study compares two ablation techniques for treating ventricular tachycardia, a fast and dangerous heart rhythm that can occur after a heart attack. Researchers will randomly assign 40 adults with ischemic heart disease and an implantable defibrillator to receive either…

This study tests a new medicine called BI 3812465 for people with diabetic macular edema, a condition that causes swelling in the center of the eye and can lead to vision loss. The trial has two parts: first, a small group gets low to high doses to check safety, then a larger gro…

This study is testing a new device called the Sphere-9 catheter, used with the Affera mapping system, to treat ventricular tachycardia (VT) — a fast, dangerous heart rhythm. The procedure uses heat to destroy small areas of scarred heart tissue that cause the abnormal rhythm. The…

This trial compares two rescue procedures for people who have a stroke caused by a hardened, narrowed brain artery that still has significant blockage after initial endovascular treatment. About 486 participants will be randomly assigned to receive either balloon angioplasty or s…

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This study compares two telehealth programs designed to help new mothers get faster care after childbirth, especially those with low income. About 3,500 women will receive either virtual education with reminders or a more interactive telehealth model. The goal is to see which app…

This study tests whether adding an immune-boosting drug (PDS01ADC) to standard chemotherapy delivered directly to the liver can help people with colorectal, bile duct, or adrenal cancer that has spread to the liver. About 70 adults will receive the drug combination along with a s…

This study tests a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. About 261 adults with hypertension will either get the real procedure or a sham (fake) one. The goal is to see if this approach safely lowers blood pressu…

This study tests whether adding TAVNEOS to standard treatment helps control ear, nose, and throat symptoms in people with granulomatosis with polyangiitis (GPA). About 30 adults with active ENT disease will receive either TAVNEOS or a placebo for 52 weeks. The goal is to see if m…

This study tests a drug called donidalorsen in 20 children aged 2 to 12 with hereditary angioedema (HAE), a condition that causes sudden, painful swelling. The goal is to see if the drug is safe and how it works in young bodies. Researchers will monitor side effects and measure h…

This study tests a brain implant that records and stimulates brain areas to help adults with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. The main goal is to check safety, and researchers will also see if part…

This trial tests an investigational cell therapy called FT839 in people with active autoimmune diseases, including ANCA-associated vasculitis, inflammatory myositis, rheumatoid arthritis, lupus, and systemic sclerosis. Participants receive FT839 as two intravenous infusions, some…

In pulmonary arterial hypertension, the right side of the heart works against high pressure in the lungs and can weaken over time. This study tests whether temporary pacing of the right ventricle at the spot where it contracts latest can improve its pumping strength. Researchers …

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

Researchers in Baghdad are studying whether combining the Modified Caprini Score, a checklist of risk factors, with a D-Dimer blood test predicts lower extremity venous thrombosis better than either tool alone in patients recovering from heart and chest surgery. About 112 hospita…

Researchers in Iraq are studying whether the Padua Prediction Score accurately identifies thoracic surgery patients at risk of venous thromboembolism, a type of blood clot. The study enrolls 150 inpatients who stay in the hospital for more than three days and have their clot risk…

This study tests whether a handheld, ultra-widefield eye scanner (OCT) can accurately identify preterm infants with severe retinopathy of prematurity (ROP), a condition that can harm vision. The scanner takes detailed images of the retina without touching the eye, potentially red…

This study is testing whether a device that measures how long it takes for a pulse to travel through the arms and legs can detect peripheral artery disease (PAD), a condition where leg arteries become narrowed. Researchers will compare this new method to the standard ankle-brachi…

Researchers are testing a new ultrasound technique called Sound Touch Viscoelastography (STVi) to see if it can predict portal hypertension in people with cirrhosis without needing an invasive procedure. The study compares STVi measurements of the liver with the standard invasive…

Researchers are testing whether a newer type of CT scan, called photon-counting detector CT, can identify dangerous plaque in heart arteries and predict future heart attacks, chest pain hospitalizations, or heart-related death. The study enrolls 500 adults scheduled for a routine…

Researchers are testing whether the Hilo Band, a cuffless wrist device, can measure blood pressure as accurately as the standard 24-hour ambulatory monitor. The study enrolls 40 young adults aged 21 to 35, including those with normal, low, or high blood pressure. Participants wea…

This study tests a new imaging test (PET-CT scan) that can detect blood clots in the heart arteries from outside the body. Researchers will recruit 80 adults who recently had a heart attack to see if the scan can identify which heart attacks are caused by clots. The goal is to he…

This study is testing a new wrist device that uses light to measure blood pressure without needing a traditional arm cuff. Researchers will compare its readings to standard methods in 200 adults aged 22 to 59 over one week. The goal is to see if the device is accurate and safe en…

This study is testing a device called Laser Speckle Contrast Imaging (LSCI) that uses a laser to measure blood flow in the leg. The goal is to see if it can help doctors monitor blood flow before, during, and after surgery to restore circulation. The study will enroll 30 people s…

This study is testing new, lower-radiation CT scan methods for taking pictures of the heart and blood vessels. Researchers want to see if these scans are accurate at finding blocked arteries and predicting future heart problems like heart attacks. About 5,000 adults who need a he…

This trial tests whether a 4-electrode tablet-based ECG (DigitalCardio) can record heart activity as quickly and clearly as the standard 10-electrode ECG. About 50 cardiology patients will undergo both methods in random order. Researchers will measure recording time and compare t…

Doctors measure pressure inside the liver's blood vessels to judge how serious portal hypertension is in people with cirrhosis. The standard method, called HVPG, threads a catheter through the veins and is invasive. This study tests whether an endoscopic ultrasound with a fine ne…

This study explores whether a low-dose CT scan without contrast dye can accurately detect pulmonary embolism (blood clots in the lungs). Researchers will enroll 750 adults suspected of having a clot and add two very low-radiation CT scans to their standard dye-based scan. The goa…

This study is testing a new type of MRI, called hyperpolarized 13C MRI, to see if it can better identify which patients with heart disease will benefit from bypass surgery. The technique measures how the heart produces energy by tracking two simple molecules. Researchers will com…

Researchers are testing a radioactive tracer called 18F/68Ga-GP1 that binds to a protein found on blood clots. Adults with suspected, newly diagnosed, or previously treated thrombi receive one intravenous injection and then undergo PET/CT or MRI imaging. The study measures how mu…

Researchers are studying whether thromboelastography, a blood test that measures clot formation, can predict outcomes for people having surgery for glial brain tumors. The trial enrolls about 100 adults who are scheduled for tumor removal or biopsy. By tracking clotting measureme…

Researchers test whether a portable low-field MRI scanner in the emergency department can help diagnose ischemic stroke faster and guide treatment. The trial enrolls 60 adults who arrive within 6 hours of stroke symptoms and are eligible for clot-busting drugs or clot removal. By…

Paramedics and other prehospital providers often interpret ECGs under time pressure without expert backup. Missing a blocked coronary artery delays life-saving treatment, while false alarms send patients for unnecessary procedures. This trial randomizes 144 prehospital providers …

Preeclampsia is a serious high blood pressure condition that can develop during pregnancy and is a leading cause of death for mothers and babies in Africa. Doctors struggle to predict which women with high blood pressure will become severely ill because current tests are not accu…

This study aims to create an objective way to diagnose and monitor light sensitivity by measuring facial features, pupil reactions, and nerve responses to light. Researchers will compare 120 people with and without light sensitivity (due to traumatic brain injury or migraine) to …

Researchers are testing whether a radioactive tracer called 18F-DPA714 can help PET/CT scans spot inflammation in the brain. The study includes adults with conditions linked to brain inflammation, such as stroke and neurodegenerative diseases. Each participant receives one inject…

This pilot study tests whether a special PET scan using a tracer called Florbetaben can detect inflamed plaque in arteries of people who recently had a heart attack, stroke, or mini-stroke. The goal is to see if this imaging method can identify unstable plaques that are likely to…

Preeclampsia is a dangerous pregnancy condition marked by high blood pressure and damage to blood vessels, and it can threaten both mother and baby. This study tests whether hyperspectral imaging, a non-invasive scan that measures blood flow in the skin, can predict who will deve…

This study is testing whether a new ultrasound device called SYLVER can measure blood flow in the brain as accurately as the standard CT scan. It involves 50 ICU patients with brain injuries or bleeding. If it works, doctors could monitor brain health at the bedside without movin…

This study tests whether a non-invasive imaging technique called hyperspectral imaging can help predict how preeclampsia will progress in pregnant women. Preeclampsia is a serious condition that can harm both mother and baby, and it is linked to problems in the tiny blood vessels…

Researchers in Pakistan are testing whether a mobile app that uses artificial intelligence to send personalized heat-risk alerts can reduce heat-related illness symptoms in adults with chronic conditions such as hypertension, diabetes, kidney disease, heart disease, or obesity. T…

This trial tests whether a personalized health program delivered through a WeChat mini-program and community health workers can lower blood pressure in adults at high risk of developing hypertension. Researchers will enroll 500 adults aged 35 to 65 in Beijing who have a predicted…

This study tests whether taking a daily statin (rosuvastatin) for one year can safely prevent life-threatening blood clots in people with cancer. Current clot-preventing drugs raise bleeding risks, so a safer option is needed. The trial will enroll 4,000 adults with newly diagnos…

This study will test if mindfulness training, with or without a wearable biosensor watch, can help prevent preeclampsia in pregnant women at moderate to high risk. 90 women will be split into three groups: mindfulness plus the watch, mindfulness alone, or standard prenatal care. …

After a cesarean section, women face a higher risk of dangerous blood clots, and doctors often prescribe enoxaparin, a blood thinner given by daily injection. This trial compares enoxaparin with rivaroxaban, an oral blood thinner taken once a day, in 62 women who have an elective…

This phase 3 trial tests an experimental drug called REGN7508 to prevent blood clots in people with solid tumors who are receiving cancer treatment. About 1,120 participants will receive either the drug or a placebo. The study measures how well the drug prevents clots and checks …

Researchers test whether lowering systolic blood pressure to below 120 mm Hg prevents major cardiovascular events in adults with type 2 diabetes and high-normal blood pressure. The trial enrolls about 11,400 people aged 45 to 79. Participants receive either intensive treatment wi…

Researchers are testing whether exercise during pregnancy can reduce the risk and severity of preeclampsia, a dangerous condition marked by high blood pressure. The trial enrolls 224 healthy women at risk for preeclampsia who are less than 16 weeks pregnant. Participants take par…

Researchers are comparing two LDL cholesterol targets in adults who have had a small vessel occlusion stroke, a type of stroke caused by blocked small arteries deep in the brain. Participants receive standard cholesterol-lowering drugs, with or without ezetimibe or PCSK9 inhibito…

This study tests whether starting a higher dose of aspirin very early in pregnancy (before 7 weeks) can lower the risk of preeclampsia and pregnancy loss in women with risk factors. About 1,150 pregnant women will take either 162 mg of aspirin daily or a placebo followed by stand…

The VISTA trial compares two approaches for people who have had a stroke or mini-stroke caused by severe narrowing of an artery in the neck that supplies the back of the brain. Participants are randomly assigned to receive either a drug-eluting stent plus blood thinners or blood …

The CEST trial compares two timings for carotid revascularization, a procedure that clears a narrowed neck artery to prevent another stroke. It enrolls adults who have had recent stroke symptoms and an MRI-confirmed small area of brain injury in the territory of that artery. Part…

People who suffer spinal cord injuries face a high risk of dangerous blood clots, and doctors usually prescribe enoxaparin, a daily injection, to prevent them. This trial compares enoxaparin with apixaban, an oral blood thinner, in 60 adults recovering from spinal cord injury at …

This study looks at whether a diet rich in whole white potatoes can improve blood sugar control and blood pressure in adults aged 50-70 who are at risk for type 2 diabetes. Participants will eat either a potato-rich healthy diet or a typical Western diet for 12 weeks. Researchers…

This Phase 2 study tests whether a daily pill called EVO756 can prevent migraines in adults who have not had success with other preventive treatments. About 330 participants will receive either EVO756 or a placebo, and researchers will track how many migraine days they have each …

This study looks at whether adjusting deep brain stimulation (DBS) can improve movement, speech, and swallowing in people already implanted with DBS for conditions like tremor, stroke, or traumatic brain injury. Researchers will test hand dexterity, grip strength, facial movement…

Hereditary hemorrhagic telangiectasia (HHT) causes tangled blood vessels that lead to frequent, hard-to-stop nosebleeds and low hemoglobin. Researchers are testing whether intravenous bevacizumab, given once or twice a year after nasal electrocoagulation, reduces nosebleed severi…

This study looks at whether doing resistance exercises (like leg presses) can reduce swelling in the lower legs of people with lymphedema. It also checks if wearing compression garments during exercise makes a difference. Thirty-six adults with lower limb lymphedema will exercise…

This study tests whether adding motivational interviewing (a type of counseling) to a home exercise program can improve pain and arm function in people with thoracic outlet syndrome (TOS). Seventy adults with TOS will be randomly assigned to either exercise alone or exercise plus…

Researchers are testing whether MLC901 (NeuroAiD II), a natural capsule, helps people recover after a mild to moderate ischemic stroke. The trial enrolls 80 adults aged 18 to 80 who are within 2 to 10 days of their stroke. Participants receive either MLC901 plus standard stroke c…

Researchers are testing whether taking a 20mg sildenafil tablet before exercise helps people with pulmonary arterial hypertension reach a higher maximum workload than a dextrose candy tablet. The trial enrolls about 20 adults with stable PAH who are already on standard treatment.…

Researchers are testing whether transcranial direct current stimulation, a gentle electrical current applied to the scalp, combined with a cognitive behavioural programme can reduce fatigue in people who have had a stroke. The trial enrolls 75 adults who had a stroke at least six…

People who lose arm and hand function after stroke or injury often need more therapy than clinics can provide. Researchers are studying ReHandyBot, a robotic device that guides hand and forearm exercises using virtual reality and touch feedback. The trial checks whether patients …

After a stroke, some people develop unilateral spatial neglect, where they ignore one side of their body or surroundings. Researchers are testing whether an immersive virtual reality program that involves playing a virtual piano can improve this condition. Adults with stroke and …

Researchers at Sohag University are comparing two operations for advanced hemorrhoids in adults. One uses an energy-based device to seal blood vessels without stitches, while the other is the standard Milligan-Morgan technique that ties off vessels with sutures. The trial measure…

This study tests zavegepant (Zavzpret), a nasal spray already approved for migraines, in 200 adults who also take CGRP-targeting preventive medications. Researchers want to see if it provides headache relief within 2 to 4 hours and improves daily function. The goal is to find a s…

This study tests whether adding a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to standard physical therapy can improve arm and hand function in people who have had a first ischemic stroke. Sixty-six adults aged 18 to 80 with…

Researchers compare two types of rubber bands used to treat internal hemorrhoids: latex and non-latex. Adults with grade 2 or 3 hemorrhoids who are scheduled for banding join the study and are randomly assigned to one band type. The team tracks bleeding and prolapse symptoms afte…

Acute coronary syndrome, which includes heart attacks, often triggers intense anxiety during the rush to hospital. Researchers are testing whether playing music for 20 minutes in the ambulance, on top of usual care, lowers anxiety and pain more than usual care alone. The trial en…

Tricuspid regurgitation happens when the heart's tricuspid valve leaks, letting blood flow backward. Open heart surgery to fix it carries high risks, and some people are not eligible for other catheter-based repairs. This study tests the Lux-Valve Plus, a replacement valve delive…

This pilot study tests whether a device called IVS3 is tolerable and easy to use for arm recovery in people who had a stroke at least 6 months ago. The device uses mirrored video to create the illusion that the affected arm is moving. Researchers will track how many sessions part…

This study tests whether forced aerobic exercise (using a bike that helps move your legs) can improve arm and leg recovery after a stroke better than traditional therapy. About 66 people who had a stroke 3-9 months ago will take part. Researchers will also check if this approach …

This pilot trial tests whether a home-based, technology-supported hand training program can improve hand function in adults who had a stroke at least six months ago. Participants receive either remotely guided hand activities via video conferencing or a standard home exercise pam…

Care homes face shortages of trained staff, and more than half of residents have some form of dementia. Researchers are testing whether retired volunteers can lead a group music and discussion program called Making Connections Thru Music. The study enrolls 196 people: volunteers …

Researchers are testing a digital app called BRAIN that uses artificial intelligence to personalize cognitive stimulation for people with dementia. The app tailors activities to each person's interests and background, aiming to improve engagement, quality of life, and relationshi…

Researchers are testing whether combining transcranial random noise stimulation (tRNS) with neurofeedback can improve attention in adults who have sustained a brain injury from stroke, trauma, or lack of oxygen. Participants receive sessions that pair 10 minutes of tRNS with 20 m…

This study tests an oral medication called ubrogepant, already approved for adults, to see if it safely and effectively treats migraine attacks in children and adolescents aged 6 to 17. About 1,059 participants with a history of migraine will receive either a low or high dose of …

This study tests a treatment called repetitive transcranial magnetic stimulation (rTMS) for people who have had a stroke more than six months ago and still feel very tired. Fatigue is a common problem after a stroke that can make daily activities hard. The researchers will give r…

Researchers at the University of South Florida are testing whether stroke survivors with chronic aphasia can improve their spontaneous speech by listening to recordings of themselves and correcting mistakes. Participants complete language tasks and then use tablets and headphones…

Researchers at Georgetown University are testing whether a mild electrical brain stimulation called transcranial random noise stimulation (tRNS) can boost the effects of visual training in people who have lost part of their vision from brain damage. The study includes 30 adults w…

Researchers are testing whether electroacupuncture can prevent migraines that strike around a woman's period. The trial enrolls 40 women aged 18 to 45 who have regular cycles and at least three headache days during each menstrual window. Participants receive either real electroac…

Researchers are testing whether blocking blood vessels in the middle meningeal artery with a liquid material called SQUID can reduce the number of migraine days in people with chronic resistant migraine. The study enrolls 30 adults aged 21 to 70 who have had chronic migraine for …

This study tests a wearable sensor that tracks neck muscle activity during swallowing exercises, providing real-time feedback to patients. Researchers want to see if adding this device to standard therapy improves swallowing more than therapy alone. The study includes 120 adults …

This study tests an 8-week mindfulness program designed to reduce anxiety and improve quality of life in women with coronary artery disease. Researchers will enroll 70 women who have had CAD for at least a month and have elevated anxiety. The program includes meditation, breathin…

Researchers are testing whether giving a neuroprotective drug called 3-n-butylphthalide directly into the brain's arteries is safe and practical for people having a stroke caused by a blocked vessel. Participants are adults who are already scheduled for endovascular therapy, a pr…

This study tests whether a small, wearable device that stimulates the ear with mild electricity can reduce long-term pain after a stroke. Researchers will enroll 24 adults who have had a stroke at least 6 months ago and still have pain in their upper arm. Participants will use th…

Researchers at the University of Rochester are testing a home-based computer program that trains people to detect visual stimuli in their blind field. The trial enrolls adults who have lost part of their vision because of damage to the brain's visual cortex, often from a stroke. …

Researchers are testing an experimental oral drug called BGE-102 in adults with diabetic macular edema, a condition where fluid leaks into the center of the retina and blurs vision. The trial enrolls about 180 people with type 1 or type 2 diabetes and center-involved DME. Partici…

Researchers are testing whether giving a neuroprotective drug called 3-n-butylphthalide directly into the brain's arteries is safe and practical for people who have had an ischemic stroke and cannot receive standard clot-removing therapy. The study enrolls 30 adults with moderate…

Researchers are testing whether Tai Chi training or acupuncture can reduce migraine attacks in Hong Kong Chinese women with episodic migraine. The trial assigns 132 participants to either 24 weeks of Tai Chi or a course of acupuncture. The team tracks migraine frequency and days,…

Researchers are testing a device called the Pedal Pump, which pumps both feet for 10 minutes to mobilize the body and improve lymphatic flow. The trial enrolls 30 hospitalized patients with lower extremity edema caused by heart failure, chronic venous insufficiency, kidney diseas…

This trial asks whether breathing supplemental oxygen during a 6-minute walk test helps people with pulmonary vascular disease (PAH or CTEPH) walk farther than they would on ambient air. Participants will complete two walk tests—one with oxygen via nasal cannula and one without—t…

This trial tests whether breathing supplemental oxygen during exercise helps people with pulmonary vascular disease walk farther compared to breathing regular air. Participants will perform a standard six-minute walk test twice—once with oxygen and once without—to see if oxygen i…

This study tests whether a home-based telerehabilitation program, using games, exercises, and video calls with therapists, can improve arm function and reduce disability in people who had a stroke 90-150 days ago. 202 participants will be randomly assigned to receive telerehabili…

This study tests whether a community-based exercise program can improve walking ability and heart health in people with peripheral artery disease who have recently had a procedure to open blocked leg arteries. Researchers will enroll 30 participants and measure how long they can …

This study tests a drug called N-acetyl-L-leucine for people aged 4 and older with CACNA1A gene disorders, which can cause coordination problems, dizziness, and migraines. About 60 participants will receive either the drug or a placebo, then switch, to see if it improves movement…

This study tests a once-daily pill called orforglipron in about 1205 people with peripheral artery disease (PAD) who have leg pain when walking. The goal is to see if the drug helps them walk farther without pain and improves their quality of life. Participants will be followed f…

This study tests a new behavioral therapy called PICTURE IT, delivered via telemedicine, to help people with aphasia after a stroke. The therapy uses pictures and spoken words to stimulate the right side of the brain, aiming to improve language skills. Researchers will compare it…

This study tests a system called STRIVE, which turns a hospital room TV into a motion-tracking gaming console for stroke patients. Using a camera and laptop, it tracks arm and hand movements during games that involve reaching and grasping, without needing controllers or wearable …

This trial tests whether a single application of Kinesio Taping can quickly reduce symptoms and improve grip strength and hand dexterity in adults with thoracic outlet syndrome, a condition where nerves or blood vessels are compressed in the shoulder area. Participants are random…

This study tests whether a special dermocosmetic cream can reduce facial redness and visible blood vessels in people with a common type of rosacea. Fifty adults will apply the cream to one side of their face and a placebo to the other, twice daily for two months, then continue wh…

This Phase 2 trial tests a new type of radiation therapy designed to avoid key brain areas involved in memory and thinking. Sixty adults with 1 to 3 small brain metastases will receive cognitive-sparing stereotactic radiosurgery. The main goal is to see if this approach better pr…

This study looks at whether a computer-assisted vacuum procedure to remove blood clots from the lungs is safe and improves quality of life for cancer patients with a moderate-risk pulmonary embolism. About 25 adults with cancer and a confirmed clot in a major lung artery will tak…

This study tests whether a tongue endurance exercise program can improve swallowing in adults who have had a stroke. Seventy participants will be randomly assigned to either the tongue exercise group or a sham therapy group. They will do home-based exercises for 8 weeks and have …

This study tests whether combining a gentle brain stimulation technique (tDCS) with repetitive arm and hand exercises can help people who have neglect after a stroke. Neglect means they have trouble paying attention to one side of their body or space. The study also aims to combi…

This pilot study tests whether the Voiceitt app can help people with speech impairments caused by conditions like cerebral palsy, stroke, ALS, or Parkinson's disease communicate more effectively. Participants use the app to see if it improves speech clarity and daily communicatio…

This study tests if blocking the middle meningeal arteries in the brain is safe and feasible for people with hard-to-treat chronic migraines. About 13 participants will undergo the procedure and be followed for 6 months. The goal is to reduce migraine-causing substances in the br…

This study looks at whether yoga is a practical and helpful activity for adults who have had a stroke at least three months ago. Forty participants in Nova Scotia will try both virtual and in-person yoga classes twice a week for 90 minutes, plus one recorded session. Researchers …

This study tests whether escitalopram (Lexapro), a common antidepressant, combined with computer-based naming therapy can improve language recovery in people with aphasia after a stroke. About 88 participants who had a left-hemisphere stroke within the past 5 days will receive ei…

This early study tests a 14-day course of the oral drug zuranolone in 6 stroke survivors with moderate to severe depression. Researchers want to see if the drug is safe, well-tolerated, and improves mood. Participants take 50 mg daily and complete mood questionnaires and blood te…

This study tests whether whole-body vibration therapy, given after a Botox injection, can reduce muscle tightness and improve balance in stroke survivors. Fifty participants with ankle spasticity will either receive vibration or a placebo for 4 weeks. Researchers will measure cha…

Researchers are building a large database of cognitive, behavioral, lifestyle, and genetic information from people with neurodegenerative diseases such as Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. The goal is to find biomarkers that help do…

This study follows 65 infants who had a stroke around birth, tracking their brain development and motor skills over two years. Researchers use MRI scans, brain stimulation, and movement tests to find markers of recovery. The goal is to understand how the brain heals, which could …

This study uses cone-beam CT scans to map the alveolar antral artery, a small blood vessel in the upper jaw that can be injured during dental implant or sinus lift procedures. Researchers will analyze 1,000 existing scans to document the artery's typical location, size, and varia…

This study is collecting medical data and biological samples from people with genetic conditions affecting the heart and blood vessels, their relatives, and healthy volunteers. The goal is to better understand these diseases, improve diagnosis, and lay the groundwork for future t…

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…

This study tracks over 16,000 teens and adults with severe asthma to see if the drug tezepelumab raises the risk of serious heart problems like heart attack, stroke, or heart-related death. Researchers will compare those taking tezepelumab to those on standard asthma treatments. …

This study looks at whether lying flat (0 degrees) or with the head raised (30 degrees or more) after a stroke clot removal procedure helps people recover better. About 2240 adults who had a stroke from a large blood vessel blockage will be randomly assigned to one of the two hea…

This study aims to uncover genetic changes that cause autoimmune diseases in people native to Peru. Researchers will collect blood, urine, and stool samples from 300 participants, including patients with conditions like lupus and rheumatoid arthritis, their family members, and he…

This study follows 100 adults with diabetic eye disease who are already receiving standard anti-VEGF injections for swelling in the center of the retina. Researchers will use advanced vision tests and imaging to track changes over time. The goal is not to test a new drug, but to …

This study looks at how deep brain stimulation (DBS) changes movement in people with conditions like Parkinson's disease or essential tremor. About 60 people scheduled for DBS surgery will have extra temporary electrodes placed on the brain to measure muscle activity during stimu…

This observational study aims to better understand what happens inside artery plaques in people with peripheral artery disease (PAD). Researchers will use special PET-CT scans to look for signs of inflammation, calcium buildup, and blood clots in the legs and other parts of the b…

Researchers are studying whether an ischemic stroke in the middle cerebral artery territory triggers inflammation and scarring in the heart muscle. The trial enrolls 44 adults with acute stroke and 24 people with stroke-like symptoms but no brain infarct as a comparison group. Pa…

This study follows 100 people who had heart bypass surgery guided by a special CT scan, to see if imaging details and a blood fat called Lp(a) can predict how well they do afterward. Researchers will track symptoms, quality of life, and major heart events like heart attacks or st…

People admitted for acute coronary syndrome, which includes heart attacks and unstable angina, face a higher risk of dangerous heart rhythms such as sustained ventricular tachycardia and ventricular fibrillation. Hospitals monitor these patients, but the exact rate of these rhyth…

This study is testing a new way to measure liver function in adults who have had the Fontan procedure, a surgery for certain heart defects. Researchers will use a dual cholate clearance test (a special blood test) and a heart MRI to see how well the liver is working. They will co…

This study follows 400 adults diagnosed with pulmonary embolism (a blood clot in the lungs) at a Swedish hospital. Researchers will repeatedly check heart tests and blood markers during the first 48 hours to see if early changes can better predict who will worsen. The goal is to …

Researchers are studying how well people who have had a stroke learn a complex arm and hand skill when they train with one arm versus both arms. Participants include healthy volunteers, people in the early days after a stroke, and people more than six months past a stroke. They p…

This observational study will look back at past cases and follow new patients to compare two surgical methods for repairing aorto-iliac aneurysms (a bulge in the main artery in the belly and pelvis). One method uses a standard surgical graft, the other uses a special stent that p…

Researchers at Xiangya Hospital are building a tool that uses several types of brain monitoring to predict whether patients with severe acute brain injury will be awake, comatose, or deceased 90 days after ICU admission. The study enrolls 200 adults aged 18 to 80 with conditions …

Researchers at University Hospital Essen are studying donated tissue from people with hereditary hemorrhagic telangiectasia (HHT), a genetic condition that causes abnormal blood vessel tangles called telangiectasias. The study compares tissue with and without these malformations,…

This study looks at how social and lifestyle factors—like education, race, and income—affect a person's thinking and memory after a stroke. Researchers will interview 450 adults who had a stroke and review their brain scans and medical records. The goal is to understand why some …

Researchers are building a global registry to collect patient-reported surveys, genetic test results, and medical records from people with Charcot-Marie-Tooth disease and related inherited neuropathies. The study is open to children and adults with a confirmed or suspected diagno…

Researchers are studying whether abnormal connections between arteries and veins in the brain's covering, called intracranial dural arteriovenous fistulae, affect the brain's waste-clearance system, known as the glymphatic system. About 20 adults who are already scheduled for sta…

Researchers are studying blood proteins in people who have a severe ischemic stroke caused by a blocked artery in the front of the brain. All 800 participants receive endovascular treatment, a procedure that threads a catheter through blood vessels to remove the clot. The team me…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study aims to learn more about lipid disorders—conditions that affect fats like cholesterol in the blood. Researchers will observe up to 2,000 people with abnormal cholesterol levels to better understand how these disorders develop and how to diagnose them. Participants will…

This study is for people with certain autoinflammatory diseases (like NOMID, DIRA, CANDLE, SAVI, and others) and their healthy relatives. Researchers want to learn more about what causes these diseases and how they affect the body over time. Participants will have medical tests a…

Researchers are studying how non-invasive tools can characterize tricuspid regurgitation, a heart valve condition linked to heart failure and liver problems. The trial enrolls 450 adults with moderate or worse tricuspid regurgitation and uses a lung fluid sensor and a liver stiff…

Researchers are tracking outcomes for 30 people with severe pure aortic regurgitation who receive a transcatheter aortic valve implantation using the JenaValve or J-Valve system. All participants are considered high-risk for open heart surgery. The study uses CT scans at 6 months…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This study is a large registry that collects detailed information from 120,000 patients with venous thromboembolism (blood clots). The goal is to help doctors better understand the disease and identify who is at highest risk for complications like bleeding or another clot. By inc…

This study aims to better understand and treat people with certain inherited metabolic or genetic disorders. Researchers will use standard medical tests like blood work and imaging to diagnose and care for participants, who may also join other related studies. The goal is to expa…

This study looks at how the body's innate immune system responds to certain environmental exposures by measuring inflammation markers in blood. Researchers will collect blood samples from up to 725 healthy volunteers aged 18-45 to analyze how specific genes and proteins react. Th…

This study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…

This study tests whether a structured shared decision-making process helps patients with severe aortic stenosis choose between two valve replacement options: TAVR (less invasive) and SAVR (surgery). 140 patients aged 70+ will be randomly assigned to either the structured approach…

This study looks at the causes and effects of food allergies and related conditions like eczema and eosinophilic esophagitis. Researchers will collect blood, skin, and genetic samples from up to 1,800 people over many years. The goal is to find biomarkers and pathways that explai…

This natural history study follows 270 adults with pulmonary arterial hypertension (PAH) and healthy volunteers to track how the disease changes over time. Researchers will use blood tests, heart and lung imaging, and a six-minute walk test to find new markers of disease severity…

Researchers at the University of Miami are studying whether advanced eye imaging devices can reveal useful information about the eye in health and disease. The study has two parts: one observes the eyes of healthy people and people with conditions such as multiple sclerosis, dry …

This study will look at 54,000 adults having surgery with general anesthesia to see how different oxygen levels affect their recovery. Patients will receive lower, intermediate, or higher oxygen during their operation. The goal is to find which oxygen level reduces the risk of or…

Researchers want to know whether training one arm after a stroke can improve the other arm, and which brain regions make that possible. The study includes healthy adults, people in the early days after a stroke, and people with long-term stroke effects. Participants play serious …

This study will follow 450 people with diabetes (and some without) for several years to track how their eyes change. Researchers will use advanced eye tests like visual field analysis, contrast sensitivity, and retinal imaging to see which measurements best show disease progressi…

Researchers are comparing two ways of running the heart-lung machine during coronary artery bypass surgery to see which triggers less body-wide inflammation. The study follows 80 adults having planned bypass surgery, split by the circulation technique their surgical team uses. In…

This study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronis…

This study is observing 400 people aged 12 and older who have noncirrhotic portal hypertension (NCPH) or are at risk for it. NCPH is a liver condition that increases blood pressure in the liver's blood vessels without causing cirrhosis, and often has no early symptoms. Researcher…

This study looks at how brief mental stress affects heart function and brain health in 450 adults aged 40-60. Participants complete two sessions: one with stress tests and heart monitoring, another with brain scans and memory tests. The goal is to understand links between stress …

Researchers at Hospital de Clínicas de Porto Alegre are translating and culturally adapting the EmPHasis-10 questionnaire, a short survey that measures how pulmonary hypertension affects patients' quality of life, into Brazilian Portuguese. The study enrolls 50 adults with pulmon…

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…

This study follows up to 3,500 people with sickle cell disease to learn more about how the condition progresses and what complications arise. Participants receive their usual medical care outside the hospital and visit the clinic for check-ups and research tests. No experimental …

This registry is following 4,000 people who have been treated with Medtronic devices for brain aneurysms or ischemic stroke. Researchers are tracking how well the devices work in everyday medical practice, including how often aneurysms are fully closed and how many patients regai…

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and raises the risk of strokes and dementia, over nine years. Researchers will use brain scans, blood tests, and other exams to track how the disease changes blood vessels and thinkin…

Researchers at 24 hospitals in Japan are following 500 people who had an acute ischemic stroke while also living with active cancer. The study measures how often a second stroke occurs within three months and which clinical factors, such as cancer type, stroke features, and test …

This study aims to develop and test new MRI methods for imaging the heart and blood vessels to improve diagnosis and management of heart disease. It will enroll up to 3,400 adults, including both patients with heart conditions and healthy volunteers. Participants will undergo MRI…

This observational study will follow 2000 adults with type 2 diabetes to see how their eating habits, body composition, and grip strength change over time. Researchers hope to identify patterns that could help improve care. Participants must be 18 or older and able to complete ba…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis, a condition causing muscle stiffness after stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume using ultrasound and motion analysis. The goal…

This global registry will follow 800 patients receiving a new, less-invasive tricuspid valve replacement (TTVR) for leaky heart valves. Researchers aim to track complications like pacemaker needs and how well the valve works over time. The study does not test a new drug but gathe…

This study looks at whether handgrip strength—a simple measure of muscle function—can help predict changes in blood flow through the liver's main vein in people with cirrhosis. Researchers will measure blood pressure and flow in the portal vein and nearby veins before and after a…

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This study looks at sleep problems in healthy Somali Americans and how they might raise the risk of high blood pressure. Researchers will use sleep studies and 24-hour blood pressure monitors on 240 adults. The goal is to find hidden sleep issues and understand their link to bloo…

This study is testing a new type of MRI scan that looks at how the heart uses energy. It involves 15 people: 6 healthy volunteers and 9 patients with severe heart disease who are scheduled for bypass surgery. The goal is to see if this new scan can better measure heart muscle hea…

Researchers are observing adults undergoing coronary artery bypass grafting to see how often cardiac output falls below a set threshold in the 30 minutes after general anesthesia begins. The study uses continuous arterial waveform monitoring to record cardiac index, blood pressur…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE Suit affects their balance and risk of falling over time. Participants will be followed routinely, and researcher…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study follows 8,000 adults who have had a stroke to learn why some develop memory and thinking problems afterward. Researchers will track changes in cognition, brain scans, and blood samples over time. The goal is to help doctors identify who is at risk for dementia and pave…

Calciphylaxis is a rare disorder where calcium builds up in small blood vessels in the skin, causing painful lesions. Researchers at Massachusetts General Hospital are building a biobank and patient registry to collect samples and health information from up to 300 adults with the…

Some cancer drugs cause rare but serious heart and metabolic problems. This study follows 5,000 cancer patients across several French hospitals who receive a dedicated heart checkup and ongoing follow-up through cardio-oncology programs. Researchers track how many patients benefi…

Researchers are following 10,000 registered nurses in Xiamen, China, to see how genes, lifestyle, and environment relate to common chronic diseases like high blood pressure, heart disease, stroke, diabetes, kidney disease, and some cancers. The study collects health and lifestyle…

This study follows 200 people having beating heart bypass surgery to see how well Getinge's devices perform and if they cause any problems. The devices help stabilize the heart and improve visibility during surgery. No extra tests or visits are needed—just information from the ho…

This study is checking if a computer model can accurately predict why some people have a prolonged blood clotting time (APTT). The model uses data from routine blood tests to tell if the cause is harmless or a sign of a clotting disorder. Researchers will test it on 1,500 patient…

This study is testing a new PET scan tracer called 18F-GP1 that sticks to activated platelets in blood clots. Researchers will scan 120 adults who recently had an ischemic stroke to see if they can find where clots are coming from. The goal is to better understand different types…

Researchers are building a large database of high-resolution MRI scans from stroke patients in China to study the fatty plaques inside brain arteries. The study enrolls adults who recently had an ischemic stroke and have a specific plaque in a major brain artery. By tracking thes…

Immune checkpoint inhibitors help the body's immune system fight cancer, but in some patients they trigger dangerous heart inflammation and other cardiovascular problems. Researchers are combing through the World Health Organization's global drug safety database, two French natio…

This study collects tissue and blood samples from adults with HIV, other immune disorders, or cancers thought to be caused by viruses. Researchers will compare genes in cancer tissue to normal tissue to find genetic changes that drive these cancers. The goal is to better understa…

This study is creating a registry of up to 1,000 people with rare lymphatic system disorders. Researchers will collect information from medical records and yearly surveys to understand how these diseases progress, what treatments are used, and how they affect quality of life. The…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

Researchers at University Hospital Basel are collecting information from routine care to compare treatments for coronary artery disease. The registry follows people who receive a percutaneous coronary intervention, including complex procedures, and who are treated with drug-eluti…

Researchers at six Italian headache centers are following about 800 adults with trigeminal autonomic cephalalgias, a group of rare headaches that includes cluster headache, paroxysmal hemicrania, SUNCT, SUNA, and hemicrania continua. The study observes routine care rather than as…

This study investigates whether an ultrasound measurement of the internal jugular vein in the neck can help assess fluid status in pregnant women with preeclampsia, compared to those with normal blood pressure. Researchers will measure the vein's collapsibility index before cesar…

This trial tests whether using a risk score and a rapid blood test in the ambulance can help decide where to take patients with chest pain. About 1,048 adults at intermediate or high risk for a heart attack will be randomly assigned to either this new triage method or usual care.…

This study wants to improve how we measure children's recovery and experience after surgery and anesthesia. Researchers will translate and test a recovery scale for Danish children aged 4-12, and also develop a new questionnaire that lets children describe their own hospital expe…

This study aims to understand why heart disease develops differently in women compared to men. Researchers will measure inflammation markers and hormone levels in 6,000 women with chest pain. They hope to uncover how female sex hormones and inflammation interact to influence hear…

This registry is collecting information from 35,000 adults with type 2 diabetes, high blood pressure, heart failure, and/or chronic kidney disease. Researchers want to see how these conditions are managed in everyday medical practice, what treatments people receive, and how often…

This study tests whether a wearable Holter monitor can detect early signs of fainting in people with orthostatic hypotension or reflex syncope. Forty adults who have already had a tilt-table test will wear the monitor for up to 21 days. The goal is to see if the device can pick u…

This study looks at whether certain carbon dioxide (CO2) measurements in the blood can help predict a serious complication called low cardiac output syndrome (LCOS) in children after heart surgery. LCOS happens when the heart doesn't pump enough blood, which can lead to longer ho…

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This observational study is looking at whether people with primary aldosteronism (a cause of high blood pressure) have hormone levels that vary in cycles or differ between day and night. Researchers will collect urine samples over 24 hours from 100 participants to see if this met…

This study is testing a new non-invasive device that uses laser speckle to measure blood flow and structure inside the eye. Researchers will compare these images with standard vision tests in 500 people with various retinal conditions. The goal is to see if this technology can be…

This study looks at whether unconscious patients with brain injuries who show brain activity in response to music and language on an EEG are more likely to wake up and recover. Researchers will monitor 300 adults in the ICU, along with healthy volunteers, to see if these brain si…

This study involves 40 adults undergoing aortic arch surgery to repair aneurysms or dissections. Researchers are testing a new bedside system that measures brain chemicals in near real-time to detect early signs of oxygen deprivation. The goal is to prevent strokes and confusion …

This pilot study tests whether a larger trial comparing two methods of harvesting the left internal mammary artery (LIMA) for heart bypass surgery is feasible. About 35 adults having planned bypass surgery will be randomly assigned to either the skeletonized method (isolating the…

This study examines plaques removed from the carotid arteries of about 3,500 people during surgery, along with imaging scans and blood samples, to find features that make some plaques prone to rupture and cause heart attacks or strokes. Researchers will track participants over se…

This observational study follows 350 adults with pulmonary hypertension to see if certain biomarkers in urine and blood are linked to worsening kidney function. Participants undergo standard tests but receive no experimental treatment. The goal is to better understand how kidney …

This study collects blood and urine samples from healthy adults and patients with heart, lung, or blood vessel conditions. Researchers will use these samples to study genes, proteins, and other substances in the lab. The goal is to support basic and translational research that co…

This study is creating a large collection of health information and biological samples (like blood, saliva, and eye tissue) from people with and without retinal diseases. Researchers aim to use this database to better understand conditions like age-related macular degeneration an…

This study looks at how people with spontaneous coronary artery dissection (SCAD) and fibromuscular dysplasia (FMD) respond to different types of exercise. Researchers will measure changes in blood pressure, breathing, and symptoms during and after exercise. The goal is to better…

This study follows 700 cancer patients who take blood thinners and are scheduled for surgery or medical procedures. Researchers will track how often major bleeding or clotting events occur within 30 days after the procedure. The goal is to see if current blood thinner management …

This study looks at whether damage to the blood-brain barrier right after a stroke can help predict who will have memory or thinking problems later. Researchers will follow 150 stroke survivors for three years, checking their thinking skills by phone. The goal is to better unders…

This study is testing a new bedside device called CardiAQ MCG that measures the heart's magnetic fields to detect blocked arteries (ischemia). Researchers will enroll 150 adults scheduled for heart catheterization to see if the device can accurately predict heart attack status. T…

This study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…

This study collects blood samples from 1,000 healthy adults aged 18 and older to help researchers understand blood vessel and immune system diseases. Participants give about 10 tablespoons of blood at the NIH Clinical Center and may return for up to 10 years. The samples will be …

Researchers are testing whether a new 2026 AHA/ACC classification system, which sorts patients with acute pulmonary embolism into categories A through E, can predict who will have a major adverse event within 30 days. The study will enroll 600 adults diagnosed with pulmonary embo…

This study aims to find genes that cause high blood pressure starting in childhood. Researchers will follow 2,300 people aged 2 and older, including those with childhood-onset hypertension and their healthy relatives, for up to 10 years. Participants provide blood, urine, and che…

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This study will analyze health records from 15,000 adults with high blood pressure in Brazil's public primary care system. Researchers want to see how often patients with uncontrolled blood pressure get their treatment adjusted. The goal is to understand patterns of care and iden…

This study asks how the nervous system tells blood vessels to narrow during stress, and whether obesity or high blood pressure changes that signal. Researchers will measure nerve activity and blood flow in about 100 adults, some with obesity, some with hypertension, and some with…

This study looks at why some adults who had the Fontan procedure as children develop serious liver scarring. Researchers will use blood tests, imaging, and liver biopsies to track changes and find early markers of disease. The goal is to better understand the process and pave the…

This study looks at 958 people having a severe stroke to find out if general anesthesia (being fully asleep) or procedural sedation (being drowsy but breathing on your own) leads to better recovery after a procedure to remove a blood clot from the brain. Participants will be rand…

This study follows about 1,400 people with coronary heart disease who undergo a stent procedure, called PCI, to open blocked arteries. Even with standard treatment, these patients still face a risk of major heart events. Researchers will measure levels of a protein called hsCRP, …