Vascular disorder

Researchers are testing a new adhesive system that seals the great saphenous vein in people with varicose veins. The trial compares this adhesive, delivered through a tube, with radiofrequency ablation, a standard treatment that uses heat to close the vein. About 179 adults with …

Researchers compare two versions of a mesh stent used to treat unruptured brain aneurysms. One version has a special coating and is paired with a single blood-thinning drug; the other is the standard device paired with two blood-thinning drugs. The trial measures tiny brain lesio…

This phase 3 trial tests whether adding a clot-busting drug (alteplase) directly into the brain artery during mechanical clot removal improves recovery for people with severe stroke. About 440 participants with large vessel blockages will be randomly assigned to receive the drug …

This study compares video-based nurse consultations to standard in-person visits for people who recently had a stroke. About 196 participants will be randomly assigned to either telecare or face-to-face follow-up. The goal is to see if remote care can maintain or improve disabili…

This study tests whether drinking a protein beverage after leg-strengthening exercises helps stroke survivors rebuild muscle better than exercise alone. About 93 people who had a stroke more than 3 months ago will take part. Researchers will measure changes in thigh muscle size, …

Researchers are testing sorafenib, a drug that blocks enzymes tumors need to grow and cuts off their blood supply, in people with angiosarcoma that is locally advanced, has spread, or cannot be removed by surgery. The trial enrolls about 88 participants and measures how many rema…

This study looks at how well minimally invasive procedures (like balloons and stents) work for people with severe blockages in the leg arteries. It will track 1000 patients to see if these treatments restore blood flow and keep arteries open over time. The goal is to find the bes…

Researchers are testing a 12-week low-fat, plant-based diet program delivered in a doctor's office. The program encourages whole grains, vegetables, legumes, and fruits, with no animal products or added oils, and no calorie counting. The study measures changes in weight, blood pr…

Researchers at Marmara University are testing whether a 12-week telenursing program helps people with hypertension feel more confident about managing their condition and improves their quality of life. The program combines face-to-face education, home blood pressure monitoring tr…

This study tests whether a combination of stereotactic (computer-guided) surgery and a clot-dissolving drug can help people recover from a deep brain hemorrhage. The trial enrolls 380 adults with small-to-moderate bleeds in the basal ganglia who have significant disability. The g…

This early-phase study tests a new drug called ERAS-601, alone or with other cancer treatments, in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find safe doses and check for side effects. About 90 participants will take pa…

Researchers compare two ways of managing blood flow during carotid endarterectomy, a surgery that clears plaque from the neck artery to prevent stroke. One group receives a shunt routinely, while the other gets a shunt only when a pressure measurement suggests it is needed. The t…

Researchers at Tanta University are testing whether a high-dose version of the eye injection aflibercept (8 mg) can improve vision in people with diabetic macular edema or retinal vein occlusion that has not responded well to earlier anti-VEGF treatments. The study enrolls 60 adu…

Researchers test whether a connected pillbox with pre-filled trays and automated text or phone reminders helps people with type 2 diabetes, high blood pressure, or high cholesterol take their medications as prescribed. The study enrolls about 50 adults who have struggled to stay …

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

Researchers compare two approaches for proliferative diabetic retinopathy, a condition where abnormal blood vessels grow in the retina and can cause vision loss. One group receives standard pan-retinal laser photocoagulation alone. The other receives the same laser treatment plus…

This completed study tested whether eplerenone, a drug that blocks a hormone called aldosterone, improves blood flow and reduces scarring in the heart more than another drug, chlorthalidone, in 79 people with obesity and high blood pressure. Participants took one of the two drugs…

Researchers are testing whether intensive blood pressure lowering slows heart and valve damage in people with asymptomatic moderate to severe aortic valve stenosis. The trial enrolls 60 adults with high blood pressure and a narrowed aortic valve but no symptoms. Half receive stan…

Researchers are comparing two ways to treat blocked leg arteries: doing the procedure as an outpatient visit versus keeping patients overnight in the hospital. The study enrolls 160 adults with peripheral arterial disease who need a minimally invasive procedure to open their arte…

This study tests two different medicines given before a procedure to remove a blood clot from the brain in people having a major stroke. The goal is to see which medicine helps more people recover with little or no disability. About 800 adults who arrive at the hospital within 24…

Researchers are testing an experimental drug called TAK-935 in children aged 2 to 17 with Dravet syndrome or Lennox-Gastaut syndrome, two severe forms of epilepsy that often resist treatment. The trial compares TAK-935 added to standard anti-seizure medications against a placebo …

Researchers are testing whether adding a stent retriever device to a suction-based clot removal technique works better than suction alone for people with a specific type of stroke clot. The trial enrolls adults who have a large blood vessel blockage in the brain and a clot that s…

This study tested whether a half-dose blood thinner (ticagrelor) taken alone after heart stent placement works as well as the standard two-drug therapy in East-Asian patients with chronic coronary syndrome. Sixty participants were randomly assigned to one of three treatment group…

People with peripheral arterial disease often need minimally invasive procedures that thread catheters through the femoral artery in the groin. Afterward, doctors use closure devices to stop bleeding at the puncture site. This trial randomly assigns participants to one of two dev…

Pre-eclampsia is a serious pregnancy complication that can harm both mother and baby, and the only cure is delivering the baby. Researchers are testing whether citrulline, a natural amino acid, can safely prolong pregnancy for women hospitalized with pre-eclampsia before 36 weeks…

Researchers are testing a stent-like device called the DynamX Drug-Eluting Coronary Bioadaptor System in people with complex coronary artery blockages, including long lesions, chronic total occlusions, and blockages at artery branches. The study enrolls about 55 adults and measur…

This study looks at whether alirocumab, a drug that lowers cholesterol, can reduce the risk of heart attack, stroke, or death in people who have hardened arteries but have never had a heart attack or stroke before. Researchers will analyze data from routine medical care to compar…

This study followed 591 adults with eosinophilic granulomatosis with polyangiitis (EGPA) across Europe to see how well mepolizumab 300mg every 4 weeks works over the long term in everyday medical practice. Researchers looked at disease control, lung function, and safety by review…

Researchers are studying the long-term safety and effectiveness of the Barostim Neo System in people with uncontrolled high blood pressure who already received the implant. Participants continue their usual blood pressure medications while the device stimulates nerves in the neck…

Researchers are studying whether an enhanced package of care helps people with advanced HIV in Malawi stay in treatment and keep the virus suppressed. The package adds CD4 and TB-LAM tests and starts patients on TB preventive therapy, delivered through a hub-and-spoke system of c…

This study tested whether giving the cholesterol-lowering drug evolocumab within 24 hours after clot-busting treatment (thrombolysis) can prevent early neurological decline in people with acute ischemic stroke. 132 participants were randomly assigned to receive evolocumab plus st…

This study tests whether giving doctors a reminder and providing patients with a one-page handout can help women who had gestational diabetes or high blood pressure during pregnancy get a primary care visit within six months of delivery. The goal is to prevent future diabetes and…

This early-stage trial tests whether exosomes from stem cells can help people recover from a recent stroke. 29 participants will receive either the exosome treatment or a placebo, and researchers will check for safety and any signs of improved function. The study is small and exp…

This study tested a special sheath (the Protrieve Sheath) placed in a large vein to catch any blood clots that might break loose during a procedure to remove deep vein clots (DVT). The goal was to prevent those clots from reaching the lungs and causing a pulmonary embolism. The s…

This trial tests whether giving older adults with hypertension a personalized 'Heart Age' report during a routine doctor's visit can boost their awareness of cardiovascular risk and encourage healthier habits. Participants receive a one-page report based on their annual health ch…

This phase 2 study tests a new treatment plan for diabetic macular edema, a condition that causes vision loss. Instead of waiting for severe swelling, patients receive two dexamethasone implants 12 weeks apart, then additional injections only as needed. The goal is to improve vis…

This phase 3 study tests whether the drug AGSAVI can lower blood pressure in people with essential hypertension that is not well controlled by the drug AGLS. About 318 adults with high blood pressure will receive either AGSAVI or AGLS, and their sitting blood pressure will be mea…

This study compares two treatments to help blood clot in severely injured trauma patients who are bleeding heavily. One is a standard frozen blood product (cryoprecipitate) that takes time to thaw, and the other is a dry powder (fibrinogen concentrate) that can be given at the be…

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This completed Phase 4 trial tested whether adding a second drug (B55R2) to standard treatment (B55R1) works better for people with non-proliferative diabetic retinopathy, an early stage of diabetic eye disease. 52 adults with mild to severe disease took either the combination or…

This study tests whether a nurse-led smoking cessation program with free drugs and follow-up at healthy life centers helps heart patients quit smoking better than just giving them written information. About 221 daily smokers hospitalized for a heart event will be split into two g…

This trial asks whether adding ozone gel to ultrasound treatment helps chronic venous leg ulcers heal better than either treatment alone. Venous leg ulcers are open sores that occur when leg veins fail to return blood to the heart, and they can be slow to heal. Researchers will c…

This trial is evaluating a new device called the Bifurcated Multilayer Flow Modulator (BMFM) for treating abdominal aortic aneurysms that involve the iliac arteries. The device is designed to be implanted inside the blood vessel to help stabilize the aneurysm and prevent it from …

This trial tests whether a home-based virtual reality rehabilitation program called Muvity can improve arm function, balance, and quality of life in people who had a stroke more than six months ago. Participants will be split into two groups: one doing the Muvity program at home …

This trial tests a virtual reality system called RGS that guides stroke survivors through reaching, grasping, and placing virtual objects to aid motor and cognitive recovery. The study enrolls adults who have had a first stroke with mild to moderate arm weakness. Participants use…

This study tested whether the drug rimegepant can help prevent migraines in Chinese adults. 787 participants took either rimegepant or a placebo every other day for 12 weeks. The main goal was to see if rimegepant reduced the number of migraine days per month compared to placebo.…

This trial tests an implant called OTX-TIC, which is placed inside the eye and slowly releases travoprost, a drug that lowers eye pressure. The study includes adults with open-angle glaucoma or ocular hypertension, a condition of high pressure in the eye. Participants receive eit…

This study tested a set of simple, affordable robots called Rehab CARES to help older adults who had a stroke improve arm and hand function. Twenty-seven participants used the robots for one-hour sessions, three times a week for four weeks, while also receiving standard therapy. …

This trial compares two types of technology-assisted balance training for people who had a stroke at least six months ago. One group trains balance using ankle movements, the other uses hip movements, and both also receive a standard rehabilitation program. The goal is to see whi…

This trial tests whether delivering electrical stimulation underwater can help people recovering from a stroke regain hand grip strength and arm movement. Participants who had a stroke within the past six months will receive either real underwater faradic stimulation or a sham ve…

This study tests whether a gamification program, along with support from a partner and updates to their doctor, can help 84 adults with high blood pressure and high cholesterol take their medications more consistently. Participants who have struggled with adherence will either re…

This study tests whether eating wild blueberry powder every day can lower blood pressure and improve blood vessel health in middle-aged and older men and postmenopausal women with slightly high blood pressure. Researchers will measure artery function and stiffness over time. The …

This study tested an experimental drug called RZ402 in 94 people with diabetic macular edema, a condition that causes vision loss in people with diabetes. The goal was to see if the drug is safe and can reduce swelling in the retina and improve eyesight compared to a placebo. Par…

This trial asks whether adding motor imagery—mentally rehearsing hand movements without physically moving—to robot-assisted hand rehabilitation can improve daily living skills in people recovering from stroke. Forty participants will be randomly assigned to receive either robot-a…

This study tests whether collecting and re-infusing unwashed shed blood during off-pump coronary artery bypass surgery can reduce the need for donor blood transfusions and lower complications. Fifty adults undergoing this surgery will have their shed blood returned via a special …

This study looks at two ways to perform coronary artery bypass grafting, a surgery that reroutes blood around blocked heart arteries. One method uses a single chest artery for the graft, while the other uses both chest arteries. Researchers will compare long-term survival, stroke…

This phase 2 trial tests whether taking colchicine, an anti-inflammatory drug, once daily can prevent major cardiovascular events like heart attacks and strokes in people who have just had a brain bleed (intracerebral hemorrhage). The study includes about 100 adults who have had …

This trial tests a behavioral program for African American women with high blood pressure. The program combines standard education on diet, exercise, and medication with a social component: sharing blood pressure management information with peers. Researchers will measure blood p…

This study tests whether adding culturally tailored heart-health education to medically tailored meal programs helps people with type 2 diabetes and high blood pressure eat better and improve their blood sugar and blood pressure. About 176 adults from low-income New York City nei…

This trial tests whether pairing vagus nerve stimulation (VNS) with rehabilitation can improve arm function in people who have had an ischemic stroke. Participants receive an implanted VNS device and undergo weeks of therapy, with some receiving active stimulation and others a sh…

This study tests whether the blood thinner edoxaban can prevent strokes in people with atrial fibrillation (an irregular heartbeat) who have already survived a brain bleed. About 948 participants will receive either edoxaban or non-anticoagulant therapy (like aspirin or no blood …

This trial tests three medications, phenylephrine, norepinephrine, and ephedrine, to see which one best manages low blood pressure that can occur after spinal anesthesia in women with preeclampsia having a cesarean delivery. Researchers will give each participant one of the three…

This trial tests whether a rehabilitation technique called error-augmented walking can improve gait and brain activity in people who have had a stroke. Participants walk on a split-belt treadmill, which makes the two belts move at different speeds to create a deliberate mismatch,…

This phase 2 trial tests whether levosimendan, a heart medication that widens blood vessels, can reduce dangerous artery spasms and delayed brain injury after a type of bleeding stroke called aneurysmal subarachnoid hemorrhage. Thirty adults in intensive care will receive either …

This clinical trial is testing a new medication called HGP2102 for people with essential hypertension, or high blood pressure. The study compares HGP2102 to a control drug to see how well it lowers blood pressure over a full 24-hour period. Participants are adults with high blood…

This trial tests whether a four-week course of electroacupuncture changes tongue appearance in people recovering from an ischemic stroke. Researchers will use an automated tongue imaging system to capture and analyze tongue color, shape, and coating before and after treatment. Th…

This trial tests whether a personalized tissue-engineered vein, made in the lab with a functioning valve, can safely replace a damaged vein segment in people with severe chronic venous insufficiency. Each participant undergoes surgery to swap a non-working valve in their femoral …

This trial tests whether taking vitamin K2 (with vitamin D) every day can slow the progression of calcium buildup in the coronary arteries—a key risk factor for heart attacks. It enrolls 400 men and women with severe coronary calcification, who are randomly assigned to receive th…

This trial tests whether a specific acupuncture technique, called Xingnao Kaiqiao (or 'Brain Awakening'), can improve arm movement in people recovering from a stroke. It compares this method to standard electroacupuncture. The study involves 66 adults aged 40-80 who had a stroke …

This trial compares two guiding catheters—GUIDEX and Launcher—used during a procedure to open narrowed heart arteries (percutaneous coronary intervention, or PCI). About 150 adults with coronary artery disease will be randomly assigned to receive one of the two catheters. The goa…

This trial tests whether using detailed CT images of the heart's arteries to plan invasive procedures can reduce radiation exposure, procedure time, contrast use, and tools needed. Adults with stable angina and significant blockages are randomly assigned to receive either standar…

This trial tests whether adding respiratory muscle training to a standard post-stroke wellness program improves breathing strength, physical activity, and quality of life more than the wellness program alone. Stroke survivors who are at least six months post-stroke will participa…

This trial asks whether apixaban or rivaroxaban, two standard blood thinners, causes fewer bleeding problems during the first three months of treatment for acute pulmonary embolism (blood clots in the lungs). About 540 adults with confirmed pulmonary embolism will be randomly ass…

This early-stage trial is testing an experimental drug called INZ-701 in adults with end-stage kidney disease who are on hemodialysis and have low levels of a natural substance called pyrophosphate, which helps prevent calcium buildup in blood vessels. The study aims to see if we…

This study tests whether time-restricted eating—eating only between 11 am and 7 pm—can safely and effectively boost the benefits of standard cardiac rehabilitation for people with coronary artery disease. About 45 participants will be randomly assigned to either standard rehab al…

This trial tests whether hydroxychloroquine, an anti-inflammatory drug, can reduce cardiovascular disease risk in people with chronic kidney disease (CKD). Participants with moderate-to-severe CKD will receive either hydroxychloroquine or a placebo for 18 months. Researchers will…

This trial compares two types of contrast agents used during optical coherence tomography (OCT), a test that takes detailed pictures of the heart's arteries. The study will see if one agent uses less contrast, produces clearer images, and causes fewer heart rhythm changes than th…

This trial compares two types of drug-eluting stents—tiny mesh tubes that prop open arteries—in people with completely blocked coronary arteries. One stent uses a coating that dissolves over time (bioresorbable polymer) to release the drug sirolimus, while the other has a permane…

This trial tests whether a structured support program can help people with coronary artery disease maintain regular exercise after completing cardiac rehabilitation. Participants receive group counseling calls, personal phone check-ins, and introductions to community exercise pro…

This phase 2 trial tests whether short-term consumption of concentrated beetroot juice, which is rich in inorganic nitrate, can improve blood flow to the heart and legs, and enhance walking performance in people with peripheral arterial disease (PAD). PAD causes leg pain during e…

This trial tests whether giving the clot-busting drug alteplase directly into the brain artery, right after a mechanical thrombectomy has reopened a blocked vessel, can improve recovery from acute ischemic stroke. The study enrolls adults with large-vessel blockages in the front …

This trial compares two medications, ephedrine and phenylephrine, used to treat sudden low blood pressure during carotid surgery. The main question is whether one drug better preserves oxygen levels in the brain during the procedure. The study involves adults undergoing planned c…

This pilot study tests a new laser device for treating open-angle glaucoma and ocular hypertension. The device uses a laser through the sclera (the white of the eye) to lower eye pressure, avoiding the need for a lens to touch the cornea. Researchers will check how safe the proce…

This trial tests whether low-intensity focused ultrasound (LIFU) can safely stimulate the brain to help people recover arm and hand function after a stroke. Researchers will try different intensities and frequencies of ultrasound in stroke survivors to find the best settings that…

This trial tests an automated system that monitors blood pressure and delivers medications to keep it stable during spinal anesthesia for cesarean sections. The system aims to prevent low blood pressure, which can cause side effects for both mother and baby. The study includes wo…

This trial tests whether giving a clot-busting drug called tenecteplase directly into the brain artery, right after a standard procedure to remove a clot, can help people who have had a severe ischemic stroke. The study includes adults aged 18-85 with a blocked artery in the fron…

This early-stage trial is testing a new gene therapy called AB-1002 in people with advanced heart failure (NYHA Class III). The therapy is given as a single infusion directly into the heart's blood vessels, aiming to deliver a gene that may help heart muscle pump more effectively…

This phase 3 trial investigates whether N-acetyl cysteine (NAC), an antioxidant supplement, can improve recovery in people hospitalized with an acute ischemic stroke. Participants receive either NAC or a placebo (saline) shortly after admission, and researchers track their neurol…

This trial tests whether a new device called SynFlow 3.0 can safely support the heart during high-risk angioplasty (a procedure to open blocked coronary arteries) as well as the standard VA-ECMO device. About 222 people with severe coronary artery disease and a weakened heart (ej…

This trial tests whether stroke patients with bulbar palsy—a condition that makes swallowing difficult—are less likely to develop pneumonia if they receive nutrition through a nasogastric tube or through an IV (total parenteral nutrition). The study will compare the incidence of …

This trial tests whether giving the sedative dexmedetomidine during and after reconstructive microsurgery can help transplanted tissue (flaps) survive better in cancer patients. The study will compare flap health at 48 hours after surgery in patients receiving dexmedetomidine ver…

This trial tests whether a nasal spray containing bevacizumab, a drug typically used for cancer, can reduce frequent nosebleeds in people with hereditary hemorrhagic telangiectasia (HHT). The study enrolls 20 adults who have at least 10 nosebleeds per month. The goal is to see if…

This trial tests whether specially made cookies containing pumpkin seeds and walnuts can improve cholesterol levels in adults with atherosclerosis. For six weeks, one group eats a daily cookie while the other receives usual care alone. Researchers measure changes in LDL and HDL c…

This trial tests whether a procedure called renal denervation — which uses ultrasound to calm overactive nerves around the kidneys — can lower blood pressure and reduce anxiety in people with uncontrolled hypertension. Sixty adults aged 30 to 70 with high blood pressure and eleva…

This trial investigates whether a 10-week Zumba-based exercise program can help lower blood pressure in adults with hypertension. Participants will either join three 50-minute Zumba sessions per week or maintain their usual lifestyle. Researchers will also measure changes in body…

This study tests whether an implanted device that stimulates the vagus nerve, combined with physical therapy, can improve arm movement in people who have had a stroke. The trial includes adults with chronic upper-limb weakness who have already received the implant and completed r…

This phase 2 trial tests whether vericiguat, a drug already used for heart failure, can improve blood vessel function in people with vasospastic angina—a type of chest pain caused by spasms in the heart's small arteries, not by blockages. About 57 adults with frequent angina symp…

This trial investigates whether the antibiotic minocycline can reduce brain injury in people with acute ischemic stroke who undergo mechanical thrombectomy (clot removal). Minocycline may protect the blood-brain barrier and limit damage from restored blood flow. The study enrolls…

This trial investigates whether adding a dexamethasone implant (Ozurdex) to standard aflibercept (Eylea) injections can better control diabetic macular edema that has not responded to anti-VEGF therapy alone. Adults with persistent retinal swelling will receive either the combina…

This trial tests whether a special compression device called NewMan can reduce bleeding and bruising after a shoulder artery procedure compared to a standard pressure bandage. The study involves 229 adults with blocked leg arteries who need a catheter inserted through the arm. Do…

This study follows over 500 adults with migraine who have not responded well to other preventive treatments. Participants take atogepant as prescribed by their doctor and are monitored for a year to see how well it reduces headache and migraine days, and how long they stay on the…

This study investigates whether a noninvasive brain stimulation technique called transcranial direct current stimulation (tDCS) can enhance recovery from spatial neglect — a condition where stroke survivors ignore one side of their world. Participants who had a stroke 3 to 12 mon…

This pilot study explores whether an eight-week mindfulness course or a short guided forest bathing program can lower stress and blood pressure in women over 60 who are already taking medication for hypertension. Sixty women are split into three groups: one learns mindfulness, on…

This study is testing a special balloon catheter coated with the drug paclitaxel to treat blocked arteries in the legs, a condition called peripheral artery disease. The balloon is inflated inside the artery to open it up, and the drug helps prevent the artery from narrowing agai…

This study looks at the long-term safety and effectiveness of bimatoprost SR, a tiny implant placed in the eye that slowly releases medication to lower eye pressure. It includes people with open-angle glaucoma or ocular hypertension who have already used bimatoprost SR in earlier…

This trial tests whether a prehabilitation program — including exercise, education, and breathing techniques — helps people recover faster after planned heart surgery. The study enrolls adults scheduled for surgery for coronary artery disease, valve problems, or other heart condi…

This trial studies how long to cool the body after a cardiac arrest to protect the brain. It includes adults who are in a coma after being resuscitated from an out-of-hospital cardiac arrest. Participants are cooled to a target temperature and then rewarmed slowly, with different…

This study tests a new device that uses sound waves (lithotripsy) to break up hard calcium deposits in leg arteries, a condition called peripheral artery disease. About 75 adults with moderate to severe symptoms will receive the treatment. The goal is to see if the device safely …

This study looks at a modified surgical technique for children with primary congenital glaucoma, a condition that causes high eye pressure and can lead to blindness if untreated. The surgery combines two procedures to create a better drainage channel for fluid inside the eye. Res…

This trial tests two techniques for treating severely calcified coronary arteries before placing a stent. One uses a super high-pressure balloon to crack the calcium; the other uses intravascular lithotripsy, which sends shockwaves through the artery wall. The study includes 80 a…

This trial evaluates a device called the TORUS Stent Graft, a mesh tube placed inside the leg artery to keep it open in people with peripheral artery disease (PAD). The study includes about 188 adults with blockages in the thigh or behind-the-knee arteries. The goal is to see if …

This trial tests a gene therapy called valoctocogene roxaparvovec for people with severe hemophilia A who have developed inhibitors (antibodies that block standard treatment). The therapy uses a harmless virus to deliver a working copy of the gene for clotting factor VIII, so the…

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This trial is testing a new stent called Renzan to treat blockages in the leg arteries (superficial femoral or popliteal arteries). The study includes about 135 people with moderate to severe peripheral artery disease. Researchers want to see if the stent is safe and effective at…

This pilot study tests whether the DASH diet, lifestyle advice, or a combination of both can lower blood pressure in adults with prehypertension—a condition where blood pressure is higher than normal but not yet in the high blood pressure range. Researchers randomly assigned 32 p…

This clinical trial tests whether adding the drug glenzocimab to standard endovascular therapy (a procedure to remove blood clots) improves recovery in people with acute ischemic stroke. The study includes adults aged 18 and older who are eligible for clot removal within 24 hours…

This study tests whether injections of ranibizumab, a drug that blocks abnormal blood vessel growth, can help clear bleeding inside the eye in people with diabetes. The bleeding, called diabetic vitreous hemorrhage, can blur or block vision. Participants receive the injection and…

This study tests whether a robotic hand device can help people recovering from a stroke improve hand strength and dexterity better than standard physical therapy. Thirty adults with sub-acute stroke (2 weeks to 6 months post-stroke) will be randomly assigned to receive either rob…

This trial tests whether an experimental drug called Y-3, given as an injection for 10 days, helps people recover better after an acute ischemic stroke. The study includes Chinese adults who had a stroke within the past 48 hours and have moderate to severe symptoms. Participants …

This study tests whether infusing cold saline directly into the brain during emergency clot removal can improve recovery after a severe stroke. About 258 adults aged 18 to 80 with a large-vessel blockage in the front part of the brain will be randomly assigned to receive either s…

This study tests whether adding a traditional Chinese herbal decoction (Buyang Huanwu Decoction combined with Wuling Powder) to standard stroke care helps people recover better after an acute ischemic stroke. Participants receive either standard care alone or standard care plus t…

This study tests whether a structured nursing program, based on the Plan-Do-Check-Act quality improvement cycle, can reduce lung infections in stroke patients who have a tracheostomy (a breathing tube in the neck). The program includes careful airway care, suctioning, and early r…

This trial investigates whether a daily dose of olive leaf extract (atherolive) can help control blood pressure and improve cholesterol levels in adults with hypertension. Participants are randomly assigned to receive either the extract or a placebo for three months. The study ai…

This trial compares two ways to insert a catheter into the heart during a heart attack: through the wrist (conventional) or through the hand (distal). The goal is to see which method is faster and causes fewer complications, such as blocking the wrist artery. About 550 heart atta…

This study follows people with two inherited eye conditions—choroideremia and X-linked retinitis pigmentosa—who previously received gene therapy. Researchers monitor their safety and vision over several years to see if the treatment remains safe and helps preserve sight. Particip…

This study compares atogepant and topiramate, two daily pills used to prevent migraines, to see which one people tolerate better. About 545 adults with frequent migraines (at least 4 per month) will take one of the two drugs for 24 weeks, then all eligible participants will recei…

This study compares a virtual reality (VR) rehabilitation program that combines movement and cognitive training in realistic everyday environments with conventional occupational therapy for people who have had a stroke. The goal is to see if the VR program leads to greater improv…

This study tests whether having a pharmacist call both patients with heart disease and their doctors can increase the use of high-intensity statins—powerful cholesterol-lowering drugs that prevent future heart problems. The trial includes adults aged 18 to 75 with atherosclerotic…

This study tests whether an automated phone system that calls smokers with coronary heart disease after hospital discharge can help them quit. Participants receive calls at several time points over six months, checking on their smoking and offering support. The goal is to see if …

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This phase 2 trial investigates whether metformin, a standard diabetes medication, can improve lung blood pressure and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension. Participants take metformin or a placebo for 1…

This study tests whether a smart bracelet system can help hospitals treat stroke patients faster. The bracelets track where patients are in the emergency room and send alerts if treatment is delayed. The goal is to shorten the time between arrival and life-saving clot-busting the…

This phase 2 trial tested a new gel called OTR4132 in 60 people who had a stroke and received a clot-removal procedure. The gel is designed to help repair damaged brain tissue. Researchers measured neurological function at 24 hours and disability at 3 months to see if the gel imp…

This study tested whether a drug-coated balloon can stabilize fatty plaques in heart arteries that are at risk of rupturing and causing a heart attack. Researchers treated 45 patients with a recent heart condition, using a special balloon to deliver medication directly to the pla…

This study examines how well a biosimilar (a lower-cost copy) of the drug ranibizumab works for diabetic macular edema, a condition that causes vision loss in people with diabetes. Researchers will review medical records of 60 adults who received at least one injection of the bio…

This study tests whether a 10-week program of balance and multicomponent exercises can improve muscle strength, flexibility, balance, and endurance in adults over 50 who have high blood pressure. Participants will do exercises like sit-to-stand, bicep curls, and walking tests. Th…

This study looked at how well a mechanical device works to remove blood clots from the brain during a stroke. Researchers followed 230 adults who had a stroke within the previous 8 hours and received the procedure. The goal was to see if the treatment helps patients recover and r…

This trial tests whether a new 3D-imaging method called vFFR works as well as the standard pressure-wire technique (FFR) to guide treatment for narrowed heart arteries. About 2,200 adults with stable chest pain or a recent non-emergency heart attack will be randomly assigned to o…

This study followed 48 people who received the Nellix system, a device that seals abdominal aortic aneurysms from the inside using stents and polymer-filled bags. Researchers tracked how well the device worked right after the procedure and for up to 5 years. The goal was to see i…

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This trial investigates whether bosentan, a drug that blocks endothelin and relaxes blood vessels, can help people who suddenly lose vision from giant cell arteritis (Horton's disease). Standard steroid treatment often fails to restore sight once blindness occurs. The study enrol…

This phase 2 trial tests whether baricitinib, an anti-inflammatory drug, can improve neurological outcomes in people who have had a spontaneous intracerebral hemorrhage (a type of stroke caused by bleeding in the brain). About 110 adults in China will receive either baricitinib p…

This study investigates whether delivering a clot-dissolving drug directly into the lung arteries via a thin tube (catheter) can improve outcomes for people with a serious type of pulmonary embolism (a blood clot in the lung). Participants have intermediate-high risk clots, meani…

This pilot study tested whether a shorter course of blood thinner (LMWH) followed by aspirin is as good as the standard 6 weeks of LMWH for preventing blood clots after childbirth. The study enrolled 30 women at moderate to high risk of clots. The main goal was to see if women wo…

This study tested whether Mongolian medicine ZhenBao Pills help people recover arm function after an ischemic stroke. 216 adults who had a stroke within the past 30 days took either the pills or a placebo twice daily for 90 days. The main goal was to see if arm movement improved …

This study tests a drug called faricimab (VABYSMO) in people with diabetic macular edema, a condition where diabetes causes fluid buildup in the center of the retina, leading to vision loss. Participants receive injections of faricimab into the eye every four weeks. The goal is t…

This large, completed phase 3 trial enrolled over 5,400 people undergoing total hip or knee replacement to compare two approaches for preventing venous thromboembolism (blood clots). Participants received either aspirin alone or a short course of rivaroxaban followed by aspirin. …

This study tested a device called the PQ Bypass System in 78 people with severe peripheral artery disease (blocked leg arteries). The device is designed to create a bypass inside the artery using small tubes (stent grafts) placed through a needle puncture, avoiding the need for t…

This study tested whether briefly stopping blood flow to the aorta before surgery (called ischemic pre-conditioning) could reduce complications in people undergoing open repair of a thoracoabdominal aortic aneurysm. 65 patients were randomly assigned to receive either the pre-con…

This phase 3 trial tested whether adding the oral drug atogepant (QULIPTA) to standard Botox injections can safely and effectively prevent chronic migraine in adults. 75 participants took atogepant daily for 24 weeks alongside their regular Botox. Researchers monitored side effec…

This study follows about 1,100 Japanese adults with high blood pressure who are prescribed Entresto tablets. Researchers track side effects like low blood pressure, high potassium, and kidney issues over 52 weeks. The goal is to see how safe and effective Entresto is in everyday …

This study tested whether giving low-income adults with high blood pressure free fruits and vegetables for 6 months could help lower their blood pressure. 104 participants from West Dallas, Texas received the produce prescription program. Researchers measured blood pressure chang…

This study tests whether using a blood test to guide antiplatelet medication can reduce the risk of a second stroke. People who have had a non-cardioembolic ischemic stroke and are already taking aspirin will be assigned to either continue standard aspirin or switch to a differen…

This study tested whether doing a simple handgrip squeezing exercise three times a week for 24 weeks could lower blood pressure in people with hypertension. 139 adults with controlled high blood pressure took part. The goal was to see if this easy exercise could help manage blood…

This study looked at whether eating a plant-based diet for 12 weeks could lower blood pressure and change gut bacteria in 102 kidney transplant recipients. Participants either followed a plant-based diet or their usual diet. The goal was to see if this diet could help manage hear…

This study tested a special stent graft (WRAPSODY) against the usual balloon treatment for vein blockages in people on dialysis. The goal was to see if the stent graft could keep the vein open longer and reduce the need for repeat procedures. A total of 357 patients took part acr…

This study tested whether a daily oral medication called atogepant (brand name Qulipta) can prevent migraines in Japanese adults who have 4 to 14 migraine days per month. Over 500 participants were randomly assigned to receive one of three doses of atogepant or a placebo for 12 w…

This study tested whether a daily dose of the hormone DHEA can help adults with COPD who also have high blood pressure in their lungs. Sixty participants took either DHEA or a placebo for one year. Researchers measured how far they could walk in six minutes and checked heart and …

This study looked at 100 people with severe leg artery disease (including some with diabetes) who needed bypass surgery above the knee. Doctors compared using a man-made tube (Dacron or PTFE) versus the patient's own leg vein to reroute blood flow. The goal was to see which metho…

This study tested an oral medication called APX3330 in 103 adults with moderate to severe diabetic retinopathy, a leading cause of vision loss. The pill aims to reduce inflammation and low-oxygen stress in the eye. Researchers measured whether the drug could improve the severity …

This study tested whether blood thinners (DOACs) work better than aspirin to prevent valve damage and serious heart problems after a less invasive aortic valve replacement (TAVI). 360 patients aged 65-80 were randomly assigned to take either a DOAC or aspirin daily. The main goal…

This study tested whether giving a more powerful antiplatelet drug (prasugrel or ticagrelor) for one month after a heart attack, along with a standard blood thinner, could reduce heart attacks, strokes, and deaths in people with atrial fibrillation. The 602 participants were then…

Researchers are studying whether a machine-learning monitor can predict low blood pressure episodes in patients having lung surgery with one-lung ventilation. The study enrolls about 77 adults scheduled for lobectomy or pneumonectomy. During surgery, the team records standard blo…

This study is testing a chest-patch that uses light to measure blood pressure without a traditional arm cuff. Researchers will compare its readings over 24 hours to the standard cuff-based method in 600 adults with or without high blood pressure. The goal is to see if the patch i…

Researchers at Hanoi Medical University are studying whether two blood markers, AFP-L3 and PIVKA-II, can accurately detect hepatocellular carcinoma, the most common form of liver cancer. The trial enrolls 200 adults, including people with liver cancer and people with benign liver…

Researchers at the University of Salerno are testing whether an artificial intelligence system can grade glaucoma severity from standard visual field tests as reliably as an expert ophthalmologist. The study follows about 50 adults with glaucoma or suspected glaucoma who have vis…

This study tests whether a simpler device called pOpmètre can accurately measure arterial stiffness in children aged 4 to 8. Arterial stiffness is an important sign of heart and blood vessel health. The standard device, Sphygmocor, is harder to use in children. If pOpmètre works …

Researchers are studying how measurements from two different optical coherence tomography (OCT) machines compare when scanning the back of the eye. The trial includes 338 adults with diabetes and diabetic macular oedema. Participants receive OCT scans on both a Heidelberg Spectra…

Researchers are testing whether a bedside ultrasound of the eye can help emergency doctors tell ischemic stroke (caused by a clot) from hemorrhagic stroke (caused by bleeding). The team measures the optic nerve sheath diameter, a marker linked to pressure inside the skull, in adu…

This study tests whether a software program called ElucidVivo can accurately predict blood flow blockages in the heart using images from a standard CT scan. The software analyzes plaque buildup in the coronary arteries to estimate a value called FFRct, which indicates how much a …

Researchers are studying whether ultrasound images of carotid artery plaques can reveal which plaques are unstable and more likely to cause a stroke. They compare scan features with the actual tissue composition of plaques removed during surgery, and they track plaque growth, str…

This study tested whether videonystagmography (VNG) with caloric testing, a standard balance exam, can distinguish people with vestibular migraine from those with other migraines and healthy individuals. Researchers compared eye movement patterns in 173 participants across three …

This trial tests whether a special CT scan, called CT perfusion, can measure blood flow in the feet of people with critical limb ischemia, a severe blockage of leg arteries. Researchers will scan 80 patients before and three days after they undergo surgery to restore blood flow. …

This trial tests whether an AI software called AI-Gatekeeper can help doctors predict if a patient has significant coronary artery narrowing (at least 50% blockage) using only routine tests like blood work, ECG, chest X-ray, and echocardiogram. About 450 adults with chest pain an…

This trial tests a wearable device called CAVA that records eye and head movements for 30 days in people with dizziness conditions like Meniere's disease and BPPV. The goal is to see if the device can accurately detect episodes of nystagmus, an eye movement linked to dizziness, a…

This trial tests whether a new device, placed gently in the ear canal, can accurately measure pressure inside the skull without surgery. The device works by detecting tiny changes in inner-ear activity that reflect pressure shifts in the brain. It will be compared to the standard…

This study tests whether a new device that records chest vibrations from a distance can detect heart and lung diseases. Researchers will compare the vibration patterns of people with known cardiac or pulmonary conditions to those of healthy volunteers. If the technique works, it …

This trial evaluates a new high-sensitivity blood test (Mindray hs-cTnI) for diagnosing heart attacks in people arriving at the emergency room with symptoms like chest pain. Researchers will compare the test's accuracy against an existing approved test, using blood samples taken …

This study explores whether a cardiac MRI can safely and effectively gather the same heart pressure and flow measurements normally obtained through right heart catheterization, a more invasive procedure. Researchers will attempt to perform the catheterization inside the MRI machi…

This study tests whether the inferior vena cava (the body's main vein) can serve as a reliable reference point for measuring blood pressure in the liver during an endoscopic ultrasound. Normally, doctors use a hepatic vein for this, but in people with advanced liver scarring, tho…

This trial evaluates an artificial intelligence algorithm, AutoAS, that analyzes ultrasound images of the heart to detect aortic stenosis — a narrowing of the heart's main valve. Researchers will collect images from adults scheduled for a standard echocardiogram and test how well…

This study compares cardiac MRI to the standard right heart catheterization for monitoring people with pulmonary arterial hypertension (PAH), a condition that strains the heart. Researchers want to see if the non-invasive MRI can reliably detect when a patient's condition is wors…

This study looked at 105 people to find the best blood test values for diagnosing primary hyperaldosteronism, a condition where the adrenal glands make too much aldosterone hormone, causing high blood pressure. Researchers measured aldosterone and renin levels using advanced lab …

This study tested a new tool called BESTA, designed to quickly diagnose aphasia (language problems) in people who just had a stroke. Researchers compared BESTA to an existing test in 395 participants, including stroke patients and healthy volunteers. The goal was to see if BESTA …

This study looked at whether measuring two proteins in the blood (GST-π and PRDX1) can accurately determine if a stroke occurred within the last 4.5 hours. That time window is critical because it determines if patients can receive clot-busting medication. Researchers enrolled 935…

This pilot study tested whether a quick, 20-second ultrasound of the brain's blood vessels could help paramedics identify patients with a severe stroke caused by a large blocked artery. The study included 60 participants: healthy volunteers and suspected stroke patients. Research…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This study tested whether a fingerstick blood test (LumiraDx INR test) gives accurate results for people taking the blood thinner phenprocoumon. Researchers compared fingerstick results to standard lab tests in 102 adults. The goal is to see if this quick test can reliably monito…

This study uses a non-invasive ultrasound called transcranial Doppler (TCD) to measure blood flow in the brains of pregnant women with preeclampsia. Researchers will compare 50 women with preeclampsia to 50 healthy pregnant women to see if TCD can detect early signs of serious co…

This study tested a new diagnostic tool that uses imaging flow cytometry to examine platelets in blood samples. Researchers compared it to standard lab tests in 31 patients suspected of having platelet disorders or heparin-induced thrombocytopenia. The goal was to see if the new …

This study tests whether giving probiotics (LactoLevure) to ICU patients on ventilators can prevent ventilator-associated pneumonia. The trial will enroll 186 adults with head injury, stroke, or brain hemorrhage. Patients receive probiotic or placebo capsules twice daily for 30 d…

Very premature infants born before 28 weeks often have a blood vessel near the heart, called the patent ductus arteriosus, that stays open when it should close. A large opening can strain the heart and may affect brain development. In this trial, researchers use an early echocard…

Researchers are testing whether 24 weeks of Tai Chi training can prevent episodic migraines in Chinese women as effectively as standard preventive medication. The trial enrolls 220 women aged 18 to 65 who have two to six migraines a month. Participants in the Tai Chi group attend…

Researchers are testing whether a home telehealth system can prevent complications after vascular surgery that involves a groin incision. Patients scheduled for these procedures are randomly assigned to receive either standard discharge instructions or a tablet with a weight scal…

Researchers are testing a new drug called VMX-C001 to see if it can help blood clot normally in people who take common blood thinners. The trial gives single doses of VMX-C001 or a placebo to healthy volunteers, and also to healthy older adults who take one of three blood thinner…

This pilot trial tests whether a multi-part program given to emergency department patients with metabolic syndrome can encourage more walking and healthier habits. Participants receive a Fitbit, watch a short educational video, get a written exercise prescription, receive text re…

This trial tests whether a structured lifestyle program—combining exercise, healthy eating, cognitive training, and social activities—can slow cognitive decline in older adults at risk of dementia. Participants aged 60-80 with modifiable risk factors will be randomly assigned to …

This trial tests a program called TEAM, designed to help people at high risk for stroke lower their risk factors. The program involves nurses and peer educator pairs working with patients and their care partners through one-on-one and group sessions. The goal is to see if this ap…

This study follows people at high risk for diabetes who previously took part in a program testing intensive lifestyle changes or the drug metformin. The goal is to see if these approaches can prevent or delay diabetes and reduce long-term health problems like heart disease and ca…

This trial tests whether a 12-week program led by a heart health educator can lower cholesterol and improve heart health in spouses, siblings, and children of people hospitalized with coronary heart disease. Participants work with an educator to create a personal plan for smoking…

This study tested whether using a device that electrically stimulates arm muscles can prevent blood clots caused by PICC catheters in critically ill patients. 120 adults in intensive care units were randomly assigned to receive either standard care or standard care plus two daily…

This study tests if adding dance therapy to standard physical therapy helps people with chronic stroke (at least 6 months after) improve their balance and walking. Sixteen participants will be split into two groups: one gets standard therapy plus dance, the other only standard th…

Researchers at the University of Washington are testing whether combining non-invasive spinal stimulation with an ankle exoskeleton can improve walking in people with neurologic conditions such as cerebral palsy, stroke, and premature birth. The study includes up to 10 participan…

Researchers test whether an 8-session dance workshop improves balance in adults with hemiparesis, a weakness on one side of the body. Participants are randomly assigned to either the dance program or an upper-limb rehabilitation program. The study measures changes in walking and …

Researchers in Finland are testing a web-based neuropsychological rehabilitation program for adults who have recently had an acquired brain injury from causes such as stroke, encephalitis, or trauma. The program, called the iRENE Digital Pathway, uses online sessions and question…

This study tests a special adhesive patch made with zinc oxide to hold catheters (thin tubes placed in veins) in place for hospitalized adults. The goal is to see if it reduces complications like the catheter moving, skin irritation, vein swelling, and pain. About 400 patients wh…

Researchers are studying whether a 6-month home walking program can help people with peripheral arterial disease of the legs. Participants wear a smartwatch that counts daily steps and receive weekly phone calls from a researcher who reviews their activity and offers guidance. Th…

Researchers test whether adjusting cardiac rehabilitation to each person's muscle power profile and heart rate variability helps heart attack survivors recover better. Adults who had acute coronary syndrome in the past six months and received a stent or bypass surgery join the st…

Researchers are testing whether certain ingredients in toothpaste can trigger migraines. Adults with migraine who do not take preventive medicines join one of two groups: one swaps toothpaste for saline solution when brushing, the other keeps using toothpaste. Both groups follow …

Researchers are testing a 12-week home-based programme that combines aerobic exercise, strength training, stretching, and self-management education for people who had a stroke more than six months earlier. The trial enrolls 30 community-dwelling survivors aged 20 to 59 who can wa…

Researchers are testing whether a dual-task exercise program helps stroke survivors walk while doing a mental task. The study compares dual-task training, which combines walking with cognitive activities, to single-task training, where walking and thinking are practiced separatel…

This study tests whether playing specially designed, AI-powered games can improve thinking skills and arm/hand function in people who have had a stroke. Forty adults aged 45-60 with mild memory or thinking problems after a stroke will use a smartphone app and motion-sensing games…

This study tests whether combining progressive muscle relaxation and guided imagery can lower stress, anxiety, and depression in people with stable coronary artery disease. Forty adults will be split into two groups: one gets eight sessions of these mind-body techniques over four…

This study tested whether metformin, a common diabetes drug, along with a text-message activity program, could help people with pulmonary artery hypertension (PAH) walk farther and feel better day-to-day. 73 adults with PAH took part. The goal was to see if these interventions im…

Ataxia-telangiectasia is a rare, inherited disease that damages the nervous system, skin, and immune system, and it has no cure. Researchers are testing sirolimus, an immune-suppressing drug, in children under 17 with the condition. The six participants take sirolimus by mouth fo…

Researchers are testing whether applying ice around an intravenous catheter before an oxacillin injection can lower pain and reduce peripheral phlebitis, an inflammation of the vein. The trial enrolls 86 hospitalized adults aged 20 to 60 who receive oxacillin through a hand vein.…

People with peripheral artery disease often need procedures that thread a catheter through an artery in the groin. Doctors usually use a closure device to seal the puncture, but manual pressure may work just as well and cost less. This pilot study tests whether 30 patients can sa…

This study tests whether dry needling (inserting thin needles into tight muscles) can reduce spasticity—stiffness that makes movement hard—in people who have had a stroke. About 28 adults who can walk independently will receive either real or sham (fake) needling once a week for …

Researchers are testing whether a structured Enhanced Recovery After Surgery (ERAS) program improves recovery for people having their first coronary artery bypass graft. The program bundles 31 care steps before, during, and after surgery, including patient education, nutrition su…

Researchers are testing whether one 50-minute Pilates session changes blood pressure over the next 24 hours in women aged 50 and older with elevated blood pressure. Participants also complete a treadmill walking session for comparison. Each woman wears a portable blood pressure m…

This study tested a self-management app for women who had high blood pressure during pregnancy. 99 new mothers used the app to track their blood pressure, stress, and mood, or received usual care. The goal was to see if the app helps lower blood pressure and improve mental health…

This study tests whether atogepant, a drug already used to prevent migraines, can also treat migraine attacks quickly. About 1300 adults with a history of migraines will take either atogepant or a placebo when they have a migraine, and then report pain levels and symptoms after 2…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This study tests whether a nerve block called the serratus posterior superior intercostal plane block can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults will be randomly assigned to receive either the nerve block plus standard…

This trial tests a support package called CaknaStrok for people caring for a family member who just had a stroke. The package includes a mobile app with videos and tools, plus a guidebook, all tailored for Malaysian caregivers. Researchers compare caregivers who get the package w…

This study tests whether special knee strengthening exercises can improve balance and body awareness (proprioception) in people who had a stroke. About 34 participants who had a stroke 3 months to 1 year ago will do either isokinetic knee exercises or standard rehab. The goal is …

People with liver cirrhosis often have abnormal cholesterol and triglyceride levels. Researchers at Northern Jiangsu People's Hospital are following 150 cirrhosis patients who undergo laparoscopic splenectomy and azygoportal disconnection, a common operation for bleeding caused b…

This study tests a remote program called teleABLE that helps people who had a stroke within the past year reduce their sitting time. Participants either get 12 behavioral coaching sessions or 6 health education sessions. The goal is to see if the program improves quality of life …

Researchers are testing whether an electromyography-controlled functional electrical stimulator (FitFES) helps stroke survivors regain arm and hand function. The device reads muscle signals and delivers electrical stimulation during task-oriented exercises. Fifty adults who had a…

Researchers are testing whether a hybrid cardiac rehabilitation programme can help adults recover after heart surgery. Participants start with two weeks of supervised exercise at the hospital, then continue training at home for six weeks using heart-rate monitors, a cloud care pl…

This study tests whether eptinezumab can reduce migraine days and improve quality of life in 164 adults who previously did not get enough relief from other CGRP-targeting migraine drugs. Participants receive the drug and report changes in migraine frequency and severity over time…

Researchers want to know if a wireless peripheral nerve stimulator, already implanted in some patients for chronic arm pain, can also make paralyzed muscles contract. The trial enrolls adults with stroke or spinal cord injury who have the device on nerves in the arm. Participants…

This study tests whether balance training guided by artificial intelligence can improve pelvic alignment and reduce fall risk in people who have had a stroke. Thirty-eight stroke survivors will wear sensors and perform static and dynamic balance exercises. The AI adjusts the exer…

Researchers are testing an experimental oral drug called XY03-EA in adults who have just had an acute ischemic stroke. The trial compares several doses of the drug with a placebo to see whether it improves recovery and reduces disability. About 360 participants receive treatment …

Stroke often damages trunk control, balance and walking ability. Researchers are testing whether combining transcranial direct current stimulation, a mild electrical current applied to the scalp, with pelvic proprioceptive neuromuscular facilitation, a hands-on stretching and mov…

This study tested a nerve block called a stellate ganglion block for people with chronic migraine that didn't get better with other treatments. 42 patients received the injection under ultrasound guidance. Researchers tracked changes in monthly headache days and pain scores over …

Researchers are testing whether nicotinamide riboside, a form of vitamin B3 sold as a supplement, can reduce immune system activation in people with mild to moderate psoriasis. The trial enrolls adults aged 18 to 80 who are not on biologic therapy. Participants take either the su…

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tests a rehabilitation method called modified constraint-induced movement therapy (mCIMT) for people recovering from a stroke. Participants wear a mitten on their unaffected arm for several hours a day while practicing tasks with the affected arm. The goal is to see if…

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study tests whether allopurinol, a common gout medication, can improve heart function in African American veterans with resistant hypertension. Participants take allopurinol for 8 weeks, and researchers measure changes in heart function, exercise ability, and quality of life…

This trial tests whether playing different types of music during retinopathy of prematurity (ROP) eye exams can reduce pain and improve comfort in premature infants. ROP exams are necessary but can be painful and stressful for babies. Researchers will compare pain and comfort sco…

This completed study looked at 200 adults having hemorrhoid surgery. Half also had a small cut in a muscle around the anus (lateral internal sphincterotomy). Researchers measured pain and accidental leakage of gas or stool after surgery. The goal was to see if the extra cut helps…

This trial tests whether two types of talking therapy can help people with chronic migraine. One is standard cognitive behavioral therapy, and the other is a traditional Islamic psychotherapy that blends psychological methods with Islamic principles. Adults aged 18 to 40 with a n…

This study looked at whether prayer can help people with migraines feel less pain and improve anxiety and depression. About 100 adults, half with migraines and half without, took part. They compared the effects of prayer versus reading a neutral text on pain sensitivity and emoti…

This study tested a device that sends mild electrical pulses to a nerve in the ear (trigeminal nerve) to see if it helps people with migraine. 102 adults with episodic migraine received either real or sham stimulation three times a week for 12 weeks. Researchers measured headache…

This study looks at whether fremanezumab, a migraine prevention drug, can reduce the emotional burden on caregivers of people with migraine and depressive symptoms. Researchers will measure caregiver stress and the quality of the couple's relationship before and after six months …

This study looks at whether doing special breathing exercises before heart bypass surgery can help improve oxygen levels afterward. It will include 45 men aged 50 to 60. Some will use an incentive spirometer, some will use an inspiratory muscle trainer, and others will receive st…

This study tests whether wearable sensors and goal-setting sessions with a physiotherapist can help stroke survivors stay active after leaving inpatient rehabilitation. Participants wear sensors to track activity, sleep, and sedentary behavior, and some receive feedback and set g…

This trial tests whether applying cold packs to the wrist after transradial coronary angiography reduces pain, bruising, and discomfort. About 104 adults who had this heart procedure will be randomly assigned to receive either cold packs or standard care. Researchers will measure…

This study tests whether starting gentle movement earlier than usual can reduce back pain in people who have had a procedure to open blocked heart arteries. After this procedure, patients often lie flat for hours, which can cause back pain. The study will compare early mobilisati…

This trial tests whether a single educational session about how pain works, given before coronary artery bypass surgery, can lessen chronic pain after the operation. Adults scheduled for elective bypass will either receive this pain neuroscience education plus routine care, or ro…

This study explores whether interactive music and guided imagery, delivered via telehealth, can help ease migraines. Researchers will check if the approach is practical and acceptable for Veterans, and whether it leads to meaningful changes in headache frequency and related outco…

This study tests whether intensive robotic arm training can help people recovering from a stroke improve arm movement and reduce stiffness. Participants will use two types of robotic devices in 12 sessions over four weeks. Researchers will also use a technique called muscle syner…

This trial explores whether exposure to artificial light that mimics natural sunlight can improve brain activity, heart rate regulation, and movement in people who have had a stroke. Thirty chronic stroke survivors will undergo light sessions while their brain waves and heart rhy…

This study tests whether a walking program that uses FitBit tracking and personalized coaching can help people who recently had a leg amputation due to diabetes or peripheral artery disease become more physically active. Participants will use a FitBit to monitor their steps and r…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This trial investigates whether injecting Botox near a nerve bundle in the face, called the sphenopalatine ganglion, can reduce the number of severe headache days in people with chronic migraine that hasn't improved with other treatments. Participants receive either Botox or a pl…

This trial tests whether adding a double nerve block (femoral and sciatic) before general anesthesia can reduce pain and morphine use after femoropopliteal bypass surgery in people with peripheral arterial disease. The block, using levobupivacaine and clonidine, may also widen bl…

This study tests whether online cognitive-behavioral therapy (CBT) for insomnia, combined with CBT for pain, can reduce headaches and improve sleep in adolescents aged 11-17 who have both migraine and insomnia. Participants receive internet-delivered programs focusing on sleep hy…

This study tests whether health education videos redesigned using semiotics—the science of signs and symbols—can help stroke survivors improve daily activities, sleep, anxiety, and depression. Two hundred stroke patients will be randomly assigned to watch either these optimized v…

This trial investigates whether wearing AI-powered active noise-cancelling headphones during rotational atherectomy — a heart procedure that generates loud drilling noise — can reduce patient anxiety and improve heart rate stability. One hundred adults with severe coronary artery…

This trial compares a newer, minimally invasive laser procedure to standard surgery for grade II and III hemorrhoids. The laser technique aims to shrink hemorrhoid tissue with less pain and faster recovery. Researchers will measure postoperative pain, patient satisfaction, and ho…

This study tested whether fast arm movement training helps people who had a stroke regain arm function better than standard accuracy training. 44 chronic stroke survivors with mild to moderate arm weakness participated. The training focused on moving quickly, and researchers meas…

This study tested whether adding mental practice of swallowing to standard therapy helps people who have trouble swallowing after a stroke. 43 adults were split into three groups: one watched swallowing videos then imagined the action, one just imagined swallowing, and one had on…

This study tested a new occupational therapy called HABIT, designed to help stroke survivors use their affected hand more in everyday activities. Eleven adults with mild hand weakness after stroke participated. Researchers measured hand use and satisfaction with daily tasks befor…

This study tested whether adding augmented cues—like visual and auditory feedback from a sensor-based glove—to standard physical therapy could improve hand function in people recovering from a stroke. Fifty patients with subacute ischemic stroke were randomly assigned to receive …

This pilot study tested whether adding a 16-week meditation program to standard cardiac rehabilitation helps people with coronary artery disease feel less stressed and anxious. Forty participants were split into two groups: one did meditation plus rehab, the other did rehab alone…

This study tested whether combining somatotherapy (body awareness and movement exercises) with occupational therapy (training in daily tasks like dressing and cooking) could improve cognitive function in 50 adults who had a stroke. Participants received 35-minute sessions five da…

This study tested a new, standardized process for providing assistive devices (like special tools) to help people put on and take off compression stockings. 220 adults who need these stockings long-term took part. The goal was to see if the new method improves how often people us…

This phase 2 trial tests whether daily injections of unacylated ghrelin, a natural hormone, can improve walking ability in people aged 55 and older with peripheral artery disease (PAD). Participants receive either the hormone or a placebo for four months. The study measures chang…

This study looked at whether a single educational phone call from a nurse, before a doctor's appointment, could help people with medication overuse headaches. 88 adults with frequent migraines took part. The goal was to see if the call reduced the number of headache days in the m…

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

This study compares three ways of teaching midwifery students about preeclampsia and eclampsia: a digital game, a simulation, and traditional lectures. The goal is to see which method boosts knowledge, motivation, and attitude the most. 120 fourth-year midwifery students will tak…

Some people develop an irregular heartbeat called atrial fibrillation after a stroke or mini-stroke. Researchers want to understand what causes this by comparing nerve function, inflammation, and heart rate patterns in three groups: patients with this post-stroke irregular heartb…

This study tested whether a home rehabilitation program, with daily activity tasks and heart rate monitoring sent by text or email, helps people recover better after a serious blood clot in the lung (pulmonary embolism). 32 adults who had been hospitalized for this condition took…

Researchers are studying how two types of ulcerative colitis treatment, tofacitinib and anti-TNF drugs, affect platelet function and the body's clotting system. The trial enrolls adults with ulcerative colitis and compares blood and tissue samples before and after they start trea…

This study looks at whether using a mobile health app (called Penelope) is a cost-effective way to manage high blood pressure disorders during pregnancy. About 250 pregnant women at risk for conditions like preeclampsia will either use the app or track their health on paper. Rese…

Researchers are observing how two osmotic therapies, 20% mannitol and 10% hypertonic saline, affect outcomes in adults with severe subarachnoid hemorrhage, a type of bleeding around the brain. The study follows patients at multiple hospitals who receive standard care chosen by th…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This study looked at how doctors make decisions about dosing the blood thinner warfarin based on a patient's genetic background. Researchers used virtual reality to simulate patient visits with different racial and socioeconomic backgrounds. 196 internal medicine residents partic…

This study looked at data from over 1,600 African Americans aged 30-55 with severe high blood pressure. Researchers examined genetic, behavioral, and social factors to find out why this group is more affected by hypertension. No new participants were enrolled; the goal was to lea…

This Mayo Clinic study measures how well the autonomic nervous system works after spinal cord injury. Researchers will test blood pressure control and nerve responses in 69 people with and without injury. Participants also wear a smartwatch to track skin signals, heart rate, and …

This study aims to adapt a program called Staying Healthy After Childbirth (STAC) for Black women and birthing persons. Researchers will work with community organizations and advisory boards to identify barriers and facilitators to implementation. The goal is to make the program …

This study looks at how four types of central venous catheters (thin tubes placed in large veins) affect the body's clotting system. Researchers will take blood samples from 88 adults right after catheter insertion and again after flushing, to measure clotting changes. The goal i…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This study looked at how often air bubbles accidentally get into the bloodstream during bronchoscopy, a common lung procedure. About 500 adults having diagnostic or therapeutic bronchoscopy were monitored with heart and brain ultrasound to detect these bubbles. The goal was to fi…

This study measured how common pulmonary hypertension (high blood pressure in the lungs) is in adults with sickle cell anemia. Nearly 1,000 participants had heart ultrasounds and blood tests, then were contacted by phone for up to 3 years to track their health. The goal was to un…

This clinical trial is testing a medical device that has not been approved or cleared by the U.S. FDA. The trial's status is currently withheld, meaning key details about its progress and results are not publicly available. The purpose appears to be gathering information about th…

Researchers at Gazi University are studying whether Behçet's disease, which causes mouth sores and eye inflammation, is connected to gum disease. They compare 40 people with Behçet's plus gingivitis or periodontitis against 47 people with gum disease alone. The team measures infl…

This study tests two leg devices—the geko® nerve stimulator and an intermittent pneumatic compression (IPC) sleeve—to see if they increase blood flow to the brain in people who recently had an ischemic stroke. Eighty adults within 36 hours of stroke onset will use one of the devi…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study looks at whether early-onset preeclampsia (a serious pregnancy condition) affects the size of two brain areas in the fetus: the fornix and hippocampus. Researchers will use ultrasound to measure these areas in 84 pregnant women—half with early-onset preeclampsia and ha…

This study looked at whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery helps preserve diaphragm movement and reduce lung problems after surgery. Sixty adults having elective coronary artery bypass surgery were randomly assigned to receive either…

This completed study looked at how brain lesions from strokes impact cognitive control—the ability to focus, switch tasks, and make decisions. Researchers tested 184 healthy adults and stroke patients using behavioral tasks, brain scans (MRI), and EEG. The goal was to understand …

This study looked at how stimulating a nerve in the ear (tVNS) affects pupil size in stroke survivors and healthy adults. Researchers compared stimulation on one side versus both sides to see which causes a bigger pupil response. The goal is to use pupil changes as a guide for pe…

This study used a non-invasive brain stimulation technique called TMS to measure how the motor cortex responds in people who have had a stroke. Researchers compared brain excitability between 24 stroke survivors and healthy individuals. The goal was to better understand how strok…

Animal-derived heart valves replace damaged human valves, but many fail within about a decade. Researchers suspect the recipient's immune response may speed up that breakdown. This international study follows people who receive pig, cow, or horse tissue valves, using echocardiogr…

Researchers want to know whether the number of other health conditions a person has affects their quality of life after transcatheter aortic valve implantation. The study follows 150 patients aged 75 and older who receive a new aortic valve through a catheter. Before the procedur…

This study looked at 120 adults having open heart surgery to see if an AI program could correctly judge whether a pain-relieving nerve block was placed properly. Researchers compared the AI's assessment to that of a human expert and checked if better block placement led to less p…

This study examines how primary healthcare facilities in Nigeria and Sri Lanka manage high blood pressure, assessing readiness and patient outcomes. Researchers will survey facilities and patients, measure blood pressure, and interview patients, caregivers, and healthcare provide…

This study analyzed health records from over 400,000 adults who had heart surgery to see if the sedative dexmedetomidine helped prevent problems like confusion, kidney injury, or death within 30 days. Researchers compared patients who received the drug around surgery time to thos…

Thoracic aortic aneurysms affect men more often than women, yet women face higher risks of dissection and death. Researchers are collecting aortic wall tissue from 30 adults undergoing elective aneurysm surgery to measure estrogen and testosterone receptor levels. The goal is to …

People with liver cirrhosis and portal hypertension often have kidney problems because of reduced blood flow and fluid buildup. Researchers at one hospital are reviewing medical records of patients who had laparoscopic splenectomy and azygoportal disconnection, a minimally invasi…

This study followed over 1,000 people who had a heart attack and were given a quick-acting intravenous blood thinner called cangrelor during a procedure to open blocked arteries. Researchers wanted to see how often bleeding occurred when patients then switched to a different oral…

This observational study follows about 236 adults with diabetic macular edema (DME) who did not respond well to anti-VEGF injections and are now starting treatment with a dexamethasone implant (DEX-I). The implant slowly releases steroid medication into the eye. Researchers will …

This study looked at how the virus that causes COVID-19 reduces the number of infection-fighting white blood cells (lymphocytes) in the blood. Researchers collected blood samples and medical records from 240 adults with or recovering from COVID-19. The goal was to learn more abou…

This study looks at 100 people having a mechanical thrombectomy (clot removal) for a major stroke. Researchers will monitor their blood sugar continuously during the procedure and check recovery 3 months later. The goal is to see if lower blood sugar at the time of reperfusion (w…

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

This study aims to find out which patient factors influence how well a nerve block works for medication-overuse headache. Researchers will give 70 adults an ultrasound-guided injection and track their pain and medication use for one month. The goal is to better predict who will b…

This study tested two advanced rehabilitation devices—a treadmill and an overground walking trainer—to help 80 stroke patients regain their ability to walk. Participants used either the C-Mill treadmill or the Andago overground device alongside standard therapy. The goal was to s…

This study tested how well blood pressure cuffs work on the upper arm, forearm, thigh, and lower leg compared to a standard arterial line. Researchers measured 84 adults during planned surgery. The goal was to see if other sites give accurate readings when the upper arm can't be …

This study follows 140 working-age stroke survivors in France to find out what factors help or hinder their return to work. Researchers will look at medical details, personal beliefs, and job-related issues. The goal is to create better support plans for people recovering from a …

Researchers at the University of Ioannina are studying stroke patients who have both movement and vision problems. They will evaluate each patient twice, once shortly after the stroke and again weeks later, to measure how these deficits change. The goal is to see whether improvem…

This study looked at how fast treadmill walking, with or without a small electrical stimulation to the ankle muscles, helps people who have had a stroke walk better. Fifty-five participants who were at least six months past their stroke took part. The goal was to understand the b…

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …

This completed study observed over 4,500 adults with atherosclerotic cardiovascular disease who had never had a heart attack or stroke. Researchers compared those taking alirocumab (a cholesterol-lowering drug) to those not on similar therapy, using real-world data to see if the …

This trial tests whether rituximab, a drug used for ANCA-associated vasculitis, leaves patients with a weakened immune system. Researchers give pneumococcal vaccines to patients treated with rituximab, patients with the disease but not on rituximab, and healthy volunteers. They c…

This study checks if a new melt-in-the-mouth version of a migraine drug works the same as the approved tablet. It involves 36 healthy adults who will take both forms at different times. The goal is to see if the body absorbs the drug similarly, not to treat migraines.

Researchers are reviewing records from 60 people with liver cirrhosis and portal hypertension who had colon polyps removed during a colonoscopy. The goal is to see whether bleeding right after the procedure or in the following days happens more often in this group. The study also…

This study looks at how nerve reflexes in the thigh muscle affect walking in people who have had a stroke and have a stiff-knee gait. Researchers will use mild electrical stimulation to measure reflex activity while participants walk. The goal is to better understand why some str…

This study looks at two medicines, alirocumab and inclisiran, that help lower bad cholesterol (LDL-C) in people with heart disease. Researchers will use real-world data from about 124 patients to see which drug reduces cholesterol more over time. The goal is to understand how the…

Researchers are studying blood samples from people who have had a stroke to understand how blood clotting and inflammation affect recovery. They will take samples at several time points during the first week and measure markers of coagulation and inflammation. The goal is to see …

This study looks at whether a new care plan can help more people with pulmonary embolism (a blood clot in the lungs) go home from the emergency room instead of being admitted to the hospital. Researchers are working with 14 hospital ERs in Michigan to track changes in how often l…

This study checked how well 109 heart attack survivors in Nepal took their prescribed medicines and what made it hard for them. Researchers used a simple questionnaire to find out. The goal is to help doctors and patients improve medicine-taking habits and prevent future heart pr…

This study looks back at the medical records of 150 adults in Brazil diagnosed with adrenocortical carcinoma, a rare cancer of the adrenal glands. Researchers will collect details on age, gender, location, tumor stage, hormone activity, and treatments received since the year 2000…

This study examines whether the duration a patient spends on cardiopulmonary bypass (heart-lung machine) and with the aorta clamped during coronary artery bypass surgery is linked to how long they stay in the intensive care unit afterward. Researchers will review medical records …

This completed study looked at 670 African American adults to understand how genetics, lifestyle, and social factors like stress and neighborhood affect heart disease risk. Researchers collected blood samples, medical tests, and surveys to find links between ancestry-related DNA …

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study is testing whether two dietary supplements, Goodphyte IB Defense and Goodphyte Immunity, are acceptable and easy for adults with chronic diseases like IBD, hypertension, anemia, or multiple sclerosis to take. Researchers will also check if the supplements improve how w…

This study looked at over 3,600 adults having major surgery to find out which of two blood pressure drugs (norepinephrine or phenylephrine) works best to prevent complications like kidney injury or death. Patients received one of the two drugs during their operation. The goal was…

This study looked at 886 adults with suspected traumatic brain injury to better understand how the brain changes after injury. Participants had MRI scans, blood tests, and thinking tests within 48 hours of injury, with optional follow-ups up to a year. The goal was to find better…

This study is creating a large network of hospitals across Italy to improve the diagnosis and understanding of rare cerebrovascular diseases (rCVDs), such as CADASIL, Fabry disease, and Moyamoya. Researchers will collect medical information and blood samples from 500 patients to …

This study screened up to 1,000 people with severe allergic conditions—like anaphylaxis, eczema, and asthma—along with their relatives to find genetic causes. Researchers collected blood samples and medical history to link specific gene mutations to these diseases. No treatment w…

This study looked at adrenal gland tumors to understand why they form, why some release extra hormones, and why some are cancerous. Researchers studied 690 people with known or suspected adrenal tumors. Participants underwent tests like blood draws, imaging scans, and urine colle…

This study tests whether a practice resource called PReDAS helps occupational therapists who work with stroke patients feel more confident and make better decisions about driving. Eight occupational therapists on acute stroke units will receive the resource and a one-hour trainin…

This study is tracking over 1,200 adults in Kazakhstan who have high blood pressure to see how many also have signs of chronic kidney disease (CKD). Researchers will measure things like protein in urine and kidney function. The goal is to understand how often CKD goes undiagnosed…

This study is looking at whether the level of bicarbonate in the blood can help predict if a patient will die or need intensive care within 48 hours of arriving at the emergency department. Researchers will track 6,500 adults who have a blood test done as part of their regular ca…

This study looks at people with a rare inherited condition that causes extremely high cholesterol and early heart disease. Researchers used special tests to measure artery hardening before it becomes life-threatening. The goal was to gather information to help develop future trea…

This study follows thousands of Korean adults recently diagnosed with high blood pressure to see how often they develop silent organ damage, such as heart, kidney, or eye problems. Researchers will track these participants over time to identify factors that predict future heart a…

This trial is testing whether an artificial intelligence (AI) tool can accurately predict how patients with acute ischemic stroke will recover. The AI analyzes patient data in real time to forecast outcomes, such as functional disability, which is then compared with the actual ou…

This study is looking at whether peripheral artery disease (PAD) is linked to lower levels of regenerative cells in the blood. Researchers will compare blood samples from adults with PAD to those without the condition, measuring the number of certain progenitor cells and markers …

This study is testing whether an advanced ultrasound technique can identify which carotid artery plaques are dangerous (vulnerable) and likely to cause a stroke. Researchers will compare ultrasound images taken before surgery with the actual plaque tissue removed during the opera…

This study looks back at the medical records of 244 adults in France with hereditary hemorrhagic telangiectasia (HHT), also called Rendu-Osler disease, who were treated with the drug bevacizumab. The goal is to describe how the drug was used and to measure its impact on bleeding,…

This study looks at whether a protein in the blood, called soluble CD95 ligand, plays a role in ANCA-associated vasculitis, a rare group of diseases that cause inflammation of blood vessels. Researchers will collect blood and urine samples from 48 adults with the condition and tr…

This study aims to measure how common glaucoma is among people aged 50 and older in the Bangkoknoi district of Bangkok, Thailand. Researchers will examine about 1,470 volunteers using standard eye tests and advanced imaging to detect signs of glaucoma and gather normal eye measur…

This study tests whether a specialized training program called off-script diagnosis and differential diagnosis (D&D) training can improve neurology residents' ability to diagnose and manage acute ischemic stroke. The training focuses on structured analysis of stroke causes, mimic…

This study looks at people with acute brain injuries from trauma, bleeding, or aneurysm. Researchers will measure blood markers of oxidative and nitrosative stress—chemical imbalances that may harm brain cells—during the early phase after injury. They will track how these markers…

This study is testing whether measuring residual blood volume and excess fluid during hemodialysis can predict the risk of intradialytic hypotension—a sudden drop in blood pressure that can cause dizziness, nausea, or fainting. Researchers will follow 60 adults with chronic kidne…

This study is developing and testing computer models, called FORECAST-PC, to predict how well people will recover 90 days after a stroke caused by a blockage in the back of the brain. The models use information from when a patient arrives at the hospital and 24 hours later to est…

This study looks at whether levels of a protein called zonulin, found in blood and semen, differ between infertile men with and without varicocele (enlarged veins in the scrotum). Researchers will measure zonulin in 119 men and compare it with standard semen quality measures like…

This study investigates whether fibromuscular dysplasia (FMD), a condition that causes abnormal growth in artery walls, is more common in people who have had a spontaneous coronary artery dissection (SCAD) — a tear in a heart artery that can cause a heart attack, often in young w…

This study is looking at thousands of premature and low-birth-weight babies in China to understand how common retinopathy of prematurity (ROP) is today. ROP is an eye condition that can lead to blindness if not caught early. The researchers want to find out the best time and crit…

This trial tests whether an Apple Watch paired with a special app can accurately measure how far people with pulmonary arterial hypertension (PAH) can walk in six minutes — both in the clinic and at home. Researchers want to see if daily home-based walk tests can detect changes i…

This trial investigates whether a short stay at high altitude (up to 3,545 meters) is safe for people with asymptomatic moderate or severe aortic stenosis. Participants will undergo heart tests—including ECG, echocardiography, and exercise stress tests—both at low altitude and af…

This study investigates whether changes in a brain network called the default mode network (DMN) are linked to the nocebo effect — experiencing side effects from negative expectations rather than from a treatment itself. Researchers will use functional MRI to scan the brains of 4…

This study investigates whether systemic ozone therapy, used for conditions like chronic pain and osteoarthritis, damages the corneal endothelium—the eye's inner layer that keeps the cornea clear. Researchers will compare 48 patients receiving ozone therapy with 48 healthy matche…

This pilot study investigates whether certain blood markers (DIC markers and thrombin generation parameters) can predict thrombotic and hemorrhagic complications in adults on ECMO life support. Researchers will observe these markers in patients with and without complications. The…

This study tests a two-year educational program for medical and physician assistant students in rural areas. The curriculum includes classroom sessions, simulations, and community rotations to improve teamwork skills. Researchers measure changes in knowledge, attitudes, and team …

This study compares three devices that measure how well blood clots — ClotPro, ROTEM, and TEG — in patients undergoing liver surgery, neurosurgery, or cesarean section. The goal is to see how closely the results from these devices agree with each other. The findings may help doct…

This study investigates whether women who had high blood pressure during pregnancy (hypertensive disorders) show differences in brain health in midlife compared to those with normal pregnancies. Participants undergo MRI scans, blood tests, cognitive assessments, and sleep monitor…

This study compares two ways to access blocked leg arteries during a procedure to restore blood flow: through the arm (brachial artery) or the groin (femoral artery). The goal is to see which approach leads to fewer complications, such as bleeding or artery damage. Participants a…

This study investigates whether a blood test measuring how platelets clump under high shear forces can distinguish a first acute coronary syndrome from a recurrent one. Researchers will enroll 97 adults with unstable angina or early heart attack. The goal is to see if this test o…

This study looks at how often chronic kidney disease (CKD) is diagnosed in adults with high blood pressure who have early signs of kidney trouble but no prior CKD diagnosis. Researchers will review medical records and follow patients over time to see how many are formally diagnos…

This study uses French national health data to compare the risk of major heart problems—like heart attack, stroke, and death—in people with Takayasu arteritis versus similar people without the disease. It also looks at how steroid use may affect these risks. The goal is to better…

This study looks at whether cardiac autonomic neuropathy (nerve damage that affects heart rate control) changes the heart's electrical recovery time (QT interval) in people having coronary artery bypass surgery. Researchers will test nerve function before surgery and measure hear…

This study tests a tablet- and smartphone-based system designed to help ICU staff decide when and how to safely start moving patients with severe brain injuries. The system checks safety factors and suggests mobility levels, from simple stretches to walking. Researchers will see …

This study investigates how often cancer patients with COVID-19 develop dangerous blood clots (venous thromboembolism). Researchers will screen participants using ultrasound and blood tests to detect clots, whether or not they cause symptoms. The goal is to understand the true ra…

This study looks at how well existing risk models predict dangerous blood clots in people with diffuse large B-cell lymphoma (DLBCL), a common type of blood cancer. Researchers will review medical records from over 1,500 patients across multiple hospitals to see which factors are…

This study follows adults with migraine who have been prescribed rimegepant (a dissolving tablet) for acute attacks. Researchers want to see how consistently the drug provides meaningful pain relief across multiple attacks and how satisfied people are with it. The study also look…

This study investigates whether certain genetic differences make children with nephroblastoma (kidney cancer) or acute lymphoblastic leukemia (blood cancer) more likely to develop a serious liver condition called hepatic veno-occlusive disease (VOD) during chemotherapy. Researche…

This study aims to create a simple rule that emergency call handlers can use to predict whether an older adult (65+) who has fallen and hit their head is at risk of a brain bleed. Researchers will collect information from 1,100 calls to the SAMU emergency center in Toulouse, Fran…

This study examined bleeding inside the heart muscle (intramyocardial hemorrhage) in 60 patients who had a severe type of heart attack called STEMI. Researchers compared two treatment strategies: giving clot-busting drugs followed by a procedure to open the artery, versus going s…

This study looked at whether a special ultrasound check (called VExUS) can help doctors set the ideal dry weight for people on hemodialysis. The idea is that by spotting hidden fluid buildup, doctors can safely remove more fluid during dialysis to better control blood pressure. T…

This study looked at how two types of drug-coated heart stents (Orsiro and Resolute Integrity) heal inside the arteries of 50 people with stable heart disease. Researchers used a special camera to check the healing 4 months after the stents were placed. The goal was to see if one…

This study looked back at 80 French patients with calciphylaxis, a rare and often fatal condition causing painful skin ulcers, mostly in people with severe kidney disease. Researchers aimed to describe patient characteristics, how doctors diagnose and treat the condition, and wha…

This study looked at 100 people with coronary artery disease who had a heart procedure through the wrist. Half got a short sheath and half got a long sheath. The goal was to see which one leads to fewer blockages in the radial artery. Researchers used ultrasound to check for bloc…

This study looked at over 2,100 patients aged 80 and older with atrial fibrillation who were taking the blood thinner warfarin. Researchers wanted to see if having multiple other health conditions (comorbidities) made it harder to keep their blood thinning levels stable. The goal…

This study looked at why some people have trouble balancing while sitting after a stroke. Researchers used a special pressure-sensing pad and motion trackers to measure how 32 stroke survivors shifted their weight and moved their head and trunk. The goal was to better understand …

This completed study looked at 172 patients who received either a new-generation biological aortic valve or a traditional one during heart surgery. Researchers tracked survival and valve function over five years to see how the newer valves compare. The goal is to provide real-wor…

This study looks at whether a specific gene variant (ApoE4) is more common in people with certain brain MRI patterns that suggest cerebral amyloid angiopathy (CAA), a condition where proteins build up in brain blood vessels. Researchers will analyze genetic samples from 100 patie…

This study looks at whether special pacing signals from a pacemaker can improve heart function and lower blood pressure in people who need a pacemaker and also have high blood pressure. Researchers will measure heart pressure and volume using a thin catheter inside the heart. The…

This study follows 150 people with bicuspid aortic stenosis—a narrowed heart valve present from birth—who receive a transcatheter aortic valve replacement (TAVI) using the Evolut Pro or Evolut R XL device. Researchers will measure how well the valve works over time, including blo…

This study looked at how acupuncture affects the brain in people with migraine without aura. Forty adults received either real acupuncture or a sham (fake) version, and their brains were scanned with MRI before and after treatment. The goal was to see if real acupuncture causes d…

This study looked at 20 people with hard-to-treat chronic cluster headache who were already receiving occipital nerve stimulation. Researchers used brain scans to see how the stimulation changes brain activity. The goal was to understand how the treatment works, not to test if it…

This study followed 67 children with sickle cell disease who had a high risk of stroke. Researchers compared those who received a bone marrow transplant to those who got standard care, checking brain scans and thinking skills 9-10 years later. The goal was to see which approach b…

This study tested whether a new 3D ultrasound technique can predict how well patients with pulmonary hypertension will do. Researchers followed 150 patients for six months, collecting heart images and tracking deaths and hospitalizations. The goal was to see if this non-invasive …

This completed study aimed to find biological markers that could predict which migraine patients respond best to a new class of drugs called CGRP monoclonal antibodies. Researchers studied 243 adults with severe migraine, using genetic, brain imaging, and other tests. The goal is…

This study tested whether screening high-risk patients for hidden peripheral arterial disease using a simple ankle blood pressure test is cost-effective. Over 600 patients were involved, and researchers compared different screening and counseling strategies. The goal was to see i…

This study looked at whether a substance in the blood called D-dimer can help predict how well people recover after a stroke. Researchers measured D-dimer levels in 102 stroke patients who had received treatment to restore blood flow. They then compared these levels with standard…

This study tested a simple flowchart to help doctors monitor and manage heart conduction problems after transcatheter aortic valve replacement (TAVR). The goal was to see if this approach could safely reduce the need for intensive care and permanent pacemakers. Researchers follow…

This study looked at hormone levels in 26 people within 48 hours of a brain bleed from a burst aneurysm. Researchers checked cortisol and thyroid hormones and did a stimulation test to see if the pituitary gland was working properly. They then tracked complications like rebleedin…

This completed study looked at 114 adults with a type of brain bleed called subarachnoid hemorrhage from a ruptured aneurysm. Researchers measured the optic nerve sheath on early CT scans to see if the size could predict whether a patient would survive for 6 months. The goal was …

This study looked at a thin layer of proteins and sugars that lines blood vessels, called the glycocalyx, in 28 people having heart surgery. The goal was to see if changes in this layer relate to fluid leaking out of blood vessels, which can cause swelling. By measuring glycocaly…

This completed study observed 528 adults who had heart surgery and were admitted to the intensive care unit (ICU). Researchers tracked deaths, serious complications like stroke or infection, and patient details to identify risk factors. The goal is to use this information to impr…

This study looked at small molecules called microRNA in the blood and in plaques removed from the carotid arteries of 14 adults during surgery. The goal was to find new biomarkers that could help understand or track carotid artery disease. The study did not test any treatment, bu…

This study tested whether daily mood check-ins via a mobile app could help predict and prevent depression in people who recently had a stroke. Over 400 participants used the app for three months while researchers tracked their emotional symptoms. The goal was to see if this kind …

This study tested whether a special type of CT scan (dual energy CT) can help doctors better understand and predict the severity of pulmonary hypertension, a condition of high blood pressure in the lungs. Researchers looked at lung images from 60 adults already diagnosed with the…