Two salts, one goal: which brain swelling treatment works best?
NCT ID NCT05858060
First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time
Summary
Researchers are observing how two osmotic therapies, 20% mannitol and 10% hypertonic saline, affect outcomes in adults with severe subarachnoid hemorrhage, a type of bleeding around the brain. The study follows patients at multiple hospitals who receive standard care chosen by their doctors. By comparing the two groups, the team wants to learn whether hypertonic saline leads to outcomes that are no worse than mannitol.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- osmotic therapy with 20% mannitol or 10% hypertonic saline
- What this could lead to
- If the two treatments perform similarly, doctors could choose between them based on availability, cost, or patient factors without worrying about worse outcomes.
- What could go wrong
- This is an observational study, so it cannot prove cause and effect. Patients are not randomly assigned, and differences in their condition could explain any outcome differences rather than the choice of osmotic therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
124 people
The number who actually took part.
- Started
-
Jul 2023
- Finished
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Jan 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients who meet inclusion and exclusion criterias will be consecutively included. Treatment will be given according to expert consensus of local center, including neurosurgical and intensive management.
- Ages
-
18 to 85 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * ①age ≥18； ②aneurysmal subarachnoid hemorrhage; ③Hunt-Hess 3-5级 Exclusion Criteria: * previous cranial decompression surgery, cerebrospinal fluid leakage or drainage, * bilateral pupils fixed or dilated, * hemodynamic instability, * hemoglobin \< 8g / L, * serum osmolality \> 320 mOsm / L, ⑥ combined with severe organ dysfunction (cardiac, pulmonary, hepatic, renal and so on); ⑦ serious electrolyte disorders (serum sodium concentration \<125 mmol / L or \>170 mmol / L), and difficult to correct within limited time; ⑧ serious acid-base balance disorders, and difficult to correct within limited time; ⑨ use of mannitol or HSS within previous six hours; ⑩ being pregnant.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Xuanwu Hospital
Beijing, Beijing Municipality, 100053, China
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