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Zapping the vagus nerve: a new hope for Stroke-Weakened arms?

NCT ID NCT07736573

Disease control Sponsor: Beijing Chao Yang Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This study tests whether an implanted device that stimulates the vagus nerve, combined with physical therapy, can improve arm movement in people who have had a stroke. The trial includes adults with chronic upper-limb weakness who have already received the implant and completed rehabilitation. Researchers will measure changes in motor function, spasticity, and quality of life, and use brain scans to explore how the treatment affects brain activity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
an implanted device that stimulates the vagus nerve, paired with arm rehabilitation exercises
What this could lead to
If it works, this approach could offer a new way to improve arm movement and quality of life for people with long-term weakness after a stroke.
What could go wrong
This is a very small, early study with only 12 participants and no comparison group. The results may not apply to everyone, and the procedure requires surgery to implant the device.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

12 people

The number who actually took part.

Started

Jan 2025

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants with chronic stroke-related upper-limb motor dysfunction who underwent invasive vagus nerve stimulation paired with rehabilitation at Beijing Chao-Yang Hospital, Capital Medical University.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults aged 18 years or older. 2. Documented history of stroke with persistent upper-limb motor dysfunction. 3. Completion of invasive vagus nerve stimulation implantation. 4. Completion of paired upper-limb rehabilitation after stimulation. 5. Availability of clinical assessments during follow-up. Exclusion Criteria: 1. Other central nervous system disorders affecting motor function assessment. 2. Severe disturbance of consciousness or inability to complete standardized functional assessments. 3. Severe cognitive, communication, musculoskeletal, or peripheral nerve disorders interfering with upper-limb function evaluation. 4. Missing key clinical or follow-up data.

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Conditions

The condition(s) this trial relates to.

intracerebral hemorrhage stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intracerebral hemorrhage Stroke Upper extremity motor function

Contacts and locations

Locations

  • Beijing Chao-Yang Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100020, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.