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Can a stent retriever plus suction clear stroke clots faster?

NCT ID NCT04139486

Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers are testing whether adding a stent retriever device to a suction-based clot removal technique works better than suction alone for people with a specific type of stroke clot. The trial enrolls adults who have a large blood vessel blockage in the brain and a clot that shows a certain signature on MRI. The goal is to see if the combined approach clears the blockage more completely after a few attempts, which could lead to better recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a stent retriever device (Embotrap II or III) added to contact aspiration, compared with contact aspiration alone
What this could lead to
If the combined approach works better, doctors could remove stroke-causing clots faster and more completely, which may improve recovery for people with this specific clot type.
What could go wrong
This is a procedure comparison, not a new drug, and results may not apply to all stroke patients. The combined approach could take longer or cause more vessel injury, and the trial may not show a clear difference between the two methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

526 people

The number who actually took part.

Started

Nov 2019

Finished

Oct 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 and older (i.e., candidates must have had their 18th birthday) * Puncture carried out within 24 hours of first symptoms * Suitable 1.5T MRI T2 \* Gradient echo that shows a clear susceptibility vessel sign facing the occlusion * Neuroimaging demonstrates large vessel proximal occlusion (distal ICA through MCA bifurcation, M1 or proximal M2) * Patient or trustworthy person informed about the study and having orally consented to participation in the study. If the patient is unable to receive information and no trustworthy person can be contacted during screening for the study, trial inclusion will be completed as an emergency procedure by the investigator, in compliance with the French laws * With or without intravenous thrombolysis Exclusion Criteria: * Absence of large vessel occlusion on non-invasive imaging * Known or suspected pre-existing (chronic) large vessel occlusion in the symptomatic territory * Suspected pregnancy; if, in a woman is of child-bearing potential, a urine or serum beta HCG test is positive * Severe contrast medium allergy or absolute contraindication to use of iodinated products * Clinical history, past imaging or clinical judgment suggests that the intracranial occlusion is chronic * Patient has severe or fatal comorbidities that will likely prevent improvement or follow-up or that will render the procedure unlikely to benefit the patient * Acute ischemic stroke involving posterior circulation (vertebro-basilar occlusion) * Angiographic evidence of carotid dissection or tandem cervical occlusion or stenosis requiring treatment * Pregnant or breast-feeding women * Patient benefiting from a legal protection * Non-membership of a national insurance scheme * Opposition of the patient or (in case of inclusion as a matter of urgency) of the trustworthy person * Patient with modified Rankin score \> 3 before qualifying stroke

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Conditions

The condition(s) this trial relates to.

intracranial thrombosis large artery stroke thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intracranial thrombosis

Contacts and locations

Locations

  • CH Angers

    Angers, France

  • CH Bretagne Atlantique

    Vannes, France

  • CH Côte Basque

    Bayonne, 64109, France

  • CH PAU

    Pau, 64000, France

  • CHRU Brest

    Brest, France

  • CHU Amiens-Picardie

    Amiens, France

  • CHU Gui de Chauliac

    Montpellier, France

  • CHU Limoges

    Limoges, France

  • CHU Marseille - Hôpital la Timone

    Marseille, 13385, France

  • CHU Nancy

    Nancy, France

  • CHU Strasbourg

    Strasbourg, 67000, France

  • CHU de Nantes

    Nantes, France

  • Fondation Ophtalmologique Adolphe de Rothschild

    Paris, 75019, France

  • Hospices Civils Lyon

    Lyon, France

  • Hôpital Bicêtre

    Le Kremlin-Bicêtre, France

  • Hôpital Bretonneau - CHU Tours

    Tours, France

  • Hôpital FOCH

    Suresnes, France

  • Hôpital Maison Blanche - CHU Reims

    Reims, France

  • Hôpital Pellegrin - CHU Bordeaux

    Bordeaux, France

  • Hôpital Pontchaillou - CHU Rennes

    Rennes, France

  • Hôpital Roger Salengro - CHR Lille

    Lille, France

  • Hôpital Ste Anne

    Paris, France

  • La Pitié Salpétrière

    Paris, France

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