Nantes University Hospital

This study compares two different drug combinations given before a stem cell transplant to adults with acute myeloid leukemia (AML) that's in remission. Researchers want to see if one combination (clofarabine/busulfan) helps patients live longer without the cancer returning compa…

This study is testing whether giving the steroid dexamethasone early after severe burns can prevent life-threatening complications and reduce deaths. The trial will enroll 478 adults with major burns who are on breathing machines, treating them within 48 hours of injury. Research…

This study is testing whether using a remote monitoring platform at home for 30 days after colorectal surgery helps patients recover better and avoid being readmitted to the hospital. It will compare this approach to the usual discharge process. The goal is to see if the remote m…

This study compares two approaches for treating suspected pneumonia in patients on breathing machines in intensive care. It tests whether waiting for lab confirmation before starting antibiotics is as safe as starting them immediately. Researchers will enroll 686 ICU patients to …

This study aims to find out if a simpler, narrower-spectrum antibiotic (amoxicillin) works as well as a stronger, broader-spectrum one (amoxicillin/clavulanate) for treating community-acquired pneumonia in people aged 65 and older who are hospitalized outside the intensive care u…

This study is testing if a drug called belatacept can help protect the kidneys of heart transplant patients. Standard anti-rejection drugs can damage kidneys over time. Researchers want to see if using belatacept can reduce this kidney damage without increasing the risk of the bo…

This study is testing if a newer pacemaker technique is better than the standard method for patients who need a pacemaker after a TAVI heart valve procedure. The newer method aims to make the heart beat more naturally to prevent future heart failure and hospital stays. Researcher…

This study is testing a new way to prevent graft-versus-host disease (GVHD), a serious complication where donor immune cells attack the patient's body after a stem cell transplant for blood cancer. Researchers want to see if a short, intense course of two drugs (cyclophosphamide …

This study is testing whether adding a special brain training program to standard ADHD medication helps adults who also have problems with addiction. Researchers want to see if this combined approach improves daily functioning and reduces ADHD symptoms both immediately and six mo…

This study is testing whether seeing a doctor every month for the first three months helps people with new shoulder tendon pain recover faster and better than the usual approach of a single check-up at three months. Researchers want to see if this closer follow-up, where treatmen…

This early-stage study is testing a new cell therapy designed to prevent blood cancers from coming back after a stem cell transplant. Researchers will give patients specially engineered immune cells that can target and kill leftover cancer cells. A key safety feature is a built-i…

This study is testing if a personalized recovery program that starts early in the ICU and continues at home helps patients regain strength and mobility better than usual care. It will involve 830 adults who were on a ventilator and blood pressure medication in the ICU. The progra…

This study is testing whether offering routine heart ultrasound scans to nursing home residents helps catch heart problems early and reduces emergency hospital visits. Researchers will compare nursing homes that offer the scans to those that provide usual care, tracking how many …

This study aims to see if a more detailed 3D dental scan (CBCT) is better than the standard 2D dental X-ray (OPT) at finding hidden mouth infections in patients who have been hospitalized with a serious heart infection called infective endocarditis. Researchers will enroll 170 pa…

This study is testing a new type of imaging scan to see if it can better detect and monitor liver cancer (hepatocellular carcinoma). Researchers will use a special PET/CT scan with a radioactive tracer to take detailed pictures of the cancer in 40 patients. The goal is to see if …

This study is testing a new brain monitoring system designed for babies and young children in intensive care. It aims to better detect seizures and other brain problems that often go unnoticed. The system combines a simplified brain wave monitor with tools to help doctors interpr…

This study is testing a new imaging method called 'multiplexed PET' to see if it can better find and map out two types of cancer: liver cancer (HCC) and certain digestive tract tumors (GEP-NETs). Instead of needing two separate scans, this method uses two different radioactive tr…

This study aims to see if a quick finger-prick blood test is as accurate as a standard blood draw from the arm for measuring carbon monoxide levels in the blood. It will involve 120 adults who come to the emergency room with symptoms that suggest possible carbon monoxide poisonin…

This study is testing a new imaging agent called 89Zr-TLX250 to see if it can help doctors better detect and locate three specific types of cancer using a PET-CT scan. The trial will involve 60 adults with liver cancer, bile duct cancer, or certain neuroendocrine tumors. The main…

This study aims to see if a fast, bedside ultrasound performed by an emergency doctor can safely rule out a small bowel obstruction (a blockage in the intestines). If successful, this could help many patients avoid an unnecessary CT scan, which involves radiation, higher costs, a…

This study is testing a new type of PET scan to see if it can better detect and track multiple myeloma, a type of blood cancer. It will compare the new scan, which uses a tracer called [68Ga]Ga-PentixaFor, to a standard FDG-PET scan in 45 patients who are either newly diagnosed o…

This study is testing a new type of heart scan to see if it can accurately detect remaining blockages in heart arteries after someone has had a heart attack. Researchers want to know if this non-invasive scan can work as well as the current standard test, which requires inserting…

This study is testing if a smartwatch can help doctors better monitor patients for irregular heartbeats after heart surgery. It will compare the watch's continuous monitoring for a year against the standard method of occasional ECG check-ups. The goal is to see if the watch helps…

This study aims to find out if a drug called posaconazole is given at a high enough dose to prevent serious fungal infections in patients who have received a stem cell transplant. It will enroll 30 adult patients with blood cancers who are at high risk for these infections. Resea…

This study is testing a new, game-like training program designed to help children aged 3 to 6 have an MRI scan without needing sedation or general anesthesia. The program uses an immersive, underwater-themed experience to help kids practice staying still and getting used to the s…

This study aims to find the best anesthesia drug for safely placing breathing tubes in surgery patients who are at risk of stomach contents entering their lungs. Researchers will compare three different anesthesia options in over 1,200 patients to see which one most reliably allo…

This study is testing whether a single injection of botulinum toxin (Botox) into the uterine wall can reduce severe menstrual pain. It involves 222 women whose severe cramps have not improved with standard pain medications and hormonal treatments. Participants are randomly assign…

This study is testing whether a high-concentration capsaicin (the compound that makes chili peppers hot) skin patch can relieve chronic pain at the tailbone (coccygodynia). It will involve 188 adults in France who have had this pain for over 3 months and have not gotten enough re…

This study is testing whether following a specific diet low in certain food compounds (polyamines) for one week before and after major abdominal surgery can help reduce post-operative pain. Researchers want to see if this diet lowers patients' pain scores and their need for morph…

This study aims to see if training nursing home staff in oral health care improves the quality of life for elderly residents. Researchers will train caregivers and then measure changes in residents' oral health comfort and staff anxiety levels over six months. The goal is to prov…

This study follows children who were born prematurely to understand if their early body composition affects their risk of developing insulin resistance as they grow. Researchers will measure body fat, insulin resistance, kidney function, and eating habits in 114 children ages 8-1…

This study aims to understand why multiple sclerosis (MS) is mild for some people and aggressive for others. Researchers will analyze blood samples from 130 people, including those with aggressive MS, non-aggressive MS, and healthy volunteers. They will look for differences in ge…

This study aims to find the best settings for a specialized breathing machine used during a minimally invasive tumor treatment. Researchers will compare standard pressure settings to a new method that customizes the pressure based on a patient's height. The goal is to see if the …

This study aims to understand the relationship between low oxygen levels and cardiac arrest in organ donors. Researchers will observe 50 donors during a specific type of donation procedure to measure oxygen levels at the moment of arrest. The goal is to see if these oxygen levels…

This study aims to find better, non-invasive ways to measure how well the right side of the heart is pumping in people with serious heart valve disease. Researchers will compare measurements from standard heart scans to measurements taken during a special catheter procedure, whic…

This study aims to better understand acute hidrosadenitis, a chronic inflammatory skin condition. Researchers will follow 465 patients over time to identify different disease patterns and examine how lifestyle and environmental factors affect the condition. The goal is to gather …

This study is observing 403 adults with primary hyperparathyroidism to understand the long-term effects of surgery versus simple monitoring. Researchers will track patients for up to 5 years to see if surgery improves heart, bone, and kidney health, as well as quality of life. Th…

This study aims to find out which tool helps paramedics and doctors place a breathing tube correctly on the first try during emergencies outside the hospital. It will compare using a standard tube alone versus using the tube with a flexible guide called a bougie. The goal is to i…

This study aims to understand why some people with inherited high cholesterol develop hidden blockages in their heart arteries, while others do not. Researchers will observe 600 adults with this condition who have not yet had a heart attack or stroke. They will use heart scans an…

This study aims to understand if consuming oleic acid-rich sunflower oil changes how cholesterol is processed in abdominal fat tissue. Researchers will compare two types of sunflower oil in 40 women with obesity who are scheduled for weight-loss surgery. The goal is to gather kno…

This study aims to understand how patients with advanced cancer feel about the idea of reducing or stopping some of their medications, a process called 'deprescribing.' Researchers will interview and survey about 325 patients to learn their attitudes and beliefs. The goal is to g…

This study aims to understand how eating more plant-based foods during pregnancy affects both the mother's health and the baby's development. Researchers will follow 670 pregnant women in France, tracking their diets and measuring various health markers throughout pregnancy and a…

This study aims to understand why over half of babies born with serious heart defects later develop learning, thinking, or movement difficulties. Researchers will follow 450 infants from before birth to 6 months old, checking for early signs of developmental delays. They will loo…

This study aims to understand if gut bacteria are linked to where fat is stored during weight restoration in people with severe anorexia. Researchers will enroll 60 women hospitalized for treatment to collect stool and blood samples and measure body composition. The goal is to le…

This study aims to understand why some patients with chronic lymphocytic leukemia (CLL) stop responding to two common types of targeted drugs. Researchers will collect blood, bone marrow, and lymph node samples from 60 patients whose cancer has become resistant to both drug types…

This study aims to understand how a specific diabetes measurement, called the Hemoglobin Glycation Index (HGI), naturally varies over time. It will observe 750 adults with diabetes who already use continuous glucose monitors. The goal is to gather knowledge, not to test a new tre…

This study aims to understand the causes of a serious kidney disease called idiopathic nephrotic syndrome (INS). Researchers will compare samples from 30 patients with INS to patients with other kidney diseases. They will look for differences in gut bacteria and specific immune c…

This study aims to better understand the risks faced by children born with large pigmented birthmarks (congenital nevi). Researchers will follow over 800 children under age 2 for several years to learn how often these birthmarks are linked to brain development delays or skin canc…

This study aims to better understand what factors influence the course of behavioral addictions and how well patients stick with their treatment plans. Researchers at Nantes University Hospital will follow over 2,700 patients seeking help for various behavioral addictions. They w…

This international study observes how patients recover from heart or chest surgery during the COVID-19 pandemic. Researchers are comparing recovery between patients who test positive for COVID-19 around their surgery and those who test negative. The goal is to understand how COVI…

This study aims to collect long-term health information and blood/tissue samples from 730 lung cancer patients treated at Nantes University Hospital. By tracking patients from diagnosis through their entire treatment journey, researchers hope to understand how treatments work in …