Could your gut bacteria trigger kidney disease? new study investigates

NCT ID NCT04924712

Knowledge-focused Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study examines 30 adults with idiopathic nephrotic syndrome, a kidney condition that can lead to kidney failure. Researchers will analyze blood immune cells and bacteria from stool and urine samples to see if changes in gut or urinary bacteria are linked to immune system problems. The goal is to better understand what causes the disease, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to: If successful, this could point toward new ways to treat or manage idiopathic nephrotic syndrome by targeting the immune system or gut bacteria.
What could go wrong: This is a small observational study (30 people) that only measures differences, not treatments. It may not find clear links or lead to direct therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2022

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with idiopathic nephrotic syndrome (LGM or HSF type) will be considered in the main objective, patients with IgA or GEM type nephrotic syndrome or other glomerulopathy will be integrated into the control group for the secondary objectivets

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria : * Patient treated in participating centers * In nephrotic attack, defined biologically by: Proteinuria \> 3g 24h or A proteinuria/creatinuria ratio \> 3 or Defined at the discretion of the clinician Non inclusion Criteria : * Patient with a history of NIS flare-ups resistant to corticosteroid therapy * Patient treated with immunosuppressant * Patient treated with corticosteroids \> 10 mg/d * Weight \<50 kg * Pregnant woman * Patient under guardianship / curatorship

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Conditions

The condition(s) this trial relates to.

focal segmental glomerulosclerosis glomerulosclerosis idiopathic nephrotic syndrome lipoid nephrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B-lymphocytes Glomerulosclerosis Microbiota T-lymphocytes

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

2 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Could your gut bacteria trigger kidney disease? new study investigates

What the study statuses mean